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Study sets matching "pharmacology antimicrobials"

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Study sets matching "pharmacology antimicrobials"

12 terms
Pharmacology-Antimicrobials
Penicillins
Anti-staph penicillins
Aminopenicillins
Antipseudomonal penicillinis
Treat: bacterial with cell wall. Gram + cocci and bacilli, Gr…
Drugs: methicillin, cloxacillin, dicloxacillin, oxacillin, fl…
Ampicillin: Acute bacterial meningitis, available with Sulbac…
Drugs: carbenicllin, Ticarcillin, Piperacillin... Treat: higher…
Penicillins
Treat: bacterial with cell wall. Gram + cocci and bacilli, Gr…
Anti-staph penicillins
Drugs: methicillin, cloxacillin, dicloxacillin, oxacillin, fl…
15 terms
Pharmacology: Antimicrobials
Characteristics of Gram Positive Bacte…
Characteristics of Gram Negative Bacte…
Gram + Cocci
Gram + Bacilli
Thick, sturdy cell wall... Exposed peptidoglycan wall--> visible…
1. Thinner peptidoglycan wall and outer membrane... 2. Space bet…
enterococcus, staphylococcus, streptococcus, (pyrogens, virid…
Bacillus anthracis, clostridum (difficile, perfringens, dipht…
Characteristics of Gram Positive Bacte…
Thick, sturdy cell wall... Exposed peptidoglycan wall--> visible…
Characteristics of Gram Negative Bacte…
1. Thinner peptidoglycan wall and outer membrane... 2. Space bet…
40 terms
Pharmacology Antimicrobials
antibiotics
empiric therapy
definitive therapy
prophylactic therapy
medications used to treat bacterial infections
treatment of infection before labs come back
treating the specific infection when labs comes back
preventing infections ex. given before surgery or dental work
antibiotics
medications used to treat bacterial infections
empiric therapy
treatment of infection before labs come back
185 terms
Pharmacology--Antimicrobials
Any drug that kills or inhibits a micr…
Substances produced by one organism th…
What is the difference between -cidal…
What type of microbe are antibiotics u…
Antimicrobial
Antibiotic
-cidal means it kills the microbes... -static means it inhibits…
Bacteria
Any drug that kills or inhibits a micr…
Antimicrobial
Substances produced by one organism th…
Antibiotic
64 terms
Pharmacology - Antimicrobials
-cidal
-static
What is the goal of Antimicrobial ther…
Minimum inhibitory concentration (MIC)
Drug that kills an organism
Drug that inhibit or slow down replication, but does not kill
To kill or disable pathogens without killing the host
The lowest concentration of drug which will stop the growth o…
-cidal
Drug that kills an organism
-static
Drug that inhibit or slow down replication, but does not kill
105 terms
Pharmacology- Antimicrobials
Banned in food producing animals
Not for use with poultry or lactating…
Causes aplastic anemia if not handled…
Causes non-inflammatory erosive arthro…
Quinolones, Aminoglycosides, Chloramphenicols, Metronidazole
Tetracycline
Chloramphenicol
Quinolones
Banned in food producing animals
Quinolones, Aminoglycosides, Chloramphenicols, Metronidazole
Not for use with poultry or lactating…
Tetracycline
91 terms
Antimicrobials- Pharmacology
Two Processes of Drug Development
Therapeutic Index
Drug Resistance Mechanisms, some examp…
Drug Combination Theory
Rational Process: hypothesize a structure and generate a drug…
A measure of drug safety:... TD50/ ED50
Mutation- most common... Biotransformation/insufficient activati…
Decreases the rate of resistance development- TB tx... Increases…
Two Processes of Drug Development
Rational Process: hypothesize a structure and generate a drug…
Therapeutic Index
A measure of drug safety:... TD50/ ED50
21 terms
Pharmacology (ANTIMICROBIALS)
antimicrobials
acquired resistance to antimicrobials
Superinfection
S.I.
(a.k.a. antibiotics, antibacterials, anti-infectives) treat i…
a bacterium that was once sensitive to a given antimicrobial…
a new infection that develops during the treatment of an exis…
The antimicrobial used for the existing infection destroys no…
antimicrobials
(a.k.a. antibiotics, antibacterials, anti-infectives) treat i…
acquired resistance to antimicrobials
a bacterium that was once sensitive to a given antimicrobial…
80 terms
Pharmacology -- Antimicrobials
indications for Sulfonamides
sulfonamides MOA
sulfonamides ADRs
Sulfonamides drug names
community acquired MRSA, UTIs, and PCP treatment and prophyla…
-folic acid inhibitor ... - some gram (+), some gram (-)
*Steven Johnson Syndrome... - renal damage ... - bone marrow suppre…
Sulfamethoxazole-trimethoprim, silver sulfadiazine ... "sulfas"
indications for Sulfonamides
community acquired MRSA, UTIs, and PCP treatment and prophyla…
sulfonamides MOA
-folic acid inhibitor ... - some gram (+), some gram (-)
56 terms
Pharmacology Antimicrobials
Penicillin G
Phenoxymethyl Penicillin
Procaine Penicillin G
Sodium and Potassium Penicillin G
B lactam... Active against Gram + (STREP) Anaerobes... Adverse Effe…
B lactam... Active against Gram + (STREP) Anaerobes... Oral formula…
B lactam... Active against Gram + (STREP) and Anaerobes... Only giv…
B lactam... Active against Gram + (STREP) and Anaerobes ... Given I…
Penicillin G
B lactam... Active against Gram + (STREP) Anaerobes... Adverse Effe…
Phenoxymethyl Penicillin
B lactam... Active against Gram + (STREP) Anaerobes... Oral formula…
PHARMACOLOGY - ANTIMICROBIALS
What is the definition of the term SEL…
What is a SPECTRUM in regards to an an…
What is the TISSUE PENETRATION of an a…
What are the major STRUCTURES of a bac…
- a drug will be harmful to pathogens but not the patient who…
- the RANGE of bacteria that will be SUSCEPTIBLE to the antim…
- the locations where the antibiotic will reach in the body... -…
- CELL WALL (human cells do not have a cell wall at all)... - RI…
What is the definition of the term SEL…
- a drug will be harmful to pathogens but not the patient who…
What is a SPECTRUM in regards to an an…
- the RANGE of bacteria that will be SUSCEPTIBLE to the antim…
120 terms
Pharmacology Antimicrobials
Antibiotic
Bacteriocidal
Bacteriostatic
Resistance
any drug that is produced by a living microorganism that can…
an antibiotic that kill the bacteria
an antibiotic that suppresses the growth of bacteria but does…
occurs when the growth of a microorganism is no longer suppre…
Antibiotic
any drug that is produced by a living microorganism that can…
Bacteriocidal
an antibiotic that kill the bacteria
90 terms
Pharmacology: Antimicrobials
What are some ways we can fight pathog…
Antiseptics
Disenfectants
What is Chemotherapy?
1. Antiseptics... 2. Disenfectants... 3. Vaccines... 4. Antivirals... 5.…
hand santizer in hospital.... applied to skin, but not taken int…
things like bleach for surfaces. Too toxic for skin, but used…
To use chemical agents to treat disease. Does not have to be…
What are some ways we can fight pathog…
1. Antiseptics... 2. Disenfectants... 3. Vaccines... 4. Antivirals... 5.…
Antiseptics
hand santizer in hospital.... applied to skin, but not taken int…
13 terms
Pharmacology - Antimicrobials
Is the incidence of superinfections lo…
What are 3 examples of superinfections?
Are the following examples of bacteric…
Are the following examples of bacteric…
Lower incidence with narrow spectrum antibiotics
1. Antibiotic-associated pseudomembranous colitis (AAPC)... 2. C…
All are bactericidal
All are bacteriostatic
Is the incidence of superinfections lo…
Lower incidence with narrow spectrum antibiotics
What are 3 examples of superinfections?
1. Antibiotic-associated pseudomembranous colitis (AAPC)... 2. C…
27 terms
Pharmacology: Antimicrobials
Name some anti-pseudomonal penicillins.
What is the mechanism of resistance of…
What are some adverse effects of high…
What route of administration is used f…
piperacillin, carbenicillin, ticarcillin, mezlocillin
beta-lactamase production
sodium overload, thrombocytopenia
IV
Name some anti-pseudomonal penicillins.
piperacillin, carbenicillin, ticarcillin, mezlocillin
What is the mechanism of resistance of…
beta-lactamase production
85 terms
Pharmacology antimicrobials
selective toxicity
sulfonamide antibiotics
narrow vs broad
antibiotic selection
ability of drug to injure target cell or target organisms w/o…
1. broad spectrum inhibit enzyme needed to make folic acid ... 2…
narrow (preferred): act against limited group of bacteria... bro…
1. identity of infecting organism... 2. drug sensitivity of infe…
selective toxicity
ability of drug to injure target cell or target organisms w/o…
sulfonamide antibiotics
1. broad spectrum inhibit enzyme needed to make folic acid ... 2…
51 terms
Pharmacology - Antimicrobials
Sulfonamides
SMX/TMP
Cycloserine
Trimethoprim
Synthetic Antimicrobial. Bacteriostatic. G+/-. PABA analogue.…
Sulfamethoxazole/Trimethoprim - 5/1 ratio. Strong inhibition…
D-Alanine psuedosubstrate. Inhibit Alanine racemase preventin…
Synthetic Antimicrobial. Bacteriostatic. Inhibits dihydrofoli…
Sulfonamides
Synthetic Antimicrobial. Bacteriostatic. G+/-. PABA analogue.…
SMX/TMP
Sulfamethoxazole/Trimethoprim - 5/1 ratio. Strong inhibition…
Pharmacology- Antimicrobials
Characteristics of Antibiotics
Cell wall
Beta-lactam antibiotics
B-lactam drugs and characteristics
bactericidal- killing bacteria... bacteriostatic- inhibit/stop g…
target for many antibiotics... cell wall responsible for cell in…
e.g. penicillins/cephalosporins/carbapenems... effective against…
penicillins- e.g. penicillin, amoxicillin, ampicillin... very ef…
Characteristics of Antibiotics
bactericidal- killing bacteria... bacteriostatic- inhibit/stop g…
Cell wall
target for many antibiotics... cell wall responsible for cell in…
58 terms
Pharmacology of antimicrobials
What is the mechanism of action of ant…
What are bacteriostatic antibiotics?
What are bacteriocidal antibiotics?
What are the relative benefits and neg…
There aim is to prevent the growth and/or survival of invadin…
Antibiotics that prevent replication but do not kill suscepti…
Kill susceptible bacteria ... E.g. fluoroquinolones, b-lactams,…
Broad - select for resistance in wide population but no need…
What is the mechanism of action of ant…
There aim is to prevent the growth and/or survival of invadin…
What are bacteriostatic antibiotics?
Antibiotics that prevent replication but do not kill suscepti…
65 terms
Pharmacology- Antimicrobials
Antimicrobial Drug
Selective Toxicity
Narrow-spectrum, Broad-spectrum
Suprainfection
Any agent that has the ability to kill or suppress microorgan…
Ability of an antibiotic to kill or suppress infecting microb…
____ Active against only a few species of microorganisms... ____…
New infection that appears during the course of treatment for…
Antimicrobial Drug
Any agent that has the ability to kill or suppress microorgan…
Selective Toxicity
Ability of an antibiotic to kill or suppress infecting microb…
36 terms
Pharmacology Antimicrobials
Antibacterials
Empiric Theory
Superinfection
Penicillin
Bactericidal: Directly lethal to bacteria... Bacteriostatic: Inh…
Giving an antibiotic before you know what you are trying to k…
Infections that happen during antibiotic therapy. Caused by k…
INDICATIONS: Gram + and some Gram -... Bacteriocidal (inhibits…
Antibacterials
Bactericidal: Directly lethal to bacteria... Bacteriostatic: Inh…
Empiric Theory
Giving an antibiotic before you know what you are trying to k…
41 terms
Pharmacology - Antimicrobials
Bacteria treated with narrow spectrum…
Narrow spectrum penicillins are bacter…
Bacteria treated with very narrow spec…
Bacteria treated with broad spectrum p…
Gram-positive bacilli, Streptococci, pneumococci, meningococc…
Gram-positive cocci, gram-positive rods, gram-negative cocci,…
Staphylococci (except MRSA)
Streptococci, H. influenzae, H. pylori, E. coli, Listeria mon…
Bacteria treated with narrow spectrum…
Gram-positive bacilli, Streptococci, pneumococci, meningococc…
Narrow spectrum penicillins are bacter…
Gram-positive cocci, gram-positive rods, gram-negative cocci,…
7 terms
Pharmacology antimicrobials
Pharmacology: antimicrobial agents, sp…
Tetracyclines and macrolides
Bacteriostatic (they halt protein synt…
Tigecycline - a glycyl cycline.
...
Resistance to these protein synthesis inhibitors is COMMON
Proteins synthesis are mostly...bacterioSTATIC or bacterioCID…
Newest tetracycline?
Pharmacology: antimicrobial agents, sp…
...
Tetracyclines and macrolides
Resistance to these protein synthesis inhibitors is COMMON
21 terms
Pharmacology - Antimicrobials
Antimicrobials
Culture
Sensitivity
Bactericidal
Purpose is to decrease the number of microorganisms to a leve…
A specimen of the infected area is taken to identify the micr…
A series of drugs are applied to the microorganisms to determ…
Kills bacteria
Antimicrobials
Purpose is to decrease the number of microorganisms to a leve…
Culture
A specimen of the infected area is taken to identify the micr…
28 terms
Antimicrobials Pharmacology
Absorbs the purple/violet stain... Typica…
Does not absorb the purple/violet stai…
Drugs that are produced by one micro-o…
Inhibits the growth of bacteria, slows…
Gram + stain
Gram - stain
Antimicrobials
Bacteriostatic
Absorbs the purple/violet stain... Typica…
Gram + stain
Does not absorb the purple/violet stai…
Gram - stain
43 terms
Pharmacology Antimicrobials
Pharmacodynamics
Pharmacokinetics
Agonist
Antagonist
The study of how a drug acts on a living organism, including…
The study of the ACTION of drugs within the body, including s…
A drug that produces a desired physiologic effect on binding…
A drug that diminishes or eradicates the physiologic effect o…
Pharmacodynamics
The study of how a drug acts on a living organism, including…
Pharmacokinetics
The study of the ACTION of drugs within the body, including s…
8 terms
Pharmacology Antimicrobials
PRINCIPLES OF ANTIMICROBIAL THERAPY
Postantibiotic effect
MIC measured by
Minimal Bactericidal Concentration (MBC)
...
Killing action of drug continues even after drug below measur…
Broth or tube dilution... Disk sensitivity test
Concentration with 99.9% colony decline
PRINCIPLES OF ANTIMICROBIAL THERAPY
...
Postantibiotic effect
Killing action of drug continues even after drug below measur…
68 terms
pharmacology - antimicrobials
MIC
Cmax
Tmax
AUC
minimal inhibitory concentration... lowest antibiotic concentrat…
peak drug concentration after admin
time to reach peak drug concentration (Cmax)
area under the curve - used to calculate drug bioavailability
MIC
minimal inhibitory concentration... lowest antibiotic concentrat…
Cmax
peak drug concentration after admin
14 terms
Pharmacology Antimicrobials
Empiric therapy
Prophylactic therapy
Reputed response
Sub therapeutic response
Treatment for an infection before a specific culture results…
Treatment with antibiotics to prevent infection
A decrease in the S/S of infection is noted ... decreased fever…
S/S of infection do not improve
Empiric therapy
Treatment for an infection before a specific culture results…
Prophylactic therapy
Treatment with antibiotics to prevent infection
31 terms
Pharmacology: Antimicrobials
Tetracycline
tissue
Slow
staining (permanent)
*What antimicrobial is metabolized by the liver and undergoes…
What kind of damage can occur with tetracycline IM injections?
resistance to tetracycline can happen slow or fast?
Tetracycline can cause what to young animals teeth?
Tetracycline
*What antimicrobial is metabolized by the liver and undergoes…
tissue
What kind of damage can occur with tetracycline IM injections?
31 terms
Pharmacology Antimicrobials
Cefadroxil
Cephalothin
Cephalexin
Ceftiofur
1st Generation Cephalosporin
1st Generation Cephalosporin
1st Generation Cephalosporin
3rd Generation Cephalosporin
Cefadroxil
1st Generation Cephalosporin
Cephalothin
1st Generation Cephalosporin
44 terms
Pharmacology- Antimicrobials
bacteriostatic
bacteriocidal
antibiotic resistance
broad spectrum
stops the bacteria from replicating so that the host's immune…
kills the bacterium directly.
the evolution of populations of pathogenic bacteria that anti…
A chemical that kills gram-positive bacteria and gram-negativ…
bacteriostatic
stops the bacteria from replicating so that the host's immune…
bacteriocidal
kills the bacterium directly.
13 terms
Pharmacology - Antimicrobials
Beta-lactam drugs
Narrow-spectrum penicillins
Antistaphylococcal penicillins
Penicillinase (beta-lactamase)-sensiti…
Penicillins, cephalosporins, carbapenems, monobactams
Penicillin G, penicillin V
Methicillin, nafcillin, oxacillin, cloxacillin, dicloxacillin
Penicillin G and V, amoxicillin, ampicillin
Beta-lactam drugs
Penicillins, cephalosporins, carbapenems, monobactams
Narrow-spectrum penicillins
Penicillin G, penicillin V
56 terms
Pharmacology - Antimicrobials
Fluoroquinolones mechanism of action
What topoisomerase is specifically tar…
Why is ciprofloxacin good for treating…
Primary adverse effects of Fluoroquino…
Trap/inhibit topoisomerase such that DNA cannot be repaired
gram(-): Topoisomerase II (DNA gyrase)- give Ciprofloxacin
Eliminated renally
1. C. difficile diarrhea ("Antibiotic associated diarrhea")... 2…
Fluoroquinolones mechanism of action
Trap/inhibit topoisomerase such that DNA cannot be repaired
What topoisomerase is specifically tar…
gram(-): Topoisomerase II (DNA gyrase)- give Ciprofloxacin
44 terms
pharmacology- antimicrobials
bacteriostatic
bacteriocidal
narrrow spectrum
broad spectrum
inhibit growth or multiplication of microorganisms
kill microorganisms
only kill a few organisms... only useful when organism is identi…
kill many different organisms... useful when organism is not ide…
bacteriostatic
inhibit growth or multiplication of microorganisms
bacteriocidal
kill microorganisms
32 terms
Pharmacology - Antimicrobials
What enzyme do B-lactams inhibit (prim…
What is the MOA of Vancomycin?
What are the glycopeptide antibiotics?
Glycopeptide antibiotics only treat wh…
Dipeptidase
Inhibits transglycosylases that creates linear chains (pre-cr…
Vancomycin and telavancin ( a derivative of vanco)
G+
What enzyme do B-lactams inhibit (prim…
Dipeptidase
What is the MOA of Vancomycin?
Inhibits transglycosylases that creates linear chains (pre-cr…
11 terms
Pharmacology: Antimicrobials
Microbes
Examples of Gram Positive
Examples of Gram Negative
Examples of Atypicals
Bacteria, virus, fungus, parasites
Streptococcus, Staphylococcus, Enterococcus, Clostridium, Lis…
Coccobacilli, Cocci, Bacilli
Chlamydia, Mycoplasma, Rickettsia
Microbes
Bacteria, virus, fungus, parasites
Examples of Gram Positive
Streptococcus, Staphylococcus, Enterococcus, Clostridium, Lis…
83 terms
PHARMACOLOGY - ANTIMICROBIALS
What is the definition of the term SEL…
What is a SPECTRUM in regards to an an…
What is the TISSUE PENETRATION of an a…
What are the major STRUCTURES of a bac…
- a drug will be harmful to pathogens but not the patient who…
- the RANGE of bacteria that will be SUSCEPTIBLE to the antim…
- the locations where the antibiotic will reach in the body... -…
- CELL WALL (human cells do not have a cell wall at all)... - RI…
What is the definition of the term SEL…
- a drug will be harmful to pathogens but not the patient who…
What is a SPECTRUM in regards to an an…
- the RANGE of bacteria that will be SUSCEPTIBLE to the antim…
88 terms
Pharmacology: Antimicrobials
invader direct infection
invader indirect infection
two components of treatment of undesir…
choosing a drug to wipe out an invadin…
release of toxins
invasion of tissue, or triggering of the bodies inflammatory…
1) destruction or removal of invading organism with drugs... 2)…
1) what the invading organism is... 2) the location of the organ…
invader direct infection
release of toxins
invader indirect infection
invasion of tissue, or triggering of the bodies inflammatory…
138 terms
Pharmacology: Antimicrobials
What is Selective Toxicity?
How are antibiotics classified?
What is another name for protein Synth…
Nonlethal inhibitors or protein synthe…
Ability of a drug to injure a target cell / organism without…
1) What is the susceptible organism?... 2) Are they narrow or br…
bacteriocidal
bacteriostatic
What is Selective Toxicity?
Ability of a drug to injure a target cell / organism without…
How are antibiotics classified?
1) What is the susceptible organism?... 2) Are they narrow or br…
44 terms
Pharmacology of Antimicrobials
DNA-Affecting Drugs
Cell Wall Synthesis Inhibitors
Protein Synthesis Inhibitors
Anti-Fungals
All are broad-spectrum... Folate Synthesis Inhibitors:... -Sulfon…
All are bactericidal... ß-Lactams... -Penicillins:... a). Gram Pos…
30s Ribosomal subunit:... a). Aminoglycosides (Bactericidal; GN…
Plasma Membrane Disruptors:... ... a). Azoles... i). Fluconazole... b)…
DNA-Affecting Drugs
All are broad-spectrum... Folate Synthesis Inhibitors:... -Sulfon…
Cell Wall Synthesis Inhibitors
All are bactericidal... ß-Lactams... -Penicillins:... a). Gram Pos…
32 terms
Pharmacology - Antimicrobials
What is the definition of resistance?
How do bacteria develop resistance?
What are the desired properties of an…
What are the first line treatment for…
No inhibition or no killing by the antibacterial agent at dru…
1) Altered target site for antibacterial... 2) Altered uptake of…
1) Only target the microorganism and not mammilian cells... 2) C…
1) Rifampicin... 2) Isoniazid... 3) Pyrazinamide... 4) Ethambutol
What is the definition of resistance?
No inhibition or no killing by the antibacterial agent at dru…
How do bacteria develop resistance?
1) Altered target site for antibacterial... 2) Altered uptake of…
10 terms
Pharmacology of Antimicrobials
MOA of sulfamethoxazole/trimethoprim
MOA of aminoglycogsides - gentamicin a…
MOA of nitrofurantoin
MOA of metronidazole
folic acid metabolism; ... SMX competitively inhibits the incorp…
alters protein synthesis; 30S inhibitors
...
...
MOA of sulfamethoxazole/trimethoprim
folic acid metabolism; ... SMX competitively inhibits the incorp…
MOA of aminoglycogsides - gentamicin a…
alters protein synthesis; 30S inhibitors
18 terms
Antimicrobial Pharmacology
Selective Toxicity
Narrow Spectrum
Broad Spectrum
Bactericidal
The ability of a drug to injure a target organism without inj…
Drugs active against only a few species of microorganisms.
Drugs active against a wide variety of microorganisms.
Drugs that are directly lethal to bacteria at clinically achi…
Selective Toxicity
The ability of a drug to injure a target organism without inj…
Narrow Spectrum
Drugs active against only a few species of microorganisms.
21 terms
Antimicrobial Pharmacology
What are the 3 classes of chemotherape…
What are the 3 subclassifications of a…
What are the 5 targets of antibiotics?
Explain the difference between broad v…
(1) Antimicrobials (2) Antiparasitics (3) Antineoplastics
(1) Antibacterial (2) Antifungal (3) Antiviral
(1) Cell wall destruction (2) Protein synthesis inhibition (3…
Narrow spectrum targets selectively. Broad spectrum targets b…
What are the 3 classes of chemotherape…
(1) Antimicrobials (2) Antiparasitics (3) Antineoplastics
What are the 3 subclassifications of a…
(1) Antibacterial (2) Antifungal (3) Antiviral
10 terms
antimicrobial pharmacology
cidal vs static
synergy vs antagonistic
inhibitors of cell wall synthesis... (cla…
MOA of pencillins
kills vs stop growth
drugs together gives a greater effect than either drug indivi…
1. pencillin... 2. cephalosporin... 3. imipenim/meropenim... 4.aztreon…
1. bind PBPs ( binding protein)... 2. inhibit transpeptidation (…
cidal vs static
kills vs stop growth
synergy vs antagonistic
drugs together gives a greater effect than either drug indivi…
Antimicrobial Pharmacology
Bacteriostatic vs Bactericidal
Adverse effects of antibiotics
Methods/mechanisms of antibiotic drug…
amoxicillin
-static: inhibits reproduction/growth of bacteria... -icidal: ki…
Hypersensitivity - ranging from urticaria to anaphylaxis... GI t…
a. Decreased drug uptake... b. Increased drug efflux... c. Inactiva…
From Penicillium mold... Interferes with synthesis of bacterial…
Bacteriostatic vs Bactericidal
-static: inhibits reproduction/growth of bacteria... -icidal: ki…
Adverse effects of antibiotics
Hypersensitivity - ranging from urticaria to anaphylaxis... GI t…
11 terms
Antimicrobial Pharmacology
Example of Gram Positive Bacteria
Example of Gram negative
Example of Anaerobe
B-lactam
Staphylococcus
E.coli
Bacteroides
Penicillin. Inhibits synthesis of peptidoglycan
Example of Gram Positive Bacteria
Staphylococcus
Example of Gram negative
E.coli
12 terms
PHARMACOLOGY-ANTIMICROBIALS
Penicillin (Beta Lactam)
Cephalosporins
Triglyceride Glycopeptide (Vancomycin)
Monobactum (Aztreonam)
MOA: cell wall synthesis ... Spectrum: Broad (Gram + Gram-).... Res…
MOA: cell wall synthesis... Spectrum: ... 1st- Gram + not resistant…
MOA: cell wall synthesis... Spectrum: narrow; Gram + bacteria (C…
MOA: cell wall synthesis... A strong antibiotic.... Causes severe G…
Penicillin (Beta Lactam)
MOA: cell wall synthesis ... Spectrum: Broad (Gram + Gram-).... Res…
Cephalosporins
MOA: cell wall synthesis... Spectrum: ... 1st- Gram + not resistant…
186 terms
Pharmacology - antimicrobial
Last step, 3rd step, transpeptidation…
Beta lactam ring
6-aminopenicillanic acid
Inihibits the last step in the peptido…
Step in peptidoglycan synthesis that is inhibited by beta lac…
Site of action of beta lactamase.... Site of action of amidase.
Parent compound of penicillin.
MOA of penicillin.
Last step, 3rd step, transpeptidation…
Step in peptidoglycan synthesis that is inhibited by beta lac…
Beta lactam ring
Site of action of beta lactamase.... Site of action of amidase.
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