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Study sets matching "nucleic acid synthesis"

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Study sets matching "nucleic acid synthesis"

9 terms
Automated Nucleic Acid Synthesis
1.
2.
3.
4.
Detritylation with trichloroacetic acid
Activation of Phosporamidite with tetrazole
Addition of Activated phosphoramidite to growing chain
Capping: acetylation of 5'OH groups unreaced
1.
Detritylation with trichloroacetic acid
2.
Activation of Phosporamidite with tetrazole
24 terms
Nucleic Acid and Protein Synthesis
DNA
gene
binary fission
budding
double helix, is an organism's genetic material
code for a certain trait, part of DNA; discrete unit of hered…
(for all prokaryotes)... 1. DNA copies itself (attach to cell me…
1. "bud" of a new yeast cell... 2. nucleus stretches with bud as…
DNA
double helix, is an organism's genetic material
gene
code for a certain trait, part of DNA; discrete unit of hered…
37 terms
Nucleic Acid and Protein Synthesis
nucleic acids
deoxyribonucleic acid
ribonucleic acid
genetic code
Large, complex organic molecules composed of C, O, H, N, P.
DNA stands for _______________.
RNA stands for _______________.
DNA carries the _______ ____.
nucleic acids
Large, complex organic molecules composed of C, O, H, N, P.
deoxyribonucleic acid
DNA stands for _______________.
53 terms
inhibitors of nucleic acid synthesis
Prontosil rubrum (red dye) was effecti…
Bacteria must synthesize its own _____…
Folic acid is composed of
How sulfonamides interferes with the s…
streptococcal infection... (prodrug couldn't be activated)
folate
Pteridine ring... p-aminobenzoic acid (PABA), and ... Glutamate
Sulfonamides structurally resembles PABA (p-amino benzoic acid)
Prontosil rubrum (red dye) was effecti…
streptococcal infection... (prodrug couldn't be activated)
Bacteria must synthesize its own _____…
folate
35 terms
Nucleic Acid Synthesis
What are the three purine bases?
Name the corresponding nucleosides to…
Name the corresponding nucleotides to…
What is the form of the sugar in nucle…
Adenine, guanine, and xanthine
Adenosine, guanosine, inosine
adenylate, guanylate, IMP
Ribose
What are the three purine bases?
Adenine, guanine, and xanthine
Name the corresponding nucleosides to…
Adenosine, guanosine, inosine
30 terms
Nucleic Acid Synthesis inhibtors
what are the 4 classes of nucleic acid…
what are the 2 inhibitors of folate sy…
what are the sulfa antimicrobials comm…
what is the prodrug that developed the…
1. inhibitors of folate synthesis... 2. fluoroquinolones... 3. Misc…
Sulfa antimicrobials and Trimethoprim
sulfonamides... (sulfanilamide)
protonsil
what are the 4 classes of nucleic acid…
1. inhibitors of folate synthesis... 2. fluoroquinolones... 3. Misc…
what are the 2 inhibitors of folate sy…
Sulfa antimicrobials and Trimethoprim
39 terms
Nucleic Acid Synthesis Inhibitors
Objectives slide
Target of Nucleic Acid Synthesis Inhib…
What is folic acid?
Introduction
DNA
Humans need folic acid in our DIET... Important in the formatio…
Objectives slide
Target of Nucleic Acid Synthesis Inhib…
DNA
81 terms
Nucleic Acid and Protein Synthesis
Transcription
Transcribed into RNA
Translation
Contains adenine-uracil pairs
Process by which the genetic code of DNA is copied into a str…
An expressed gene is one that does what?
Process of decoding MRNA into a polypeptide chain is know as…
Example that doesn't describe the structure of DNA
Transcription
Process by which the genetic code of DNA is copied into a str…
Transcribed into RNA
An expressed gene is one that does what?
61 terms
Nucleic acids/ protein synthesis
Nucleic acids
DNA
Nucleotide
Nitrogenous bases
- DNA ... - RNA
- double stranded helix... - never leaves the nucleus... - Watson,…
- building blocks of nucleic acids ... . Phosphate group... . Sugar…
Adenine... Thymine... Cytosine... Guanine
Nucleic acids
- DNA ... - RNA
DNA
- double stranded helix... - never leaves the nucleus... - Watson,…
5 terms
inhibition of nucleic acid synthesis
what do Quinolones and Fluoroquinolone…
antiviral drugs
what do Nucleotide or nucleoside analo…
what does Rifampin do?
Act against prokaryotic DNA gyrase that coils and uncoiling r…
Acyclovir, Nucleotide analogs, Ribiviran
-Interfere with function of nucleic acids... -Distort shapes of…
-Inhibitors of RNA polymerase during transcription... -binds to…
what do Quinolones and Fluoroquinolone…
Act against prokaryotic DNA gyrase that coils and uncoiling r…
antiviral drugs
Acyclovir, Nucleotide analogs, Ribiviran
45 terms
Nucleic Acids and Protein Synthesis
DNA
RNA
Nucleotides
Bases
deoxyribonucleic acid
ribonucleic acid
DNA and RNA are unbranched polymers of repeating monomer unit…
the nitrogen-containing bases in nucleic acids are derivative…
DNA
deoxyribonucleic acid
RNA
ribonucleic acid
24 terms
Nucleic Acids and Protein Synthesis
Function of DNA
Structure of DNA
Structure of RNA
Goal of Transcription
to store and transmit genetic information that controls how a…
long chain of nucleotides (made of 5 carbon sugar, phosphate…
long chain of nucleotides (made of 5 carbon sugar, phosphate…
DNA (gene) is copied into a complementary sequence of RNA
Function of DNA
to store and transmit genetic information that controls how a…
Structure of DNA
long chain of nucleotides (made of 5 carbon sugar, phosphate…
10 terms
Nucleic Acid Synthesis Inhibitors
Fluoroquinolones
Antifolates
Sulfonamides
Trimethoprim
Inhibit the action of Topoisomerase II in G- bacteria ... Topois…
Sulfonamides, Folate reductase inhibitors (trimethoprim)
Acts by inhibiting dihydropteroate synthetase... Absorbed and e…
Inhibitor of bacterial dihydrofolate reductase ... It s used in…
Fluoroquinolones
Inhibit the action of Topoisomerase II in G- bacteria ... Topois…
Antifolates
Sulfonamides, Folate reductase inhibitors (trimethoprim)
41 terms
Nucleic acid synthesis inhibitors
Nifurantoin
Furazidin
Nitrofuroxazide
Nifurzid
Nitrofuran
Nitrofuran
Nitrofuran
Nitrofuran
Nifurantoin
Nitrofuran
Furazidin
Nitrofuran
12 terms
Nucleic Acid Synthesis Inhibitors
Fluoroquinolones
fluoroquinolone pharma
cipro
cipro use
ciprofloxacin (older)... levofloxacin, moxifloxacin (advanced or…
well absorbed in small intestine. but like tetracyclines: bin…
greatest ability against aerobic gram- bacilli.
UTI, osteomyelitis, chronic prostatitis/epididymitis, infecti…
Fluoroquinolones
ciprofloxacin (older)... levofloxacin, moxifloxacin (advanced or…
fluoroquinolone pharma
well absorbed in small intestine. but like tetracyclines: bin…
111 terms
Nucleic Acid & Protein Synthesis
DNA
Substance of Inheritance
Hereditary Information
Biochemical, Anatomical, Physiological…
In 1953, James Watson and Francis Crick... introduced an elegant…
DNA, the _____, is the most celebrated molecule of our time.
Encoded in DNA and reproduced in all cells of the body.
This DNA program directs the development of four different tr…
DNA
In 1953, James Watson and Francis Crick... introduced an elegant…
Substance of Inheritance
DNA, the _____, is the most celebrated molecule of our time.
35 terms
Nucleic Acid & Protein Synthesis
Nucleotide Parts... (DNA)
DNA(Name)
# of Strands... (DNA)
Nitrogen Bases... (DNA)
5 carbon Sugar ... A phosphate group... Nitrogenous base
Deoxribonucleic Acid
(2)double helix
Adenine... Guanine... Cytosine... Thymine
Nucleotide Parts... (DNA)
5 carbon Sugar ... A phosphate group... Nitrogenous base
DNA(Name)
Deoxribonucleic Acid
31 terms
Nucleic Acid Synthesis Inhibitors
Topoisomerase Inhibitors
Quinolones/Fluoroquinolones (FQs) MOA
FQs Spectrum
FQ 1st Generation EXAMPLE
Quinolones... Fluoroquinolones (FQs)
MOA - inhibit DNA replication by interfering with the action…
Broad G- coverage... Newer, "respiratory" FQs with improved G+…
Nalidixic acid - not used now
Topoisomerase Inhibitors
Quinolones... Fluoroquinolones (FQs)
Quinolones/Fluoroquinolones (FQs) MOA
MOA - inhibit DNA replication by interfering with the action…
9 terms
Nucleic Acid Synthesis Inhibitors
Fluoroquinolones - MOA
Fluoroquinolones - MOR
Fluoroquinolones - Uses
Sulfonamides - MOA
Inhibit DNA gyrase (in G- bacteria) and topoisomerase IV (in…
Active efflux of drug, modification of drug by bacterial enzy…
Ciprofloxacin - G- bacteria (including Pseudomonas and ESBL p…
PABA analogs; competitively inhibit dyhydropteroate synthase…
Fluoroquinolones - MOA
Inhibit DNA gyrase (in G- bacteria) and topoisomerase IV (in…
Fluoroquinolones - MOR
Active efflux of drug, modification of drug by bacterial enzy…
28 terms
Nucleic Acids and Protein Synthesis
The process of DNA copying itself
Ribosomes are made up of two subunits:…
Nitrogenous base that bonds with guanine
Nucleic acid that stores the genetic c…
replication
rRNA
cytosine
DNA
The process of DNA copying itself
replication
Ribosomes are made up of two subunits:…
rRNA
21 terms
Nucleic acids and protein synthesis
Nucleotide
Deoxyribose and ribose - differences
Purines
Pyrimidines
Monomer of nucleic acids, consisting of:... 5 carbon sugar (ribo…
Ribose (RNA) - OH group on carbon 2'... Deoxyribose (DNA) - one…
Double ring structure... Adenine and guanine
Single ring structure... Cytosine, thymine and uracil
Nucleotide
Monomer of nucleic acids, consisting of:... 5 carbon sugar (ribo…
Deoxyribose and ribose - differences
Ribose (RNA) - OH group on carbon 2'... Deoxyribose (DNA) - one…
23 terms
Nucleic acid synthesis inhibitors
Fluoroquinolone
Fluoroquinolone
Fluoroquinolone
Nitroimidazoles
Synthetic agents that inhibit DNA gyrase
Antibacterial
Ciprofloxacin
anaerobic conditions reduce the molecule which damages DNA an…
Fluoroquinolone
Synthetic agents that inhibit DNA gyrase
Fluoroquinolone
Antibacterial
10 terms
Nucleic Acids and Protein Synthesis
Structure of DNA
Purine Bases
Pyrimidine Bases
ATP Structure
- Phosphate group... - Pentose Sugar... - Nitrogenous base
- 2 rings... - Adenine... - Guanine
- 1 ring... - Thymine... - Uracil... - Cytosine
- Ribose sugar... - 3 Phosphate Groups
Structure of DNA
- Phosphate group... - Pentose Sugar... - Nitrogenous base
Purine Bases
- 2 rings... - Adenine... - Guanine
28 terms
Nucleic Acid Synthesis Inhibitors
Naldixic Acid
Norfloxacin
Ofloxacin
Topoisomerase I
1st generation quinolone... Urinary infxn (mostly G-, minor effe…
2nd generation quinolone (similar to Cipro)... - Treat UTIs... - Ac…
2nd generation quinolone
Cuts ONE strand of DNA, opens up negative supercoil in bacter…
Naldixic Acid
1st generation quinolone... Urinary infxn (mostly G-, minor effe…
Norfloxacin
2nd generation quinolone (similar to Cipro)... - Treat UTIs... - Ac…
34 terms
Nucleic Acid Synthesis Inhibitors
Agents
Cellular targets
DNA gyrase (Topoisomerase II) function
Topoisomerase IV function
Rifamycin... Fidaxomycin... Fluoroquinolone... Metronidazole
DNA gyrase (Topoisomerase II)... Topoisomerase IV
Forms (-) supercoil by cutting, passing through, and reanneal…
Unknots by cutting and reannealing
Agents
Rifamycin... Fidaxomycin... Fluoroquinolone... Metronidazole
Cellular targets
DNA gyrase (Topoisomerase II)... Topoisomerase IV
34 terms
Nucleic Acids and Protein Synthesis
Nucleic Acids
Bases
Pentose Sugars
Nucleoside
-DNA and RNA are comprised of monomers called nucleotides... -co…
-derivatives of the heterocyclic amines pyrimidine or purine…
(5C)... -Ribose in RNA... -Deoxyribose in DNA (no O atom on C2)... -ha…
-Base+Sugar, no phosphate ... -base linked to by a glycosidic bo…
Nucleic Acids
-DNA and RNA are comprised of monomers called nucleotides... -co…
Bases
-derivatives of the heterocyclic amines pyrimidine or purine…
11 terms
Nucleic acid synthesis inhibitors
Nucleic acid synthesis inhibitors like…
Ansamacrolides cannot have
Side effects of ansamacroldies
Resistance to ansamacrolides
inhibit DDRP. Looks like that big mess of a molecule with HIG…
double bonds shifted, need the lactic and double bonds on the…
hepatotox... CYP inducer
Mutation of rpo B gene decreases binding to DDRP
Nucleic acid synthesis inhibitors like…
inhibit DDRP. Looks like that big mess of a molecule with HIG…
Ansamacrolides cannot have
double bonds shifted, need the lactic and double bonds on the…
22 terms
Nucleic Acid Synthesis Inhibitors
Nucleic Acid Synthesis Inhibitors
Fluoroquinolones Mechanism
Topoisomerase II
Topoisomerase IV
Target enzymes required for nucleic acid synthesis... Quinolone…
ENTER HOST CELLS (active against intracellular pathogens),…
DNA Gyrase... Relieves tension in ds DNA, relaxes supercoils
Separates & unlinks DNA for the next DNA replication
Nucleic Acid Synthesis Inhibitors
Target enzymes required for nucleic acid synthesis... Quinolone…
Fluoroquinolones Mechanism
ENTER HOST CELLS (active against intracellular pathogens),…
19 terms
Nucleic acid synthesis inhibitors
Nalidixic acid, ciprofloxacin, levoflo…
MOA: Inhibition of DNA topoisomerases
MOA: competitive inhibition of *dihydr…
MOA: inhibition of folate metabolism a…
Quinolones / fluoroquinolones
Quinolones / fluoroquinolones
Sulfonamides
Trimethoprim-sulfamethoxazole (cotrimoxazole)... Trimethoprim... Su…
Nalidixic acid, ciprofloxacin, levoflo…
Quinolones / fluoroquinolones
MOA: Inhibition of DNA topoisomerases
Quinolones / fluoroquinolones
9 terms
Nucleic Acid Synthesis Inhibitors
fluoroquinolones
fluoroquinolone moa
ciprofloxacin use
fluoroquinolone pharma
ciprofloxacin, levofloxacin, moxifloxacin
inhibits DNA gyrase and type IV topoisomerase
aerobic, gram-. UTI (E. coli), Osteomyelitis (P. aeruginosa),…
oral, IV, topical. absorbed in SI. like tetracyclines: bind d…
fluoroquinolones
ciprofloxacin, levofloxacin, moxifloxacin
fluoroquinolone moa
inhibits DNA gyrase and type IV topoisomerase
11 terms
Nucleic acid synthesis inhibitors
Topoisomerase inhibitors
FQ's
Second generation FQ
3rd generation FQ
Quinolones/Fluoroquinolones (FQs)... They inhibit DNA replicati…
Bactericidal and CONCENTRATION DEPENDENT killing ... Has broad…
Ciprofloxacin - UTI, GI and DOC for anthrax!
Levofloxacin - UTI, GI, URI and skin
Topoisomerase inhibitors
Quinolones/Fluoroquinolones (FQs)... They inhibit DNA replicati…
FQ's
Bactericidal and CONCENTRATION DEPENDENT killing ... Has broad…
6 terms
Inhibitors of nucleic acid synthesis
Nalidixic acid- bacteriocidal
Nalidixic acid- mechanism of action
Ciproflaxacin- bacteriacidal
Ciproflaxacin-mechanism of action
Nalidixic acid is a quinolone antibacterial agent,it has mark…
Evidence exists for Nalidixic acid that its active metabolite…
Ciprofloxacin is a broad-spectrum antiinfective agent of the…
The mechanism of action of ciprofloxacin results from inhibit…
Nalidixic acid- bacteriocidal
Nalidixic acid is a quinolone antibacterial agent,it has mark…
Nalidixic acid- mechanism of action
Evidence exists for Nalidixic acid that its active metabolite…
59 terms
Nucleic acid and protein synthesis
Types of nucleic acid
DNA
RNA
Nucleic acid is a
DNA ... RNA
Deoxyribonucleic acid
Ribonucleic acid
Organic molecule that contain all of the essential elements (…
Types of nucleic acid
DNA ... RNA
DNA
Deoxyribonucleic acid
21 terms
Nucleic Acid and Protein Synthesis
DNA
Nucleotides
3 parts of a nucleotide
4 N bases of DNA
Deoxyribonucleic acid; Made of nucleotides
Building blocks of DNA
5 Carbon Sugar... Phosphate Group... Nitrogen Base
Adenine... Thymine... Guanine... Cytosine
DNA
Deoxyribonucleic acid; Made of nucleotides
Nucleotides
Building blocks of DNA
11 terms
+nucleic acid and protein synthesis
chromosomes are made of
a gene Is a
dna determines the
the chromosomes of an eye cell compare…
dna which wraps around protein to condense
segment of dna with the instructions to build one protein
proteins made by an organism which then determines its traits
identical
chromosomes are made of
dna which wraps around protein to condense
a gene Is a
segment of dna with the instructions to build one protein
54 terms
Inhibitors of nucleic acid synthesis
Can humans synthesize folate?
Can bacteria synthesize folate?
Where do antibiotics compete with...
Folate is utilized for DNA synthesis b…
No... - Must be provided in the diet
Yes... - From precursors like p-aminobenzoic acid (PABA)
PABA for active site on enzyme (dihydropteroate synthase)
Humans & Bacteria
Can humans synthesize folate?
No... - Must be provided in the diet
Can bacteria synthesize folate?
Yes... - From precursors like p-aminobenzoic acid (PABA)
19 terms
Nucleic acid synthesis inhibitors
what are the abx classes of nucleic ac…
what is the MOA for nucleic acid synth…
fluoroquinolones inhibit what two enzy…
Cipro... infection
fluoroquinolones... metronidazole
prevent DNA replication by inhibiting key enzymes involved in…
DNA gyrase... type IV topoisomerase
UTI's... osteomyelitis... chronic prostatitis/epididymitis... infectio…
what are the abx classes of nucleic ac…
fluoroquinolones... metronidazole
what is the MOA for nucleic acid synth…
prevent DNA replication by inhibiting key enzymes involved in…
15 terms
NUCLEIC ACID SYNTHESIS
Helicases
SSB proteins
Dna polymerase 1
Dna polymerase 3
Unwinds double helix with the help of ATP
Hold the two strands apart
Dna repair
Dna replication
Helicases
Unwinds double helix with the help of ATP
SSB proteins
Hold the two strands apart
39 terms
Nucleic Acid Synthesis and Metabolism
DNA
RNA
Nucleotides
Nucelosides
Missing an O on 2' C
O on all C
Nitrogenous base, sugar, and phosphate group
Nitrogenous base attached to a 5 C sugar (sugar has no phosph…
DNA
Missing an O on 2' C
RNA
O on all C
16 terms
Nucleic Acid Synthesis Inhibitors
List the 5 main categories of Nucleic…
List the 4 generations of Fluoroquinol…
What is the mechanism of action for qu…
What is the mechanism of action for Qu…
Fluoroquinolones ... Polymyxin B ... Metronidazole... Nitrofurantoin... D…
1) Nalidixic acid - not used much anymore ... 2) CON ... Ciprofloxa…
inhibition of topoisomerase 4 enzyme
inhibition of DNA gyrase enzyme
List the 5 main categories of Nucleic…
Fluoroquinolones ... Polymyxin B ... Metronidazole... Nitrofurantoin... D…
List the 4 generations of Fluoroquinol…
1) Nalidixic acid - not used much anymore ... 2) CON ... Ciprofloxa…
35 terms
Nucleic Acid Synthesis
What are the three purine bases?
Name the corresponding nucleosides to…
Name the corresponding nucleotides to…
What is the form of the sugar in nucle…
Adenine, guanine, and xanthine
Adenosine, guanosine, inosine
adenylate, guanylate, IMP
Ribose
What are the three purine bases?
Adenine, guanine, and xanthine
Name the corresponding nucleosides to…
Adenosine, guanosine, inosine
51 terms
Nucleic Acid and Protein Synthesis
Anticodon
Base pairing
Chromosome
Codon
a sequence of three ribonucleotides on tRNA that recognizes t…
the paring of bases connected by hydrogen bonding (G-C and A-…
a complex of proteins and DNA; visible during cell division.
a sequence of three ribonucleotides in the messenger RNA chai…
Anticodon
a sequence of three ribonucleotides on tRNA that recognizes t…
Base pairing
the paring of bases connected by hydrogen bonding (G-C and A-…
101 terms
Nucleic Acid Synthesis Inhibitors
quinolones, metronidazole, rifampin
inhibit enzymes required for DNA repli…
dna gyrase
topoisomerase 4
nucleic acid synthesis inhibitors
quinolones mechanism of action
where do quinolones bind to in gram negative organisms
where do quinolones bind to in gram positive organisms
quinolones, metronidazole, rifampin
nucleic acid synthesis inhibitors
inhibit enzymes required for DNA repli…
quinolones mechanism of action
66 terms
Nucleic Acids and Protein Synthesis
Friedrich Miescher
Frederick Griffith
Transformation
Oswald Avery
1869 Germany was studying chemistry of cells (white blood cel…
1920's trying to find a cure for pneumonia, a bacteria called…
incorporation of a piece of foreign DNA into the genome of a…
did a follow up to Griffith's experiment and concluded it was…
Friedrich Miescher
1869 Germany was studying chemistry of cells (white blood cel…
Frederick Griffith
1920's trying to find a cure for pneumonia, a bacteria called…
9 terms
Inhibitors of Nucleic Acid Synthesis
Sulfamethoxazole
Sulfadiazine
Sulfasalazine
Sulfacetamide
Sulfonamides... MOA: stops dihydropteroate synthase (PABA). com…
Sulfonamides... MOA: stops dihydropteroate synthase (PABA). com…
Sulfonamides... MOA: stops dihydropteroate synthase (PABA). com…
Sulfonamides... MOA: stops dihydropteroate synthase (PABA). com…
Sulfamethoxazole
Sulfonamides... MOA: stops dihydropteroate synthase (PABA). com…
Sulfadiazine
Sulfonamides... MOA: stops dihydropteroate synthase (PABA). com…
22 terms
Nucleic Acid Synthesis Inhibitors
What are the 2 main subgroups that fal…
Fluoroquinolones are derived from ____…
Fluoroquinolones inhibit the DNA gyras…
Fluouroquinolones are bacteri_____.
Fluoroquinolones... Rifamycins
Urinary naldixic acid
topoisomerase destroys the human cell's DNA.
bactericidal
What are the 2 main subgroups that fal…
Fluoroquinolones... Rifamycins
Fluoroquinolones are derived from ____…
Urinary naldixic acid
44 terms
nucleic acids and protein synthesis
what is the monomer for nucleic acids?
what is the segment of DNA where mRNA…
what is transcription?
what is translation?
nucleotides
promoter
the copying of one strand of DNA into mRNA so that it can lea…
a ribosome changing the mRNA into an amino acid sequence and…
what is the monomer for nucleic acids?
nucleotides
what is the segment of DNA where mRNA…
promoter
51 terms
Nucleic Acid and Protein Synthesis
Anticodon
Base pairing
Chromosome
Codon
a sequence of three ribonucleotides on tRNA that recognizes t…
the paring of bases connected by hydrogen bonding (G-C and A-…
a complex of proteins and DNA; visible during cell division.
a sequence of three ribonucleotides in the messenger RNA chai…
Anticodon
a sequence of three ribonucleotides on tRNA that recognizes t…
Base pairing
the paring of bases connected by hydrogen bonding (G-C and A-…
inhibitors of nucleic acid synthesis
Rifampin
Fidoxamin
Fluoroquinolones
Sulfonamides
RNA polymerase inhibitor... Induces metabolism of other drugs... Us…
RNA polymerase inhibitor... narrow spectrum... C. diff
Ciprofloxacin, levofloxacin, moxifloxacin... Inhibit DNA replica…
Indirect inhibition of DNA synthesis... Competitive inhibitor in…
Rifampin
RNA polymerase inhibitor... Induces metabolism of other drugs... Us…
Fidoxamin
RNA polymerase inhibitor... narrow spectrum... C. diff
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