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Study sets matching "pharmacology usmle"

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Study sets matching "pharmacology usmle"

50 terms
USMLE pharmacology (immunopharmacology and toxicology)
cyclosporin and tacrolimus
azathioprine
anti-D immunoglobulin
abciximab
MOA: bind to cyclophilin (cyclosporine) or FK beinding protei…
immunosuppressant converted to 6 mercaptopurine - same proper…
human IgG antibodies to red cell D antigen (rhesus antigen)... U…
antiplatelet - antagonist of IIb/IIIa receptors
cyclosporin and tacrolimus
MOA: bind to cyclophilin (cyclosporine) or FK beinding protei…
azathioprine
immunosuppressant converted to 6 mercaptopurine - same proper…
30 terms
USMLE Step 1 -- Pharmacology
Wat is the prototype Beta-Lactam antib…
What is the MOA of penicillin and othe…
What are the clinical uses for penicil…
What comes to mind when discussing pen…
Penicillin... Penicillin G = I.V.... Penicillin V = Oral... Penicill…
(1) bind penicillin binding proteins... (2) block transpeptidase…
Gram-Positive Organisms... First line for Syphilis
Beta-lactamases which cleave the beta-lactam ring... N.B. anoth…
Wat is the prototype Beta-Lactam antib…
Penicillin... Penicillin G = I.V.... Penicillin V = Oral... Penicill…
What is the MOA of penicillin and othe…
(1) bind penicillin binding proteins... (2) block transpeptidase…
46 terms
USMLE - Pharmacology (Antimicrobials)
Aminopenicillins (ampicillin, amoxicil…
Amphotericin B
Nystatin
Azoles (fluconazole, ketoconazole, etc.)
Mechanism: binds PBPs (transpeptidases) to disrupt CW synthes…
Mechanism: binds ergosterol to form membrane pores... Indication…
Mechanism: binds ergosterol to form membrane pores... Indication…
Mechanism: inhibits fungal ergosterol synthesis by binding la…
Aminopenicillins (ampicillin, amoxicil…
Mechanism: binds PBPs (transpeptidases) to disrupt CW synthes…
Amphotericin B
Mechanism: binds ergosterol to form membrane pores... Indication…
210 terms
USMLE Pharmacology (Katzung)
Abciximab
Acetaminophen
Acetazolamide, dorzolamide
Acetylcholine
Monoclonal antibody to fibrin receptor (glycoprotein IIb/IIIa…
Antipyretic analgesic: very weak cyclooxygenase inhibitor; no…
Carbonic anhydrase inhibitor diuretic: produces a NaHCO3 diur…
Cholinomimetic prototype: transmitter in CNS, ENS, all ANS ga…
Abciximab
Monoclonal antibody to fibrin receptor (glycoprotein IIb/IIIa…
Acetaminophen
Antipyretic analgesic: very weak cyclooxygenase inhibitor; no…
210 terms
USMLE Pharmacology (Katzung)
Abciximab
Acetaminophen
Acetazolamide, dorzolamide
Acetylcholine
Monoclonal antibody to fibrin receptor (glycoprotein IIb/IIIa…
Antipyretic analgesic: very weak cyclooxygenase inhibitor; no…
Carbonic anhydrase inhibitor diuretic: produces a NaHCO3 diur…
Cholinomimetic prototype: transmitter in CNS, ENS, all ANS ga…
Abciximab
Monoclonal antibody to fibrin receptor (glycoprotein IIb/IIIa…
Acetaminophen
Antipyretic analgesic: very weak cyclooxygenase inhibitor; no…
32 terms
USMLE - Pharmacology (Autonomics)
Bethanechol
Carbachol
Pilocarpine
Methacholine
Cholinomimetic for ileus and urinary retention
Cholinomimetic for glaucoma (constricts pupil to relieve high…
Cholinomimetic for open- and closed-angle glaucoma; potent st…
Cholinomimetic for challenge test for asthma diagnosis
Bethanechol
Cholinomimetic for ileus and urinary retention
Carbachol
Cholinomimetic for glaucoma (constricts pupil to relieve high…
51 terms
USMLE: Psychiatry Pharmacology
anxiety drug with minimal to no hypnot…
mechanism of buspirone
clinical use of buspirone
buspirone: onset: Takes ........... to…
buspirone
selective agonist at the 5HT1a receptor
generalized anxiety disorder
1-2 weeks
anxiety drug with minimal to no hypnot…
buspirone
mechanism of buspirone
selective agonist at the 5HT1a receptor
20 terms
USMLE - Pharmacology (Cardio)
Dihydropyridine CCBs (amlodipine, nimo…
Non-dihydropyridine CCBs (verapamil, d…
Hydralazine
Nitroprusside
Mechanism: block L-type Ca channels on vascular s. m. to prom…
Mechanism: block L-type Ca channels on cardiac mm. to reduce…
Mechanism: inc cGMP -> s. m. relaxation -> vasodilation (aa.)…
Mechanism: release NO -> inc cGMP -> vasodilation... Indications…
Dihydropyridine CCBs (amlodipine, nimo…
Mechanism: block L-type Ca channels on vascular s. m. to prom…
Non-dihydropyridine CCBs (verapamil, d…
Mechanism: block L-type Ca channels on cardiac mm. to reduce…
21 terms
USMLE - Pharmacology, Pharmacokinetics and Pharmacodynamics
Pharmacokinetics
Pharmacodynamics
Bioavailability (F)
Volume of distribution (Vd)
The effects of the body on the drug. ... ADME: ... Absorption ... Dis…
The effects of the drug on the body. Includes concepts of rec…
Fraction of administered drug that reaches systemic circulati…
Theoretical volume occupied by the total absorbed drug amount…
Pharmacokinetics
The effects of the body on the drug. ... ADME: ... Absorption ... Dis…
Pharmacodynamics
The effects of the drug on the body. Includes concepts of rec…
49 terms
USMLE World pharmacology
What can be used to prevent methotrexa…
what degrades 6-mercaptopurine?
how do you acquire resistance to fluor…
how do you acquire resistance of amino…
Leucovorin (folinic acid)--converted into THF
xanthine oxidase
mutations in DNA gyrase
transfer actyl/adenyl/phosphate groups onto aminoglycoside to…
What can be used to prevent methotrexa…
Leucovorin (folinic acid)--converted into THF
what degrades 6-mercaptopurine?
xanthine oxidase
14 terms
USMLE - Pharmacology (Respiratory)
1st generation H1 blockers (diphenhydr…
2nd generation H1 blockers (loratadine…
Guaifenesin
N-acetylcysteine
Mechanism: H1 blockade (peripheral and CNS)... Use: allergy, mot…
Mechanism: H1 blockade (peripheral, doesn't cross BBB)... Use: a…
Expectorant which thins respiratory secretions but does not s…
Mucolytic that loosens mucous plugs in CF pts; also the antid…
1st generation H1 blockers (diphenhydr…
Mechanism: H1 blockade (peripheral and CNS)... Use: allergy, mot…
2nd generation H1 blockers (loratadine…
Mechanism: H1 blockade (peripheral, doesn't cross BBB)... Use: a…
382 terms
USMLE Pharmacology II
What are the side effects of Ethylene…
What are the side effects of Methanol,…
What is the treatment for OD with eith…
What cofactors are required by Acetald…
CNS depression... Metabolic Acidosis!! (Oxalic Acid)... Nephrotoxic…
Respiratory failure... Metabolic acidosis... Ocular damage*** with…
Fomepizole...Alcohol Dehydrogenase inhibitor.
Thiamine... and... Folate!! This is how alcoholics get deficient in…
What are the side effects of Ethylene…
CNS depression... Metabolic Acidosis!! (Oxalic Acid)... Nephrotoxic…
What are the side effects of Methanol,…
Respiratory failure... Metabolic acidosis... Ocular damage*** with…
166 terms
USMLE Pharmacology (Katzung)
Abciximab
Acetazolamide, dorzolamide
Acyclovir
Adenosine
Monoclonal antibody to fibrin receptor (glycoprotein IIb/IIIa…
Carbonic anhydrase inhibitor diuretic: produces a NaHCO3 diur…
Antiviral: inhibits DNA synthesis in herpes simplex and varic…
Antiarrhythmic: unclassified ("Group V"); parenteral only. Hy…
Abciximab
Monoclonal antibody to fibrin receptor (glycoprotein IIb/IIIa…
Acetazolamide, dorzolamide
Carbonic anhydrase inhibitor diuretic: produces a NaHCO3 diur…
45 terms
USMLE - Pharmacology Principles
7 important Weak Acid drugs?
4 important Weak Base drugs?
Why is Lactulose useful in Hepatic Enc…
How would you increase the renal clear…
> Aspirin... > Penicillins and Cephalosporins... > Thiazide and Loo…
> Morphine... > Local Anesthics... > Amphetamines... > PCP
Gut bacteria metabolize lactulose --> lactic acid, acidifying…
> Acidify the urine with NH4Cl (or vitamin C, cranberry juice)
7 important Weak Acid drugs?
> Aspirin... > Penicillins and Cephalosporins... > Thiazide and Loo…
4 important Weak Base drugs?
> Morphine... > Local Anesthics... > Amphetamines... > PCP
12 terms
USMLE - Pharmacology (Endo)
Insulin
Biguanides (metformin)
Sulfonylureas (tolbutamide, chlorpropa…
Glitazones/thiazolidinediones (pioglit…
Mechanism: binds insulin receptor -> Y kinase activity -> glc…
Mechanism: inc insulin sensitivity... Use: 1st line T2DM, PCOS... T…
Mechanism: blocks K channel on B-cell to inc insulin release…
Mechanism: PPAR-gamma -> inc insulin sensitivity... Use: mono T2…
Insulin
Mechanism: binds insulin receptor -> Y kinase activity -> glc…
Biguanides (metformin)
Mechanism: inc insulin sensitivity... Use: 1st line T2DM, PCOS... T…
296 terms
USMLE: Lange Pharmacology
Penicillin- Pen G (IV), Pen V (O)
Ampicillin/Amoxicillin
Piperacillin/Ticarcillin
Methicillin/Nafcillin
Structural analogs of D-Ala-D-Ala... Cocci (both gram + and -)…
"AMinoPenicillins are AMPed up penicillins:" wider spectrum... S…
bind PBPs blocking cross-linking... Tx for pseudomonas & gram…
Beta-Lactamase resistant - bulkier structure... MRSA is somethin…
Penicillin- Pen G (IV), Pen V (O)
Structural analogs of D-Ala-D-Ala... Cocci (both gram + and -)…
Ampicillin/Amoxicillin
"AMinoPenicillins are AMPed up penicillins:" wider spectrum... S…
10 terms
USMLE - Pharmacology (MSK)
Aspirin
NSAIDs (ibuprofen, naproxen, ketorolac…
COX-2 inhibitors (celecoxib)
Acetaminophen
Mechanism: irreversible inhibition of COX-1/2 by covalent ace…
Mechanism: reversible inhibition of COX-1/2 to block PG synth…
Mechanism: reversible inhibition of COX-2 (spares COX-1 to ma…
Mechanism: reversible inhibition of COX, mostly in the CNS (i…
Aspirin
Mechanism: irreversible inhibition of COX-1/2 by covalent ace…
NSAIDs (ibuprofen, naproxen, ketorolac…
Mechanism: reversible inhibition of COX-1/2 to block PG synth…
241 terms
USMLE Pharmacology/Rapid Review
Abciximab, eptifibatide, tirofiban
Acarbose, Miglitol
Acetaminophen
Acetazolamide, dorzolamide
Monoclonal antibody to fibrin receptor (glycoprotein IIb/IIIa…
oral hypoglycemic drugs: alpha-glucosidase inhibitors (brush…
Antipyretic analgesic: very weak cyclooxygenase inhibitor; no…
Carbonic anhydrase inhibitor diuretic: produces a NaHCO3 diur…
Abciximab, eptifibatide, tirofiban
Monoclonal antibody to fibrin receptor (glycoprotein IIb/IIIa…
Acarbose, Miglitol
oral hypoglycemic drugs: alpha-glucosidase inhibitors (brush…
202 terms
Pharmacology USMLE High Yield
What are the Sulfa Drugs
What are the Sulfa Adverse Effects?
SIADH causing drugs
Interstitial Nephritis
Scary Sulfa Pharm Facts... Sulfa Antibiotics... Sulfasalazine... Prob…
Steven Johnson Syndrome... SLE Syndrome... Hemolytic Anemia... Thrombo…
Can't Concentrate Serum Sodium... Carbamezapine... Cyclophosphamid…
Methicillin... NSAIDS... Furosemide
What are the Sulfa Drugs
Scary Sulfa Pharm Facts... Sulfa Antibiotics... Sulfasalazine... Prob…
What are the Sulfa Adverse Effects?
Steven Johnson Syndrome... SLE Syndrome... Hemolytic Anemia... Thrombo…
241 terms
USMLE Pharmacology (Katzung)
Abciximab
Acetaminophen
Acetazolamide, dorzolamide
Acetylcholine
Monoclonal antibody to fibrin receptor (glycoprotein IIb/IIIa…
Antipyretic analgesic: very weak cyclooxygenase inhibitor; no…
Carbonic anhydrase inhibitor diuretic: produces a NaHCO3 diur…
Cholinomimetic prototype: transmitter in CNS, ENS, all ANS ga…
Abciximab
Monoclonal antibody to fibrin receptor (glycoprotein IIb/IIIa…
Acetaminophen
Antipyretic analgesic: very weak cyclooxygenase inhibitor; no…
296 terms
USMLE: Lange Pharmacology
Penicillin- Pen G (IV), Pen V (O)
Ampicillin/Amoxicillin
Piperacillin/Ticarcillin
Methicillin/Nafcillin
Structural analogs of D-Ala-D-Ala... Cocci (both gram + and -)…
"AMinoPenicillins are AMPed up penicillins:" wider spectrum... S…
bind PBPs blocking cross-linking... Tx for pseudomonas & gram…
Beta-Lactamase resistant - bulkier structure... MRSA is somethin…
Penicillin- Pen G (IV), Pen V (O)
Structural analogs of D-Ala-D-Ala... Cocci (both gram + and -)…
Ampicillin/Amoxicillin
"AMinoPenicillins are AMPed up penicillins:" wider spectrum... S…
60 terms
USMLE- Pharmacology (Toxicity)
Which drugs cause Atropine-like side e…
What drugs cause coronary vasospasms?
What drugs cause cutaneous flushing?
What drugs cause dilated cardiomyopathy?
TCAs...also, low-dose neuroleptics, antihistimines (delerium…
Cocaine, sumatriptan...also, amphetamines
VANC- Vancomycin, Adenosine, Niacin (treat with aspirin), Ca+…
Doxorubicin, daunorubicin
Which drugs cause Atropine-like side e…
TCAs...also, low-dose neuroleptics, antihistimines (delerium…
What drugs cause coronary vasospasms?
Cocaine, sumatriptan...also, amphetamines
13 terms
USMLE Pharmacology - ANS Receptors
alpha-1
alpha-2
beta-1
beta-2
Vasoconstriction, pupillary dilation, bladder/GI sphincter
Decreases NE and 5HT release from presynaptic terminals, lipo…
Increases HR/contractility, renin release, lipolysis
Smooth muscle relaxation - bronchodilation, vasodilation, ute…
alpha-1
Vasoconstriction, pupillary dilation, bladder/GI sphincter
alpha-2
Decreases NE and 5HT release from presynaptic terminals, lipo…
42 terms
USMLE: Gastrointestinal Pharmacology
4 H2 blockers used for GI problems
clinical use of H2 blockers (3)... Cimet…
toixicity of Cimetidine, ranitidine,…
mechanism of action of H2 blockers
all the "tidine" ... Cimetidine, ranitidine, famotidine, nizatid…
peptic ulcer... gastritis... mild esophageal reflux
Cimetidine: potent inhibitor of cytochrome P-450 ; antiandrog…
Reversible block of histamine H2-receptors --> decrease H+ s…
4 H2 blockers used for GI problems
all the "tidine" ... Cimetidine, ranitidine, famotidine, nizatid…
clinical use of H2 blockers (3)... Cimet…
peptic ulcer... gastritis... mild esophageal reflux
50 terms
USMLE 1 Pharmacology
explain the parasympathetic pathway of…
how many sympathetic pathways are ther…
sympathetic pathway of the sweat gland…
sympathetic pathway of the cardiac/smo…
preganglion: ACh on Nicotinic... postganglion: ACh on Muscarinic
5 pathways... 1. sweat glands... 2. cardiac/smooth muscle, glands,…
preganglion: ACh on Nicotinic... postganglion: ACh on Muscarinic…
preganglion: ACh on Nicotinic... postganglion: E or NE on Beta o…
explain the parasympathetic pathway of…
preganglion: ACh on Nicotinic... postganglion: ACh on Muscarinic
how many sympathetic pathways are ther…
5 pathways... 1. sweat glands... 2. cardiac/smooth muscle, glands,…
39 terms
USMLE - Pharmacology (Neurology)
Epinephrine
Brimonidine
Beta-blockers (timolol, betaxolol, car…
Diuretics (acetazolamide)
Mechanism: alpha-1 vasoconstriction to decrease synthesis of…
Mechanism: alpha-2 agonist to decrease aqueous humor synthesi…
Mechanism: dec aqueous humor synthesis... Use: glaucoma
Mechanism: dec aqueous humor synthesis via inhibition of carb…
Epinephrine
Mechanism: alpha-1 vasoconstriction to decrease synthesis of…
Brimonidine
Mechanism: alpha-2 agonist to decrease aqueous humor synthesi…
505 terms
USMLE - BRS Pharmacology
beclomethasone
thioridazine
thioridazine
valproic acid
synthetic glucocorticoid that readily penetrates the airway m…
low potency dopamine receptor blocker
side effects are retinal deposits, torsades, postural hypoten…
causes neural tube defects
beclomethasone
synthetic glucocorticoid that readily penetrates the airway m…
thioridazine
low potency dopamine receptor blocker
75 terms
USMLE: Psychiatry Pharmacology II
CNS stimulants: NAME 3
CNS stimulants: Methylphenidate, dextr…
CNS stimulants: Methylphenidate, dextr…
Haloperidol, trifluoperazine, fluphena…
Methylphenidate, dextroamphetamine, methamphetamine.
catecholamines in the synaptic cleft, especially norepinephr…
ADHD, narcolepsy, appetite control.
Typical Antipsychotics (neuroleptics)
CNS stimulants: NAME 3
Methylphenidate, dextroamphetamine, methamphetamine.
CNS stimulants: Methylphenidate, dextr…
catecholamines in the synaptic cleft, especially norepinephr…
43 terms
USMLE neurology (pharmacology)
For the following drug name it's MOA,…
For the following drug name it's MOA,…
For the following drug name it's MOA,…
For the following drug name it's MOA,…
MOA - Na+ channel blocker... IND - Tonic-clonic, partial and Jac…
MOA - may block T type Ca2+ channels in thalamus... IND - absenc…
MOA - facilitates GABA action by increaasing frequency of Cl…
MOA - blocks Na+ channels... IND - adjuvant antiepileptic agent…
For the following drug name it's MOA,…
MOA - Na+ channel blocker... IND - Tonic-clonic, partial and Jac…
For the following drug name it's MOA,…
MOA - may block T type Ca2+ channels in thalamus... IND - absenc…
31 terms
USMLE - Pharmacology (Hem/Onc)
Heparin
Arbatroban, bivalrudin, hirudin
Warfarin
Direct Xa inhibitors (apixaban, rivaro…
Mechanism: activates ATIII to dec IIa and Xa... Use: immediate a…
Mechanism: direct inhibition of thrombin (IIa)... Use: HIT hepar…
Mechanism: inhibits epoxide reductase to decrease gamma-carbo…
Mechanism: bind/inhibit Xa... Use: DVT, PE, CVA with Afib prophy…
Heparin
Mechanism: activates ATIII to dec IIa and Xa... Use: immediate a…
Arbatroban, bivalrudin, hirudin
Mechanism: direct inhibition of thrombin (IIa)... Use: HIT hepar…
88 terms
USMLE - Psychiatry Pharmacology
Alcohol withdrawal rx
Bulimia rx
Anxiety rx
ADHD rx
Benzodiazepines... (clonazepam)
SSRIs
Benzodiazepines, ... Buspirone, ... SSRIs
Methylphenidate (Ritalin)... Amphetamines (Dexedrine)
Alcohol withdrawal rx
Benzodiazepines... (clonazepam)
Bulimia rx
SSRIs
210 terms
USMLE Pharmacology/Rapid Review
Abciximab
Acetaminophen
Acetazolamide, dorzolamide
Acetylcholine
Monoclonal antibody to fibrin receptor (glycoprotein IIb/IIIa…
Antipyretic analgesic: very weak cyclooxygenase inhibitor; no…
Carbonic anhydrase inhibitor diuretic: produces a NaHCO3 diur…
Cholinomimetic prototype: transmitter in CNS, ENS, all ANS ga…
Abciximab
Monoclonal antibody to fibrin receptor (glycoprotein IIb/IIIa…
Acetaminophen
Antipyretic analgesic: very weak cyclooxygenase inhibitor; no…
41 terms
COMLEX/USMLE PHARMACOLOGY AUTONOMICS
Bethanachol
Carbechol
Methacholine
Pilocarpine
CHOLinergic (bethanaCHOL)... Post op and neurogenic ileus Urinar…
CHOLinergic (carbeCHOL)... Pupillary contraction... Relief of IOP (…
CHOLinergic (methaCHOLine)... Bronchospasm (Asthma Challenge Test)
CHOLinergic ("piloCHOLpine")... Stimulates sweat (CF Sweat Test)
Bethanachol
CHOLinergic (bethanaCHOL)... Post op and neurogenic ileus Urinar…
Carbechol
CHOLinergic (carbeCHOL)... Pupillary contraction... Relief of IOP (…
USMLE World pharmacology
What can be used to prevent methotrexa…
what degrades 6-mercaptopurine?
how do you acquire resistance to fluor…
how do you acquire resistance of amino…
Leucovorin (folinic acid)--converted into THF
xanthine oxidase
mutations in DNA gyrase
transfer actyl/adenyl/phosphate groups onto aminoglycoside to…
What can be used to prevent methotrexa…
Leucovorin (folinic acid)--converted into THF
what degrades 6-mercaptopurine?
xanthine oxidase
13 terms
USMLE pulmonary (pharmacology)
albuterol
inhaled corticosteroids (beclomethason…
cromolyn
ipratropium
MOA - B2 agonist > bronchodilator, short acting... IND - asthma…
MOA - antiinflammatory; inhibits histamine release from mast…
MOA - anti-inflammatory; inhibits histamine release from mast…
MOA - bronchodilator; cholinergic antagonist... IND - COPD... TOX -…
albuterol
MOA - B2 agonist > bronchodilator, short acting... IND - asthma…
inhaled corticosteroids (beclomethason…
MOA - antiinflammatory; inhibits histamine release from mast…
35 terms
USMLE CNS Pharmacology
Mechanism of action of benzos and barb…
When are barbiturates contraindicated?
What can be used to treat status epile…
What can be used to treat insomnia?
Benzo: ... Facilitates GABA action by increasing frequency of Cl…
Porphyrias ... Also is an inducer of P450 enzymes so should use…
Diazepam and lorazepam
Oxazepam, triazolam,temazepam
Mechanism of action of benzos and barb…
Benzo: ... Facilitates GABA action by increasing frequency of Cl…
When are barbiturates contraindicated?
Porphyrias ... Also is an inducer of P450 enzymes so should use…
140 terms
USMLE Cardiology (pharmacology)
what are the 3 classes of antianginal…
how do nitrates cause vasodilation?
describe how nitrates reduce angina
what is the most common side effect of…
1. organic nitrates... 2. B blockers... 3. calcium channel blockers
nitrates are metabolized to NO > NO causes increase in cyclic…
1. vasodilation cause venous pooling, which reduces preload a…
headache
what are the 3 classes of antianginal…
1. organic nitrates... 2. B blockers... 3. calcium channel blockers
how do nitrates cause vasodilation?
nitrates are metabolized to NO > NO causes increase in cyclic…
345 terms
USMLE Pharmacology III
What type of drug is Nevirapine?
What is particularly beneficial about…
Drug interactions of Nevirapine?
Side effects of Nevirapine?
A non-nucleoside reverse transcriptase inhibitor
A one time single dose at the time of delivery DRAMATICALLY r…
It is an inducer of P450
Rash... Liver damage
What type of drug is Nevirapine?
A non-nucleoside reverse transcriptase inhibitor
What is particularly beneficial about…
A one time single dose at the time of delivery DRAMATICALLY r…
86 terms
USMLE gastroenterology (physiology and pharmacology)
which 3 glands produce saliva?
name 3 important functions of saliva:
what determines the relative compositi…
how is the regulation of saliva produc…
1. parotid... 2. submandibular... 3. sublingual
1. protection of dental health by buffering oral bacterial ac…
flow rate
it is stimulated by both parasympathetic and sympathetic acti…
which 3 glands produce saliva?
1. parotid... 2. submandibular... 3. sublingual
name 3 important functions of saliva:
1. protection of dental health by buffering oral bacterial ac…
Reproductive Pharmacology - USMLE
Leuprolide MOA: (Pulsatile vs. Constan…
Leuprolide clinical uses?
Testosterone effects on LDL and HDL?
Finasteride MOA and Uses?
1. GnRH agonist ... - Pulsatile - increased LH/FSH secretion ... -…
1. Prostate cancer (with flutamide) - initial burst then no L…
1. Decreased HDL, Increased LDL
1. 5Alpha Reductase Inhibitor - less DHT from testosterone ... -…
Leuprolide MOA: (Pulsatile vs. Constan…
1. GnRH agonist ... - Pulsatile - increased LH/FSH secretion ... -…
Leuprolide clinical uses?
1. Prostate cancer (with flutamide) - initial burst then no L…
168 terms
Flashcards for USMLE Step 1 Pharmacology
Michaelis-Menten Kinetics
Lineweaver-Burk
Enzyme Inhibition
Reversible Competitive Inhibitiors
[S] = Concentration of substrate... V = Velocity... Km is inversely…
↑ y-intercept, ↓ Vmax... The further to the right, the x-interce…
Reversible competitive inhibitors cross each other competitiv…
Resemble Substrate: Yes... Overcomed by ↑ [S]: Yes... Binds Active…
Michaelis-Menten Kinetics
[S] = Concentration of substrate... V = Velocity... Km is inversely…
Lineweaver-Burk
↑ y-intercept, ↓ Vmax... The further to the right, the x-interce…
99 terms
High Yield - Pharmacology USMLE
a1 receptor (class q)
a2 receptor (class i)
b1 receptor (class s)
b2 receptor (class s)
Vascular smooth muscle contraction, ↑pupillary dilation (mydr…
↓sympathetic release ↓insulin release ↓lipolysis ↑platelet ag…
↑heart rate and contractility, ↑renin release, ↑cAMP, ↑lipoly…
vasodilation, bronchodilation, ↓uterine tone (tocolysis), DOE…
a1 receptor (class q)
Vascular smooth muscle contraction, ↑pupillary dilation (mydr…
a2 receptor (class i)
↓sympathetic release ↓insulin release ↓lipolysis ↑platelet ag…
270 terms
USMLE Step 1 Pharmacology
Penicillin G; Penicillin V
Amoxicillin... Ampicillin
Dicloxacillin... Nafcillin... Oxacillin
Piperacillin... Ticarcillin
MOA: Bind PBP (transpeptidase) and block tranpeptidase crossl…
MOA: Same as penicillin; Combine with clavulanic acid to prot…
MOA: Same as penicillin; narrow spectrum; penicillinase resis…
MOA: Same as penicillin; extended spectrum; use with a beta-l…
Penicillin G; Penicillin V
MOA: Bind PBP (transpeptidase) and block tranpeptidase crossl…
Amoxicillin... Ampicillin
MOA: Same as penicillin; Combine with clavulanic acid to prot…
858 terms
USMLE STEP 1 Pharmacology- Autonomics
What are the major functions of the α1…
What are the major functions of the α2…
What are the major functions of the β1…
What are the major functions of the β2…
Increase vascular smooth muscle contraction, increase pupilla…
Decrease sympathetic outflow, decrease insulin release, decre…
Increase heart rate, increase contractility, increase renin r…
Vasodilation, bronchodilation, increase lipolysis, increase i…
What are the major functions of the α1…
Increase vascular smooth muscle contraction, increase pupilla…
What are the major functions of the α2…
Decrease sympathetic outflow, decrease insulin release, decre…
671 terms
Pharmacology- USMLE Step 1
Neutropenia
TMP-SMZ
Ceftriaxone
Rifampin (DOC), minocycline
A common side effects of Interferon (INF) treatment is?
Antimicrobial prophylaxis for a history of recurrent UTIs
Antimicrobial prophylaxis for Gonorrhea
Antimicrobial prophylaxis for Meningococcal infection
Neutropenia
A common side effects of Interferon (INF) treatment is?
TMP-SMZ
Antimicrobial prophylaxis for a history of recurrent UTIs
166 terms
GI-Pharmacology (USMLE)
List 2 disorders associated with gastr…
List 3/6 symptoms of gastroparesis
What 3 receptors are acted upon by met…
Which 2 receptors mediates the anti-em…
diabetes... Parkinson's disease... * post-surgical, idiopathic
abdominal distension... hypoglycemia (diabetes)... nausea... premat…
D2 antagonist... 5-HT3 antagonist... 5-HT4 agonist
D2 antagonist in the chemoreceptor trigger zone in the CNS... 5…
List 2 disorders associated with gastr…
diabetes... Parkinson's disease... * post-surgical, idiopathic
List 3/6 symptoms of gastroparesis
abdominal distension... hypoglycemia (diabetes)... nausea... premat…
173 terms
USMLE STEP 1 Pharmacology
Insulin lispro,aspart, and glulisine
Regular Insulin (humulin R)
Insulin NPH
Insulin glargine and determir
-Fast-acting... -Binds insulin receptor (tyrosine kinase activit…
-Aggregates as hexamer... -Variable absorption, later onset... -Onl…
-Intermediate-acting... -More variable absorption and onset... -Giv…
-Slow-acting (1-2x daily)... -Multiple AA substitutions, myristo…
Insulin lispro,aspart, and glulisine
-Fast-acting... -Binds insulin receptor (tyrosine kinase activit…
Regular Insulin (humulin R)
-Aggregates as hexamer... -Variable absorption, later onset... -Onl…
129 terms
USMLE STEP 1 Pharmacology
Km is __________ related to the affini…
Vmax is ___________ proportional to th…
On lineweaver-burk plot, the further t…
One lineweaver-burk plot, ____________…
Inversely
directly
Greater; lower
Reversible comptetive; noncompetitive
Km is __________ related to the affini…
Inversely
Vmax is ___________ proportional to th…
directly
91 terms
USMLE STEP I Pharmacology
Relationship between VMAX and enzyme c…
Relationship between KM and substrate…
The effect on Km, VMAX and pharmacodyn…
The effect on Km, VMAX and pharmacodyn…
directly proportional (i.e. the higher the VMAX the greater t…
Inversely proportional (i.e.The higher the KM the lower the a…
Km will remain the same... Vmax will decrease... decrease efficacy…
Km will increase... Vmax remains the same... decrease the potency o…
Relationship between VMAX and enzyme c…
directly proportional (i.e. the higher the VMAX the greater t…
Relationship between KM and substrate…
Inversely proportional (i.e.The higher the KM the lower the a…
30 terms
USMLE Step 1 Pharmacology
Cyclosporine
Tacrolimus (FK506)
Sirolimus (Rapamycin)
Daclizumab... Basiliximab
calcineurin inhibitor, binds cyclophilin. prevents IL-2 trans…
calcineurin inhibitor, binds FK506 binding protein. prevent I…
mTOR inhibitor; binds FK506. prevent response to IL-2 (T cell…
monoclonal Abs, block IL-2R... use- kidney transplant rejection…
Cyclosporine
calcineurin inhibitor, binds cyclophilin. prevents IL-2 trans…
Tacrolimus (FK506)
calcineurin inhibitor, binds FK506 binding protein. prevent I…
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