Study sets matching "parkinson's disease"

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Study sets matching "parkinson's disease"

67 terms
Parkinson's Disease and Parkinsonism
Describe the relationship between age…
Parkinson's is a neurochemical disorde…
What affect does PD have on the cholin…
Why is recovery difficult once symptom…
-older populations are at higher risk of PD... -only a 10% onset…
-substantia nigra loses ability to produce dopamine
-leads to disinhibition of the cholinergic system--causing ac…
there is an 80% loss of dopamine production before symptoms a…
Describe the relationship between age…
-older populations are at higher risk of PD... -only a 10% onset…
Parkinson's is a neurochemical disorde…
-substantia nigra loses ability to produce dopamine
70 terms
Parkinson's Disease
Name 6 classes of drugs you could give…
Parkinson's Disease is the ______ most…
The prevalence of Parkinson's Disease…
Risk factors for developing Parkinson'…
Levadopa/Carbidopa... COMT inhbitiorsDopamine agonists... MAO-B inh…
2nd
increasing age... ... 1/100,000 in 30-39... 93/100,000 in 70-79
males... hispanics
Name 6 classes of drugs you could give…
Levadopa/Carbidopa... COMT inhbitiorsDopamine agonists... MAO-B inh…
Parkinson's Disease is the ______ most…
2nd
Parkinson's Disease (and Parkinsonism)
Diagnostic Criteria for Parkinsonism
Parkinsonian Syndromes- Idiopathic
Parkinsonian Syndromes- symptomatic
Secondary motor symptoms
1. Tremor at rest... 2. Bradykinesia... 3. Rigidity... 4. Loss of post…
Parkinsons Disease, Atypical Parkinsonism
Post-infectious ('Awakenings')... Toxic (MPTP, Manganese, CO)... Po…
Freezing... Micrographia... Masked faces... Unwanted accelerations... Rap…
Diagnostic Criteria for Parkinsonism
1. Tremor at rest... 2. Bradykinesia... 3. Rigidity... 4. Loss of post…
Parkinsonian Syndromes- Idiopathic
Parkinsons Disease, Atypical Parkinsonism
69 terms
Therapy- Parkinson's Disease
In which age group is Parkinson's Dise…
Which environmental factors increase t…
Which environmental factors decrease t…
What are the "key findings" in Idiopat…
>85 years old
MPTP (in animal models), pesticide/herbicide exposure, well w…
Cigarettes and caffeine
Loss of DA producing neurons in substantia nigra pars compact…
In which age group is Parkinson's Dise…
>85 years old
Which environmental factors increase t…
MPTP (in animal models), pesticide/herbicide exposure, well w…
17 terms
Parkinson's Disease and Parkinsonism
What types of drugs can cause Parkison…
What two structural changes occur in PD?
What are two unique features (symptom…
What is a pathognomonic for PD?
Drugs that reduce the amount of available dopamine such as ne…
1. Lose melanin producing cells in substantia nigra... 2. Accumu…
- Is an asymmetric disorder with symptoms usually presenting…
Resting tremor that at times affects solely the thumb.
What types of drugs can cause Parkison…
Drugs that reduce the amount of available dopamine such as ne…
What two structural changes occur in PD?
1. Lose melanin producing cells in substantia nigra... 2. Accumu…
32 terms
Parkinson's Disease
Pathophysiology of Parkinson's DZ
Symptoms of Parkinson's
Off episode
Sinemet
Substantia Nigra die off (neurone in substantia nigra die off…
A resting tremor, so called because it's a shaking that typic…
Period of time with muscle stiffness, slow movements, difficu…
Carbidopa + Levodopa... Darkens urine, body fluids (saliva, swe…
Pathophysiology of Parkinson's DZ
Substantia Nigra die off (neurone in substantia nigra die off…
Symptoms of Parkinson's
A resting tremor, so called because it's a shaking that typic…
27 terms
Parkinson's Disease
What are the three major dopaminergic…
What is the Dopamine tract that when a…
What are the enzymes involved in the b…
Which of these dopamine receptor famil…
Note:... Substantial nigra to the striatum (Nigrostriatal) cont…
a.
MOA and COMT
a. only D1 and D5
What are the three major dopaminergic…
Note:... Substantial nigra to the striatum (Nigrostriatal) cont…
What is the Dopamine tract that when a…
a.
23 terms
Parkinson's Disease
Parkinson's disease affects
Dopamine content of the substantia nigra
MPTP
A molecular aspect of PD involves
the basal ganglia
less than 10% of normal in PD patient brains postmortem
is a compound used experimentally to study Parkinson's diseas…
Lewy bodies in various parts of the brain
Parkinson's disease affects
the basal ganglia
Dopamine content of the substantia nigra
less than 10% of normal in PD patient brains postmortem
67 terms
Parkinson's Disease
What is Parkinson's Disease?
What does Parkinson's Disease result f…
What part of the brain is responsible…
What do the fibers in the substantia n…
A chronic, progressive neurological disorder
degeneration of dopaminergic neurons in a region of the brain…
Substantial nigra
connect to both sides of the brain and control movement and c…
What is Parkinson's Disease?
A chronic, progressive neurological disorder
What does Parkinson's Disease result f…
degeneration of dopaminergic neurons in a region of the brain…
26 terms
Parkinson's Disease
Most effective medication for the trea…
First-choice therapy for treatment of…
Medications used for the treatment of…
Anticholinergic side effects
Carbidopa-Levodopa
Rasagiline - Role in therapy
Anitcholinergic agents - Role in therapy
Dry eyes and mouth, constipation, decreased sweating (increas…
Most effective medication for the trea…
Carbidopa-Levodopa
First-choice therapy for treatment of…
Rasagiline - Role in therapy
8 terms
Parkinson's Disease
Parkinson's Disease impairment of
Etiology of Parkinson
Qi and Blood Deficiency... tonify qi, no…
Qi and Blood Deficiency Rx:... tonify qi…
movement, rigidity and tremor, which results from damage to b…
Overwork and excessive sexual activity... Diet... Emotional Stress
long standing pronounced tremor of limbs, sallow complexion,…
Ren Shen Yang Rong Tang... Gb 20, Li 11, Xiao chanxue, Sj 5, Gb…
Parkinson's Disease impairment of
movement, rigidity and tremor, which results from damage to b…
Etiology of Parkinson
Overwork and excessive sexual activity... Diet... Emotional Stress
13 terms
Parkinson's Disease Introduction
Parkinson's Disease
Parkinson's Disease Description
Tremor
Bradykinesia
This disease is ... -The 2nd most common neuro-degenerative dis…
A neurodegenrative disorder characterized by movement dysfunc…
A symptom of Parkinson's Disease, and is normally an early sy…
A symptom of Parkinson's Disease which involves the slowness…
Parkinson's Disease
This disease is ... -The 2nd most common neuro-degenerative dis…
Parkinson's Disease Description
A neurodegenrative disorder characterized by movement dysfunc…
58 terms
Drugs for Parkinson's Disease
Neurodegenerative... disorder
Dyskinesia
Tremor
Akinesia
neurodegenerative disease is an umbrella term for a range of…
abnormality or impairment of voluntary movement.
A tremor is an involuntary, somewhat rhythmic, muscle contrac…
loss or impairment of the power of voluntary movement.
Neurodegenerative... disorder
neurodegenerative disease is an umbrella term for a range of…
Dyskinesia
abnormality or impairment of voluntary movement.
7 terms
[PARKINSON'S DISEASE]
[PARKINSON'S]: [RISK FACTORS]
[PARKINSON'S]: [DRUG-INDUCED] DISEASE
[PARKINON'S]: [CLINICAL PREDICTORS]
[PARKINSON'S]: [CLINICAL PRESENTATION]
-------------------------------------------------------------…
-------------------------------------------------------------…
o [WORSE PROGNOSIS] if:... -----------------------------------…
-------------------------------------------------------------…
[PARKINSON'S]: [RISK FACTORS]
-------------------------------------------------------------…
[PARKINSON'S]: [DRUG-INDUCED] DISEASE
-------------------------------------------------------------…
5 terms
Parkinson's Disease - Acetylcholine
Adverse Effects
Contradictions
PROCYCLIDINE
BIPERIDEN
Intraocular pressure, urinary retention, cardiac disfunction,…
Glaucoma, enlarged prostate, obstructed bladder
Brand: Kemadrin ... -risk to fetal development
Brand: Akineton ... -antimuscarinic effects: muscle rigidity, fa…
Adverse Effects
Intraocular pressure, urinary retention, cardiac disfunction,…
Contradictions
Glaucoma, enlarged prostate, obstructed bladder
8 terms
Parkinson's Disease- Dopamine
L-DOPA
LEVODOPA W/ CARBIDOPA
LEVODOPA/CARBIDOPA/ENTACAPONE
BROMOCRIPTINE
Brand: Dopar, Larodopa... -DOC... -converted to dopamine ... -may caus…
Brand: Sinemet/CR... -used during drug holiday
Brand: Stalevo ... -used w/ wearing off effect of levodopa ... -ent…
Brand: Parlodel ... -mimics dopamine effects ... -dry up breast mil…
L-DOPA
Brand: Dopar, Larodopa... -DOC... -converted to dopamine ... -may caus…
LEVODOPA W/ CARBIDOPA
Brand: Sinemet/CR... -used during drug holiday
22 terms
Parkinson's Disease
What is PD?
Some medication considerations
What are some medications that may ind…
Drug Tx for PD
A brain disorder that occurs when the substantia niagra neuro…
Pts w/ PD have a high incidence of depression. The agents w/…
Caused by antagonism of dopamine receptors ... Phenothiazines (…
Sinemet is the most effective agent and is sometimes better t…
What is PD?
A brain disorder that occurs when the substantia niagra neuro…
Some medication considerations
Pts w/ PD have a high incidence of depression. The agents w/…
15 terms
Parkinson's disease
Levodopa... (L-DOPA)
Selegiline... (Eldepryl)
Rasagiline... (Azilect)
Tolcapone... (Tasmar)
Parkinson's disease... Combine with Carbidopa,Sinement ... Increase…
Parkinson's disease... Combine with L-DOPA... MAO-B inhibitor
Parkinson's disease... Combine with L-DOPA or alone... MAO-B inhibi…
Parkinson's disease... Combine with L-DOPA + Carbidopa ... COMT inh…
Levodopa... (L-DOPA)
Parkinson's disease... Combine with Carbidopa,Sinement ... Increase…
Selegiline... (Eldepryl)
Parkinson's disease... Combine with L-DOPA... MAO-B inhibitor
Parkinson's Disease
Etiology
Symptoms
Stage progression
Stage I
Hypokinetic CNS mvmt... -idiopathic... -slowly progressive... -degene…
A)Begins insidiously with testing "pill-rolling" tremor of on…
Hoehn and Yahr's five stage scale
-Unilateral tremor... -rigidity... -akinesia... -minimal/no functional…
Etiology
Hypokinetic CNS mvmt... -idiopathic... -slowly progressive... -degene…
Symptoms
A)Begins insidiously with testing "pill-rolling" tremor of on…
11 terms
Parkinson's Disease
What is PD?
What are the 4 primary manifestations…
Why do these manifestations occur?
What is the focus of treatment for PD?
a progressively debilitating disease that grossly affects mot…
Bradykinesia ---> slow movement... Tremors... Muscle rigidity ... Post…
acetylcholine overstimulates the basal ganglia... depletion of d…
Increasing amount of dopamine... Decreasing amount of acetylchol…
What is PD?
a progressively debilitating disease that grossly affects mot…
What are the 4 primary manifestations…
Bradykinesia ---> slow movement... Tremors... Muscle rigidity ... Post…
29 terms
parkinson's disease
primary s/s of parkinsons
depression in parkinsons
antipsychotic of choice in parkinsons
drug-induced parkinsonism
TRAP ... Tremor - seen during resting, usually worsened by anxie…
TCAs - especially secondary amines are DOC (i.e. nortriptylin…
quetiapine
phenothiazines ... first generation antipsychotics ... second gen A…
primary s/s of parkinsons
TRAP ... Tremor - seen during resting, usually worsened by anxie…
depression in parkinsons
TCAs - especially secondary amines are DOC (i.e. nortriptylin…
44 terms
Parkinson's Disease
What neurotransmitter is lost in Parki…
Where is dopamine made? (mainly)
Where does the substantia nigra projec…
What collections of protein are found…
Dopamine
Substantia nigra
Striatum... (nigrostriatal pathway)
Lewy bodies (seen in post mortem)
What neurotransmitter is lost in Parki…
Dopamine
Where is dopamine made? (mainly)
Substantia nigra
Management of Parkinson's Disease
Exercise and ambulation
Self-management
Injury prevention
Nutrition
Freezing gaith and postural instablility
Perform own ADL's
Sleep problems, fall asleep while driving
Individual nutrition plan... Low protein, High fiber
Exercise and ambulation
Freezing gaith and postural instablility
Self-management
Perform own ADL's
29. Parkinson's Disease
what is the mean age of onset of PD?
What is the main pathological feature…
are men or women more likely to get PD?
what are the key motor symptoms of PD?
65 years
Degeneration of neuromelanin containing neurones in the pars…
men are 1.5x more likely to get PD
- shaking ... - stiffness ... - slowness ... - poverty of movement
what is the mean age of onset of PD?
65 years
What is the main pathological feature…
Degeneration of neuromelanin containing neurones in the pars…
21 terms
Parkinson's Disease
Etiology of Parkinson's
Classic triad of symptoms in Parkinson's
Why do you also see depression, dement…
Effect of dopamine on direct/indirect…
Loss of dopamine neurons in the substantia nigra pars compact…
1. Akinesia (or bradykinesia) ... - lack of facial expression;…
Additional groups of neurons degenerate... - noradrenergic neur…
Increase direct (D1)... Decrease indirect (D2)... **increase mvt
Etiology of Parkinson's
Loss of dopamine neurons in the substantia nigra pars compact…
Classic triad of symptoms in Parkinson's
1. Akinesia (or bradykinesia) ... - lack of facial expression;…
101 terms
Parkinson's Disease OS
Early symptoms of Parkinson's Disease…
Other nonmotor symptoms include
The term parkinsonism is a generic ter…
Secondary parkinsonism results from a…
loss of sense of smell... constipation... rapid eye movement ... sleep…
altered bladder function... excessive saliva... integumentary chang…
basal ganglia (BG)
viruses... toxins... drugs... tumors
Early symptoms of Parkinson's Disease…
loss of sense of smell... constipation... rapid eye movement ... sleep…
Other nonmotor symptoms include
altered bladder function... excessive saliva... integumentary chang…
79 terms
NAPLEX parkinson's disease
when do motor sx of Parkinson's Diseas…
four main symptoms of PD
amantadine is useful for
apomorphine is used for
when 80% of DA neurons destroyed
tremor, bradykinesia, ridgidity, postural instability "TRAP"
dyskinesias in later stages; antagonizes NMDA receptor
SC - severe freezing episodes
when do motor sx of Parkinson's Diseas…
when 80% of DA neurons destroyed
four main symptoms of PD
tremor, bradykinesia, ridgidity, postural instability "TRAP"
38 terms
NAPLEX-Parkinson's Disease
Parkinsons disease
Substantia Nigra
S/Sx of Parkinsons
Antidepressants with highest efficacy…
Occurs when neurons in a part of the brain called the substan…
Responsible for making dopamine
unilateral tremor, Bradykinesia or akinesia, Cogwheel rigidit…
Tricyclics
Parkinsons disease
Occurs when neurons in a part of the brain called the substan…
Substantia Nigra
Responsible for making dopamine
44 terms
Parkinson's Disease
Median age of onset.
Receptor sites/cells for this neurotra…
Drug induced pseudoparkinsonism caused…
Symptoms described by the TRAP acronym:
60 yrs
Dopamine
antipsychotics, metoclopramide, prochlorperazine. Removing ag…
Tremor, Rigidity, Akinesia/bradykinesia, Postural/gait instab…
Median age of onset.
60 yrs
Receptor sites/cells for this neurotra…
Dopamine
23 terms
Parkinson's Disease (PD)
Epidemiology of Parkinson's Disease
Pathology
Clinical presentation
Clinical Presentations Motor symptoms…
-Increases with age ... -Usual onset: 60 years... -Risk factors: ru…
-Destruction of nigrostriatal dopamine neurons projecting to…
- Limb muscle rigidity... • Increased resistance to passive moti…
- Micrographia ... - Hypomimia ... - Hypophonia -... - Diminished- ... -…
Epidemiology of Parkinson's Disease
-Increases with age ... -Usual onset: 60 years... -Risk factors: ru…
Pathology
-Destruction of nigrostriatal dopamine neurons projecting to…
30 terms
Drugs for Parkinson's Disease
Parkinson's Disease
Dopaminergic Agents
Centrally Acting Anticholinergic Agents
Levodopa
A Disorder of the extrapyramidal system... When the extrapyramid…
Levodopa/ Carbidopa... Pramipexole... Ropinirole... Entacapone... Selegil…
Benztropine... Diphenhydramine (Benadryl)
MOA: Reduces the symptoms of PD by promoting synthesis of dop…
Parkinson's Disease
A Disorder of the extrapyramidal system... When the extrapyramid…
Dopaminergic Agents
Levodopa/ Carbidopa... Pramipexole... Ropinirole... Entacapone... Selegil…
Parkinson's Disease Introduction
Parkinson's Disease
Parkinson's Disease Description
Tremor
Bradykinesia
This disease is ... -The 2nd most common neuro-degenerative dis…
A neurodegenrative disorder characterized by movement dysfunc…
A symptom of Parkinson's Disease, and is normally an early sy…
A symptom of Parkinson's Disease which involves the slowness…
Parkinson's Disease
This disease is ... -The 2nd most common neuro-degenerative dis…
Parkinson's Disease Description
A neurodegenrative disorder characterized by movement dysfunc…
30 terms
Drugs for Parkinson's Disease
Parkinson's Disease
Dopaminergic Agents
Centrally Acting Anticholinergic Agents
Levodopa
A Disorder of the extrapyramidal system... When the extrapyramid…
Levodopa/ Carbidopa... Pramipexole... Ropinirole... Entacapone... Selegil…
Benztropine... Diphenhydramine (Benadryl)
MOA: Reduces the symptoms of PD by promoting synthesis of dop…
Parkinson's Disease
A Disorder of the extrapyramidal system... When the extrapyramid…
Dopaminergic Agents
Levodopa/ Carbidopa... Pramipexole... Ropinirole... Entacapone... Selegil…
Parkinson's Disease
Non Commutable
Neuroimaging
Substantia Nigra
Olfactory System
Commutable or Non Commutable?
Diagnosis Method with SPECT and PET scans
part of brain parkinson's disease mainly affects
system used by body to detect smell
Non Commutable
Commutable or Non Commutable?
Neuroimaging
Diagnosis Method with SPECT and PET scans
Parkinson's Disease
What is a goal of physical medicine?
Summary of Parkinson's Disease
Neurophysiology of PD
What entails clinical presentation of PD
to improve motor performance
-Chronic progressive movement disorder... -Basal ganglia dysfunc…
-onset caused by deterioration of neurons in the Substantia N…
~50%-70% of the dopaminergic neurons degenerate
What is a goal of physical medicine?
to improve motor performance
Summary of Parkinson's Disease
-Chronic progressive movement disorder... -Basal ganglia dysfunc…
19 terms
Parkinson's Disease
Drugs which can cause parkinsonism
Sinemet
Parcopa RapiTab
Can Sinemet SR be split?
Phenothiazines (i.e. prochlorperazine)... 1st generation antipsy…
Carbidopa/levodopa... *** ... Usual starting dose 25/100 TID; ... 70-1…
Carbidopa/levodopa (tab on the tongue)
Yes (just not chewed or crushed)
Drugs which can cause parkinsonism
Phenothiazines (i.e. prochlorperazine)... 1st generation antipsy…
Sinemet
Carbidopa/levodopa... *** ... Usual starting dose 25/100 TID; ... 70-1…
Parkinson's Disease
What is Parkinson's Disease?
Where does degeneration occur?
What is the basal ganglia responsible…
What are the risk factors for PD?
- Chronic progressive disease of the motor components of the…
Basal Ganglia
- movement control ... - associative learning... - working memory... -…
- Age... - Family history... - Genetic factors... - Environment
What is Parkinson's Disease?
- Chronic progressive disease of the motor components of the…
Where does degeneration occur?
Basal Ganglia
14 terms
Parkinson's Disease (CNS)
Benztropine
Trihexiphenidyl
Carbidopa-levodopa
Entacapone
(Cogentin®) Anticholinergics Parkinson's Disease
(Artane®) Anticholinergics Parkinson's Disease
(Sinemet®, Parcopa) Dopamine Precursor/ Decarboxylase Inhibit…
(Comtan®) COMT inhibitors Parkinson's Disease
Benztropine
(Cogentin®) Anticholinergics Parkinson's Disease
Trihexiphenidyl
(Artane®) Anticholinergics Parkinson's Disease
Neuropsychology: Parkinson's Disease
Neuropathology
The 4 Cardinal Symptoms
Tremor
Rigidity
1) Loss of neurons in substantia nigra... 2) Decreased levels of…
1) Tremor... 2) Rigidity... 3) Bradykinesia... 4) Postural Disturbance…
pill rolling presentation; tremor at rest
constant muscle tension; cogwheel rigidity = "rachety"
Neuropathology
1) Loss of neurons in substantia nigra... 2) Decreased levels of…
The 4 Cardinal Symptoms
1) Tremor... 2) Rigidity... 3) Bradykinesia... 4) Postural Disturbance…
16 terms
Parkinson's Disease
Hoen and Yahr stage 1
Hoen and Yahr stage 2
Hoen and Yahr stage 3
Hoen and Yahr stage 4
unilateral, Symptoms mild, Symptoms inconvenient but not disa…
Symptoms are bilateral;... Minimal disability;... Posture and gait…
Significant slowing of body movements;... Early impairment of eq…
Severe symptoms;... Can still walk to a limited extent;... Rigidity…
Hoen and Yahr stage 1
unilateral, Symptoms mild, Symptoms inconvenient but not disa…
Hoen and Yahr stage 2
Symptoms are bilateral;... Minimal disability;... Posture and gait…
19 terms
Parkinson's Disease
Liver Yin Deficiency with Internal Wind
Nourish Liver and Kidney Yin, Extingui…
Liver Qi Stagnation and Blood Stagnation
Move Liver Qi, Extinguish Wind... Lv 3, L…
Muscular stiffness, hand and foot or... lower jaw trembling, a…
Liver Yin Deficiency with Internal Wind
Head, lower jaw, hand and foot shaking, especially at rest an…
Liver Qi Stagnation and Blood Stagnation
Liver Yin Deficiency with Internal Wind
Muscular stiffness, hand and foot or... lower jaw trembling, a…
Nourish Liver and Kidney Yin, Extingui…
Liver Yin Deficiency with Internal Wind
118 terms
Parkinson's disease
Cardinal symptoms of Parkinsons... 5... 💧…
Resting tremor is exhibited by what ki…
Regidity is exhibited by what kind of…
Akinesia is impairment of which type o…
1. Resting tremor... 2. Regidity... 3. akinesia... 4. Postural di…
pill rolling in between thumb & index finger
cogwheel
automatic
Cardinal symptoms of Parkinsons... 5... 💧…
1. Resting tremor... 2. Regidity... 3. akinesia... 4. Postural di…
Resting tremor is exhibited by what ki…
pill rolling in between thumb & index finger
Parkinson's Disease
Define PD
Pathophysiology of PD
Risk factors of PD
Symptoms of PD
Motor system disorder resulting from the loss of neurons whic…
activates basal ganglia, chemical signals cannot move from th…
Advancing age, males are more likely, family history, agricul…
tremor, rigidity, akinesia, postural changes
Define PD
Motor system disorder resulting from the loss of neurons whic…
Pathophysiology of PD
activates basal ganglia, chemical signals cannot move from th…
20 terms
Parkinson's Disease
Parkson's Disease is a deficiency in w…
Usual age of onset for Parkinson's Dis…
Parkinson's Disease typically affects?
A form of reversible parkinsonism can…
Dopamine
45-65
males the same as females in all ethnic groups. Some genetics…
reserpine... haloperidol (Haldol)... metoclopramide (Reglan)
Parkson's Disease is a deficiency in w…
Dopamine
Usual age of onset for Parkinson's Dis…
45-65
10 terms
Parkinson's Disease Drugs
Precursor to DA
Direct-acting DA receptor Agonist
Indirect-acting DA Agonists
MAO-B inhibitors
Levodopa/Carbidopa (Sinemet)
pramipexole, ropinirole, apomorphine
amantadine, benztropine, selegiline, rasagiline, tolcapone, e…
selegiline, rasagilene
Precursor to DA
Levodopa/Carbidopa (Sinemet)
Direct-acting DA receptor Agonist
pramipexole, ropinirole, apomorphine
117 terms
Parkinson's Disease
Diagnosis of Parkinsons
4 Cardinal Signs of Parkinsons
Parkinsons Epidemiology
Parkinsons etiology
Based on clinical examination, with no true diagnostic test…
rigidity, tremor, bradykinesia, and postural instability
Most studies demonstrate PD affects men more than woman... Mean…
Lack of dopamine-producing neurons in substantial nigra and p…
Diagnosis of Parkinsons
Based on clinical examination, with no true diagnostic test…
4 Cardinal Signs of Parkinsons
rigidity, tremor, bradykinesia, and postural instability
Parkinson's Disease
Parkinsonism
a hand tremor in repose commonly seen…
a symmetrical essential tremor that mo…
a tremor that is maximal in repose and…
Rest Tremor
Postural Tremor
Resting Tremor
Parkinsonism
a hand tremor in repose commonly seen…
Rest Tremor
40 terms
Parkinson's Disease
What is the gold stand treatment for P…
What is the distinguishing characteris…
What are the goals of Parkinson Drugs?
Parkinson's Disease:... - need loss of _…
Carbidopa + Levodopa ... - treats all 4 signs/symptoms of PD
- the progressive dysfuctioning of the dopaminergic neurons i…
- decrease the excess acetylcholine... - increase dopamine acti…
80%
What is the gold stand treatment for P…
Carbidopa + Levodopa ... - treats all 4 signs/symptoms of PD
What is the distinguishing characteris…
- the progressive dysfuctioning of the dopaminergic neurons i…
55 terms
PH: Parkinson's Disease
PD
Major features for PD
Features
Dopamine
chronic progressive movement disorder
tremor - unilateral... rigidity... bradykinesia ... postural instability
Tremor is usually unilateral and is often the first symptom o…
substancia nigra neurons are lost... dopamine decreases while a…
PD
chronic progressive movement disorder
Major features for PD
tremor - unilateral... rigidity... bradykinesia ... postural instability
29 terms
Parkinson's Disease
Symptoms
Sporadic PD
Familial PD
PD Stats
-shaking... -Rigidity... -Slowness... -Difficulty Walking... -Sleep distu…
-late onset... -occur because of insectecides and other toxins l…
-SNCA... -DJ-1... -PINK1
-Parkinson's affects up to 1 million people in the U.S.... -Men…
Symptoms
-shaking... -Rigidity... -Slowness... -Difficulty Walking... -Sleep distu…
Sporadic PD
-late onset... -occur because of insectecides and other toxins l…
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