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Study sets matching "parkinson's disease"

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Study sets matching "parkinson's disease"

70 terms
Parkinson's Disease
Name 6 classes of drugs you could give…
Parkinson's Disease is the ______ most…
The prevalence of Parkinson's Disease…
Risk factors for developing Parkinson'…
Levadopa/Carbidopa... COMT inhbitiorsDopamine agonists... MAO-B inh…
2nd
increasing age... ... 1/100,000 in 30-39... 93/100,000 in 70-79
males... hispanics
Name 6 classes of drugs you could give…
Levadopa/Carbidopa... COMT inhbitiorsDopamine agonists... MAO-B inh…
Parkinson's Disease is the ______ most…
2nd
53 terms
Parkinson's Disease (and Parkinsonism)
Diagnostic Criteria for Parkinsonism
Parkinsonian Syndromes- Idiopathic
Parkinsonian Syndromes- symptomatic
Secondary motor symptoms
1. Tremor at rest... 2. Bradykinesia... 3. Rigidity... 4. Loss of post…
Parkinsons Disease, Atypical Parkinsonism
Post-infectious ('Awakenings')... Toxic (MPTP, Manganese, CO)... Po…
Freezing... Micrographia... Masked faces... Unwanted accelerations... Rap…
Diagnostic Criteria for Parkinsonism
1. Tremor at rest... 2. Bradykinesia... 3. Rigidity... 4. Loss of post…
Parkinsonian Syndromes- Idiopathic
Parkinsons Disease, Atypical Parkinsonism
69 terms
Therapy- Parkinson's Disease
In which age group is Parkinson's Dise…
Which environmental factors increase t…
Which environmental factors decrease t…
What are the "key findings" in Idiopat…
>85 years old
MPTP (in animal models), pesticide/herbicide exposure, well w…
Cigarettes and caffeine
Loss of DA producing neurons in substantia nigra pars compact…
In which age group is Parkinson's Dise…
>85 years old
Which environmental factors increase t…
MPTP (in animal models), pesticide/herbicide exposure, well w…
67 terms
Parkinson's Disease and Parkinsonism
Describe the relationship between age…
Parkinson's is a neurochemical disorde…
What affect does PD have on the cholin…
Why is recovery difficult once symptom…
-older populations are at higher risk of PD... -only a 10% onset…
-substantia nigra loses ability to produce dopamine
-leads to disinhibition of the cholinergic system--causing ac…
there is an 80% loss of dopamine production before symptoms a…
Describe the relationship between age…
-older populations are at higher risk of PD... -only a 10% onset…
Parkinson's is a neurochemical disorde…
-substantia nigra loses ability to produce dopamine
17 terms
Parkinson's Disease and Parkinsonism
What types of drugs can cause Parkison…
What two structural changes occur in PD?
What are two unique features (symptom…
What is a pathognomonic for PD?
Drugs that reduce the amount of available dopamine such as ne…
1. Lose melanin producing cells in substantia nigra... 2. Accumu…
- Is an asymmetric disorder with symptoms usually presenting…
Resting tremor that at times affects solely the thumb.
What types of drugs can cause Parkison…
Drugs that reduce the amount of available dopamine such as ne…
What two structural changes occur in PD?
1. Lose melanin producing cells in substantia nigra... 2. Accumu…
13 terms
Parkinson's Disease Introduction
Parkinson's Disease
Parkinson's Disease Description
Tremor
Bradykinesia
This disease is ... -The 2nd most common neuro-degenerative dis…
A neurodegenrative disorder characterized by movement dysfunc…
A symptom of Parkinson's Disease, and is normally an early sy…
A symptom of Parkinson's Disease which involves the slowness…
Parkinson's Disease
This disease is ... -The 2nd most common neuro-degenerative dis…
Parkinson's Disease Description
A neurodegenrative disorder characterized by movement dysfunc…
27 terms
Parkinson's Disease
What are the three major dopaminergic…
What is the Dopamine tract that when a…
What are the enzymes involved in the b…
Which of these dopamine receptor famil…
Note:... Substantial nigra to the striatum (Nigrostriatal) cont…
a.
MOA and COMT
a. only D1 and D5
What are the three major dopaminergic…
Note:... Substantial nigra to the striatum (Nigrostriatal) cont…
What is the Dopamine tract that when a…
a.
32 terms
Parkinson's Disease
Pathophysiology of Parkinson's DZ
Symptoms of Parkinson's
Off episode
Sinemet
Substantia Nigra die off (neurone in substantia nigra die off…
A resting tremor, so called because it's a shaking that typic…
Period of time with muscle stiffness, slow movements, difficu…
Carbidopa + Levodopa... Darkens urine, body fluids (saliva, swe…
Pathophysiology of Parkinson's DZ
Substantia Nigra die off (neurone in substantia nigra die off…
Symptoms of Parkinson's
A resting tremor, so called because it's a shaking that typic…
139 terms
29. Parkinson's Disease
what is the mean age of onset of PD?
What is the main pathological feature…
are men or women more likely to get PD?
what are the key motor symptoms of PD?
65 years
Degeneration of neuromelanin containing neurones in the pars…
men are 1.5x more likely to get PD
- shaking ... - stiffness ... - slowness ... - poverty of movement
what is the mean age of onset of PD?
65 years
What is the main pathological feature…
Degeneration of neuromelanin containing neurones in the pars…
101 terms
Parkinson's Disease OS
Early symptoms of Parkinson's Disease…
Other nonmotor symptoms include
The term parkinsonism is a generic ter…
Secondary parkinsonism results from a…
loss of sense of smell... constipation... rapid eye movement ... sleep…
altered bladder function... excessive saliva... integumentary chang…
basal ganglia (BG)
viruses... toxins... drugs... tumors
Early symptoms of Parkinson's Disease…
loss of sense of smell... constipation... rapid eye movement ... sleep…
Other nonmotor symptoms include
altered bladder function... excessive saliva... integumentary chang…
13 terms
Parkinson's Disease Introduction
Parkinson's Disease
Parkinson's Disease Description
Tremor
Bradykinesia
This disease is ... -The 2nd most common neuro-degenerative dis…
A neurodegenrative disorder characterized by movement dysfunc…
A symptom of Parkinson's Disease, and is normally an early sy…
A symptom of Parkinson's Disease which involves the slowness…
Parkinson's Disease
This disease is ... -The 2nd most common neuro-degenerative dis…
Parkinson's Disease Description
A neurodegenrative disorder characterized by movement dysfunc…
8 terms
Parkinson's Disease
Parkinson's Disease impairment of
Etiology of Parkinson
Qi and Blood Deficiency... tonify qi, no…
Qi and Blood Deficiency Rx:... tonify qi…
movement, rigidity and tremor, which results from damage to b…
Overwork and excessive sexual activity... Diet... Emotional Stress
long standing pronounced tremor of limbs, sallow complexion,…
Ren Shen Yang Rong Tang... Gb 20, Li 11, Xiao chanxue, Sj 5, Gb…
Parkinson's Disease impairment of
movement, rigidity and tremor, which results from damage to b…
Etiology of Parkinson
Overwork and excessive sexual activity... Diet... Emotional Stress
23 terms
Parkinson's Disease
Parkinson's disease affects
Dopamine content of the substantia nigra
MPTP
A molecular aspect of PD involves
the basal ganglia
less than 10% of normal in PD patient brains postmortem
is a compound used experimentally to study Parkinson's diseas…
Lewy bodies in various parts of the brain
Parkinson's disease affects
the basal ganglia
Dopamine content of the substantia nigra
less than 10% of normal in PD patient brains postmortem
67 terms
Parkinson's Disease
What is Parkinson's Disease?
What does Parkinson's Disease result f…
What part of the brain is responsible…
What do the fibers in the substantia n…
A chronic, progressive neurological disorder
degeneration of dopaminergic neurons in a region of the brain…
Substantial nigra
connect to both sides of the brain and control movement and c…
What is Parkinson's Disease?
A chronic, progressive neurological disorder
What does Parkinson's Disease result f…
degeneration of dopaminergic neurons in a region of the brain…
44 terms
Parkinson's Disease
What neurotransmitter is lost in Parki…
Where is dopamine made? (mainly)
Where does the substantia nigra projec…
What collections of protein are found…
Dopamine
Substantia nigra
Striatum... (nigrostriatal pathway)
Lewy bodies (seen in post mortem)
What neurotransmitter is lost in Parki…
Dopamine
Where is dopamine made? (mainly)
Substantia nigra
58 terms
Drugs for Parkinson's Disease
Neurodegenerative... disorder
Dyskinesia
Tremor
Akinesia
neurodegenerative disease is an umbrella term for a range of…
abnormality or impairment of voluntary movement.
A tremor is an involuntary, somewhat rhythmic, muscle contrac…
loss or impairment of the power of voluntary movement.
Neurodegenerative... disorder
neurodegenerative disease is an umbrella term for a range of…
Dyskinesia
abnormality or impairment of voluntary movement.
26 terms
Parkinson's Disease
Most effective medication for the trea…
First-choice therapy for treatment of…
Medications used for the treatment of…
Anticholinergic side effects
Carbidopa-Levodopa
Rasagiline - Role in therapy
Anitcholinergic agents - Role in therapy
Dry eyes and mouth, constipation, decreased sweating (increas…
Most effective medication for the trea…
Carbidopa-Levodopa
First-choice therapy for treatment of…
Rasagiline - Role in therapy
11 terms
Parkinson's Disease
What is PD?
What are the 4 primary manifestations…
Why do these manifestations occur?
What is the focus of treatment for PD?
a progressively debilitating disease that grossly affects mot…
Bradykinesia ---> slow movement... Tremors... Muscle rigidity ... Post…
acetylcholine overstimulates the basal ganglia... depletion of d…
Increasing amount of dopamine... Decreasing amount of acetylchol…
What is PD?
a progressively debilitating disease that grossly affects mot…
What are the 4 primary manifestations…
Bradykinesia ---> slow movement... Tremors... Muscle rigidity ... Post…
12 terms
Parkinson's Disease
Non Commutable
Neuroimaging
Substantia Nigra
Olfactory System
Commutable or Non Commutable?
Diagnosis Method with SPECT and PET scans
part of brain parkinson's disease mainly affects
system used by body to detect smell
Non Commutable
Commutable or Non Commutable?
Neuroimaging
Diagnosis Method with SPECT and PET scans
40 terms
Parkinson's Disease
Parkinsonism
a hand tremor in repose commonly seen…
a symmetrical essential tremor that mo…
a tremor that is maximal in repose and…
Rest Tremor
Postural Tremor
Resting Tremor
Parkinsonism
a hand tremor in repose commonly seen…
Rest Tremor
55 terms
PH: Parkinson's Disease
PD
Major features for PD
Features
Dopamine
chronic progressive movement disorder
tremor - unilateral... rigidity... bradykinesia ... postural instability
Tremor is usually unilateral and is often the first symptom o…
substancia nigra neurons are lost... dopamine decreases while a…
PD
chronic progressive movement disorder
Major features for PD
tremor - unilateral... rigidity... bradykinesia ... postural instability
13 terms
FPC- Parkinson's Disease
Lewy Body
Parkinson's Disease
parkinson's disease
DAT-scan
histological finding in parkinson's
decrease in dopamine in the basal ganglia
bradykinesia, rigidity, loss of postural reflexes, resting tr…
radiograph showing dopamine in the basal ganglia
Lewy Body
histological finding in parkinson's
Parkinson's Disease
decrease in dopamine in the basal ganglia
15 terms
Parkinson's disease
Levodopa... (L-DOPA)
Selegiline... (Eldepryl)
Rasagiline... (Azilect)
Tolcapone... (Tasmar)
Parkinson's disease... Combine with Carbidopa,Sinement ... Increase…
Parkinson's disease... Combine with L-DOPA... MAO-B inhibitor
Parkinson's disease... Combine with L-DOPA or alone... MAO-B inhibi…
Parkinson's disease... Combine with L-DOPA + Carbidopa ... COMT inh…
Levodopa... (L-DOPA)
Parkinson's disease... Combine with Carbidopa,Sinement ... Increase…
Selegiline... (Eldepryl)
Parkinson's disease... Combine with L-DOPA... MAO-B inhibitor
22 terms
Parkinson's Disease
What is PD?
Some medication considerations
What are some medications that may ind…
Drug Tx for PD
A brain disorder that occurs when the substantia niagra neuro…
Pts w/ PD have a high incidence of depression. The agents w/…
Caused by antagonism of dopamine receptors ... Phenothiazines (…
Sinemet is the most effective agent and is sometimes better t…
What is PD?
A brain disorder that occurs when the substantia niagra neuro…
Some medication considerations
Pts w/ PD have a high incidence of depression. The agents w/…
9 terms
Parkinson's Disease
Etiology
Symptoms
Stage progression
Stage I
Hypokinetic CNS mvmt... -idiopathic... -slowly progressive... -degene…
A)Begins insidiously with testing "pill-rolling" tremor of on…
Hoehn and Yahr's five stage scale
-Unilateral tremor... -rigidity... -akinesia... -minimal/no functional…
Etiology
Hypokinetic CNS mvmt... -idiopathic... -slowly progressive... -degene…
Symptoms
A)Begins insidiously with testing "pill-rolling" tremor of on…
23 terms
PHARMACOLOGY Parkinson's disease, Parkinsonism, disease
Parkinson's disease:
Spectrum of James Parkinson's disease:…
Secondary Parkinsonism - causes
Action of 1-methyl-4-phenyl-1,2,3,6 te…
augmented inhibition of inhibitory system with bradykinesia
*Primary Parkinson's disease: *bradykinesia, tremor, muscle r…
Postencephalitis (inflammation)... Toxins: MPTP, CO, ethanol, me…
MPTP (contaminant of synthetic heroin) inhibits NADH-ubiquino…
Parkinson's disease:
augmented inhibition of inhibitory system with bradykinesia
Spectrum of James Parkinson's disease:…
*Primary Parkinson's disease: *bradykinesia, tremor, muscle r…
10 terms
Parkinson's Disease
Etiology of PD? What causes it?
Parkinson's is characterized by the fo…
Two types of rigidity
Cardinal signs of PD
disorder caused by disruption to dopamine production in the b…
degeneration of dopaminergic neurons in substantia nigra... deve…
cogwheel... lead pipe
1. Rigidity... 2. Bradykinesia (related to muscle recruitment an…
Etiology of PD? What causes it?
disorder caused by disruption to dopamine production in the b…
Parkinson's is characterized by the fo…
degeneration of dopaminergic neurons in substantia nigra... deve…
10 terms
Neuropsychology: Parkinson's Disease
Neuropathology
The 4 Cardinal Symptoms
Tremor
Rigidity
1) Loss of neurons in substantia nigra... 2) Decreased levels of…
1) Tremor... 2) Rigidity... 3) Bradykinesia... 4) Postural Disturbance…
pill rolling presentation; tremor at rest
constant muscle tension; cogwheel rigidity = "rachety"
Neuropathology
1) Loss of neurons in substantia nigra... 2) Decreased levels of…
The 4 Cardinal Symptoms
1) Tremor... 2) Rigidity... 3) Bradykinesia... 4) Postural Disturbance…
33 terms
Parkinson's Disease
PD
at time of dx..
where are dopamine producing cells in…
who gets PD
-long, variable course... --20 yrs constipation, smell... --10 yrs…
-significant loss of dopaminergic neurons... -top of brainstem:…
substantia nigra
-60 yrs... -1 milli in US... -men>>... -genetic component but some sp…
PD
-long, variable course... --20 yrs constipation, smell... --10 yrs…
at time of dx..
-significant loss of dopaminergic neurons... -top of brainstem:…
14 terms
Parkinson's Disease
Parkinson's Disease
Idiopathic PD
Iatrogenic Parkinsonism
Atherosclerotic Parkinsonism
Loss of dopamine signaling due to neuronal death ... 3 types of…
Degeneration in dopaminergic neurons
Anti-psychotic meds that block dopamine signaling
Mainly caused by old age. - buildup of blood in the regions o…
Parkinson's Disease
Loss of dopamine signaling due to neuronal death ... 3 types of…
Idiopathic PD
Degeneration in dopaminergic neurons
36 terms
Parkinson's Disease
Parkinson's Disease
tremors
depression
Constipation
A progressive disease that causes a section of the brain to d…
continuous quivering or shaking
A prolonged feeling of helplessness, hopelessness, and sadness
Hard, slow stools that are difficult to eliminate; often a re…
Parkinson's Disease
A progressive disease that causes a section of the brain to d…
tremors
continuous quivering or shaking
13 terms
parkinson's disease (PD)
what is it?
characteristics
etiology & patho
stages
- degenerative neurological disease... - no known cause... - no Dx…
- bradykinesia... - rigidity - increased muscle tone... - resting t…
- degeneration of dopamine- producing neurons... - disrupts dopa…
- mild & unilateral - mild tremor... - mild and bilateral - faci…
what is it?
- degenerative neurological disease... - no known cause... - no Dx…
characteristics
- bradykinesia... - rigidity - increased muscle tone... - resting t…
10 terms
Parkinson's Disease
Parkinson's Disease
Epidemiology
Pathophysiology
Clinical Manifestations of Parkinsons
A slow progressing neurological degenerative disorder of the…
Mostly effects men and occurs more often in non-smokers.
Parkinson's is a disease of the Substantia Nigra. Neurons in…
After 70% of the neurons in the Substantia Nigra have degener…
Parkinson's Disease
A slow progressing neurological degenerative disorder of the…
Epidemiology
Mostly effects men and occurs more often in non-smokers.
49 terms
Parkinson's Disease
PD Pathophysiology
PD Epidemiology
Diagnosis of PD
Definite PD Diagnosis
Dopaminergic neuron apoptosis in substantia nigra... Lewy bodies…
2nd most common ... Men>Women... Associated with genetics and envir…
Must have bradykinesia and at least 1 of the following:... Muscl…
3 of more of the following requirements:... - Unilateral onset... -…
PD Pathophysiology
Dopaminergic neuron apoptosis in substantia nigra... Lewy bodies…
PD Epidemiology
2nd most common ... Men>Women... Associated with genetics and envir…
24 terms
Parkinson's Disease treatment
Levodopa
Symptoms NOT responsive to Levodopa
Carbidopa
Sinemet
Mechanism of Action: Decarboxylated in the brain to form dopa…
1. Motor:... postural instability... freezing... 2. Speech abnormalit…
Blocks peripheral dopa decarboxylase ... 75 to 100mg... Increases t…
Sinemet® (carbidopa/levodopa)... onset of effect... 15-30 minutes,…
Levodopa
Mechanism of Action: Decarboxylated in the brain to form dopa…
Symptoms NOT responsive to Levodopa
1. Motor:... postural instability... freezing... 2. Speech abnormalit…
117 terms
Parkinson's Disease
Diagnosis of Parkinsons
4 Cardinal Signs of Parkinsons
Parkinsons Epidemiology
Parkinsons etiology
Based on clinical examination, with no true diagnostic test…
rigidity, tremor, bradykinesia, and postural instability
Most studies demonstrate PD affects men more than woman... Mean…
Lack of dopamine-producing neurons in substantial nigra and p…
Diagnosis of Parkinsons
Based on clinical examination, with no true diagnostic test…
4 Cardinal Signs of Parkinsons
rigidity, tremor, bradykinesia, and postural instability
118 terms
Parkinson's disease
Cardinal symptoms of Parkinsons... 5... 💧…
Resting tremor is exhibited by what ki…
Regidity is exhibited by what kind of…
Akinesia is impairment of which type o…
1. Resting tremor... 2. Regidity... 3. akinesia... 4. Postural di…
pill rolling in between thumb & index finger
cogwheel
automatic
Cardinal symptoms of Parkinsons... 5... 💧…
1. Resting tremor... 2. Regidity... 3. akinesia... 4. Postural di…
Resting tremor is exhibited by what ki…
pill rolling in between thumb & index finger
13 terms
Parkinson's Disease
Basal Ganglia
Basal ganglia thalamo-circuit (BGTC)
Motor program
Direct pathway
A group of structures linked to the thalamus in the base of t…
Projects to the cortex via the thalamus; controls preparation…
A set of motor commands needed to execute a motor action
From putamen to GPi/SNr (mediated by D1 type dopamine recepto…
Basal Ganglia
A group of structures linked to the thalamus in the base of t…
Basal ganglia thalamo-circuit (BGTC)
Projects to the cortex via the thalamus; controls preparation…
11 terms
Parkinson's Disease - Pharmacology
Parkinson's Disease
Akinesia
Masklike facial expression
Bradykinesia
Disorder of dopamine-producing neurons resulting in an imbala…
absence or poverty of movement
decreased facial mobility, eyes stare
slowness of movement
Parkinson's Disease
Disorder of dopamine-producing neurons resulting in an imbala…
Akinesia
absence or poverty of movement
21 terms
Parkinson's disease (SS)
Symptoms - Motor
Symptoms - Non motor
Secondary parkinsonism
Sporadic
Hypokinesia ... Bradykinedia... Muscle rigidity ... Tremor (pill rolli…
Dementia Depression ... Autonomic disturbance: ... Dysautonomia... CVS…
Impaired dopaminergic transmission due to ... DRUGS, NS DISORDER…
No genetic cause from birth ... (60+)
Symptoms - Motor
Hypokinesia ... Bradykinedia... Muscle rigidity ... Tremor (pill rolli…
Symptoms - Non motor
Dementia Depression ... Autonomic disturbance: ... Dysautonomia... CVS…
37 terms
Parkinson's Disease Rx.
Dopamine precursors
Levodopa pharm
Levodopa AE
Carbidopa pharm
Levodopa... Carbidopa
Converted to DA in the striatum
Nausea/anorexia/vomiting... Postural hypotension
Given with levodopa to avoid adverse effects ... Prevents breakd…
Dopamine precursors
Levodopa... Carbidopa
Levodopa pharm
Converted to DA in the striatum
Parkinson's Disease
The neurons affected by PD are located…
Main symptoms of PD (4)
Main signs of PD (4)
Co-morbid problems (6)
Substantia nigra
1. Bradykinesia --> akinesia... 2. Resting, asymmetrical tremor…
1. Akinesia... 2. Rigidity... 3. Tremor... 4. Gait disturbance
1. Daytime sleepiness... 2. Hallucinations... 3. Psychosis... 4. Depre…
The neurons affected by PD are located…
Substantia nigra
Main symptoms of PD (4)
1. Bradykinesia --> akinesia... 2. Resting, asymmetrical tremor…
8 terms
Parkinson's Disease- Dopamine
L-DOPA
LEVODOPA W/ CARBIDOPA
LEVODOPA/CARBIDOPA/ENTACAPONE
BROMOCRIPTINE
Brand: Dopar, Larodopa... -DOC... -converted to dopamine ... -may caus…
Brand: Sinemet/CR... -used during drug holiday
Brand: Stalevo ... -used w/ wearing off effect of levodopa ... -ent…
Brand: Parlodel ... -mimics dopamine effects ... -dry up breast mil…
L-DOPA
Brand: Dopar, Larodopa... -DOC... -converted to dopamine ... -may caus…
LEVODOPA W/ CARBIDOPA
Brand: Sinemet/CR... -used during drug holiday
29 terms
Parkinson's Disease
Symptoms
Sporadic PD
Familial PD
PD Stats
-shaking... -Rigidity... -Slowness... -Difficulty Walking... -Sleep distu…
-late onset... -occur because of insectecides and other toxins l…
-SNCA... -DJ-1... -PINK1
-Parkinson's affects up to 1 million people in the U.S.... -Men…
Symptoms
-shaking... -Rigidity... -Slowness... -Difficulty Walking... -Sleep distu…
Sporadic PD
-late onset... -occur because of insectecides and other toxins l…
25 terms
Parkinson's Disease
Physical symptoms
Organization of movement
Basal Ganglia and Cerebellum ... (striatum)
Dopamine synthesis
main motor symptom are tremor and muscle rigidity... tremor usua…
Basal Ganglia and Cerebellum are large collections of nuclei…
Loaded into vesicles using the vesicular monoamine transporte…
Physical symptoms
main motor symptom are tremor and muscle rigidity... tremor usua…
Organization of movement
60 terms
Rx: Parkinson's Disease
Parkinson's Disease
Parkinson's Disease Diagnosis
Parkinson's Disease Symptoms
Parkinson's Disease Cause
Chronic, progressive movement disorder
Two or more features:... Tremor... Rigidity... Bradykinesia... Postural I…
- Tremor: usually unilateral, often the first symptom ... - Pill…
Dysfunction of the extrapyramidal system - the basal ganglia…
Parkinson's Disease
Chronic, progressive movement disorder
Parkinson's Disease Diagnosis
Two or more features:... Tremor... Rigidity... Bradykinesia... Postural I…
27 terms
Parkinson's Disease
Signs and Symptoms
Motor Symptoms of PD
Non Motor Symptoms of PD
Diagnosis of PD
Resting Tremor: first, most common, begins in hand + unilater…
Tremor... Rigidity... Bradykinesia ... Postural Instability
Depression... Dementia... Psychosis... Hallucinations... Dysphagia ... GIT d…
Based on clinical criteria (motor symptoms) + no signs of neu…
Signs and Symptoms
Resting Tremor: first, most common, begins in hand + unilater…
Motor Symptoms of PD
Tremor... Rigidity... Bradykinesia ... Postural Instability
22 terms
Parkinson's Disease
Parkinson's Disease
Who is affected?
Gender and Ethnicity?
Cause
progressive, neurodegenerative disease that causes... characteri…
60,000 Americans are diagnosed... with PD annually and more than…
Males are predominantly affected with a male-to-female... ratio…
caused by deterioration of the dopaminergic... neurons in the ex…
Parkinson's Disease
progressive, neurodegenerative disease that causes... characteri…
Who is affected?
60,000 Americans are diagnosed... with PD annually and more than…
27 terms
Parkinson's Disease
Characteristics of Parkinsons
Autonomic Parkinsons
Stages of Parkinsons
Where does 80% of the brain's dopamine…
- Muscle rigidity and weakness... - Tremor... - "Pill rolling"... - Sh…
- Orthostatic hypotension... - Constipation... - Difficulty urinati…
I - unilateral; minimal... II - b/l with impairment of balance... I…
nigrostrial system
Characteristics of Parkinsons
- Muscle rigidity and weakness... - Tremor... - "Pill rolling"... - Sh…
Autonomic Parkinsons
- Orthostatic hypotension... - Constipation... - Difficulty urinati…
29 terms
parkinson's disease
primary s/s of parkinsons
depression in parkinsons
antipsychotic of choice in parkinsons
drug-induced parkinsonism
TRAP ... Tremor - seen during resting, usually worsened by anxie…
TCAs - especially secondary amines are DOC (i.e. nortriptylin…
quetiapine
phenothiazines ... first generation antipsychotics ... second gen A…
primary s/s of parkinsons
TRAP ... Tremor - seen during resting, usually worsened by anxie…
depression in parkinsons
TCAs - especially secondary amines are DOC (i.e. nortriptylin…
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