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Study sets matching "pharm block pharmacology 2 thyroid"

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Study sets matching "pharm block pharmacology 2 thyroid"

10 terms
Pharm Thyroid Hormones - Block 2
Levothyroxine
Liothyroxine
Liotrix
Thyroid USP
T4
T3
T3 & T4
T3, T4
Levothyroxine
T4
Liothyroxine
T3
44 terms
Pharm block 2 Eicosanoid pharmacology
lipooxygenase inhibitors 2
LT receptor blockers
COX all blockers 2
COX 2 specific blocker
Zileuton... glucocorticoids
-Lukasts
NSAIDs +steroids
COXibs
lipooxygenase inhibitors 2
Zileuton... glucocorticoids
LT receptor blockers
-Lukasts
20 terms
PHARM 6 - Thyroid Pharmacology
Thyroid Hormones
Synthesis of Thyroid Hormones (Chart)
Synthesis of Thyroid Hormones
Pharmacokinetics of Thyroid Hormones
- Triiodothyronine (T3);... - Thyroxine (Tetraiodothyronine) (T4…
- Iodide enters thyrocytes by active transport system (sodium…
- Thyroid hormones highly protein bound;... - Thyroxine-binding…
Thyroid Hormones
- Triiodothyronine (T3);... - Thyroxine (Tetraiodothyronine) (T4…
Synthesis of Thyroid Hormones (Chart)
49 terms
Pharmacology II Block 7--Thyroid
What are thyroid hormones essential for
What hormones are produced by the thyr…
How does the thyroid gland store large…
How are serum levels of THs regulated
Normal growth development (CNS+++)... Maintaining metabolic home…
Thyroid Hormones (THs)... Calcitonin
In the form of thyroglobulin which releases T3 and T4
Negative feedback, pituitary TSH
What are thyroid hormones essential for
Normal growth development (CNS+++)... Maintaining metabolic home…
What hormones are produced by the thyr…
Thyroid Hormones (THs)... Calcitonin
Pharm U5: Thyroid Pharmacology
There are three chief "areas" of the t…
What is the function of the Colloid?
What is the function of Follicular cel…
What is the main function of the C cell
Colloid, Follicular cells, Parafollicular (C) Cells
Stores Thyroglobulin-bound T3/T4
Takes up iodine and transports it to the Colloid... Endosomes ta…
Secretes Calcitonin (Ca++) homeostasis
There are three chief "areas" of the t…
Colloid, Follicular cells, Parafollicular (C) Cells
What is the function of the Colloid?
Stores Thyroglobulin-bound T3/T4
38 terms
Pharm U5: Thyroid Pharmacology
There are three chief "areas" of the t…
What is the function of the Colloid?
What is the function of Follicular cel…
What is the main function of the C cell
Colloid, Follicular cells, Parafollicular (C) Cells
Stores Thyroglobulin-bound T3/T4
Takes up iodine and transports it to the Colloid... Endosomes ta…
Secretes Calcitonin (Ca++) homeostasis
There are three chief "areas" of the t…
Colloid, Follicular cells, Parafollicular (C) Cells
What is the function of the Colloid?
Stores Thyroglobulin-bound T3/T4
32 terms
Final Block Pharm: Thyroid/Antithyroid
Treatment of Hypothyroidism
Thyroid Hormone Supplementation: Organ…
Thyroid Hormone Supplementation: Synth…
Iodide Supplementation
1) Iodide Supplementation... 2) Thyroid Hormone Supplementation…
1) Thyroid USP... 2) Thyroglobulin USP
1) Levothyroxine (T4)... 2) Liothyronine (L isomer of T3)... 3)…
micrometers of Iodine are needed daily; deficiencies are rare…
Treatment of Hypothyroidism
1) Iodide Supplementation... 2) Thyroid Hormone Supplementation…
Thyroid Hormone Supplementation: Organ…
1) Thyroid USP... 2) Thyroglobulin USP
64 terms
Thyroid - Block 2
Thyroid Gland Hormones facilitate....
most active form of thyroid hormone
T4
T3
normal growth and maturation by maintaining a level of metabo…
T3
Thyroxine
Triiodothyronine
Thyroid Gland Hormones facilitate....
normal growth and maturation by maintaining a level of metabo…
most active form of thyroid hormone
T3
14 terms
2. AUA Thyroid Pharmacology
Levothyroxine
Liothyronine
Liotrix
Myxedema Coma
thyroid hormone... T4, synthroid... long half life: 7 days... use: hyp…
thyroid hormone... T3... use: hypothyroidism forms
thyroid hormone... use: hypothyroidism forms
-end state untreated hypothyroidism... -progressive weakness, st…
Levothyroxine
thyroid hormone... T4, synthroid... long half life: 7 days... use: hyp…
Liothyronine
thyroid hormone... T3... use: hypothyroidism forms
63 terms
Block 2 - Phys - (2) Thyroid
what is the thyroid gland's mission in…
how is BMR "measured" in the body?
thyroid gland production is on an axis…
TRH is released from the hypothalamus…
1. maintain BMR... 2. increase protein synthesis for growth and…
body temp
1. low BMR (low body temp)... 2. stress (alpha-adrenergic agonist)
1) hypothalamus (paracrine)... 2) anterior pituitary (endocrine…
what is the thyroid gland's mission in…
1. maintain BMR... 2. increase protein synthesis for growth and…
how is BMR "measured" in the body?
body temp
35 terms
MOORE THYROID PHARM 2
In the hypothalamic-pituitary-thyroid…
Know the 6 steps in thyroid synthesis
What is the thyroid hormones backbone?
In relationship to MIT and DIT what li…
o Hypothalamus: TRH... o Anterior Pituitary: TSH... o Thyroid: T4,…
1. Iodine converted to Iodide via peroxidase in follicular ce…
2 tyrosine molecules connected via ether link
o T3 is from MIT + DIT... o rT3 is from DIT + MIT... o T4 is from D…
In the hypothalamic-pituitary-thyroid…
o Hypothalamus: TRH... o Anterior Pituitary: TSH... o Thyroid: T4,…
Know the 6 steps in thyroid synthesis
1. Iodine converted to Iodide via peroxidase in follicular ce…
11 terms
Block 2 Minicase 5 - Thyroid
Synthroid, Levothroid, Levoxyl, Tirosi…
Armour Thyroid, Nature-Throid, Westhro…
Cytomel, Triostat
Thyrolar
levothyroxine (T4) - separate doses by 4-6 hrs, esp iron or C…
desiccated thyroid - porcine-derived, contains T3 & T4; measu…
liothyronine (T3) - 4x more potent, more expensive, high pill…
liotrix (T3 and T4) - 1:4 ratio
Synthroid, Levothroid, Levoxyl, Tirosi…
levothyroxine (T4) - separate doses by 4-6 hrs, esp iron or C…
Armour Thyroid, Nature-Throid, Westhro…
desiccated thyroid - porcine-derived, contains T3 & T4; measu…
69 terms
Pharm2: Thyroid
Treatment of choice for primary hypoth…
Synthroid is synthetic ___ and is the…
________ _____ converts T4 to T3 based…
what happens if T3 is used to treat pr…
levothyroxine, synthetic T4
T4... levothyroxine
peripheral tissues... metabolic... prohormone
peripheral tissues lose their ability to control local metabo…
Treatment of choice for primary hypoth…
levothyroxine, synthetic T4
Synthroid is synthetic ___ and is the…
T4... levothyroxine
81 terms
Pharm2: Thyroid
which thyroid hormone is produced by t…
most accurate measure of T4 and T3
triiodothyronine
which thyroid hormone is most potent?
T4 is 100%
free (unbound)
t3
t3
which thyroid hormone is produced by t…
T4 is 100%
most accurate measure of T4 and T3
free (unbound)
13 terms
Pharmacology Exam 2: Thyroid
Levothyroxine (Synthroid, Levothroid)
Subclinical hypothyroidism: Levothryox…
Hypothyroidism: Levothryoxine
Adverse effects of synthroid:
L-isomer of T4 ... uniform content ... Oral: well absorbed ... Decreas…
1 mcg/kg/day
<50 years: 1.7 mcg/kg/day (starting at ~100 mcg/day)... >50 year…
CV: angina, arrhythmias, increased BP, MI, palpitation, tachy…
Levothyroxine (Synthroid, Levothroid)
L-isomer of T4 ... uniform content ... Oral: well absorbed ... Decreas…
Subclinical hypothyroidism: Levothryox…
1 mcg/kg/day
35 terms
SGUSVM Pharm 2: THYROID
In the hypothalamic-pituitary-thyroid…
Know the 6 steps in thyroid synthesis
What is the thyroid hormones backbone?
In relationship to MIT and DIT what li…
o Hypothalamus: TRH... o Anterior Pituitary: TSH... o Thyroid: T4,…
1. Iodine converted to Iodide via peroxidase in follicular ce…
2 tyrosine molecules connected via ether link
o T3 is from MIT + DIT... o rT3 is from DIT + MIT... o T4 is from D…
In the hypothalamic-pituitary-thyroid…
o Hypothalamus: TRH... o Anterior Pituitary: TSH... o Thyroid: T4,…
Know the 6 steps in thyroid synthesis
1. Iodine converted to Iodide via peroxidase in follicular ce…
10 terms
PHARM 2 THYROID DRUGS
thyroid gland function ... - what does hy…
what do T3 and T4 do
hypothyroidim
prototype treatment for hypothyroidism
Makes thyroid hormone... T3... T4... Uses iodide from food, water, or…
Thyroid hormones:... Control cellular metabolism... Promote normal…
Congenital ... or ... as a result of dysfunction or destruction of…
levothyroxine ... Lifelong replacement of thyroid hormones that…
thyroid gland function ... - what does hy…
Makes thyroid hormone... T3... T4... Uses iodide from food, water, or…
what do T3 and T4 do
Thyroid hormones:... Control cellular metabolism... Promote normal…
52 terms
Pharmacology 2 - Thyroid
Heart effects/imbalance (thyroid hormo…
Adipose effects/imbalance (thyroid hor…
GI tract effects/imbalance (thyroid ho…
Nervous system/brain effects/imbalance…
↑ beta receptors ~ ↑ HR, AFib
Stimulates lipolysis ~ Anorexia
Maintain GI tone/motility ~ Constipation/Diarrhea
Promotes normal brain development, ↑ SNS ~ Mental retardation…
Heart effects/imbalance (thyroid hormo…
↑ beta receptors ~ ↑ HR, AFib
Adipose effects/imbalance (thyroid hor…
Stimulates lipolysis ~ Anorexia
103 terms
pharm 1 - 2 thyroid -
thyroine horme increases number of wha…
what is the most satisfactory preparat…
how must levothyroxine be administered
how long is the half life of levothyro…
Beta
levothroxine
on an empty stomach
7 days so drug must be tapered
thyroine horme increases number of wha…
Beta
what is the most satisfactory preparat…
levothroxine
21 terms
2 Pharm of HPA and Thyroid
Octreotide and lanreotide MOA?
What 4 things do somatostatin analogs…
Bromocriptine MOA?
Bromocriptine is effective at inhibiti…
long acting somatostatin analogs
GH, glucagon, insulin, and gastrin
dopamine D2 receptor agonist
prolactin
Octreotide and lanreotide MOA?
long acting somatostatin analogs
What 4 things do somatostatin analogs…
GH, glucagon, insulin, and gastrin
7 terms
Thyroid (Pharm Test 2)
Levothyroxine [Synthroid]
Levothyroxine
Levothyroxine education
Liothyronine
Thyroid replacement drug.... MoA:replaces both T4 and T3.... Used f…
SE: too much can result in thyrotoxicosis. Which have symptom…
1. Take on an empty stomach in the 30-60 mins before breakfas…
T3... Works faster than Levo and used for myxedema coma.
Levothyroxine [Synthroid]
Thyroid replacement drug.... MoA:replaces both T4 and T3.... Used f…
Levothyroxine
SE: too much can result in thyrotoxicosis. Which have symptom…
7 terms
Pharmacology Exam 2 Thyroid
Thyroid Replacement
Thionamides
Radiopharmaceuticals
Growth Hormone
*Levothyroxine (Synthroid), liothyronine (Cytomel), liotrix (…
-Anti-thyroid... *Thionamides= Propylthiouracil (PTU), Methimazo…
-Anti-thyroid... Radioactive Iodine - iodine 131... *hyperthyroidis…
-hypothalamic disorders... Somatropin (Genotropin)... *Used to stim…
Thyroid Replacement
*Levothyroxine (Synthroid), liothyronine (Cytomel), liotrix (…
Thionamides
-Anti-thyroid... *Thionamides= Propylthiouracil (PTU), Methimazo…
610 terms
Pharm block 2
Bromocriptine
Cabergoline
GnRH analogs (long acting formulations…
Pregvisomant
Dopamine agonist used to treat hyperprolactinemia
Dopamine agonist used to treat hyperprolactinemia
Precocious puberty in transgender pts to block puberty, prost…
GH receptor antagonist
Bromocriptine
Dopamine agonist used to treat hyperprolactinemia
Cabergoline
Dopamine agonist used to treat hyperprolactinemia
9 terms
Pharm Exam 2 - Thyroid
Levothyroxine "Synthroid"... - PT... - PD... -…
Steroid hormone agonists: Glucocortico…
Steroid hormone agonists continued: Gl…
The thyroid main functions
~ directly replacing thyroid hormones ~... PT: hypothyroidism... PD…
PT: ... - SUPRAPHYSIOLOGIC (have normal levels but need more) fo…
AE: Acne, thrush, moon, face, hunger, bruising of lips, gynec…
makes T3 and T4, mostly for metabolism (regulates how body br…
Levothyroxine "Synthroid"... - PT... - PD... -…
~ directly replacing thyroid hormones ~... PT: hypothyroidism... PD…
Steroid hormone agonists: Glucocortico…
PT: ... - SUPRAPHYSIOLOGIC (have normal levels but need more) fo…
25 terms
Pharm 2 Thyroid dysfunction
hyperthyroid
hypothyroid
hyperthyroidism causes every thing to…
hypothyroidism causes every thing to d…
decreased TSH (thyroid stimulating hormone) and increased T3,…
increased TSH, decreased T3 and T4
peripheral vascular resistance and urinary concentration abil…
peripheral vascular resistance increases
hyperthyroid
decreased TSH (thyroid stimulating hormone) and increased T3,…
hypothyroid
increased TSH, decreased T3 and T4
26 terms
Pharmacology Test 2- Thyroid
What cells produce thyroxine and thyro…
What is located inside the thyroid fol…
What hormone do parafollicular cells s…
How much iodine do you need daily?
Follicular cells which are located in the hollow spaces of th…
A fluid matrix called colloid
They secrete calcitonin which lowers the blood concentration…
We should take in about 150mcg daily. The thyroid takes about…
What cells produce thyroxine and thyro…
Follicular cells which are located in the hollow spaces of th…
What is located inside the thyroid fol…
A fluid matrix called colloid
516 terms
Pharmacology Block 2
Does the the somatic nervous system co…
where do neurons of the somatic nervou…
what are the neurotransmitter(s) at th…
What kind of tissues do neurons of the…
voluntary AND involuntary activity
motor neurons originate in the spinal cord and directly inner…
Acetylcholine is the neurotransmitter at neuromuscular junction
smooth muscle, cardiac muscle, and exocrine glands (basically…
Does the the somatic nervous system co…
voluntary AND involuntary activity
where do neurons of the somatic nervou…
motor neurons originate in the spinal cord and directly inner…
18 terms
Pharm Block 4: Hypothalamic Pituitary and Thyroid Hormones
what is octreotide and what does it in…
dopamine D2 receptor agonist
what is bromocriptine effective for?
what is the physiologic inhibitor of P…
somatostatin analog, inhibits release of GH, glucagon, INS, a…
bromocriptine
inhibiting PRL release, and at high doses it has some efficac…
dopamine
what is octreotide and what does it in…
somatostatin analog, inhibits release of GH, glucagon, INS, a…
dopamine D2 receptor agonist
bromocriptine
29 terms
Pharm Block 4: Endocrine Pharmacology
What kind of drugs are most widely pre…
The collection of glands of an organis…
Study of drugs that are hormones or ho…
Also known as chemical messangers
Endocrine drugs
Endocrine system
Endocrine Pharmacology
Hormones
What kind of drugs are most widely pre…
Endocrine drugs
The collection of glands of an organis…
Endocrine system
16 terms
Pharm 2, thyroid and roids
What drug is used to treat hypothyroid…
What do you want to avoid when using l…
What drug is used to treat hyperthyroi…
What disease is treated with Propylthi…
Levothyroxine
Excess cardiac stimulation (weary of elderly its)
Treating symptoms use: BB (metoprolol, atenolol) for palpitat…
Thyrotoxicosis
What drug is used to treat hypothyroid…
Levothyroxine
What do you want to avoid when using l…
Excess cardiac stimulation (weary of elderly its)
95 terms
pharm 2, 3.5: Thyroid
The thyroid gland promotes normal grow…
*the recommended daily adult intake of…
the thyroid gland is regulated by the…
how are the thyroid hormones made?... T3…
- Trascription of cell membrane Na/K ATPase... - Fatty acid oxid…
150 mcg rec'd a day of iodide... ; about 80 mcg a day used by t…
T3 and TSH
just look up:... • Thyroglobulin (glycoprotein) formed in thyro…
The thyroid gland promotes normal grow…
- Trascription of cell membrane Na/K ATPase... - Fatty acid oxid…
*the recommended daily adult intake of…
150 mcg rec'd a day of iodide... ; about 80 mcg a day used by t…
17 terms
AUC block 2 anatomy Thyroid
what are lobes connected by
how many arteries supply thyroid
2 arteries supplying thyroid
how many veins drain thyroid
istmus
2
superior thyroid artery (external carotid - 1st branch)... infer…
3
what are lobes connected by
istmus
how many arteries supply thyroid
2
122 terms
Pharmacology Block 2
Fatty acids
Triglyceride
Cholesterol
Lipids
-from diet or synthesized from glucose, etc... -saturated, monou…
-3FAs and glycerol backbone
-some from diet, most by biosynthesis... -sterol backbone... -precu…
-fats and cholesterol... -efficient energy source: gain calories…
Fatty acids
-from diet or synthesized from glucose, etc... -saturated, monou…
Triglyceride
-3FAs and glycerol backbone
132 terms
Pharmacology block 2
Local anesthetics act by blocking ____…
Local anesthetics become more effectiv…
Local anesthetics are weak (acids/base…
All local anesthetics are vaso(dilator…
Na+
lower; higher: Infected/inflammed tissues cause a decreased a…
bases: They are composed of an aromatic residue, amino group,…
dilators
Local anesthetics act by blocking ____…
Na+
Local anesthetics become more effectiv…
lower; higher: Infected/inflammed tissues cause a decreased a…
11 terms
Block 5 Anatomy 2: Thyroid Imaging
This is the imaging modality of choice…
This is the radionuclide commonly used…
These are the only stable iodine isoto…
On nuclear imaging of the thyroid this…
Ultrasound.
Technetium-99m.
I-123, I-124, I-125 and I-131.
Hot nodules.
This is the imaging modality of choice…
Ultrasound.
This is the radionuclide commonly used…
Technetium-99m.
585 terms
Pharm Block 2
Bromocriptine
Cabergoline
GnRH analogs (long acting formulations…
Pregvisomant
Dopamine agonist used to treat hyperprolactinemia
Dopamine agonist used to treat hyperprolactinemia
Precocious puberty in transgender pts to block puberty, prost…
GH receptor antagonist
Bromocriptine
Dopamine agonist used to treat hyperprolactinemia
Cabergoline
Dopamine agonist used to treat hyperprolactinemia
423 terms
Pharmacology Block 2
Introduction to Alcohols
Ethanol PK
Ethanol PK
Ethanol PK Metabolism
- Low to moderate amounts relieves anxiety and fosters a feel…
• Small water soluble molecule... • Rapidly absorbed from GI tra…
• Rapid distribution; tissue levels... ~blood concentration... • Vo…
- >90% oxidized in liver... - Remainder excreted through lungs a…
Introduction to Alcohols
- Low to moderate amounts relieves anxiety and fosters a feel…
Ethanol PK
• Small water soluble molecule... • Rapidly absorbed from GI tra…
70 terms
LG 2.5 Thyroid Pharm
Levothyroxine (t4)
Liothyronine (T3)
Thyoid Preparations
80% T4, 20% T3
Moa: T3 binds to T3 specific nuclear receptor leads gene expr…
Moa: T3 binds to T3 specific nuclear receptor leads gene expr…
Levothyroxine, liothyronine, liotrix (80% T4, 20% T3), dessic…
liotrix
Levothyroxine (t4)
Moa: T3 binds to T3 specific nuclear receptor leads gene expr…
Liothyronine (T3)
Moa: T3 binds to T3 specific nuclear receptor leads gene expr…
446 terms
Pharmacology Block 2
Guanethodine interacts with
Class of bethanechol
Neostigmine used to reverse
Dantrolene used to treat malignant hyp…
norepinephrine... - block release from storage vesicles into ner…
muscarinic receptor agonist... - cholinomimetic agent: direct…
action of competitive neuromuscular blocking agents... - paral…
blocks calcium release from sarcoplasmic reticulum... Dantrol…
Guanethodine interacts with
norepinephrine... - block release from storage vesicles into ner…
Class of bethanechol
muscarinic receptor agonist... - cholinomimetic agent: direct…
24 terms
2. AUA Pharmacology | Thyroid K
What is the treatment for Hashimoto's…
What is Myxedema Coma?
What is the treatment drug for Myxedem…
What are Thiomides?
Levothyroxine
Untreated Hypothyroidism. Clinical presentations: weakness, s…
Levothyroxine (IV). But can also use Liothyronine.
Antithyroid drugs
What is the treatment for Hashimoto's…
Levothyroxine
What is Myxedema Coma?
Untreated Hypothyroidism. Clinical presentations: weakness, s…
112 terms
SGU Pharmacology 2: Thyroid and Diabetes
In the hypothalamic-pituitary-thyroid…
Thyroid hormone has negative feedback…
What are the 6 steps to thyroid synthe…
What is the backbone of thyroid hormone?
Hypothalamus releases TRH... Anterior pituitary releases TSH... Thy…
on both the hypothalamus and anterior pituitary
1. iodine from blood enters follicular cells. iodine converte…
2 tyrosine molecules connected by ether linkage
In the hypothalamic-pituitary-thyroid…
Hypothalamus releases TRH... Anterior pituitary releases TSH... Thy…
Thyroid hormone has negative feedback…
on both the hypothalamus and anterior pituitary
51 terms
Thyroid (Pharm 2'nd lecture)
What are the 5 steps of thyroid hormon…
Once iodide is ingested, what competit…
What must happen in the Oxidation and…
What catalyzes the Formation of T3 and…
1) Iodide uptake ... 2) Oxidation and iodination... 3) Formation of…
Other ions such as Thiocyanate and perchlorate inhibit it, it…
Tyrosine has to be iodized.. but this requires the iodinating…
The same thing in the second stage, Thyroid Peroxidase. It ma…
What are the 5 steps of thyroid hormon…
1) Iodide uptake ... 2) Oxidation and iodination... 3) Formation of…
Once iodide is ingested, what competit…
Other ions such as Thiocyanate and perchlorate inhibit it, it…
28 terms
Pharmacology Block 2
ACh
directly
smooth muscle... cardiac muscle... exocrin…
skeletal muscle
What is the neurotransmitter at the neuromuscular junction?
The somatic nervous system is (?) innervated
The ANS controls what 3 things?
The ANS controls everything but
ACh
What is the neurotransmitter at the neuromuscular junction?
directly
The somatic nervous system is (?) innervated
45 terms
ENDO 2.03 Pharmacology - Thyroid
Mechanism of thyroid hormone action
What enzyme does the placenta have tha…
What happens to a fetus deprived of th…
How does thyroid hormone affect the he…
binds to nuclear receptor attached to promotor/regulator regi…
3,4-deiodinase (Deiodinase type 3)... most maternal thyroid hor…
brain development and skeleton maturation are markedly impair…
increases output of heart, with both ionotropic (force of con…
Mechanism of thyroid hormone action
binds to nuclear receptor attached to promotor/regulator regi…
What enzyme does the placenta have tha…
3,4-deiodinase (Deiodinase type 3)... most maternal thyroid hor…
156 terms
Block 2 pharmacology
the chemical messengers that enable ne…
Neurotransmitters are released from a
Large myelinated fibers conduct action…
Local circuit neurons have short axons…
neurotransmitter
presynaptic
glutamate
GABA
the chemical messengers that enable ne…
neurotransmitter
Neurotransmitters are released from a
presynaptic
181 terms
Pharm Block 2
Probenecid
Sulfinpyrazone
Allopurinol
Febuxostat
Class: Uricosuric... High doses: urate excretion ... Paradoxical ef…
Same MOA as probenecid... SE: GI issues, less hypersensitivity... A…
Xanthine oxidase inhibitor... Inhibit biosynthesis of uric acid…
More specific an inhibitor of XO than allopurinol... Reduced fre…
Probenecid
Class: Uricosuric... High doses: urate excretion ... Paradoxical ef…
Sulfinpyrazone
Same MOA as probenecid... SE: GI issues, less hypersensitivity... A…
89 terms
Pharm Block 4.10 - GI Pharmacology
Tx strategies for Dyspepsia
What are the antacids?
MOA of Antacids
General SE of Antacids
Dyspepsia = GERD, PUD, acid issues... 1. Antacids... 2. H2-Antagon…
1. Sodium Bicarbonate... 2. Calcium Carbonate (Tums)... 3. Aluminum…
1. Direct neutralization of stomach HCl... 2. Simple, relativel…
Altered abs/excr of other drugs... 1. Slowed dissolution of ta…
Tx strategies for Dyspepsia
Dyspepsia = GERD, PUD, acid issues... 1. Antacids... 2. H2-Antagon…
What are the antacids?
1. Sodium Bicarbonate... 2. Calcium Carbonate (Tums)... 3. Aluminum…
Pharmacology of Thyroid Disorders 2/1
Synthesis and Release of Thyroid Hormo…
_____ is required for production of th…
_____ has greater efficacy and potency…
Hypothyroid States
Uptake of I- through basal and apical membranes of thyroid ep…
Iodine
T3... T4
Hashimoto's Thyroiditis ... Goitrous hypothyroidism... Myxedema, Gu…
Synthesis and Release of Thyroid Hormo…
Uptake of I- through basal and apical membranes of thyroid ep…
_____ is required for production of th…
Iodine
36 terms
Block 6 Pharmacology 1: Drugs to Treat Thyroid Disorders
This is the drug of choice for hypothy…
This is the mechanism of action of lev…
This special instruction for levothyro…
Levothyroxine should be administered s…
Levothyroxine.
Synthetic T4, which is deiodinated to T3 peripherally.
Take on an empty stomach.
Impaired absorption.
This is the drug of choice for hypothy…
Levothyroxine.
This is the mechanism of action of lev…
Synthetic T4, which is deiodinated to T3 peripherally.
132 terms
Pharmacology block 2
Local anesthetics act by blocking ____…
Local anesthetics become more effectiv…
Local anesthetics are weak (acids/base…
All local anesthetics are vaso(dilator…
Na+
lower; higher: Infected/inflammed tissues cause a decreased a…
bases: They are composed of an aromatic residue, amino group,…
dilators
Local anesthetics act by blocking ____…
Na+
Local anesthetics become more effectiv…
lower; higher: Infected/inflammed tissues cause a decreased a…
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