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Study sets matching "pharma"

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Study sets matching "pharma"

13 terms
Pharmacology
Pharmacology
Drug
Terminology
Sources of drugs
Study of drugs
Any substance going into the body, has an effect on compositi…
Presentation - The form and strength of the drug... Therapeutic…
Naturally occurring... Derived from Animals (hormones)... Synthetic
Pharmacology
Study of drugs
Drug
Any substance going into the body, has an effect on compositi…
9 terms
pharmacology
local anesthetics
benzodiazepines
Albuterol
propanolol
- alter the conductance of ion channels by blocking the volta…
- binds to GABAa receptor... - GABAa receptor: chloride ion chan…
- beta 2 agonist... - used for asthma
- beta antagonist... - used for hypertension (HTN)
local anesthetics
- alter the conductance of ion channels by blocking the volta…
benzodiazepines
- binds to GABAa receptor... - GABAa receptor: chloride ion chan…
83 terms
pharmacology
pharmacology
molecular pharmacology
pharmacodynamics
pharmacogenetics
study of drugs and interactions with living organisms
study of chemical structures of drugs and the effects of drug…
mechanisms of action by which drugs produce their effects bas…
how the genetic makeup of different people affects their resp…
pharmacology
study of drugs and interactions with living organisms
molecular pharmacology
study of chemical structures of drugs and the effects of drug…
23 terms
Pharmacology
Abilify
Accupril
Aciphex
Aciphex
Abilify
Accupril
52 terms
Pharmacology
Pharmacology
Endogenous Drugs
Poisons
Toxins
The study of substances that interact with living systems thr…
Drugs that produce normal body processes, such as hormones.
Drugs that have almost exclusively harmful effects.
Poisons of biological origins, usually synthesised by plants…
Pharmacology
The study of substances that interact with living systems thr…
Endogenous Drugs
Drugs that produce normal body processes, such as hormones.
152 terms
Pharmacology
Enzyme Kinetics
Enzyme Kinetics (cont)
Enzyme Kinetics (cont x2)
Enzyme Kinetics (cont x3)
Enzyme Kinetics
Enzyme Kinetics (cont)
68 terms
Pharmacology
Adrenergic blocking agents
Metroprolol tartrate (Lopressor)
proprannolol hydrochloride (Inderal)
Adrenergics
affect the alpha receptors of adrenergic nerves
Adrenergic blocking agent
Adrenergic blocking agent
Mimic the activity of the sympathetic nervous system
Adrenergic blocking agents
affect the alpha receptors of adrenergic nerves
Metroprolol tartrate (Lopressor)
Adrenergic blocking agent
42 terms
Pharmacology
Enzyme Kinetics
Pharmacokinetics
Dosage calculations
Elimination of drugs
Enzyme Kinetics
Pharmacokinetics
86 terms
Pharmacology
D.C.
d.c.
d/c
OTC
Discontinue
Discontinue
Discontinue
Over the Counter
D.C.
Discontinue
d.c.
Discontinue
9 terms
Pharmacology
Pharmacology
Pharmac/o
-ology
Oral
the study of the nature, uses, and effects of drugs in medica…
drug
study of
Taken through the mouth and absorbed in the digestive tract.
Pharmacology
the study of the nature, uses, and effects of drugs in medica…
Pharmac/o
drug
32 terms
Pharmacology
Dosage calculations
Drug metabolism
Therapeutic index
Central and peripheral nervous system
Dosage calculations
Drug metabolism
152 terms
Pharmacology
Enzyme Kinetics
Enzyme Kinetics (cont)
Enzyme Kinetics (cont x2)
Enzyme Kinetics (cont x3)
Enzyme Kinetics
Enzyme Kinetics (cont)
31 terms
Pharmacology
Therapuetic Effect
Side Effect
Adverse Effect
Drug Toxicity
Desired effect, is the primary effect intended, that is, the…
Secondary effect, is one that is unintended. Usually they are…
More severe side effect. May justify discontinuation of a drug.
Harmful effects of a drug on an organism. Results from overdo…
Therapuetic Effect
Desired effect, is the primary effect intended, that is, the…
Side Effect
Secondary effect, is one that is unintended. Usually they are…
180 terms
Pharmacology
Medical pharmacology and toxicology
Parmaco dynamics
Pharmaco kinetics
Poisons
want to understand drug's effect on one organism ... -to prevent…
the actions of the chemical on the organism
-action of the organism on drug. ... -absorption, distribution,…
drugs that have almost exclusively harmful effects... -usually r…
Medical pharmacology and toxicology
want to understand drug's effect on one organism ... -to prevent…
Parmaco dynamics
the actions of the chemical on the organism
18 terms
Pharmacology
Liver
Achondroplasia
Pyruvate dehydrogenase deficiency
Nitoprusside infusion
glucagon - glucogenolysis-increase blood glucose
AD, sporadic 50%chance to get it, Midget.
diet of leucine and lysine (ketogenic) required
too much has cyanide poisoning give sulfur or also called sod…
Liver
glucagon - glucogenolysis-increase blood glucose
Achondroplasia
AD, sporadic 50%chance to get it, Midget.
19 terms
Pharmacology
Acepromazine
Atropine
Atipemazol
Buprenorphine
-Phenotiazine sedative/tranquilizer... -May cause significant hy…
- Anticholinergic... - Could be used for a variety indications (…
- Alpha-2-adrenergic antagonist... -Antisedan... - Adverse effects…
- Opiate partial agonist... -Can be used as an injectable or ora…
Acepromazine
-Phenotiazine sedative/tranquilizer... -May cause significant hy…
Atropine
- Anticholinergic... - Could be used for a variety indications (…
32 terms
Pharmacology
affinity
efficacy
excitation
inhibition
a drug's attraction to a receptor
a drug's ability to activate a receptor; also known as the mo…
a way a drug activates an excitatory system or blocking an in…
a way a drug activates an inhibitory system or by blocking an…
affinity
a drug's attraction to a receptor
efficacy
a drug's ability to activate a receptor; also known as the mo…
32 terms
Pharmacology
What is the name under which a drug is…
Which source contains information spec…
What is the most comprehensive referen…
The physician has written an order for…
C. Official
C. United States Pharmacopeia/National Formulary (USP-NF)
B. Drug Interaction Facts
B. Brand and Generic Name section
What is the name under which a drug is…
C. Official
Which source contains information spec…
C. United States Pharmacopeia/National Formulary (USP-NF)
62 terms
Pharmacology
Gram + only
Gram -ve only
Extended spectrum
+ve, -ve, extended
Penicillin V / Anti-staph /G... Bacitracin... Cephalosporins (1st g…
Anti-Pseudomonal penicillin... Aztreoman... Cephalosporin (2nd gene…
Amoxicillin/Ampicillin... Carbapenems ... Cepholosporins (3+4) ... Chl…
Aminoglycosides ... Clindamycin
Gram + only
Penicillin V / Anti-staph /G... Bacitracin... Cephalosporins (1st g…
Gram -ve only
Anti-Pseudomonal penicillin... Aztreoman... Cephalosporin (2nd gene…
69 terms
Pharmacology
Drugs
Roles of DH
FDA
Regulates the labeling and advertising…
chemical substances used for the diagnosis, prevention, or Tx…
1. Obtaining HH 2. Administering drugs in office. 3. Handling…
quality controlin manufacturing plants anddecides what drugs…
FDA
Drugs
chemical substances used for the diagnosis, prevention, or Tx…
Roles of DH
1. Obtaining HH 2. Administering drugs in office. 3. Handling…
56 terms
Pharmacology
Bisphosponates
Methotrexate
Biologic DMARDS
Allopurinol
Osteoporosis
Rhematoid Arthritis
Rheumatoid Arthritis
Gout
Bisphosponates
Osteoporosis
Methotrexate
Rhematoid Arthritis
123 terms
Pharmacology
Pharmacology
United States Pharmacopeia (USP)
Food and Drug Administration (FDA)
Drug Enforcement Agency (DEA)
Study of medications in humans
Sets standards for strength, quality, purity and preparation…
-Monitors and controls drug manufacturing and marketing... -Regu…
Monitors narcotic prescriptions and controlled substance sche…
Pharmacology
Study of medications in humans
United States Pharmacopeia (USP)
Sets standards for strength, quality, purity and preparation…
95 terms
pharmacology
purpose of medications
drug
medication
pharmacology
diagnostic testing, symptom relief, symptom treatment, preven…
any substance that when taken into a living organism, may mod…
medicinal substance used to treat disease or illness
the study of medicines,the discipline pertaining to how drugs…
purpose of medications
diagnostic testing, symptom relief, symptom treatment, preven…
drug
any substance that when taken into a living organism, may mod…
130 terms
Pharmacology
Define Pharmacokinetics
Pharmacodynamics
Antagonists
Distribution
Drug concentration in body fluids and tissues that influence…
A broad term which generally describes the fundamental action…
Drugs bind to site used by endogenous ligand and acts competi…
Drug that is not bound to protein is the drug that will go to…
Define Pharmacokinetics
Drug concentration in body fluids and tissues that influence…
Pharmacodynamics
A broad term which generally describes the fundamental action…
54 terms
Pharmacology
Leuoprolide - action
Leuprolide - use
Leuprolide - toxicity
What are the pharmacologic estrogens?
GnRH analog with agonist properties when used in pulsatile fa…
Infertility (pulsatile), prostate cancer (continuous use foll…
Antiandrogen, nausea, vomiting... Leuprolide can be used in Lie…
Ethinyl estradiol, Diethylstilbestrol (DES), mestranol... pg 596
Leuoprolide - action
GnRH analog with agonist properties when used in pulsatile fa…
Leuprolide - use
Infertility (pulsatile), prostate cancer (continuous use foll…
88 terms
Pharmacology
At what age is poisoning most common?
At what age is poisoning most fatal?
Where does poisoning actually occur?
Common Household poisons
1-3 years old
50
Home
Most commonly involved: Analgesics.... -Prescriptions... -Illicit d…
At what age is poisoning most common?
1-3 years old
At what age is poisoning most fatal?
50
54 terms
Pharmacology
P450 Inducers
P450 Inhibitors... MAGIC RACKS in GQ
Fluoroquinolones
Fluoroquinolones Use
Modafinil... Barbiturates (Phenobarbital)... St. John`s wort... Phenyt…
Macrolides... Amiodarone... Grapefruit juice... Isoniazid... Cimetidine…
-XACIN... Ciprofloxacin... Norfloxacin... Levofloxacin... Nalidixic acid…
-Xacin... Gram negative rods of urinary & GI tracts (pseudomonas…
P450 Inducers
Modafinil... Barbiturates (Phenobarbital)... St. John`s wort... Phenyt…
P450 Inhibitors... MAGIC RACKS in GQ
Macrolides... Amiodarone... Grapefruit juice... Isoniazid... Cimetidine…
80 terms
Pharmacology
What is psychopharmacology?
What are 3 neurotransmitters in the br…
Antidepressants
Tricyclic Antidepressants
scientific study and use of drugs that influence behavior, pe…
-Dopamine: reward and motivation... *interact>attention... -Norepin…
-Classic:... 1) Tricyclics (TCAs)... 2) Monoamine Oxidase Inhibitor…
-antidepressant... Elavil... Anafranil... Asendin... Sinequan... Norpramin... V…
What is psychopharmacology?
scientific study and use of drugs that influence behavior, pe…
What are 3 neurotransmitters in the br…
-Dopamine: reward and motivation... *interact>attention... -Norepin…
96 terms
Pharmacology
Enzyme Kinetics
Pharmacokinetics
Dosage Calculations
Elimination of Drugs
...
...
...
...
Enzyme Kinetics
...
Pharmacokinetics
...
37 terms
Pharmacology
Drug
Receptor
Effectors
Hormone receptor
Any substance that acts at a chemical level on a biological s…
specific molecules that drugs interact with to cause a functi…
molecules that translate drug binding event into biological e…
Drug
Any substance that acts at a chemical level on a biological s…
Receptor
specific molecules that drugs interact with to cause a functi…
219 terms
Pharmacology
Michaelis-Menten kinetics
Most enzymatic reactions follow a *hyp…
Lineweaver-Burk plot... The further to…
Enzyme inhibition... Reversible competiti…
Km = [S] at 1/2[Vmax], where [S] = concentration of substrate…
Most enzymatic reactions follow a ________ curve (i.e., _____…
_______ plot: increase y intercept, decrease Vmax... The furthe…
Enzyme inhibition:... __________ inhibitors cross eachother comp…
Michaelis-Menten kinetics
Km = [S] at 1/2[Vmax], where [S] = concentration of substrate…
Most enzymatic reactions follow a *hyp…
Most enzymatic reactions follow a ________ curve (i.e., _____…
141 terms
Pharmacology
What is the mechanism of Heparin?
[...] is an activator of antithrombin,…
Heparin is an activator of antithrombi…
Heparin is used for immediate anticoag…
Activator of antithrombin, decreases thrombin and factor Xa l…
Heparin... pg 405
Factor Xa levels... pg 405
Used in pregnancy (heparin does not cross placenta)... pg 405
What is the mechanism of Heparin?
Activator of antithrombin, decreases thrombin and factor Xa l…
[...] is an activator of antithrombin,…
Heparin... pg 405
50 terms
Pharmacology
Analgesics, Narcotic: morphine , Demer…
Analgestics, non-narcotic nor non- opi…
Valium, Xanax, Ativan, Tranxene
Atenolol, Propanolol, Vepramil, topril
Relieve severe pain, including postoperative pain, myocardial…
Relieve minor to moderate pain and chronic pain
Relieve anxiety, some psychosomatic disorders, muscle tension…
treat arrhythmias and restore normal heartbeat
Analgesics, Narcotic: morphine , Demer…
Relieve severe pain, including postoperative pain, myocardial…
Analgestics, non-narcotic nor non- opi…
Relieve minor to moderate pain and chronic pain
113 terms
Pharmacology
Volume of Distribution (Vd)
Clearance (CL)
Half-life (t 1/2)
Loading dose
= amount of drug in body/plasma drug concentration
= rate of elimination of drug/plasma drug concentration... = Vd…
= (0.693*Vd)/CL
= (Cp * Vd)/F
Volume of Distribution (Vd)
= amount of drug in body/plasma drug concentration
Clearance (CL)
= rate of elimination of drug/plasma drug concentration... = Vd…
76 terms
Pharmacology
Theraputic window
Bioavailability
AUC area under curve
Zero order kinetics
Range btw toxicity and minimal effective concentration
Fraction absorbed. Specifically, rate and extent the active i…
Concentration * time, which defines differences between drug…
Absorption/ elimination constant per unit time. Not dependent…
Theraputic window
Range btw toxicity and minimal effective concentration
Bioavailability
Fraction absorbed. Specifically, rate and extent the active i…
265 terms
Pharmacology
These factors act together to affect a…
Movement of drug into the bloodstream…
Target tissue may NOT be the blood, bu…
Factors controlling drug absorption
Drug absorption... Drug distribution... Drug metabolism... Drug elimin…
Drug absorption
Pharmacokinetic parameter
Physicochemical characteristics of drug (dosage form)... Route o…
These factors act together to affect a…
Drug absorption... Drug distribution... Drug metabolism... Drug elimin…
Movement of drug into the bloodstream…
Drug absorption
38 terms
Pharmacology
Partition Coefficient (P)
Low P value
High P value
C
Concentration of drug in octanol/ concentration of drug in aq…
Hydrophillic
Hydrophobic
Concentration of drug required to achieve a defined level of…
Partition Coefficient (P)
Concentration of drug in octanol/ concentration of drug in aq…
Low P value
Hydrophillic
21 terms
Pharmacology
Agonists
Endogenous drugs
exogenous drugs
Ach agonist
-drugs can act as these... - act as neurotransmitters that bind…
-ex: endorphine... -naturally occurring
- ex; heroine ... - drugs put into body
- nicotine
Agonists
-drugs can act as these... - act as neurotransmitters that bind…
Endogenous drugs
-ex: endorphine... -naturally occurring
29 terms
Pharmacology
Agranulocytosis (Neutropenia)
Chelating agents
Ethylene diamine tetra acetic acid
Epistaxis
Def: acute decrease in number of granulocytes(WBC) in periphe…
Def: a form of detoxification, involves the injection of ethy…
A synthetic amino acid which attaches to toxic substance such…
Nose bleed, can be anterior or posterior. Posterior is more s…
Agranulocytosis (Neutropenia)
Def: acute decrease in number of granulocytes(WBC) in periphe…
Chelating agents
Def: a form of detoxification, involves the injection of ethy…
15 terms
pharmacology
anesthetic agents
antibacterials
antifungals
antihistamines
reduce pain and discomfort
prevent and treat bacterial growth , such as triple antibioti…
treat fungal infections
lessen itching by reducing an allergic response
anesthetic agents
reduce pain and discomfort
antibacterials
prevent and treat bacterial growth , such as triple antibioti…
31 terms
Pharmacology
Half-live
Agonists
Antagonist
Nonspecific Drug
The half-life of a drug is the time it takes for one half of…
Drugs that produce a response
Drugs that block a response
Drugs that affect various sites are nonspecific drugs and hav…
Half-live
The half-life of a drug is the time it takes for one half of…
Agonists
Drugs that produce a response
16 terms
Pharmacology
Generic Brand
Distribution
Metabolism
Excretion
Chemical composition as (trade name)... May have many brand name…
Movement of drug through circulatory system to intended site…
A change in a drug into a more or less potent after it passes…
The removal of drugs as it metabolites through kidney, gastro…
Generic Brand
Chemical composition as (trade name)... May have many brand name…
Distribution
Movement of drug through circulatory system to intended site…
42 terms
Pharmacology
Buccal
Intradermal
Intramuscular
Deltoid
Placed btwn gum and cheek via tablet, gel or spray
Injected into dermal layer of skin at:... *10-15° angle ... *25 -2…
Injected into muscle at ... * 90°... *18-23G... *Dose: 0.5ml ... Max dose…
90... Dose: 0.5 ml... Max Dose:1ml... Needle: 21-23G
Buccal
Placed btwn gum and cheek via tablet, gel or spray
Intradermal
Injected into dermal layer of skin at:... *10-15° angle ... *25 -2…
226 terms
Pharmacology
Parasympathetic (cholinergic) neurotra…
Sympathetic (adrenergic) neurotransmit…
Does the sympathetic or parasympatheti…
What do alpha 1 receptors do?
acetylcholine
acetylcholine (preganglionic) & norepinephrine (postganglionic)
sympathetic
affects vascular smooth muscle --> vasoconstriction = increas…
Parasympathetic (cholinergic) neurotra…
acetylcholine
Sympathetic (adrenergic) neurotransmit…
acetylcholine (preganglionic) & norepinephrine (postganglionic)
58 terms
Pharmacology
Pharmacology
Kd
Drug
Medicine
the study of the effects of chemical substances on the functi…
Dissociation constant, the concentration of a ligand that giv…
A chemical substance of known structure which produces a biol…
A chemical preparation, which contains one or more drugs, adm…
Pharmacology
the study of the effects of chemical substances on the functi…
Kd
Dissociation constant, the concentration of a ligand that giv…
152 terms
Pharmacology
Enzyme Kinetics
Enzyme Kinetics (cont)
Enzyme Kinetics (cont x2)
Enzyme Kinetics (cont x3)
Enzyme Kinetics
Enzyme Kinetics (cont)
150 terms
Pharmacology
Bioavailability (F)
Bioavailability of IV drugs?
Volume of distribution
Clearance
Fraction of drug that enters systemic circulation unchanged
100%
Vd = Dose / (Plasma Drug conc.)
Volume of plasma that is cleared of drug per unit time... CL…
Bioavailability (F)
Fraction of drug that enters systemic circulation unchanged
Bioavailability of IV drugs?
100%
70 terms
Pharmacology
ADHD - Preferred drugs
Alcohol Withdrawal - Preferred drugs
Bipolar disorder - Preferred drugs
Bulimia - Preferred drugs
Methylpenidate (stimulants)
Chlordiazepoxide, Lorazepam, Diazepam (long-acting benzodia…
Lithium, Valproic Acid, atypical antipsychotics
SSRIs
ADHD - Preferred drugs
Methylpenidate (stimulants)
Alcohol Withdrawal - Preferred drugs
Chlordiazepoxide, Lorazepam, Diazepam (long-acting benzodia…
57 terms
Pharmacology
Cyclosporine - Mechanism
Cyclosporine - Use
Cyclosporine - Toxicity
Tacrolimus (FK506) - Mechanism
Calcineurin inhibitor;... Binds Cyclophilin, blocks T-cell…
Transplant rejection prophylaxis, psoriasis, rheumatoid arthr…
Nephrotoxicity, hypertension, hyperlipidemia, neurotoxicity…
Calcineurin inhibitor;... Binds FK506 binding protein (FKBP…
Cyclosporine - Mechanism
Calcineurin inhibitor;... Binds Cyclophilin, blocks T-cell…
Cyclosporine - Use
Transplant rejection prophylaxis, psoriasis, rheumatoid arthr…
92 terms
Pharmacology
Cyclosporine
Tacrolimus
Sirolimus (Rapamycin)
Daclizumab, basiliximab
Immunosuppressant... Calcinuerin inhibitor that blocks cyclop…
Immunosuppressant... Calcinuerin inhibitor that binds FK506 b…
Immunosuppressant used in Kidney transplant rejection prophyl…
Immunosuppressant monoclonal antibodies that Block IL-2R... U…
Cyclosporine
Immunosuppressant... Calcinuerin inhibitor that blocks cyclop…
Tacrolimus
Immunosuppressant... Calcinuerin inhibitor that binds FK506 b…
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