Study sets matching "pharmacology usmle"
Study sets
Diagrams
Classes
Users
What are the pharmacokinetics of pharma…
What are the pharmacodynamics of pharac…
Which form of a drug is water soluble?
Which form of a drug is lipid soluble?
ADME... Absorption... Distribution... Metabolism... Excretion... What the…
What the drug does to the body, mostly via receptor interactio…
The Ionized from (better excreted renally
The non-ionized form
What are the pharmacokinetics of pharma…
ADME... Absorption... Distribution... Metabolism... Excretion... What the…
What are the pharmacodynamics of pharac…
What the drug does to the body, mostly via receptor interactio…
Michaelis-Menten Kinetics
Lineweaver-Burk
Enzyme Inhibition
Reversible Competitive Inhibitiors
[S] = Concentration of substrate... V = Velocity... Km is inversely…
↑ y-intercept, ↓ Vmax... The further to the right, the x-intercep…
Reversible competitive inhibitors cross each other competitive…
Resemble Substrate: Yes... Overcomed by ↑ [S]: Yes... Binds Active S…
Michaelis-Menten Kinetics
[S] = Concentration of substrate... V = Velocity... Km is inversely…
Lineweaver-Burk
↑ y-intercept, ↓ Vmax... The further to the right, the x-intercep…
penicillin G... penicillin V
ampicillin... amoxicillin
oxacillin... nafcillin... dicloxacillin
ticarcillin... piperacillin
Class: beta lactam ... Mechanism: binds transpeptidase and blocks…
Class: beta lactam... Mechanism: binds transpeptidase and blocks…
Class: beta lactam (penicillinase resistant b/c of bulky R gro…
Class: beta lactam (antipseudomonal)... Mechanism: binds transpep…
penicillin G... penicillin V
Class: beta lactam ... Mechanism: binds transpeptidase and blocks…
ampicillin... amoxicillin
Class: beta lactam... Mechanism: binds transpeptidase and blocks…
Abciximab
Acetaminophen
Acetazolamide, dorzolamide
Acetylcholine
Monoclonal antibody to fibrin receptor (glycoprotein IIb/IIIa)…
Antipyretic analgesic: very weak cyclooxygenase inhibitor; not…
Carbonic anhydrase inhibitor diuretic: produces a NaHCO3 diure…
Cholinomimetic prototype: transmitter in CNS, ENS, all ANS gan…
Abciximab
Monoclonal antibody to fibrin receptor (glycoprotein IIb/IIIa)…
Acetaminophen
Antipyretic analgesic: very weak cyclooxygenase inhibitor; not…
What are the major functions of the α1…
What are the major functions of the α2…
What are the major functions of the β1…
What are the major functions of the β2…
Increase vascular smooth muscle contraction, increase pupillar…
Decrease sympathetic outflow, decrease insulin release, decrea…
Increase heart rate, increase contractility, increase renin re…
Vasodilation, bronchodilation, increase lipolysis, increase in…
What are the major functions of the α1…
Increase vascular smooth muscle contraction, increase pupillar…
What are the major functions of the α2…
Decrease sympathetic outflow, decrease insulin release, decrea…
List 2 disorders associated with gastro…
List 3/6 symptoms of gastroparesis
What 3 receptors are acted upon by meto…
Which 2 receptors mediates the anti-eme…
diabetes... Parkinson's disease... * post-surgical, idiopathic
abdominal distension... hypoglycemia (diabetes)... nausea... prematu…
D2 antagonist... 5-HT3 antagonist... 5-HT4 agonist
D2 antagonist in the chemoreceptor trigger zone in the CNS... 5-…
List 2 disorders associated with gastro…
diabetes... Parkinson's disease... * post-surgical, idiopathic
List 3/6 symptoms of gastroparesis
abdominal distension... hypoglycemia (diabetes)... nausea... prematu…
Thiazide Diuretics
Gout
Denosumab
Rituximab
Hydrochlorothiazide, chlorthalidone, metolazone... MOA: Inhibit…
ACUTE - NSAIDs (naproxen, indomethacin), colchicine, glucocort…
- RANKL inhibitor (RANK expressed on osteoclast precursor; RAN…
Monoclonal Ab against CD20 on B lymphocytes... Binding of CD20 i…
Thiazide Diuretics
Hydrochlorothiazide, chlorthalidone, metolazone... MOA: Inhibit…
Gout
ACUTE - NSAIDs (naproxen, indomethacin), colchicine, glucocort…
Pharmacokinetic characteristics
The biodispisition of a drug involves
Permeation
Diffusion down a concentration gradient
Absorbtion, distribution, metabolism, excretion
its permeation across cellular membrane barriers
solubility, concentration gradient, surface area and vasculari…
only free, unionized drug forms contribute to the concentratio…
Pharmacokinetic characteristics
Absorbtion, distribution, metabolism, excretion
The biodispisition of a drug involves
its permeation across cellular membrane barriers
Bethanechol
Carbachol
Pilocarpine
Methacholine
Direct ACh agonist... Bowel/bladder smooth muscle contraction - u…
Direct ACh agonist... Pupil constriction, ciliary muscle contract…
Direct ACh agonist... Pupil constriction, ciliary muscle contract…
Direct ACh agonist... Bronchoconstriction - challenge test for as…
Bethanechol
Direct ACh agonist... Bowel/bladder smooth muscle contraction - u…
Carbachol
Direct ACh agonist... Pupil constriction, ciliary muscle contract…
Tinea (pityriasis) versicolor
Tuberculosis
Influenza A Virus
Syphilis
selenium sulfide, topical and/or oral antifungal
Rifampin, Isoniazid, Pyrazinamide and Ethambutol... (RIPE)
Amantadine (Symmetrel)... Inhibits replication by interfering wi…
Penicillin G
Tinea (pityriasis) versicolor
selenium sulfide, topical and/or oral antifungal
Tuberculosis
Rifampin, Isoniazid, Pyrazinamide and Ethambutol... (RIPE)
Neutropenia
TMP-SMZ
Ceftriaxone
Rifampin (DOC), minocycline
A common side effects of Interferon (INF) treatment is?
Antimicrobial prophylaxis for a history of recurrent UTIs
Antimicrobial prophylaxis for Gonorrhea
Antimicrobial prophylaxis for Meningococcal infection
Neutropenia
A common side effects of Interferon (INF) treatment is?
TMP-SMZ
Antimicrobial prophylaxis for a history of recurrent UTIs
What are the major functions of the α1…
What are the major functions of the α2…
What are the major functions of the β1…
What are the major functions of the β2…
Increase vascular smooth muscle contraction, increase pupillar…
Decrease sympathetic outflow, decrease insulin release, decrea…
Increase heart rate, increase contractility, increase renin re…
Vasodilation, bronchodilation, increase lipolysis, increase in…
What are the major functions of the α1…
Increase vascular smooth muscle contraction, increase pupillar…
What are the major functions of the α2…
Decrease sympathetic outflow, decrease insulin release, decrea…
Penicillin- Pen G (IV), Pen V (O)
Ampicillin/Amoxicillin
Piperacillin/Ticarcillin
Methicillin/Nafcillin
Structural analogs of D-Ala-D-Ala... Cocci (both gram + and -)…
"AMinoPenicillins are AMPed up penicillins:" wider spectrum... So…
bind PBPs blocking cross-linking... Tx for pseudomonas & gram (…
MOA: beta lactam antibiotic, inhibits bacterial synthesis by p…
Penicillin- Pen G (IV), Pen V (O)
Structural analogs of D-Ala-D-Ala... Cocci (both gram + and -)…
Ampicillin/Amoxicillin
"AMinoPenicillins are AMPed up penicillins:" wider spectrum... So…
What are the major functions of the α1…
What are the major functions of the α2…
What are the major functions of the β1…
What are the major functions of the β2…
Increase vascular smooth muscle contraction, increase pupillar…
Decrease sympathetic outflow, decrease insulin release, decrea…
Increase heart rate, increase contractility, increase renin re…
Vasodilation, bronchodilation, increase lipolysis, increase in…
What are the major functions of the α1…
Increase vascular smooth muscle contraction, increase pupillar…
What are the major functions of the α2…
Decrease sympathetic outflow, decrease insulin release, decrea…
Antibiotics that block cell wall synthe…
Antibiotics that block peptidoglycan SY…
Antibiotics that block nucleotide synth…
Antibiotics that block DNA topoisomeras…
Beta lactams. Penicillin, methicillin, ampicillin, piperacilli…
bacitracin, vancomycin
sulfonamides, trimethoprim
Fluroquinolones
Antibiotics that block cell wall synthe…
Beta lactams. Penicillin, methicillin, ampicillin, piperacilli…
Antibiotics that block peptidoglycan SY…
bacitracin, vancomycin
What are the major functions of the α1…
What are the major functions of the α2…
What are the major functions of the β1…
What are the major functions of the β2…
Increase vascular smooth muscle contraction, increase pupillar…
Decrease sympathetic outflow, decrease insulin release, decrea…
Increase heart rate, increase contractility, increase renin re…
Vasodilation, bronchodilation, increase lipolysis, increase in…
What are the major functions of the α1…
Increase vascular smooth muscle contraction, increase pupillar…
What are the major functions of the α2…
Decrease sympathetic outflow, decrease insulin release, decrea…
What are the major functions of the α1…
What are the major functions of the α2…
What are the major functions of the β1…
What are the major functions of the β2…
Increase vascular smooth muscle contraction, increase pupillar…
Decrease sympathetic outflow, decrease insulin release, decrea…
Increase heart rate, increase contractility, increase renin re…
Vasodilation, bronchodilation, increase lipolysis, increase in…
What are the major functions of the α1…
Increase vascular smooth muscle contraction, increase pupillar…
What are the major functions of the α2…
Decrease sympathetic outflow, decrease insulin release, decrea…
What are the major functions of the α1…
What are the major functions of the α2…
What are the major functions of the β1…
What are the major functions of the β2…
Increase vascular smooth muscle contraction, increase pupillar…
Decrease sympathetic outflow, decrease insulin release, decrea…
Increase heart rate, increase contractility, increase renin re…
Vasodilation, bronchodilation, increase lipolysis, increase in…
What are the major functions of the α1…
Increase vascular smooth muscle contraction, increase pupillar…
What are the major functions of the α2…
Decrease sympathetic outflow, decrease insulin release, decrea…
What are the major functions of the α1…
What are the major functions of the α2…
What are the major functions of the β1…
What are the major functions of the β2…
Increase vascular smooth muscle contraction, increase pupillar…
Decrease sympathetic outflow, decrease insulin release, decrea…
Increase heart rate, increase contractility, increase renin re…
Vasodilation, bronchodilation, increase lipolysis, increase in…
What are the major functions of the α1…
Increase vascular smooth muscle contraction, increase pupillar…
What are the major functions of the α2…
Decrease sympathetic outflow, decrease insulin release, decrea…
What are the major functions of the α1…
What are the major functions of the α2…
What are the major functions of the β1…
What are the major functions of the β2…
Increase vascular smooth muscle contraction, increase pupillar…
Decrease sympathetic outflow, decrease insulin release, decrea…
Increase heart rate, increase contractility, increase renin re…
Vasodilation, bronchodilation, increase lipolysis, increase in…
What are the major functions of the α1…
Increase vascular smooth muscle contraction, increase pupillar…
What are the major functions of the α2…
Decrease sympathetic outflow, decrease insulin release, decrea…
What are the major functions of the α1…
What are the major functions of the α2…
What are the major functions of the β1…
What are the major functions of the β2…
Increase vascular smooth muscle contraction, increase pupillar…
Decrease sympathetic outflow, decrease insulin release, decrea…
Increase heart rate, increase contractility, increase renin re…
Vasodilation, bronchodilation, increase lipolysis, increase in…
What are the major functions of the α1…
Increase vascular smooth muscle contraction, increase pupillar…
What are the major functions of the α2…
Decrease sympathetic outflow, decrease insulin release, decrea…
Cyclosporine
Tacrolimus (FK506)
Sirolimus (Rapamycin)
Daclizumab... Basiliximab
calcineurin inhibitor, binds cyclophilin. prevents IL-2 transc…
calcineurin inhibitor, binds FK506 binding protein. prevent IL…
mTOR inhibitor; binds FK506. prevent response to IL-2 (T cell…
monoclonal Abs, block IL-2R... use- kidney transplant rejection…
Cyclosporine
calcineurin inhibitor, binds cyclophilin. prevents IL-2 transc…
Tacrolimus (FK506)
calcineurin inhibitor, binds FK506 binding protein. prevent IL…
Penicillin- Pen G (IV), Pen V (O)
Penicillinase-sensitive=Ampicillin/Amox…
PCNase-resistant=Methicillin/Nafcillin
Piperacillin/Ticarcillin
Structural analogs of D-Ala-D-Ala... Cocci (both gram + and -)…
"AMinoPenicillins are AMPed up penicillins:" wider spectrum... So…
Beta-Lactamase resistant - bulkier structure... MRSA is something…
bind PBPs blocking cross-linking... Tx for pseudomonas & gram (…
Penicillin- Pen G (IV), Pen V (O)
Structural analogs of D-Ala-D-Ala... Cocci (both gram + and -)…
Penicillinase-sensitive=Ampicillin/Amox…
"AMinoPenicillins are AMPed up penicillins:" wider spectrum... So…
What are the major functions of the α1…
What are the major functions of the α2…
What are the major functions of the β1…
What are the major functions of the β2…
Increase vascular smooth muscle contraction, increase pupillar…
Decrease sympathetic outflow, decrease insulin release, decrea…
Increase heart rate, increase contractility, increase renin re…
Vasodilation, bronchodilation, increase lipolysis, increase in…
What are the major functions of the α1…
Increase vascular smooth muscle contraction, increase pupillar…
What are the major functions of the α2…
Decrease sympathetic outflow, decrease insulin release, decrea…
What are the major functions of the α1…
What are the major functions of the α2…
What are the major functions of the β1…
What are the major functions of the β2…
Increase vascular smooth muscle contraction, increase pupillar…
Decrease sympathetic outflow, decrease insulin release, decrea…
Increase heart rate, increase contractility, increase renin re…
Vasodilation, bronchodilation, increase lipolysis, increase in…
What are the major functions of the α1…
Increase vascular smooth muscle contraction, increase pupillar…
What are the major functions of the α2…
Decrease sympathetic outflow, decrease insulin release, decrea…