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Study sets matching "pharm pharmacology 11 drug toxicity"

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Study sets matching "pharm pharmacology 11 drug toxicity"

119 terms
Pharm 10-11 - Drug Toxicity
Graded dose-response curve (2)
Quantal dose-response curve (2)
"Quantal" significance
Quantal dose-response used to determin…
-individual... -Dose increase results in increased response
-population... -Increased dose results in increased % of pop af…
-effect present or absent in individual
-median lethal dose
Graded dose-response curve (2)
-individual... -Dose increase results in increased response
Quantal dose-response curve (2)
-population... -Increased dose results in increased % of pop af…
Pharmacology 7 - Drug Toxicity
What does therapeutic index mean in wo…
How is therapeutic window defined?
Which would have a wider therapeutic w…
Why might drug toxicity occur?
-TI = TD50/ED50... This is the dose that would be toxic in 50%…
This is the range between therapeutic and toxic concentration…
Nausea
-Side effect... -Interactions (drug-drug, drug-food)... -Immune med…
What does therapeutic index mean in wo…
-TI = TD50/ED50... This is the dose that would be toxic in 50%…
How is therapeutic window defined?
This is the range between therapeutic and toxic concentration…
11 terms
Pharm 10 - Drug Toxicity
A drug can have an adverse effect even…
Diphenhydramine is an example of a dru…
Most drugs are not selective enough to…
hERG is a subunit of cardiac potassium…
Changes in exposure/sensitivity to a drug... Overdose... Alteration…
It is an antihistamine (histamine H1 receptor antagonist)... Can…
Blocks D2 receptors leading to anti-psychosis.... Also blocks 5H…
1. Long QT syndrome... 2. Cardiac arrhythmia... 3. Sudden cardiac d…
A drug can have an adverse effect even…
Changes in exposure/sensitivity to a drug... Overdose... Alteration…
Diphenhydramine is an example of a dru…
It is an antihistamine (histamine H1 receptor antagonist)... Can…
11 terms
Pharmacology: Drug distribution & toxicity
Therapeutic Window
Agonist
Partial agonist
Efficacy
concentration of drug in the blood that produces a therapeuti…
ligand that binds to the receptor so that it changes the prop…
Basically a weaker form of the agonist in that it produces a…
The degree to which the response varies for different agonist…
Therapeutic Window
concentration of drug in the blood that produces a therapeuti…
Agonist
ligand that binds to the receptor so that it changes the prop…
76 terms
!!!! Pharmacology Drug Toxicity
Toxicity
how many people die annually from drug…
Drug side effects is the ____ leading…
Causes of toxicity
is the study of poisons the adverse effects on drugs, chemica…
200,000
5th
-mix up drugs... -allergies... -overdose... -mix up name of drugs... -mis…
Toxicity
is the study of poisons the adverse effects on drugs, chemica…
how many people die annually from drug…
200,000
76 terms
Pharmacology Drug Toxicity
Toxicity
how many people die annually from drug…
Drug side effects is the ____ leading…
Causes of toxicity
is the study of poisons the adverse effects on drugs, chemica…
200,000
5th
-mix up drugs... -allergies... -overdose... -mix up name of drugs... -mis…
Toxicity
is the study of poisons the adverse effects on drugs, chemica…
how many people die annually from drug…
200,000
95 terms
Pharmacology IIB: Drugs and Toxicity
Paracelsus
Classifying unwanted effects of drugs
Toxicity: Definition
Toxicity in humans is described in ter…
All substances are poisons, there are none which is not a poi…
Classified by type and location. ... Location: CNS, Heart, Liver…
The ability of a chemical to cause a deleterious (harmful) ef…
Adverse drug reactions
Paracelsus
All substances are poisons, there are none which is not a poi…
Classifying unwanted effects of drugs
Classified by type and location. ... Location: CNS, Heart, Liver…
31 terms
Pharmacology 7 Drug Toxicity
therapeutic window
therapeutic index
what does the therapeutic index do rea…
when margin of safety is large toxicit…
the range of doses of a drug that elicits a therapeutic respo…
TD50/ED50 (TD is dose of a drug that causes a toxic response…
it provides a single number that quantifies the relative safe…
toxicity results primarily from overdoses
therapeutic window
the range of doses of a drug that elicits a therapeutic respo…
therapeutic index
TD50/ED50 (TD is dose of a drug that causes a toxic response…
16 terms
drug toxicity pharm
four categories for ADRs
type I hypersensitivity rxn
type II hypersensitivity rxn
type III hypersensitivity rxn
-ADR's resulting from drug binding to intended receptor but a…
Immediate hypersensitivity; results from production of IgE af…
-Antibody-dependent cytotoxic hypersensitivity... -Occurs when a…
-Immune-complex mediated hypersensitivity... -Antibodies formed…
four categories for ADRs
-ADR's resulting from drug binding to intended receptor but a…
type I hypersensitivity rxn
Immediate hypersensitivity; results from production of IgE af…
118 terms
Drug Toxicity (Pharm 2)
What is drug toxicity?
What can cause drug toxicity?
What is the LD50 of aspirin?
What is the LD50 of caffeine?
The systemic effects of a drug that is related to the level o…
-Accumulation of drug in the body over time... -The inability to…
200 mg/kg
192 mg/kg
What is drug toxicity?
The systemic effects of a drug that is related to the level o…
What can cause drug toxicity?
-Accumulation of drug in the body over time... -The inability to…
86 terms
Pharmacology - drug toxicities etc
acetaminophen
Ache inhibitors... organophosphates
amphetamines (basic)
antimuscarinic/ anticholinergic agents
N acetylcysteine replinishes glutathione
atrophine>pralidoxime
NH4Cl (acidify urine)
physostigmine salicylate, control hyperthermia
acetaminophen
N acetylcysteine replinishes glutathione
Ache inhibitors... organophosphates
atrophine>pralidoxime
24 terms
Pharm - Antidotes for drug toxicities
antidote for acetaminophen toxicity
antidote for salicylate toxicity
antidote for amphetamine toxicity
antidote for anticholinesterase, organ…
N-acetylcysteine
NaHCO3 to alkalinize urine, dialysis
NH4Cl (acidify urine)
atropine, pralidoxime
antidote for acetaminophen toxicity
N-acetylcysteine
antidote for salicylate toxicity
NaHCO3 to alkalinize urine, dialysis
10 terms
Pharm - Antidotes for drug toxicities
antidote for acetaminophen toxicity
antidote for amphetamine toxicity
antidote for B-blocker toxicity
antidote for digitalis toxicity
N-acetylcysteine
NH4Cl (acidify urine)
glucagon
Stop drug, normalize K+, lidocaine, anti-drug Fab fragments,…
antidote for acetaminophen toxicity
N-acetylcysteine
antidote for amphetamine toxicity
NH4Cl (acidify urine)
76 terms
Pharm Lect. 10 - Drug Toxicity
Mechanistic toxicity
Descriptive Toxicology
Regulatory Toxicology
How many regulatory agencies are there…
Trying to figure out what the mechanism is - how the toxicant…
-concerned directly with toxicity testing - provides informat…
-decides whether a drug or other chemical poses a low risk to…
EPA, FDA, OSHA, Health Admin, Consumer Products Safety Commis…
Mechanistic toxicity
Trying to figure out what the mechanism is - how the toxicant…
Descriptive Toxicology
-concerned directly with toxicity testing - provides informat…
24 terms
Pharm - Antidotes for drug toxicities
antidote for acetaminophen toxicity
antidote for salicylate toxicity
antidote for amphetamine toxicity
antidote for anticholinesterase, organ…
N-acetylcysteine
NaHCO3 to alkalinize urine, dialysis
NH4Cl (acidify urine)
atropine, pralidoxime
antidote for acetaminophen toxicity
N-acetylcysteine
antidote for salicylate toxicity
NaHCO3 to alkalinize urine, dialysis
Pharm - Antidotes for drug toxicities
antidote for acetaminophen toxicity
antidote for salicylate toxicity
antidote for amphetamine toxicity
antidote for anticholinesterase, organ…
N-acetylcysteine
NaHCO3 to alkalinize urine, dialysis
NH4Cl (acidify urine)
atropine, pralidoxime
antidote for acetaminophen toxicity
N-acetylcysteine
antidote for salicylate toxicity
NaHCO3 to alkalinize urine, dialysis
22 terms
Intro to Pharm Drugs and Toxicity
Carvedilol
Codeine
Clarithromycin and Voriconazole
Organophosphates
nonselective, beta/alpha-1 blocker, used for the treatment of…
Opiod, cough medication, metabolized by CYP2D6 to morphine-3-…
Reduce the activity of CYP3A4, resulting in opiod toxicity
Insecticides, form covalent bonds (irreversible) to the bindi…
Carvedilol
nonselective, beta/alpha-1 blocker, used for the treatment of…
Codeine
Opiod, cough medication, metabolized by CYP2D6 to morphine-3-…
24 terms
Pharm - Antidotes for drug toxicities
antidote for acetaminophen toxicity
antidote for salicylate toxicity
antidote for amphetamine toxicity
antidote for anticholinesterase, organ…
N-acetylcysteine
NaHCO3 to alkalinize urine, dialysis
NH4Cl (acidify urine)
atropine, pralidoxime
antidote for acetaminophen toxicity
N-acetylcysteine
antidote for salicylate toxicity
NaHCO3 to alkalinize urine, dialysis
24 terms
Pharm - Antidotes for drug toxicities
antidote for acetaminophen toxicity
antidote for salicylate toxicity
antidote for amphetamine toxicity
antidote for anticholinesterase, organ…
N-acetylcysteine
NaHCO3 to alkalinize urine, dialysis
NH4Cl (acidify urine)
atropine, pralidoxime
antidote for acetaminophen toxicity
N-acetylcysteine
antidote for salicylate toxicity
NaHCO3 to alkalinize urine, dialysis
18 terms
Pharmacology Toxic Effects of Drugs
What are adverse effects?
What are primary actions?
What are secondary actions?
What is hypersensitivity?
Undesired effects that may be unpleasant or dangerous.
Adverse effect that is an extension of the desired effect.
Adverse effect that occurs when a drug produces a wide variet…
When a patient is excessively responsive to either the primar…
What are adverse effects?
Undesired effects that may be unpleasant or dangerous.
What are primary actions?
Adverse effect that is an extension of the desired effect.
25 terms
Pharm: Drug Toxicities & Adjuvants
Stocking-Glove Syndrome
Hand-Foot Syndrome
Lung Fibrosis (Toxicity)
Renal Toxicity
-Platinum Drugs (Cisplatin/Carboplatin)... -Vinca Alkaloids (Vin…
-Fluorouracil (5FU)... -Capecitabine... -Cytarabine... -PEG-Liposomal…
-Cyclophosphamide... -Melphalan... -Busulfan... -Bleomycin
-Cyclophosphamide... -Ifosfamide... -Cisplatin... -Carboplatin... -Methot…
Stocking-Glove Syndrome
-Platinum Drugs (Cisplatin/Carboplatin)... -Vinca Alkaloids (Vin…
Hand-Foot Syndrome
-Fluorouracil (5FU)... -Capecitabine... -Cytarabine... -PEG-Liposomal…
8 terms
Pharm- Drug toxicities
NAT2 N-acetyl transferase is the gene…
CYP2D6
BCHE pseudo-cholinesterase
G6PD DH
poor metabolizer; hydralazine, isoniazid, procainamide; lupus…
ultra metabolizer; codeine, antipsychotics, antidepressents,…
deficient serum cholinesterase, inc. succinylcholine, prolong…
deficiency, needed for production of reduced glutathion, sulf…
NAT2 N-acetyl transferase is the gene…
poor metabolizer; hydralazine, isoniazid, procainamide; lupus…
CYP2D6
ultra metabolizer; codeine, antipsychotics, antidepressents,…
32 terms
Pharm toxicity L11
Therapeutic Window
Therapeutic Index (TI)
Drug allergies
Type I
the effective (therapeutic) dose range of a drug that does no…
the safety ratio is equal to TD50 / ED50
due to an immune response and results from interaction of dru…
(immediate hypersensitivity) by IgE: hives, eczema, anaphylac…
Therapeutic Window
the effective (therapeutic) dose range of a drug that does no…
Therapeutic Index (TI)
the safety ratio is equal to TD50 / ED50
41 terms
Pharmacology Final (Drug & Toxicity in OD)
Acetaminophen
Alteplase
Amoxicillin
Amphetamine (Mixed Salts)
Hepatoxicity at greater than 4 mg/day
Hemorrhage
Allergies (10% rate)
Hypertension, psychosis
Acetaminophen
Hepatoxicity at greater than 4 mg/day
Alteplase
Hemorrhage
18 terms
Lecture 11: drug toxicity
Therapeutic index
Therapeutic window
Type 1 hypersensitivity
Type 2 hypersensitivity
TD50/ED50
range where drug is producing therapeutic effect without any…
IgE mediated, immediate histamine release
cytolytic reactions IgG/IgM mediated
Therapeutic index
TD50/ED50
Therapeutic window
range where drug is producing therapeutic effect without any…
59 terms
PHARMACOLOGY FINAL 4: Drug Toxicity
ED50
TD50
LD50
what three factors determine the toxic…
Therapeutic effect
Toxic effect
Lethal effect
Frequency of dosing... Elimination Rate... Dose Amount
ED50
Therapeutic effect
TD50
Toxic effect
87 terms
Lecture 11- Drug Toxicity
MTC
therapeutic window
MEC
Can the therapeutic window narrow over…
minimum toxic concentration... associated w/ adverse effects
the effective (therapeutic) dose range of a drug that does no…
minimum effective concentration... associated w/ therapeutic eff…
yes- pt status changes in neurodegenerative disease
MTC
minimum toxic concentration... associated w/ adverse effects
therapeutic window
the effective (therapeutic) dose range of a drug that does no…
55 terms
pharm test 2 drug toxicity
chlorpromazine
simvastatin
HMG CoA reductase
muscle toxicity
antipsychotic drug that controls schizophrenia
used clinically to decrease cholesterol levels - intended tar…
simvastatin inhibits
an adverse effect of simvastatin therapy
chlorpromazine
antipsychotic drug that controls schizophrenia
simvastatin
used clinically to decrease cholesterol levels - intended tar…
10 terms
Veterinary Pharmacology - FINAL Toxic Drugs
NSAID
Acetaminophen
Antidepressants
ADD/ADHD
Ibuprofen, Advil, Motrin, Naproxen/Aleve
Tylenol
Effexor, Cymbalta, Prozac, Lexapro
Concerta, Adderall, Ritalin
NSAID
Ibuprofen, Advil, Motrin, Naproxen/Aleve
Acetaminophen
Tylenol
46 terms
Pharmacology: Drug Toxicities and Side Effects
Cocaine, sumatriptan, ergot alkaloids
Vancomycin, Adenosine, Niacin, CCBs (V…
Anthracyclines (doxorubicin, daunorubi…
Class III and Ia antiarrythmics, macro…
Coronary vasospasm
Cutaneous flushing
Dilated cardiomyopathy (prevent with dexrazoxane)
Torsade de pointes
Cocaine, sumatriptan, ergot alkaloids
Coronary vasospasm
Vancomycin, Adenosine, Niacin, CCBs (V…
Cutaneous flushing
23 terms
Lecture 11- Drug Toxicity
A chemical substance that seriously im…
Distinction between drug and poison is…
Dose which kills 50% of an experimenta…
This answers the question "How Safe is…
Poison
True. All drugs have potential for adverse effects
Lethal Dose (LD50)
Therapeutic Index
A chemical substance that seriously im…
Poison
Distinction between drug and poison is…
True. All drugs have potential for adverse effects
5 terms
Human Pharm - Cancer Drug Toxicities
Doxorubicin
Cisplain
Bleomycin
Vincristine
Cardiac Toxicity
Renal Toxicity
Pulmonary Toxicity
Neurotoxicity
Doxorubicin
Cardiac Toxicity
Cisplain
Renal Toxicity
28 terms
Renal Pharmacology & Toxic Action of Drugs
Mechanism of polyuria caused by type I…
Vasopressin increases äter retention i…
PKA increases the migration of water c…
Central (neurogenic) diabetes insipidu…
osmolality, water attraction (decreased reabsorption)
V2
aquaporin-2, apical
ADH (vasopressin), V2
Mechanism of polyuria caused by type I…
osmolality, water attraction (decreased reabsorption)
Vasopressin increases äter retention i…
V2
19 terms
Pharm 5 (Drug Toxicities/Pharmacogenomics)
Type A ADE - common and predictable
Type B - Rare and unpredictable
Drug Effects
Type 1 HS
Overdose, Side effects, Secondary effects, indirect effects,…
intolerance, idiosyncracy, immunologic drug rxn
Effects - Desirable (therapeutic) + undesirable -> non-delete…
typical allergy response, mediated by IgE, anaphylactic
Type A ADE - common and predictable
Overdose, Side effects, Secondary effects, indirect effects,…
Type B - Rare and unpredictable
intolerance, idiosyncracy, immunologic drug rxn
88 terms
Pharmacology: Absorption and Distribution of drugs and Toxicants
The effect of most drugs/toxicants is…
Where is the initial site of entry int…
What is the disposition of drug depend…
Can a drug be toxic?
the concentration
the site of action
ADME
Yes, a drug in a high enough dose can be toxic to the body
The effect of most drugs/toxicants is…
the concentration
Where is the initial site of entry int…
the site of action
9 terms
Pharm exam III drug toxicities
Cisplatin
Carboplatin
Bleomycin
Doxorubicin
Nephrotoxicity
Myelosuppression
Pulmonary toxicity
Cardiotoxicity
Cisplatin
Nephrotoxicity
Carboplatin
Myelosuppression
27 terms
Renal Pharm and Toxic Action of Drugs
Polyuria
Polyuria Cause: Diabetes Mellitus... and…
Polyuria Cause: Diabetes insipidus
Treatment of Diabetes insipidus
Excessive production of dilute urine (3L/24hr = twice as much…
1. Hyperglycemia --> increased urine glucose --> water follow…
1. Central (hypothalmic infection, tumors etc...) --> decreas…
1. Central = Treat pituitary disease, ADH replacement... 2. Neph…
Polyuria
Excessive production of dilute urine (3L/24hr = twice as much…
Polyuria Cause: Diabetes Mellitus... and…
1. Hyperglycemia --> increased urine glucose --> water follow…
72 terms
GI: Pharm-toxic drug interactions
drug toxicity and age
definition of drug-drug interaction
what are the three types of interactions
what is pharmacokinetics
with an increase in age there is more of a chance that the pa…
when two or more substances (not always drugs) are taken toge…
drug -drug; drug-herbal/OTC; drug-food
when the absorptiom, distribution, metabolism, or excretion (…
drug toxicity and age
with an increase in age there is more of a chance that the pa…
definition of drug-drug interaction
when two or more substances (not always drugs) are taken toge…
20 terms
Pharmacology 5&6 - Drug Toxicity and Interactions
What is a intrinsic hepatotoxin?
What is a direct intrinsic hepatotoxin?
What is an indirect intrinsic hepatoto…
What is indiosyncratic hepatotoxicity?
A drug that injures the liver as part of its structure
A substance that is able to injure the liver without being me…
A drug that is able to injure the liver after being metabolized
Sensitivity of a patient's liver to a particular molecule or…
What is a intrinsic hepatotoxin?
A drug that injures the liver as part of its structure
What is a direct intrinsic hepatotoxin?
A substance that is able to injure the liver without being me…
35 terms
Renal Pharm & Toxic Actions of Drugs
List the normal renal functions
Define polyuria
Causes of polyuria
List the types of diabetes insipidus
1. Excretion of waste products... 2. Regulation of ECF... 3. Regula…
> 3L of urine in 24 hours
1. Diabetes mellitus... 2. Diabetes insipidus
1. Central (neurogeneic) = decrease in ADH production... 2. Neph…
List the normal renal functions
1. Excretion of waste products... 2. Regulation of ECF... 3. Regula…
Define polyuria
> 3L of urine in 24 hours
34 terms
Pharm 8 - Drug Toxicity and Adverse Drug Reactions
What are three ways in which drug toxi…
What are examples of drugs that can ca…
What is an example of a drug that can…
What are examples of drugs that can ca…
Accidental poisoning, intentional poisoning, and adverse drug…
Benzodiazepines (excessive sedation),... Antiarrhythmic drugs (e…
Ganglionic blocking agents used to treat hypertension by decr…
Cardiac glycosides (like digitalis) - nausea and vomiting... Fer…
What are three ways in which drug toxi…
Accidental poisoning, intentional poisoning, and adverse drug…
What are examples of drugs that can ca…
Benzodiazepines (excessive sedation),... Antiarrhythmic drugs (e…
31 terms
Pharmacology - Lecture 4 (Drug Toxicity) Slides + Book
True or False: There are drugs with no…
What does the FDA do?
Side effects are a function of what?
What does drug toxicity cause?
False; no drug is 100% safe.
regulates drugs on the market, and drugs coming onto the mark…
the mechanisms of drug action, the size of the drug dose, and…
1.) Side Effects... 2.) Action on the target... - Inappropriate act…
True or False: There are drugs with no…
False; no drug is 100% safe.
What does the FDA do?
regulates drugs on the market, and drugs coming onto the mark…
14 terms
LIVER TOXIC (Pharm Final Drugs)
ANDROGENS (Oxandrolone, Stanozolol, Fl…
DANAZOL... (Partial progestin, androgen,…
METFORMIN
THIAZOLIDENEDIONES (TZDS) ... -Pioglitazo…
*Can cause Hepatic Adenomas
*ABNORMAL LIVER FUNCTION TESTS... *Heptatitis... *also Inhibits CYP…
Contraindicated with patient with Renal or Heptaic disease or…
*FDA Requires Hepatotoxicity Monitoring because first one mad…
ANDROGENS (Oxandrolone, Stanozolol, Fl…
*Can cause Hepatic Adenomas
DANAZOL... (Partial progestin, androgen,…
*ABNORMAL LIVER FUNCTION TESTS... *Heptatitis... *also Inhibits CYP…
14 terms
PHARM - Pharmacology of Antiparasitic Drugs
Target Snapshot
Antiparasitic Drug List
Treatment of Intestinal Protozoa
Metronidazole ('Flagyl')
Albendazole... Pyrantel pamoate... Ivermectin... Praziquantel... Paro…
Mechanism: Activated only in *anaerobes to metabolites that d…
Target Snapshot
Antiparasitic Drug List
Albendazole... Pyrantel pamoate... Ivermectin... Praziquantel... Paro…
28 terms
Lecture 2 Pharmacology Drug Distribution and Toxicity
Saturated dose-response curve
therapeutic window
agonist
receptor
receptors are saturated and adding more drug will not increas…
The range of drug concentrations in blood which produce a the…
A ligand that binds to receptors and thereby alters the propo…
A collection of cellular macromolecules that are involved dir…
Saturated dose-response curve
receptors are saturated and adding more drug will not increas…
therapeutic window
The range of drug concentrations in blood which produce a the…
14 terms
Drug Toxicity 11/29/2016
What model is used to test acute toxic…
How is the therapeutic index determine…
What two things can you not use the th…
Other than acute toxicity, what 5 test…
Animal studies (rodents)
LD50/ED50; margin of safety
Efficacy and hypersensitivity
Chronic toxicity, sensitization, neonatal toxicity, teratogen…
What model is used to test acute toxic…
Animal studies (rodents)
How is the therapeutic index determine…
LD50/ED50; margin of safety
15 terms
VATI Pharmacology Flashcards- Toxic Drug Levels
acetaminophen
aminophylline
amitriptylline
digoxin
250
20
500
2.4
acetaminophen
250
aminophylline
20
42 terms
Principles of Clinical Pharmacology: Compliance/Drug Abuse/Toxicity
Reasons why Pt do not comply
Actual Adverse Drug Reactions
Potential Adverse Drug Reactions
How to increase Compliance
-- self conscious... -- reminds pt of disease... -- pt doesn't feel…
Pts have some undesired effects when taking drugs e.g., drows…
Increased chance of hemorrhagic stroke with ASA therapy when…
Pt must understand:... -- what drugs are being taken... -- why they…
Reasons why Pt do not comply
-- self conscious... -- reminds pt of disease... -- pt doesn't feel…
Actual Adverse Drug Reactions
Pts have some undesired effects when taking drugs e.g., drows…
14 terms
11/29/16 - Drug Toxicity
Poison
Acute toxicity
Therapeutic index
What does therapeutic index NOT tell y…
1. Chemical substance that IN SMALL DOSES seriously impairs h…
1. Measured by MEDIAN LETHAL DOSE (LD50) -- Dose that kills 5…
1. Ratio between LD50 and ED50 (Effective dose)... 2. Therapeuti…
1. Whether pt will be HYPERSENSITIVE to the drug... 2. To evalua…
Poison
1. Chemical substance that IN SMALL DOSES seriously impairs h…
Acute toxicity
1. Measured by MEDIAN LETHAL DOSE (LD50) -- Dose that kills 5…
68 terms
Pharm: First Aid Pharmacology - Toxicities and SE
What is the antidote for Acetaminophen?
What is the antidote for AChE inhibito…
What is the antidote for Amphetamines?
What is the antidote for antimuscarini…
N-acetylcysteine (replenishes glutathione)
Atropine followed by pralidoxime
Since amphetamines are basic, NH4Cl (acidify urine)
Physostigmine salicylate, control hyperthermia "Physostigmine…
What is the antidote for Acetaminophen?
N-acetylcysteine (replenishes glutathione)
What is the antidote for AChE inhibito…
Atropine followed by pralidoxime
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