Study sets matching "pharmacology ii"

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Study sets matching "pharmacology ii"

616 terms
Pharmacology 2
alpha 1
contraction, mydriasis
none
M3
eye iris radial muscle sympathetic receptor
alpha 1 stimulation effect on iris radial muscle of eye
eye iris circular muscle sympathetic receptor
iris circular muscle of eye parasympathetic receptor
alpha 1
eye iris radial muscle sympathetic receptor
contraction, mydriasis
alpha 1 stimulation effect on iris radial muscle of eye
40 terms
Pharmacology - Principles of Pharmacology (2)
passive diffusion, active diffusion
permeation
aqueous, lipid
endocytosis/exocytosis, special carriers
Permeation of a drug can be achieved via two different *mec…
A drug should be able to reach its intended site of action vi…
The two types of passive diffusion are:... 1. ________________…
The two types of active diffusion are:... 1. _________________…
passive diffusion, active diffusion
Permeation of a drug can be achieved via two different *mec…
permeation
A drug should be able to reach its intended site of action vi…
128 terms
Pharmacology 2
What is the difference between conscio…
What are the three phases of general a…
What principal governs delivery of gas…
What two ways can you increase how qui…
Conscious sedation - Patient can still respond to being touch…
Induction - Should be rapid... Maintenance - Should stay deep... Em…
Movement down partial pressure gradient
1) Higher partial pressure of anesthetic... 2) High air pressure…
What is the difference between conscio…
Conscious sedation - Patient can still respond to being touch…
What are the three phases of general a…
Induction - Should be rapid... Maintenance - Should stay deep... Em…
42 terms
Pharmacology #2
Dilaudid
Roxanol
MS Contin
Meperidine
Hydromorphine
Concentrated solution containing 20mg/ml
Controlled-released tablet
Demerol
Dilaudid
Hydromorphine
Roxanol
Concentrated solution containing 20mg/ml
Pharmacology 2
morphine sulfate po dose
morphine sulfate SC/IM dose
morphine sulfate IV dose
morphine sulfate pr dose
10-30mg q4h
5-20 mg q4h
2.5-15 mg q4h
10-20mg q4h
morphine sulfate po dose
10-30mg q4h
morphine sulfate SC/IM dose
5-20 mg q4h
13 terms
Pharmacology 2
Category: Antihypertensive Drugs
not indicated as first line therapy fo…
true or false... A combination of 2 first…
Antihypertensive drugs contraindicated…
Category:... Adrenergic (alpha or beta) blockers... Angiotensin-con…
beta blockers
false... >20 mmHg systolic
ACEI, ARB and direct renin inhibitors
Category: Antihypertensive Drugs
Category:... Adrenergic (alpha or beta) blockers... Angiotensin-con…
not indicated as first line therapy fo…
beta blockers
96 terms
Pharmacology #2
What are anxiolytic Drugs?
What is Cholordiazepoxide (Librium)
What is clonazepam (Klunipin)?
What is diazepam (Valium)?
They are used to treat anxiety.
A long acting benzo. Treats anxiety.
a long acting benzo. Treats anxiety.
A long acting benzo. Treats anxiety.
What are anxiolytic Drugs?
They are used to treat anxiety.
What is Cholordiazepoxide (Librium)
A long acting benzo. Treats anxiety.
PHARMACOLOGY 2
ABCB1 MDR1
ABCC1 MRP1... ABCC2 MRP 2
MRP 3 ABCC 3
ABCC 4&5 MRP 4&5
bulky, hydrophobic, neutral and positively charged... erythromyc…
MRP1= small cell lung carcinoma... MRP1 & MRP2= Conjugated anion…
monovalent bile salts... helps recyle bile salts and bilirubin g…
narrow substrate specificity... HIV drugs and nucleotide analogs
ABCB1 MDR1
bulky, hydrophobic, neutral and positively charged... erythromyc…
ABCC1 MRP1... ABCC2 MRP 2
MRP1= small cell lung carcinoma... MRP1 & MRP2= Conjugated anion…
189 terms
PHARMACOLOGY 2
JNC8 Guidelines... Classes of Anti Hypert…
JNC8 Guidelines... Classes of Anti-HTN fo…
JNC8 Guidelines... Anti-HTN for adults w/…
Thiazide Diuretics... MOA
Thiazide type diuretics... Calcium Channel Blockers... ACE inhibito…
Thiazide type diuretics... Ca channel blockers
ACE... ARB
works in DISTAL TUBULE... inhibits Na,Cl reabsorption... promotes…
JNC8 Guidelines... Classes of Anti Hypert…
Thiazide type diuretics... Calcium Channel Blockers... ACE inhibito…
JNC8 Guidelines... Classes of Anti-HTN fo…
Thiazide type diuretics... Ca channel blockers
PHARMACOLOGY 2
Opioids
Fentanyl
Morphine
Methadone
PNS... 1) Site of inflammation ... CNS... 2) Spine - stopping afferent…
u-agonist ... Strongest... DOA = 20-30mins (Very short)
u-agonist ... Weird: emetic and then strong anti-emetic (CTZ) ... D…
u-agonist ... V.similar to morphine (NO initial v+ effect) ... Mult…
Opioids
PNS... 1) Site of inflammation ... CNS... 2) Spine - stopping afferent…
Fentanyl
u-agonist ... Strongest... DOA = 20-30mins (Very short)
100 terms
Pharmacology 2
Tyramine + MAO A inhibitor? Rx?
Where is the Tyramine found?
MAO A stands for?
Tyramine acts as ...
Hypertensive crisis.... Rx: Phentolamine (reversible alpha 1 blo…
Wine, Cheese, Chocolate and Banana.
Monoamine oxidase inhibitor.
a catecholamine releasing agent. Notably, however, it is unab…
Tyramine + MAO A inhibitor? Rx?
Hypertensive crisis.... Rx: Phentolamine (reversible alpha 1 blo…
Where is the Tyramine found?
Wine, Cheese, Chocolate and Banana.
13 terms
Pharmacology 2
Why are receptors with a lot of spare…
What is the difference between an anta…
What is efficacy?
What is potency?
Because when they pop off of one ligand they're much more lik…
An antagonist prevents an agonist from binding a receptor. An…
The strength of the biological response to the drug
The amount of drug required to get a biological response
Why are receptors with a lot of spare…
Because when they pop off of one ligand they're much more lik…
What is the difference between an anta…
An antagonist prevents an agonist from binding a receptor. An…
21 terms
Pharmacology 2
A solution contains the same concentra…
An older adult patient is prescribed a…
A patient with HIV is pregnant. Which…
Which drug is appropriate for treating…
Isotonic
Liver and kidney function may be reduced, requiring cautious…
Zidovudine
Oseltamivir
A solution contains the same concentra…
Isotonic
An older adult patient is prescribed a…
Liver and kidney function may be reduced, requiring cautious…
78 terms
Pharmacology/Pharmacologic Chapter 2
Number the following drug forms in ord…
When considering the various routes of…
The nurse is aware that excessive drug…
Drug half-life is defined as the amoun…
1-Elixers... 2-Powders... 3-Capsules... 4-Enteric-coated tablets
c. Bowel and renal tubules
b. Cumulative effect
d. be removed by the body.
Number the following drug forms in ord…
1-Elixers... 2-Powders... 3-Capsules... 4-Enteric-coated tablets
When considering the various routes of…
c. Bowel and renal tubules
60 terms
Pharmacology Review 2
Phlebitis
mycosis
immunity
Tamiflu
inflammation of a vein
any disease caused by a fungus
condition that causes individuals to resist acquiring or deve…
inhibits viral neuraminidase and virus release
Phlebitis
inflammation of a vein
mycosis
any disease caused by a fungus
Pharmacology Chapter 42 (2)
Reye's syndrome
Leukopenia
Mitosis
Mycosis
a potentially fatal illness in children and adolescents linke…
an abnormal decrease in the number of circulation of white bl…
the process in cell division by which the nucleus divides
any disease caused by a fungus
Reye's syndrome
a potentially fatal illness in children and adolescents linke…
Leukopenia
an abnormal decrease in the number of circulation of white bl…
21 terms
Pharmacology 2
Balance Anesthesia
The goal of balance Anesthesia
The mechanism of Action
Adjuncts to Anesthesia
The use of a combination of drugs to achieve a specific effect
Is to balance the therapeutic effect and the adverse effect
The MOA of each agent promotes a therapeutic effect and limit…
1) A medication given to complement the effects of general an…
Balance Anesthesia
The use of a combination of drugs to achieve a specific effect
The goal of balance Anesthesia
Is to balance the therapeutic effect and the adverse effect
92 terms
Pharmacology 2
Pharmakokinetics- the 4 key components?
Pharmacodynamics
Diagram of pharmacokinetics v. pharmac…
Administration and Absorption Key poin…
How a drug molecule moves through your body from administrati…
How a drug molecule affects its target to produce the desired…
Drugs must cross epithelial and/or endothelial cell layers to…
Pharmakokinetics- the 4 key components?
How a drug molecule moves through your body from administrati…
Pharmacodynamics
How a drug molecule affects its target to produce the desired…
9 terms
Pharmacology 2
a synthetic compound used in the treat…
s a monoamine oxidase inhibitor (MAOI)…
is used to treat symptoms of depressio…
is a glucocorticoid steroid with anti-…
Disulfiram
Phenelzine
Phenelzine
Dipropionate
a synthetic compound used in the treat…
Disulfiram
s a monoamine oxidase inhibitor (MAOI)…
Phenelzine
40 terms
pharmacology 2
Absorption
Agonist
Antagonist
Allergen
The process when a drug enters the circulatory system.
A chemical that binds to a receptor and activates the recepto…
A drug that inhibits or blocks the reaction of body's messeng…
Substance that produces an allergic response.
Absorption
The process when a drug enters the circulatory system.
Agonist
A chemical that binds to a receptor and activates the recepto…
32 terms
Pharmacology 2
Pregnancy category A
Pregnancy category B
Pregnancy category C
Pregnancy category D
failure of studies to show a risk to fetus in first trimester…
animal reproduction studies have fail to show risk to fetus
animal reproduction studies HAVE shown risk to fetus - no stu…
positive evidence of human fetal risk based on studies in hum…
Pregnancy category A
failure of studies to show a risk to fetus in first trimester…
Pregnancy category B
animal reproduction studies have fail to show risk to fetus
185 terms
Pharmacology 2
Local(to one area) anesthetics
Great advantage of local anesthesia
Ester-type anesthetics*... PE
Amide-type anesthetics*... LA
-drugs that suppress pain by blocking impulse conduction alon…
-the pain can be suppressed w/o causing generalized depressio…
-a type of local anesthetic... -represented by procaine (Novocai…
-a type of local anesthetic... -represented by lidocaine (xyloca…
Local(to one area) anesthetics
-drugs that suppress pain by blocking impulse conduction alon…
Great advantage of local anesthesia
-the pain can be suppressed w/o causing generalized depressio…
434 terms
Pharmacology 2 Unit 2
what is pain perception called?
what are the processes of nocieption?
describe the various types of transduc…
at rest if there is nothing going on w…
nociception
transduction- (changing from one form of energy to another) m…
mechanical - stretching ... Thermal - needs to get hotter than 4…
Nothing!... they do not have tone ... have to reach a threshold to…
what is pain perception called?
nociception
what are the processes of nocieption?
transduction- (changing from one form of energy to another) m…
Pharmacology 2
Diphenhydramine (antihistaminic)
Statins
Penicillin mechanism of drug toxicity
Acetaminophen mechanism of drug toxicity
On-target = somnolence due to crossing of BBB
On-target = rhabdomyolisis and myositis
Hypersensitivity & immunological reactions
Production of toxic metabolites; N-acetyl-benzoquinoneimine
Diphenhydramine (antihistaminic)
On-target = somnolence due to crossing of BBB
Statins
On-target = rhabdomyolisis and myositis
Pharmacology 2
Norephinephrine
Epinephrine
Dopamine
Isoproterenol
shock
acute hypersensitivity reaction; allergic reaction
shock
asthma, pressor agent
Norephinephrine
shock
Epinephrine
acute hypersensitivity reaction; allergic reaction
344 terms
Pharmacology 2
Types of Receptors in Adrenergic System
Alpha1 Receptor Locations
Alpha 2 Receptor Locations
Beta1 Locations
Alpha1, Alpha 2, Beta1, Beta2, Dopamine
Eye, Arterioles of (skin, viscera, mucuous membrane), Veins,…
Presynaptic nerve terminals
Heart, Kidney
Types of Receptors in Adrenergic System
Alpha1, Alpha 2, Beta1, Beta2, Dopamine
Alpha1 Receptor Locations
Eye, Arterioles of (skin, viscera, mucuous membrane), Veins,…
113 terms
Pharmacology Exam #2
What drugs should not be taken concurr…
What is a teratogen?
What is pharmacodynamics? -Kinetics?
What is the first pass effect?
Calcium channel blockers, benzodiapines, and statins
A chemical found in many medications that have proven to caus…
Pharmacodynamics: What the drug does to the body (dynamics-dr…
When drugs move through the GI and are metabolized by the liv…
What drugs should not be taken concurr…
Calcium channel blockers, benzodiapines, and statins
What is a teratogen?
A chemical found in many medications that have proven to caus…
23 terms
Pharmacology 2
drug interactions
drug-drug interaction (DDI)
drug-food interactions
drug-herb interactions
a situation in which a substance affects the activity of a drug
interaction can be between two drugs
between a drug and a food item... ex: grapefruit juice component…
between a drug and herbs... ex: St. John's wort
drug interactions
a situation in which a substance affects the activity of a drug
drug-drug interaction (DDI)
interaction can be between two drugs
24 terms
Pharmacology 2
Affinity
Efficacy
How is the receptor a molecular switch?
Agonists
the ability of a drug to bind to its receptor ... - inactive state
the ability of a drug, once bound, to activate the receptor b…
D + R -> affinity -> DR (inactive) -> efficacy -> DR (active)…
- bind and activate receptors ... - they have affinity and effic…
Affinity
the ability of a drug to bind to its receptor ... - inactive state
Efficacy
the ability of a drug, once bound, to activate the receptor b…
Pharmacology 2
Beta 2
Anticholinergic
Samas
Gmp
Receptors in smooth muscle and coronary arteries ll
Parasympathetic blocker
_____ aren't give as a bd anymore due to side effects
Decreased _____ has an anticholinergic effect, dilates
Beta 2
Receptors in smooth muscle and coronary arteries ll
Anticholinergic
Parasympathetic blocker
9 terms
(2) Pharmacology
medication computation
tough level & peak level
-pressin
collagenase (Santyl)
D: desired dose = MD prescribed... A: available does... Q: quantity…
trough level - lowest concentration in the patient's bloodstr…
ADH (anti-diuretic hormone)
enzymatic drug; eats dead tissue
medication computation
D: desired dose = MD prescribed... A: available does... Q: quantity…
tough level & peak level
trough level - lowest concentration in the patient's bloodstr…
40 terms
Pharmacology 2
Plasma albumins
Beta-globulin and glycoproteins
Effects of drugs after metabolism in l…
Types of drug metabolism
Most important and mainly bind acidic drugs... Can bind many sub…
Bind basic drugs
Change in pharmacological activity... - abolished or decreased…
Phase I Reactions... - Oxidation, hydrolysis and reduction reac…
Plasma albumins
Most important and mainly bind acidic drugs... Can bind many sub…
Beta-globulin and glycoproteins
Bind basic drugs
186 terms
Pharmacology 2
3 medications that affect the immune s…
What are 4 immunosuppressant medicatio…
Cyclosporin (Atopica)
What are the drugs that can increase t…
1. Immunosuppressant medications... 2. Chemotherapy medications…
1. Cyclosporin... 2. Mycophenolate mofetil... 3. Tacrolimus... 4. Cort…
Immunosuppressant medication. ... INDICATIONS: ... Prevention of ki…
Ditiazem (cardiac med)... Veropamil (cardiac med)... Azole antifung…
3 medications that affect the immune s…
1. Immunosuppressant medications... 2. Chemotherapy medications…
What are 4 immunosuppressant medicatio…
1. Cyclosporin... 2. Mycophenolate mofetil... 3. Tacrolimus... 4. Cort…
258 terms
Pharmacology 2
Propanolol is a _______ generation
Propanolol ADME
Adverse effects of Propanolol
Propanolol is used to treat
first generation
highly lipid soluble so mostly given PO, can be given IV... Dist…
bradycardia, AV block... heart failure... rebound cardiac excitatio…
HTN, angina pectoris, tachycardic dysrhthmias, MI
Propanolol is a _______ generation
first generation
Propanolol ADME
highly lipid soluble so mostly given PO, can be given IV... Dist…
2. Pharmacology
Orphan Drug Program
1983
Rare
grants, assistance, encourage
Special FDA program that Encourages the development and marke…
The Orphan Drug act passed in
A condition or disease that affects less than 200, 000 indivi…
The orphan drug program provides research __________, FDA ___…
Orphan Drug Program
Special FDA program that Encourages the development and marke…
1983
The Orphan Drug act passed in
217 terms
pharmacology 2
Glulisine, mechanism??
Insulin, long acting, including?
Sulfonylureas... First generation: includ…
Sulfonylureas, mechanism??
insulin rapid acting
Detemir,... glargine
chlorpropamide,... tolbutamide
Close K+ channel in β-cell membrane ->cell depolarizes-> insu…
Glulisine, mechanism??
insulin rapid acting
Insulin, long acting, including?
Detemir,... glargine
40 terms
Pharmacology 2
Factors Modifying Drug Dosage and Resp…
Factors Modifying Drug Dosage and Resp…
Factors Modifying Drug Dosage and Resp…
Factors Modifying Drug Dosage and Resp…
The digestive tract in ruminants and nonruminants.... Vomiting i…
Collies are sensitive to ivermectin... Boxers are sensitive to p…
Genetic differences
Dosages are usually calculated to the average adult individua…
Factors Modifying Drug Dosage and Resp…
The digestive tract in ruminants and nonruminants.... Vomiting i…
Factors Modifying Drug Dosage and Resp…
Collies are sensitive to ivermectin... Boxers are sensitive to p…
196 terms
Pharmacology 2
What is a retrobulbar injection?
What are two indications for fluoresce…
Why are ocular topical anesthetics not…
Are miotics, or mydriatics better for…
injection all the way behind the eyeball
look for ulcers, or to see if nasolacrimal system is patent
they are toxic to the cornea, causing damage to epithelial la…
Miotics (pupil constriction)... Mydriatics are bad because they…
What is a retrobulbar injection?
injection all the way behind the eyeball
What are two indications for fluoresce…
look for ulcers, or to see if nasolacrimal system is patent
2. Pharmacology
1. Right Medication... 2. Right dose... 3. R…
2
not
chart
The seven rights of Medication Administration:... m, d, t, r, p,…
Always use _____ methods to identify your pt... ex: wrist band,…
If you did ______ pour it, do not give it
If you gave it, ______ it immediatly
1. Right Medication... 2. Right dose... 3. R…
The seven rights of Medication Administration:... m, d, t, r, p,…
2
Always use _____ methods to identify your pt... ex: wrist band,…
26 terms
Pharmacology 2
Reversible acetylcholinesterase inhibi…
Irreversible acetylcholine esterase in…
Pralidoxime (2-PAM)
Botulinum
Neostigmine... Eserine
organophosphates:... Nerve gases (sarin)... Pesticides
prevents organophosphate aging and regenerates AChE
interferes with the fusion of the synaptic vesicles at the NM…
Reversible acetylcholinesterase inhibi…
Neostigmine... Eserine
Irreversible acetylcholine esterase in…
organophosphates:... Nerve gases (sarin)... Pesticides
173 terms
Pharmacology #2
What occurs in the zona glomerulosa?
What occurs in the zona fasciculata?
What occurs in the zona reticulata?
What are corticosteroids synthesized f…
Synthesis of mineralocorticoids, such as aldosterone. Regulat…
Synthesis of glucocorticoids, such as cortisol. Regulated by…
Synthesis of androgens, such as DHEA. Regulated by enzymes?
Cholesterol and it occurs in the mitochondria
What occurs in the zona glomerulosa?
Synthesis of mineralocorticoids, such as aldosterone. Regulat…
What occurs in the zona fasciculata?
Synthesis of glucocorticoids, such as cortisol. Regulated by…
14 terms
Pharmacology Math for Pharmacology #2
broad-spectrum
bronchodilator
cathartic
Clark's Rule
refers to antibiotics that are effective against a large rang…
drug given to dilate the bronchi, or airways in the lungs, su…
drug given to induce defecation(bowel movement) or relieve co…
most common rule used in the calculation of drug dosage for c…
broad-spectrum
refers to antibiotics that are effective against a large rang…
bronchodilator
drug given to dilate the bronchi, or airways in the lungs, su…
Pharmacology 2
Afferent Nerves
Efferent Nerves
Receptors that receive/ release acetyl…
Receptors that receive/ release norepi…
sensory neurons that carry information towards the CNS
motor neurons that carry information away from the CNS to eff…
Cholinergic Receptors
Adrenergic Receptors
Afferent Nerves
sensory neurons that carry information towards the CNS
Efferent Nerves
motor neurons that carry information away from the CNS to eff…
Pharmacology 2
Prazosin
Hydralazine
Minoxidil
Sodium nitroprusside
alpha1 receptor blocker, prevents SNS induced contraction of…
selective arterial dilator, opens K+ channels
highly effective vasodilator, opens K+ channels ... Many side ef…
Nitrate drug, vasodilator, denitrated to NO which opens K+ ch…
Prazosin
alpha1 receptor blocker, prevents SNS induced contraction of…
Hydralazine
selective arterial dilator, opens K+ channels
92 terms
Pharmacology 2
Antibiotics may be found from which of…
Which of the following is NOT true of…
Which of the following is NOT true abo…
Only a person who has a drug-resistant…
all of the above
Sulfonamides are true antibiotics.
Medications for TB, whether prophylactic or therapeutic, are…
false
Antibiotics may be found from which of…
all of the above
Which of the following is NOT true of…
Sulfonamides are true antibiotics.
pharmacology 2
when is the fetus at the greatest risk…
when is the greatest % of maternally a…
which things help or cross the placent…
what is category A
first trimester
last trimester
increased blood flow and lipid soluble drugs
remote risk in fetal harm, controlled studies in women
when is the fetus at the greatest risk…
first trimester
when is the greatest % of maternally a…
last trimester
516 terms
Pharmacology Block 2
Does the the somatic nervous system co…
where do neurons of the somatic nervou…
what are the neurotransmitter(s) at th…
What kind of tissues do neurons of the…
voluntary AND involuntary activity
motor neurons originate in the spinal cord and directly inner…
Acetylcholine is the neurotransmitter at neuromuscular junction
smooth muscle, cardiac muscle, and exocrine glands (basically…
Does the the somatic nervous system co…
voluntary AND involuntary activity
where do neurons of the somatic nervou…
motor neurons originate in the spinal cord and directly inner…
139 terms
Pharmacology 2
What is pharmacokinetics?
What is pharmacodynamics?
What does bioavailability mean?
Do drugs with extensive protein-tissue…
The study of the time course of drug and metabolite levels in…
The study of the relationship between drug effect and concent…
For an orally administered drug, only a proportion may be del…
Prolonged because release of the bound drug from tissues is s…
What is pharmacokinetics?
The study of the time course of drug and metabolite levels in…
What is pharmacodynamics?
The study of the relationship between drug effect and concent…
Pharmacology 2
What is the difference between conscio…
What are the three phases of general a…
What principal governs delivery of gas…
What two ways can you increase how qui…
Conscious sedation - Patient can still respond to being touch…
Induction - Should be rapid... Maintenance - Should stay deep... Em…
Movement down partial pressure gradient
1) Higher partial pressure of anesthetic... 2) High air pressure…
What is the difference between conscio…
Conscious sedation - Patient can still respond to being touch…
What are the three phases of general a…
Induction - Should be rapid... Maintenance - Should stay deep... Em…
Pharmacology 2
When a patient is receiving long term…
The nurse recognizes that manifestatio…
during a teaching session about antigo…
A mother calls the clinic to ask what…
Misoprostol (Cytotec)
Nausea and Vomiting
Decreasing serum uric acid levels
you can use children's dose of acetaminophen or ibuprofen but…
When a patient is receiving long term…
Misoprostol (Cytotec)
The nurse recognizes that manifestatio…
Nausea and Vomiting
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