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Study sets matching "pharmacology 3"

863 terms
Pharmacology 3
Gq
Gi
Gq
Gi
M1 GCPR class
M2 GCPR class
M3 GCPR class
M4 GCPR class
Gq
M1 GCPR class
Gi
M2 GCPR class
371 terms
Pharmacology3
Stroke Volume is largely determined by…
Myocardial contractility:
Cardiac preload
Cardiac afterload
Myocardial contractility... Cardiac preload... Cardiac afterload
force with which the heart contracts
amount of stretch in heart prior to contraction... determined by…
force against which heart has to pump against... determined by a…
Stroke Volume is largely determined by…
Myocardial contractility... Cardiac preload... Cardiac afterload
Myocardial contractility:
force with which the heart contracts
21 terms
Pharmacology 3
Receptor antagonists
Types of antagonists
Pharmacokinetic antagonists
Physiological
- inhibit agonist by binding to the same receptor ... - by far t…
1. Pharmacokinetic ... 2. Physiological ... 3. "Chemical" - antagon…
- reduce the stimulating drug concentration at site of action…
- oppose agonist by a separate physiological mechanism e.g. c…
Receptor antagonists
- inhibit agonist by binding to the same receptor ... - by far t…
Types of antagonists
1. Pharmacokinetic ... 2. Physiological ... 3. "Chemical" - antagon…
137 terms
Pharmacology 3
Pharmacodynamics and kinetics overview
ADME relationship
Passive diffusion of drug
Passive diffusion of ionized vs nonion…
Most common
Pharmacodynamics and kinetics overview
ADME relationship
100 terms
Pharmacology 3
Macula densa sense? location?
factors that affect RENIN release? 3
Angiotensin converting enzyme produced…
Bosentan use? Mechanism? SE? CI? Mon…
Sodium Chloride in DCT distal convoluted tubule.... 7.
1-Decrease BP.... 2-Decrease NaCl in macula densa.... 3-^ Sympathet…
Lung and Kidney.
Pulmonary hypertension.... Endothelin receptor antagonist (ETA).…
Macula densa sense? location?
Sodium Chloride in DCT distal convoluted tubule.... 7.
factors that affect RENIN release? 3
1-Decrease BP.... 2-Decrease NaCl in macula densa.... 3-^ Sympathet…
29 terms
3. Pharmacology
3
storage
package
returning
Always perform ______ checks at three different times.
First check. When taking med from _______ area
Second check. Before removing from _________. (before you pour)
Third check. Before ______ to storage area
3
Always perform ______ checks at three different times.
storage
First check. When taking med from _______ area
27 terms
chapter 3 vocabulary pharmacology
acetylcholine (ACh)
acetylchoinesterase (AChE)
adrenergic
adrenergic receptors
the chemical neurotransmitter of skeletal muscles... -the pregan…
also known as cholinesterase; the enzyme that deactivates ace…
...
receptors of the SNS that include the alpa and beta-receptors
acetylcholine (ACh)
the chemical neurotransmitter of skeletal muscles... -the pregan…
acetylchoinesterase (AChE)
also known as cholinesterase; the enzyme that deactivates ace…
130 terms
Advanced Pharmacology Exam 3
Hypertension
Blood Pressure
Regulation of Blood Pressure
Diuretics
Classification is determined based on the average of two or m…
Based on the mathematical equation:... BP = CO (cardiac output)…
Causes of increased CO:... -Increased fluid volume (excess sodiu…
in the normal adult approx 180 L of fluid is filtered by the…
Hypertension
Classification is determined based on the average of two or m…
Blood Pressure
Based on the mathematical equation:... BP = CO (cardiac output)…
14 terms
Pharmacology math for pharmacology #3
Efficacy
Excretion
Expectorant
Fried's Law
Therapeutic value of a drug. How well does it work?
Manner in which a drug is eliminated from the body
Any drug or medicine that liquefies mucus in the bronchi of t…
pediatric dosage law applied to children under the age of 1 y…
Efficacy
Therapeutic value of a drug. How well does it work?
Excretion
Manner in which a drug is eliminated from the body
16 terms
Pharmacology 3
A man who was working on his deck come…
A patient was bit by a poisonous snake…
An antipyretic is a drug that can:
The nurse is preparing to administer t…
Tetanus toxoid
Antivenin
Block fever
Oral
A man who was working on his deck come…
Tetanus toxoid
A patient was bit by a poisonous snake…
Antivenin
37 terms
Pharmacology 3
Aricept
Namenda
Sinemet
Mirapex
Donepezil
Memantine
Carbidopa, levadopa
Pramipexole
Aricept
Donepezil
Namenda
Memantine
25 terms
Pharmacology 3 - Intro to Pharmacology
Pharmacology is the study of...
Pharmacogenomics studies the relations…
Recombinant DNA technology:
Pharmacological Phases (3) ??
How substances interact with living organisms to produce a ch…
An individuals genetic make up to their response to specific…
DNA from 2 different molecules is combined to make new DNA. T…
1.Pharmaceutical phase... 2.Pharmacokinetic Phase... 3.Pharmacodyna…
Pharmacology is the study of...
How substances interact with living organisms to produce a ch…
Pharmacogenomics studies the relations…
An individuals genetic make up to their response to specific…
166 terms
Pharmacology 3
Levodopa
Pramipexole
Ropinirole
Rotigotine
- Treat PD... - Only 1% reach brain... - Efficacy wears off... - ADE:…
- Treat PD... - Direct acting DA receptor agonist... - First line t…
- Treat PD... - Direct acting DA receptor agonist... - First line t…
- Treat PD... - Direct acting DA receptor agonist... - First line t…
Levodopa
- Treat PD... - Only 1% reach brain... - Efficacy wears off... - ADE:…
Pramipexole
- Treat PD... - Direct acting DA receptor agonist... - First line t…
20 terms
Pharmacology 3 //
Lopressor
Tropol xl
Inderal
Zebeta
Metroprolol
Metroprolol
Propanolol
Bisoprolol
Lopressor
Metroprolol
Tropol xl
Metroprolol
Pharmacology 3
Cocaine
Nicotine
Diazepam
Buspirone
can increase BP, has some therapeutic benefit, can increase h…
can increase BP, has some therapeutic benefit, can increase h…
can be used as a hypnotic agent, enhances GABA activity
a 5-HT receptor agonist, used for long-term treatment of anxi…
Cocaine
can increase BP, has some therapeutic benefit, can increase h…
Nicotine
can increase BP, has some therapeutic benefit, can increase h…
255 terms
Pharmacology 3
What are NSIMs?
What are some uses for NSIMs?
How are NSIMs different than NSAIDs?
When are NSIMs used?
Non steroidal immune modulating drugs (cyclosporine, tacrolim…
Autoimmune dx related to multiple organs, autoimmune disease…
NSIMS don't suppress the SYSTEM as much as NSAIDs do, they fo…
Often as a 2nd line of defense for immune mediated diseases w…
What are NSIMs?
Non steroidal immune modulating drugs (cyclosporine, tacrolim…
What are some uses for NSIMs?
Autoimmune dx related to multiple organs, autoimmune disease…
19 terms
Pharmacology 3
Rifampin
Tetracycline hydrochloride (Sumycin)
Warfarin (Coumadin)
Diltiazem (Cardiazem)
Anti-tubulars
Tetracycline
Anticoagulants
Nondihydropyridine Calcium Channel Blockers
Rifampin
Anti-tubulars
Tetracycline hydrochloride (Sumycin)
Tetracycline
19 terms
Pharmacology #3
-tadine
-tadine
-terol
-thiazide
antihistamine
antiviral; anti-influenza-A
beta agonist; bronchodilator
thiazide diuretic (water pill)
-tadine
antihistamine
-tadine
antiviral; anti-influenza-A
Pharmacology #3
Estrogen you need to know
Estrogen adverse effect
Chloasma
Progestin (drugs)
- Uses: estrogen deficiency, contraceptive medication, dysmen…
- THROMBOEMBOLYTIC EVENTS (+ important), nausea (+) common, H…
Patchy brown or dark stain in women's face that may result fr…
- progesterone ending (medroxyprogesterone common)... - megestro…
Estrogen you need to know
- Uses: estrogen deficiency, contraceptive medication, dysmen…
Estrogen adverse effect
- THROMBOEMBOLYTIC EVENTS (+ important), nausea (+) common, H…
143 terms
Pharmacology#3
Corticosteroid immunosupressant
Calcineurin inhibitor immunosupressants
Enzyme inhibitor immunosupressant
Antiproliferative immunosupressant
Prednisone
1. Cyclosporin= binds to the cytosolic protein cyclophilin/im…
1. Mycophenolate mofetil= inhibits an inosine monophosphate d…
1. Azathioprine= purine analog prodrug that converts to 6-mer…
Corticosteroid immunosupressant
Prednisone
Calcineurin inhibitor immunosupressants
1. Cyclosporin= binds to the cytosolic protein cyclophilin/im…
23 terms
pharmacology3
diltiazem
diltiazem
fentanyl
fentanyl
calcium channel blocker... cardizem... indic:supraventricular tachy…
0.25mg/kg IV over 2 minutes. may repeat with .35mg/kg followe…
narcotic alagesic... sublimaze... indic:need for sedation/ pain rel…
25-100 mcg slowly IV (2-3 minutes)... ped: 2mcg/kg slow IV/IM
diltiazem
calcium channel blocker... cardizem... indic:supraventricular tachy…
diltiazem
0.25mg/kg IV over 2 minutes. may repeat with .35mg/kg followe…
466 terms
Pharmacology 3
Hemophilia is more common in
Hemophilia A
Hemophilia B
People with hemophilia should avoid
males
deficiency of Factor 8
deficiency of Factor 9
aspirin
Hemophilia is more common in
males
Hemophilia A
deficiency of Factor 8
43 terms
Pharmacology 3
Use of aspirin for progressive bony pain
Use of acyclovir ointment
Use of allopurinol for acute gout
Peak and trough levels
Salicylates (aspirin)
For treatment of herpes simplex. Cover all lesions with topic…
Allopurinol inhibits the production of uric acid by decreasin…
Peak and trough levels: based on patients weight -going to be…
Use of aspirin for progressive bony pain
Salicylates (aspirin)
Use of acyclovir ointment
For treatment of herpes simplex. Cover all lesions with topic…
126 terms
Pharmacology 3
buccal route
drug error
onset of action
per os
application of a drug within the cheek or under the cavity of…
any preventable event that may cause inappropriate drug use o…
the length of time it takes a drug to start working
giving drugs by way of the mouth
buccal route
application of a drug within the cheek or under the cavity of…
drug error
any preventable event that may cause inappropriate drug use o…
190 terms
Pharmacology 3
positive psychotic symptoms
negative psychotic symptoms
cognitive psychotic symptoms
first generation antipsychotics
delusions, hallucinations, reality distortions (bizarre/agita…
characterized by an unresponsive state and often emotional wi…
disordered thinking, loss of attention, memory disturbances
conventional, "typical" antipsychotics; have more side effect…
positive psychotic symptoms
delusions, hallucinations, reality distortions (bizarre/agita…
negative psychotic symptoms
characterized by an unresponsive state and often emotional wi…
27 terms
Pharmacology 3
Difference between gram neg and gram pos
When to use antibiotics
Principles of antibiotics
Targets for Antibiotics
Gram neg ... - cell wall have more lipid content... - possess out…
Fever and acute infection... Spreading infection w/o localizati…
Selective toxicity... Bacteriostatic - inhibits growth... Bacteri…
Bacterial cell wall synthesis... Protein synthesis... Nucleic aci…
Difference between gram neg and gram pos
Gram neg ... - cell wall have more lipid content... - possess out…
When to use antibiotics
Fever and acute infection... Spreading infection w/o localizati…
13 terms
***** Pharmacology 3
Atrovent - asthma
Proventil - asthma
propranolol - Inderal
EPInephrine... ALBUTEROL... Pseudoephedrine…
Anticholernergic
Beta II Adrenergic Agonist
Beta I Adrenergic
Sympathomimetics or Adrenergic agents?
Atrovent - asthma
Anticholernergic
Proventil - asthma
Beta II Adrenergic Agonist
226 terms
Pharmacology 3
What are analgesics.
Pain
Acute pain
Persistent pain
Medications that relieve pain without causing loss of conscio…
An unpleasant sensory and emotional experience associated wit…
Pain that is quick in onset.... Usually subsides once treated.
Pain that is persistent or recurring. ... Lasting 6 weeks or lon…
What are analgesics.
Medications that relieve pain without causing loss of conscio…
Pain
An unpleasant sensory and emotional experience associated wit…
44 terms
pharmacology 3
Sustained elevation in arterial pressu…
120/80 or less
120-139/... 85-89 (asymptotic)
140-159... 90-99 (asymptotic)
Hypertension is defined as?
Normal blood pressure ... (Evaluate in two yrs)
Pre hypertension ... (Evaluate in a year)
Stage 1 hypertension ... (Evaluate in 2months)
Sustained elevation in arterial pressu…
Hypertension is defined as?
120/80 or less
Normal blood pressure ... (Evaluate in two yrs)
41 terms
Pharmacology 3
Norflex
Soma
Orphenadrine
Carisoprodol
Orphenadrine
Carisoprodol
Norflex
Soma
Norflex
Orphenadrine
Soma
Carisoprodol
38 terms
pharmacology 3
receptor
affinity
affinity... equivilant terms
high affinity
a macromolecule whose biological function changes when the dr…
the measure of propensity of a drug to bind receptor; the for…
affinity... potency... kd dissociation constant... ed50... EC50
at small concentration it can bind the receptor and do the si…
receptor
a macromolecule whose biological function changes when the dr…
affinity
the measure of propensity of a drug to bind receptor; the for…
18 terms
Pharmacology-Chapter 3
antibacterial spectrum
antibiotic
antibiotic susceptibility
antimicrobial
bacteria that are susceptible to the antibacterial actions of…
antibacterial drug obtained from other microorganisms
identification of the antibiotics, by bacterial culture and s…
antibacterial drugs obtained by chemical synthesis and not fr…
antibacterial spectrum
bacteria that are susceptible to the antibacterial actions of…
antibiotic
antibacterial drug obtained from other microorganisms
44 terms
Pharmacology 3
aq
qh
stat
ad lib
The abbreviation for water
Every hour
The abbreviation for immediately
The abbreviation for as desired
aq
The abbreviation for water
qh
Every hour
21 terms
3. Pharmacology
Physical Depencendy
Psychological Dependency
Schedule I (C-I)
Schedule II (C-II)
Habitual use of a drug in which negative physical withdrawal…
Compulsion or craving to use to obtain a pleasurable experien…
Controlled substances Schedules: ... High Abuse potential... No Acc…
Controlled substances Schedules: ... Potential for high abuse w/…
Physical Depencendy
Habitual use of a drug in which negative physical withdrawal…
Psychological Dependency
Compulsion or craving to use to obtain a pleasurable experien…
15 terms
Pharmacology 3
Excretion
Excretion
absorption
pH
Removal of drugs from the body. Urine (kidney) most important…
Rate of _____ determines drug blood level.
some drugs undergo ___________ after renal filtration.
Drug excretion dependent on urine ____. Can manipulate _____…
Excretion
Removal of drugs from the body. Urine (kidney) most important…
Excretion
Rate of _____ determines drug blood level.
73 terms
Pharmacology 3
Natriuretic peptides
Acetazolamide
Loop diuretics
Thiazide diuretics
Relaxes vascular smooth muscle, promote GFR and natriuresis,…
Inhibits Na+ and HCO3- reabsorption by inhibition of carbonic…
Class of drugs that inhibit NKCC2 in the thick ascending loop…
Class of drugs that inhibit NCC in the distal convoluted tubu…
Natriuretic peptides
Relaxes vascular smooth muscle, promote GFR and natriuresis,…
Acetazolamide
Inhibits Na+ and HCO3- reabsorption by inhibition of carbonic…
67 terms
Pharmacology 3
Inhibitor
False substrate
Pro-drug
Catalyse
When this type of molecule binds to an enzyme the normal reac…
When this type of molecule binds to an enzyme an abnormal met…
When this type of molecule binds to an enzyme an active drug…
What do enzymes do to the conversion of a substrate into a pr…
Inhibitor
When this type of molecule binds to an enzyme the normal reac…
False substrate
When this type of molecule binds to an enzyme an abnormal met…
257 terms
Pharmacology Exam 3
Autocoids
Histamine
Mast cells and basophils
non-mast cell tissues (lungs, skin, gi…
o Local hormone***... o Diverse functions... o 3 major classes base…
o 2 biologically available pools
• stored as granules, released by exocytosis extrusion... • synt…
• synthesizes continually, rapid turnover... • function is uncle…
Autocoids
o Local hormone***... o Diverse functions... o 3 major classes base…
Histamine
o 2 biologically available pools
50 terms
Pharmacology Exam 3 Overview
Aminoglycoside
Alpha Glucosidase Inhibitor
Biguanide
Blood Urea Nitrogen (BUN)
Broad spectrum, powerful antibiotic usually administered by i…
Oral anti-diabetic drug used for DM2. ... Reduces breakdown of c…
Anti-diabetic drug. ... Decreases glycogenolysis. ... Decreases int…
Measurement of nitrogen in the form of urea in blood. ... Measur…
Aminoglycoside
Broad spectrum, powerful antibiotic usually administered by i…
Alpha Glucosidase Inhibitor
Oral anti-diabetic drug used for DM2. ... Reduces breakdown of c…
79 terms
Antibiotic Pharmacology #3, Pharmacology
What were the first antibacterial agen…
When was the synergy between SMX and T…
What is trimethoprim structurally simi…
What does trimethoprim inhibit?
-sulfa drugs
-1968
-folic acid
-dihydrofolate reductase
What were the first antibacterial agen…
-sulfa drugs
When was the synergy between SMX and T…
-1968
84 terms
Pharmacology 3
The nurse would anticipate the use of…
The nurse would monitor erythropoietin…
The client with megaloblastic anemia a…
The client who has megaloblastic anemi…
• Epoetin alfa recombinant
• Oncology client receiving Procrit
• "megaloblastic anemia results from vitamin B12 or folic aci…
macrocytic
The nurse would anticipate the use of…
• Epoetin alfa recombinant
The nurse would monitor erythropoietin…
• Oncology client receiving Procrit
15 terms
Pharmacology 3
What is the process of distribution?
Where is the one exception with distri…
What is albumin?
What is biotransformation?
The process by which a drug is carried from a site of absorpt…
The brain has the blood brain barrier and only lipophilic mol…
The principal protein to which drugs bind too
The process by which the drug is changed from the form it ent…
What is the process of distribution?
The process by which a drug is carried from a site of absorpt…
Where is the one exception with distri…
The brain has the blood brain barrier and only lipophilic mol…
21 terms
pharmacology-3
side effects
anticholinergic medications
xerostomia
meds/bowel irregularities
many medications have them and they may impact nutrition status
side effects:... -xerostomia- main... -urinary retention... -confusion…
may impair taste/swallowing; increases the risk for dental ca…
-narcotics... -sorbitol... -antibotics
side effects
many medications have them and they may impact nutrition status
anticholinergic medications
side effects:... -xerostomia- main... -urinary retention... -confusion…
10 terms
Pharmacology 3
Common side effects of medications for…
Which of the following are true of som…
Which of the following are true of glu…
Signs and symptoms of hypoglycemia/ins…
no changes in growth and cardiac function
1, 2, 4, and 5
1, 2, 3, 4, and 5
slow onset
Common side effects of medications for…
no changes in growth and cardiac function
Which of the following are true of som…
1, 2, 4, and 5
22 terms
Pharmacology 3
Pertaining to a person younger than 1…
Drugs cross the placenta by which proc…
Define diffusion.
3 factors that affect safety of fetus…
Neonate
1. Diffusion ... 2. Osmosis ... 3. Active transport... 4. Absorption
The passive movement of substance b/n different tissues from…
Drug properties... fetal gestational age... Maternal factor
Pertaining to a person younger than 1…
Neonate
Drugs cross the placenta by which proc…
1. Diffusion ... 2. Osmosis ... 3. Active transport... 4. Absorption
19 terms
Pharmacology 3
Famotidine
Nizatidine
Ranitidine
Dexlansoprazole
Pepcid
Axid
Zantac
Dexilant
Famotidine
Pepcid
Nizatidine
Axid
9 terms
Pharmacology 3
Idosyncratic reaction
Drug allergy
Toxic reaction
Side effect
Genetically related abnormal drug response
An immunologic response to a drug resulting in a reaction suc…
An extension of the pharmacologic effect resulting from a dru…
Dose-related reaction that is not part of the desired therape…
Idosyncratic reaction
Genetically related abnormal drug response
Drug allergy
An immunologic response to a drug resulting in a reaction suc…
195 terms
pharmacology 3
ischemia
atherosclerotic angina
vasospastic angina
Unstable angina
a lack of blood supply to an organ, particularly the heart
"work/effort'... associated with plaques (lipid deposits)... rest u…
"rest"... reversible spasms of coronary artieries at site of ath…
Immediate precursor to MI... MEDICAL EMERGENCY... increased frequen…
ischemia
a lack of blood supply to an organ, particularly the heart
atherosclerotic angina
"work/effort'... associated with plaques (lipid deposits)... rest u…
93 terms
Pharmacology 3
Centrally Acting Opioid Narcotic Analg…
Peripherally Acting Non-opioid Analges…
Heroin
Opiods
Opioid receptor agonists. Mu, delta, and Kappa. All types of…
Prostaglandin inhibitors. NSAIDS and Tylenol
Synthesized from morphine in 1898. Thought to be non-addictiv…
Pain relief, suppress a cough; cause sedation, urinary retent…
Centrally Acting Opioid Narcotic Analg…
Opioid receptor agonists. Mu, delta, and Kappa. All types of…
Peripherally Acting Non-opioid Analges…
Prostaglandin inhibitors. NSAIDS and Tylenol
112 terms
Pharmacology 3
Defense System Purpose
Body's Defense System
Inflammation Purpose
Clinical Presentation of Inflammation
The body has many defense systems in place ... Keeps the body in…
Barrier Defense (skin, mucous membranes, gastric acid)... Cellul…
Body's defense mechanism... Localized protective response stimul…
Calor (heat)... Caused by increased blood flow... Tumor (swelling)…
Defense System Purpose
The body has many defense systems in place ... Keeps the body in…
Body's Defense System
Barrier Defense (skin, mucous membranes, gastric acid)... Cellul…
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