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Study sets matching "pharmacology 2 cholinergic"

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Study sets matching "pharmacology 2 cholinergic"

88 terms
Cholinergic Pharmacology 2: Cholinergic Receptors
2 types of cholinergic receptors
Cholinergic receptors are localized at
2 typesof Presynaptic cholinergic rece…
Abbreviation for Nicotinic receptors
Nicotinic and Muscarinic
Postsynaptic and Presynaptic
Autoreceptors and heteroreceptors
nAChRs
2 types of cholinergic receptors
Nicotinic and Muscarinic
Cholinergic receptors are localized at
Postsynaptic and Presynaptic
31 terms
cholinergic pharmacology 2
norepinephrine and acetylcholine
places where acetylcholine is synthesi…
cholinergic nerve terminals
choline and acetyl-CoA
Only 2 neurotransmitters in the PNS
SOMATIC neurons... PRE-and POST-ganglionic neurons in PARAsympat…
where synthesis of acetylcholine takes place
the two reactants that form acetylcholine in a SINGLE STEP
norepinephrine and acetylcholine
Only 2 neurotransmitters in the PNS
places where acetylcholine is synthesi…
SOMATIC neurons... PRE-and POST-ganglionic neurons in PARAsympat…
14 terms
Pharmacology 2: Cholinergic Drugs
cholinergic drugs
direct acting drugs
derivatives of ACh
direct acting effects
mimic the actions of ACh at muscarinic receptors ... -direct act…
-bind to muscarnic receptors ... -ACh is not useful as a drug be…
-durations of action longer for these drugs than ACh... -in all…
-increase in GI secretions and motility ... -increase in genitou…
cholinergic drugs
mimic the actions of ACh at muscarinic receptors ... -direct act…
direct acting drugs
-bind to muscarnic receptors ... -ACh is not useful as a drug be…
56 terms
2-Cholinergic Pharmacology
Vesamicol
Botulinum Toxin
Botulinum Toxin Uses
Botulinum Production
Blocks the counter transfer of protons for ACh within VATs
Inhibits fusion of the vesicle containing ACh (in order for i…
Strabismus (cross-eyed)... Spasticity... Bruxism (teeth grinding)... D…
Produced by clostridium botulinum
Vesamicol
Blocks the counter transfer of protons for ACh within VATs
Botulinum Toxin
Inhibits fusion of the vesicle containing ACh (in order for i…
11 terms
Cholinergic Pharmacology 2
Suxamethonium
Pancuronium
Neostigimine
Acetylcholinesterase
depolarising NMJ blocker - muscle relaxation
Non-depolarising NMJ blocker - antagonist - muscle relaxation
anticholinesterase inhibitor - prevent breakdown of Ach for r…
true cholinesterase - specific ACh - break ach to choline + a…
Suxamethonium
depolarising NMJ blocker - muscle relaxation
Pancuronium
Non-depolarising NMJ blocker - antagonist - muscle relaxation
39 terms
Cholinergic Pharmacology - Pechnick 2
What are the 5 stages in life cycle of…
Types of cholinergic receptors, locati…
Cholinesterase enzyme
Parasympathomimetic?
...
...
...
Same as a muscarinic agonist - mimics effects of parasympathe…
What are the 5 stages in life cycle of…
...
Types of cholinergic receptors, locati…
...
34 terms
2- Cholinergic Pharmacology I
Where is there a high density of baror…
How does info get from baroreceptors t…
Difference b/w para and symp activatio…
Pathway of autonomic neurotransmission
Wall of aortic arch and walls of each internal carotid artery…
Glossopharyngeal nerve on carotid artery-> integration in med…
Para: vagus nerve travels directly from medulla to heart and…
Nerve impulse-> membrane depolarization-> Ca2+ entry-> synapt…
Where is there a high density of baror…
Wall of aortic arch and walls of each internal carotid artery…
How does info get from baroreceptors t…
Glossopharyngeal nerve on carotid artery-> integration in med…
51 terms
Pharmacology: Lecture 2, Cholinergics
What are the direct acting cholinomime…
What are the reversible indirect-actin…
What are the muscarinic inhibitor drugs?
What do cholinomimetics do?
ACh, Bethanechol, Nicotine and Pilocarpine
Edrophonium, Physostigmine and Echothiophate
Atropine, Ipratropium and Tiotropium
They mimic the action of ACh
What are the direct acting cholinomime…
ACh, Bethanechol, Nicotine and Pilocarpine
What are the reversible indirect-actin…
Edrophonium, Physostigmine and Echothiophate
13 terms
Pharmacology set 2 - Cholinergic
muscarinic receptor action
NT used in cholinergic?
which muscarinic receptors activating
which muscarinic receptors are inhibit…
decr HR, Decr AP force
Ach
M1,3,5
M2,4
muscarinic receptor action
decr HR, Decr AP force
NT used in cholinergic?
Ach
18 terms
CHOLINERGIC PHARMACOLOGY EXAM 2
Edrophonium (tensilon test)
Pilocarpine
Atropine
Physostigmine
short acting acetylcholinesterase inhibitor that improves mus…
Muscarinic Receptor Agonist... miosis- pupillary constriction ... s…
Muscarinic Receptor Antagonist... pupillary dilation
Cholinesterase inhibitor ... increases sphincter and ciliary mus…
Edrophonium (tensilon test)
short acting acetylcholinesterase inhibitor that improves mus…
Pilocarpine
Muscarinic Receptor Agonist... miosis- pupillary constriction ... s…
49 terms
Pharmacology Exam 2: Cholinergic pharmacology
cholinergic pharmacology
synthesis of acetylcholine
AChCoA
hemicholinium
physiologic effects and pharmacologic modulation of neurotran…
takes place in cholinergic nerve terminals, single step with…
produced in mitochondria and transported to cytosol as citrate
inhibits Na+ choline simperer leading to depletion of acetylc…
cholinergic pharmacology
physiologic effects and pharmacologic modulation of neurotran…
synthesis of acetylcholine
takes place in cholinergic nerve terminals, single step with…
Pharmacology Quiz 2 Cholinergics
Acetylcholine (ACh)
Muscarinic receptors
Nicotinic receptors
Direct cholinergic agonists
Endogenous neurotransmitter at cholinergic synapses and neuro…
Bind ACh and Muscarine.... Primarily on parasympathetic effecto…
Bind ACh and Nicotine.... Composed of subunits and functions as…
ACh: Not used clinically... Bethanechol: GI and GU Post-op... Piloc…
Acetylcholine (ACh)
Endogenous neurotransmitter at cholinergic synapses and neuro…
Muscarinic receptors
Bind ACh and Muscarine.... Primarily on parasympathetic effecto…
80 terms
Cholinergic Pharmacology
Targets for pharmacologic thereapy (5)
MOA of Hemicholiniums
MOA of Vesamicol
MOA of Botulinum Toxin
Synthesis, storage, release, receptor effects, termination of…
Choline carrier blocker; prevents choline from entering cell…
ACh carrier blocker; prevents uptake of ACh into vesicles for…
Pre-synaptic toxin; prevents fusion of vesicle to plasma memb…
Targets for pharmacologic thereapy (5)
Synthesis, storage, release, receptor effects, termination of…
MOA of Hemicholiniums
Choline carrier blocker; prevents choline from entering cell…
26 terms
Pharmacology 2-2- Cholinergic Inhibition
Anti-muscarinic
Anti-nicotinic
Inhibition of PS
Therapeutic overview for muscarinic an…
Primary focus is anticholinergic drugs that combine with musc…
Block nicotinic receptors ... -ganglionic blockers (N1)... -NMJ blo…
Increased HR... Increased BP... Inhibition of GI movement... Failure t…
Motion sickness... Retinal exam... inflammatory uveitis ... Excessive…
Anti-muscarinic
Primary focus is anticholinergic drugs that combine with musc…
Anti-nicotinic
Block nicotinic receptors ... -ganglionic blockers (N1)... -NMJ blo…
90 terms
Cholinergic Pharmacology Q1EX2
What are the types of Cholinergic Rece…
Where are nicotinic receptors found?
What are nicotinic receptors?
What are muscarinic receptors?
1. Muscarinic ... 2. Nicotinic
- Found on postganglionic neurons of the autonomic (parasympa…
Ligand gated ion channels (Gate for Na+)
GPCRs
What are the types of Cholinergic Rece…
1. Muscarinic ... 2. Nicotinic
Where are nicotinic receptors found?
- Found on postganglionic neurons of the autonomic (parasympa…
36 terms
Cholinergic Pharmacology
Targetable processes in neurotransmitt…
Types of cholinergic receptors
Muscarinic Receptor activation in the…
Muscarinic receptor activation in the…
*synthesis... *storage... *release... *receptor effects... *termination o…
*muscarinic: G proteins... *nicotinic: ion channel
*sphincter muscle--> M3, contraction: miosis, open canal of S…
*M2... *SA node= decreased heart rate... *decreased conduction velo…
Targetable processes in neurotransmitt…
*synthesis... *storage... *release... *receptor effects... *termination o…
Types of cholinergic receptors
*muscarinic: G proteins... *nicotinic: ion channel
Pharmacology Unit 2 Cholinergics and Anti Cholinergics
Cholinergic Agonists
Acetacholine (ACh)
Direct acting Cholinergic agonists
Direct acting Cholinergic prototype: B…
Parasympathomimetics.... Stimulate/activate the parasympathetic…
Neurotransmitter responsible for movement of nerve impulses.…
Primarily selective to muscarinic receptors but are nonspecif…
Direct acting cholinergic agonist- acts on muscarinic recepto…
Cholinergic Agonists
Parasympathomimetics.... Stimulate/activate the parasympathetic…
Acetacholine (ACh)
Neurotransmitter responsible for movement of nerve impulses.…
75 terms
Cholinergic Pharmacology
T/F: acetylcholine agonists are non-se…
bind both nicotinic and muscarinic rec…
non-selective ACh agonist used for gla…
has shown improvement in the learning…
true
non-selective ACh agonists
carbachol
arecoline
T/F: acetylcholine agonists are non-se…
true
bind both nicotinic and muscarinic rec…
non-selective ACh agonists
19 terms
Pharmacology - Cholinergic Agonists (Exam 2)
Same effects as
Cholinergic Actions
Primary Neurotransmitter
Receptor Cell Organs
Adrenergic Blockers
Eye- constrict pupils... Lungs- constrict bronchioles... Heart- dec…
Acetycholine
Muscarinic... Nicotinic
Same effects as
Adrenergic Blockers
Cholinergic Actions
Eye- constrict pupils... Lungs- constrict bronchioles... Heart- dec…
Cholinergic pharmacology
What are the G-protein subunits needed…
what effect does Gai have on cAMP?
what does cAMP activate?
what effect does Gaq/11 have on IP3/DAG?
M1, 3, 5: Gaq/11... M2, 4: Gai
dec.
protein kinase A (PKA)
- activates protein kinase C (PKC)
What are the G-protein subunits needed…
M1, 3, 5: Gaq/11... M2, 4: Gai
what effect does Gai have on cAMP?
dec.
19 terms
Pharmacology - Chapter 2 Cholinergic Agonists
Cholinergic agonists
Anticholinesterase drugs
Cholinergic agonist drugs include
Acetylcholine
Acts like acetylcholine by stimulating cholinergic receptors
Destroys acetylcholinesterase (enzyme that attacks acetylchol…
acetylcholine, bethanechol, carbachol, pilocarpine.
poorly penetrates the central nervous system (CNS), and its e…
Cholinergic agonists
Acts like acetylcholine by stimulating cholinergic receptors
Anticholinesterase drugs
Destroys acetylcholinesterase (enzyme that attacks acetylchol…
44 terms
Pharmacology Exam 2: Adrenergic and Cholinergic
sympathetic drugs
adrenergics:
adrenergic receptors have binding site…
catecholamines types
adrenergic
stimulate sympathetic nervous system
catecholamines
epinephrine and norepinephrine
sympathetic drugs
adrenergic
adrenergics:
stimulate sympathetic nervous system
16 terms
Pharmacology: Week 2 -- Cholinergics and Adrenergics
Nicotine
Varenicline
Rocuronium
Malathion
Nicotinic Agonist
Nicotinic Agonist
Nondepolarizing Neuromuscular Blocker
Organophosphate
Nicotine
Nicotinic Agonist
Varenicline
Nicotinic Agonist
30 terms
cholinergic pharmacology
Acetylcholine is made up of ___ and __…
Which ion mediates release of acetylch…
Muscarinic receptors
Nicotinic receptors
acetyl coA, choline molecules... choline acetyltransferase enzyme
Ca2+
M1-M5... parasympathetic... neuromuscular junction and sweat glands…
Nm at NMJ... Nn at neurons (ganglia and adrenal medulla)... ionotro…
Acetylcholine is made up of ___ and __…
acetyl coA, choline molecules... choline acetyltransferase enzyme
Which ion mediates release of acetylch…
Ca2+
50 terms
Pharmacology Test 2: Cholinergic Drugs
Cholinergic Drugs
Acetylcholine
Brain: plays important role in cogniti…
decreased heart rate, vasodilation, BP…
Stimulate the parasympathetic nervous system (PNS)
essential neurotransmitter released from nerve endings
how does acetylcholine play an essential role in the brain, g…
what are specific effects of direct acting cholinergics
Cholinergic Drugs
Stimulate the parasympathetic nervous system (PNS)
Acetylcholine
essential neurotransmitter released from nerve endings
39 terms
Pharmacology - Cholinergic
Acetylcholine
Bethanechol
Carbachol
Pilocarpine
Cholinergic Agonist ... Lack therapeutic importance because of i…
Cholinergic Agonist... Ester of carbamic acid ... Not hydrolyzed by…
Cholinergic Agonist ... Both nicotinic and muscarinic actions ... E…
Cholinergic Agonist ... Tertiary amine ... Stable to AChE hydrolysi…
Acetylcholine
Cholinergic Agonist ... Lack therapeutic importance because of i…
Bethanechol
Cholinergic Agonist... Ester of carbamic acid ... Not hydrolyzed by…
23 terms
Pharmacology Exam 2- Cholinergic Pathway
Vesamicol inhibits what realated to AC…
What inhibits the choline/Na+ symporter?
Physostigmine (AChE inhibitor) treats…
Neostigmine/ Pyridostigmine treat what…
ACh storage
hemicholinium
glaucoma
myasthenia gravis and eaton-lambert
Vesamicol inhibits what realated to AC…
ACh storage
What inhibits the choline/Na+ symporter?
hemicholinium
29 terms
Cholinergic Pharmacology
What are the locations for each of the…
4 primary effects of ACh on the CV sys…
Muscarinic agonists in the GI system c…
Muscarinic agonists in the urinary sys…
M1=nerves... M2 (cardiac)=heart, nerves, smooth muscle... M3=glands…
1. negative chronotropic effect (decrease HR)... 2. negative dro…
salivary and gastric secretion, GI smooth muscle tone (contra…
contraction of detrusor muscle and relaxation of bladder trig…
What are the locations for each of the…
M1=nerves... M2 (cardiac)=heart, nerves, smooth muscle... M3=glands…
4 primary effects of ACh on the CV sys…
1. negative chronotropic effect (decrease HR)... 2. negative dro…
42 terms
cholinergic pharmacology
acetylcholine
carbachol
bethanechol
nicotine
direct-acting agonist ... Non-selective... Rapidly degraded by ACE…
direct-acting agonist ... non-selective ... Not metabolized by ACE…
direct-acting agonist ... selective ... muscarinic agonist at low o…
direct-acting agonist ... Ganglionic and skeletal muscle agonist
acetylcholine
direct-acting agonist ... Non-selective... Rapidly degraded by ACE…
carbachol
direct-acting agonist ... non-selective ... Not metabolized by ACE…
11 terms
Cholinergic Pharmacology
Nicotinic (Nn) blockers a.k.a. ganglio…
Muscarinic agonists
Nicotinic agonist
Muscarinic and nicotinic agonist (both)
Hexamethonium... Mecamylamine
Bethanechol... Methacholine... Pilocarpine
Nicotine
Carbachol
Nicotinic (Nn) blockers a.k.a. ganglio…
Hexamethonium... Mecamylamine
Muscarinic agonists
Bethanechol... Methacholine... Pilocarpine
25 terms
Cholinergic pharmacology
parasympathomimetics
parasympaholytics
hemicholinium-3
vesamicol
class of drugs mimic or enhance acetylcholine
class of drugs that inhibit the actions of acetylcholine
inhibits ACh SYNTHESIS by blocking Na+--choline symporter. ... N…
inhibits ACh STORAGE by blocking H+--ACh antiporter, NOT used…
parasympathomimetics
class of drugs mimic or enhance acetylcholine
parasympaholytics
class of drugs that inhibit the actions of acetylcholine
37 terms
Cholinergic pharmacology
muscarinic agonists
muscarinic antagonists
nicotinic agonists
nicotinic antagonists
pilocarpine, carbachol/carbamylcholine, bethanecol, metnachol…
benzotropine, topicamide, propantheline, oxybutynin, tolterod…
nicotine, vernicline, succinylcholine
d tubocurarine, cisatracium, pancuronium, vencuronium, roncur…
muscarinic agonists
pilocarpine, carbachol/carbamylcholine, bethanecol, metnachol…
muscarinic antagonists
benzotropine, topicamide, propantheline, oxybutynin, tolterod…
18 terms
Cholinergic pharmacology
Cholinergic means
ganglionic blockers
Do ganglionic blockers tend toward fig…
Choline acetyltransferase
having to do with acetylcholine
block all gangionic activity in sympathetic and parasympathet…
fight/flight in dual/only parasympathetic innervation... rest/d…
Choline brought in with Na (RLS)... Acetyl-CoA from mitochondria
Cholinergic means
having to do with acetylcholine
ganglionic blockers
block all gangionic activity in sympathetic and parasympathet…
57 terms
Cholinergic Pharmacology
Places where nicotinic receptors are f…
Places where muscarinic receptors are…
M1, M3 and M5 are mainly ___ and coupl…
M2 and M4 are mainly ___ and couple to…
- postganglionic neurons of the parasympathetic nervous syste…
- GPCRs at sympathetic & parasympathetic sites
stimulatory, Gq
inhibitory, Gi
Places where nicotinic receptors are f…
- postganglionic neurons of the parasympathetic nervous syste…
Places where muscarinic receptors are…
- GPCRs at sympathetic & parasympathetic sites
20 terms
cholinergic pharmacology
clinical muscarinic agonist
clinical muscarinic antagonist
atropine role
pupil constriction
pilocarpine
atropine
reduces glandular secretions before anaesthetic
reduce symptoms of glaucoma
clinical muscarinic agonist
pilocarpine
clinical muscarinic antagonist
atropine
43 terms
Cholinergic Pharmacology
Hemicholinium
Clathrine
Botulin
Black widow venom
Inhibits Choline Transport into presynaptic cell
Initiate formation of storage vesicles
What cholinergic inhibitor acts by directly inhibiting Ach re…
Causes an increase Ach release followed by destruction of the…
Hemicholinium
Inhibits Choline Transport into presynaptic cell
Clathrine
Initiate formation of storage vesicles
83 terms
Cholinergic Pharmacology
Somatic/Voluntary Nerves
Autonomic Nervous system
PNS
SNS
Control skeletal muscle, travels via corticospinal tracts, ru…
Arises in hypothalamus, limbic system, brain stem, innervatin…
Cranialsacral output, uses Ach at all ganglionic AND neuroeff…
Thoracolumbar output, uses Ach at sympathetic ganglia, adrena…
Somatic/Voluntary Nerves
Control skeletal muscle, travels via corticospinal tracts, ru…
Autonomic Nervous system
Arises in hypothalamus, limbic system, brain stem, innervatin…
46 terms
Cholinergic Pharmacology
Cholinergic Receptors (2)
Drugs affecting muscarinic receptors (3)
Drugs affecting Nicotinic receptors (2)
Calabar bean (esere nut)
- Muscarinic Receptors... - Nicotinic Receptors
- direct acting- muscarinic agonists (parasympathomimetics)... -…
- ganglionic stimulators ... - ganglionic blockers
- extract caused contraction of pupil when dropped in eye!... -…
Cholinergic Receptors (2)
- Muscarinic Receptors... - Nicotinic Receptors
Drugs affecting muscarinic receptors (3)
- direct acting- muscarinic agonists (parasympathomimetics)... -…
39 terms
Cholinergic Pharmacology
Acetylcholine
Bethanecol
Carbochol
Methacholine
-Direct acting muscarinic agonist... -causes miosis (reduction i…
-Direct acting muscarinic agonist... -Selective mAChR agonist th…
-Direct acting muscarinic agonist... -Glaucoma... -Nonspecific chol…
-Direct acting muscarinic agonist... -Selective and potent mAChR…
Acetylcholine
-Direct acting muscarinic agonist... -causes miosis (reduction i…
Bethanecol
-Direct acting muscarinic agonist... -Selective mAChR agonist th…
13 terms
Cholinergic Pharmacology
Bethanochol
Pilocarpine
Side effects of muscarinic antagonists
M1 mechanism and site of action
Direct cholinomimetic... Increases seceretion and motor activity…
Direct cholinomimetic ... Increase salivary secretion -> used to…
Constipation, urinary retention, dry mouth
IP3 DAG, CNS + GI
Bethanochol
Direct cholinomimetic... Increases seceretion and motor activity…
Pilocarpine
Direct cholinomimetic ... Increase salivary secretion -> used to…
43 terms
Cholinergic Pharmacology
Cholinergic Pharmacology
Synthesis of Acetylcholine
Storage of Acetylcholine
Release of Acetylcholine
Physiologic effects and pharmacologic modulation of neurotran…
1. Takes place in cholinergic nerve terminals... 2. single step…
1. ACh is transported into synaptic vesicles for storage, med…
1. Release of ACh into the synaptic cleft occurs through fusi…
Cholinergic Pharmacology
Physiologic effects and pharmacologic modulation of neurotran…
Synthesis of Acetylcholine
1. Takes place in cholinergic nerve terminals... 2. single step…
61 terms
Cholinergic Pharmacology
blocks choline from entering the nerve…
blocks storage of Ach
blocks fusion of vesicles within the n…
types of cholinergic receptors
hemicholiniums
vesamicol
botulinum
muscarinic and nicotinic
blocks choline from entering the nerve…
hemicholiniums
blocks storage of Ach
vesamicol
59 terms
Cholinergic Pharmacology
Nicotinic (Cholinergic Receptor in the…
Muscarinic
Non-selective(bind both nicotinic and…
Muscarinic Selective... 1.Methacholine... 2.…
1) Found on postganglionic neurons of the parasympathetic ner…
>GPCRs found at sympathetic and parasympathetic sites... >M1,3,5…
________used for glaucoma... _________used as a stimulant
1)___________ - used to test for bronchial hyper-reactivity... 2…
Nicotinic (Cholinergic Receptor in the…
1) Found on postganglionic neurons of the parasympathetic ner…
Muscarinic
>GPCRs found at sympathetic and parasympathetic sites... >M1,3,5…
33 terms
Cholinergic Pharmacology
Muscarinic vs. Nicotinic receptors
Physiological actions of mAcRs in the…
Physiological actions of mAcRs in the…
Physiological actions of mAcRs in the…
Muscarinic receptors occur on autonomic effector cells @ end…
M1 responsible for cognition& sensory perception... M2 responsib…
Contracts pupillary sphincter (miosis)... Contracts ciliary musc…
Vagal slowing of heart rate (M2)... Decrease contractility... Minot…
Muscarinic vs. Nicotinic receptors
Muscarinic receptors occur on autonomic effector cells @ end…
Physiological actions of mAcRs in the…
M1 responsible for cognition& sensory perception... M2 responsib…
Cholinergic Pharmacology
Acetylcholine
ACh Synthesis
ACh Storage
ACh Release
Used in all pathways of peripheral
1. Takes place in cholinergic nerve terminal... 2. Signal step i…
1. ACh is transported into synaptic vesicle for storage... Media…
1. Release occurs through the fusion of the vesicle membrane…
Acetylcholine
Used in all pathways of peripheral
ACh Synthesis
1. Takes place in cholinergic nerve terminal... 2. Signal step i…
17 terms
Cholinergic Pharmacology
Direct Acting Cholinomimetics
Bethenechol
Pilocarpine
Nicotine
Bind directly to ACh receptors, mimic ACh
Muscarinic receptor AGONIST, treats Gi/Urinary paralysis
Muscarinic receptor AGONIST, treats glaucoma
Nicotinic Receptor AGONIST, Treats cigarette withdrawal
Direct Acting Cholinomimetics
Bind directly to ACh receptors, mimic ACh
Bethenechol
Muscarinic receptor AGONIST, treats Gi/Urinary paralysis
66 terms
Cholinergic Pharmacology
What type of receptors are muscarinic…
What CNs contain parasympathetics?
Where are muscarinic receptors located?
Odd Muscarinic receptors use what path…
GPCR
III, VII, IX, X
CNS, autonomic ganglia... ALL parasympathetic post-ganglionics... S…
Gq --> calcium surge --> smooth muscle (not sphincter) contra…
What type of receptors are muscarinic…
GPCR
What CNs contain parasympathetics?
III, VII, IX, X
24 terms
Cholinergic Pharmacology
Acetylcholinesterase Inhibitors
Edrophonium
Physostigmine
Neostigmine
-MINE
Acetylcholinesterase Inhibitors ... Dx Myasthenia ... Increases ACh
Acetylcholinesterase Inhibitors ... Glaucoma ... PHYXES atropine ov…
Acetylcholinesterase Inhibitors ... Myasthenia Gravis ... Ileus and…
Acetylcholinesterase Inhibitors
-MINE
Edrophonium
Acetylcholinesterase Inhibitors ... Dx Myasthenia ... Increases ACh
48 terms
Cholinergic Pharmacology
Where are Nicotinic Receptors located?
What kind of Channels are Nicotinic Re…
What kind of receptors are Muscarinic…
M1,3,5 are mainly (Stimulatory or Inhi…
Found on postganglionic neurons of the parasympathetic nervou…
Ligand Gated Ion Channels ... -Gate for Na+
GPCRs found at sympathetic and parasympathetic sites
Stimulatory coupled to Gq
Where are Nicotinic Receptors located?
Found on postganglionic neurons of the parasympathetic nervou…
What kind of Channels are Nicotinic Re…
Ligand Gated Ion Channels ... -Gate for Na+
Cholinergic Pharmacology
Non-selective
Meds that are non-selective
Muscarinic selective
Effects of ACh + agonists on Cardiovas…
bind to muscarinic + nicotinic receptors
-carbachol= used to treat glaucoma... -arecoline= has shown impr…
-Methacholine= to test for bronchial hyper reactivity... -Bethan…
Vasodilate, decrease heart rate, decrease conduction rate in…
Non-selective
bind to muscarinic + nicotinic receptors
Meds that are non-selective
-carbachol= used to treat glaucoma... -arecoline= has shown impr…
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