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Study sets matching "pharmacotherapy"

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Study sets matching "pharmacotherapy"

14 terms
pharmacotherapy
Hyponatremia
hypernitremia
hypokalemia
hyperkalemia
syndrome of inappropriate antidiurect hormone secretion
Diabetes insipidus, mellitus fluid loss vomiting and diarrhea
diarrhea vomiting, diuretic therapy, excessive sweating, refe…
burns, renal failure and response to injury
Hyponatremia
syndrome of inappropriate antidiurect hormone secretion
hypernitremia
Diabetes insipidus, mellitus fluid loss vomiting and diarrhea
65 terms
Pharmacotherapy
Na
Cl
BUN
K
135-145 mEq/L
97-110 mEq/L
8-25 Mg/dL
3.5-5 mEq/L
Na
135-145 mEq/L
Cl
97-110 mEq/L
142 terms
Pharmacotherapy
What is Pharmacokinitics
What is ADME
What is Absorption when in comes to PK
What is the definition of absorption.
What the body does to the Drug via ADME
Absorption/bioavailability, Distribution, metabolism, Excretion
The rate and extent to which a drug leaves its site of admini…
The process by which unchanged drug gets from the site of adm…
What is Pharmacokinitics
What the body does to the Drug via ADME
What is ADME
Absorption/bioavailability, Distribution, metabolism, Excretion
55 terms
Pharmacotherapy
Thiazide MOA
Thiazide Counseling
Thiazide Drug Interactions
Thiazide Monitoring
Decrease Na reabsorption in distal tubules --> decrease total…
1. Take early in the day... 2. May cause photosensitivity... 3. May…
1. Effectiveness decreased by steroids (salt retention), NSAI…
BP, weight, electrolytes and uric acid, BUN/SCr, cholesterol…
Thiazide MOA
Decrease Na reabsorption in distal tubules --> decrease total…
Thiazide Counseling
1. Take early in the day... 2. May cause photosensitivity... 3. May…
88 terms
Pharmacotherapy
Neoplesia
Benign rumors
Malignant tumors
Malignant epithelial tumors
Abnormal growth usually preceded by abnormal growth patterns
Names according to the tissues from... Which they arise and incl…
Named according to the tissues from which they arise
Carcinomas
Neoplesia
Abnormal growth usually preceded by abnormal growth patterns
Benign rumors
Names according to the tissues from... Which they arise and incl…
24 terms
Pharmacotherapy
Pharmacokinetics
Pharmacodynamics
Absorption
Factors that affect absorption
description of changes in drug concentrations over time; can…
relationship between drug concentration and drug effect ... dete…
rate and extent to which a drug leaves its site of administra…
Ability of to get drug into solution in the GI tract... Ionizati…
Pharmacokinetics
description of changes in drug concentrations over time; can…
Pharmacodynamics
relationship between drug concentration and drug effect ... dete…
24 terms
pharmacotherapy
how does aims of pharmacotherapy diffe…
what different types of compounds invo…
agonist vs antagonist
what are full, partial, and indirect a…
seek to modify biological processes underpinning motivation t…
block neural substrates of reward and euphoric effect... weak ve…
agonist - increases... antagonist - blocks
full - activate receptor to max response... partial - activate…
how does aims of pharmacotherapy diffe…
seek to modify biological processes underpinning motivation t…
what different types of compounds invo…
block neural substrates of reward and euphoric effect... weak ve…
Pharmacotherapy
Typical antipsychotis
Fluoxtine
Citalopram
Sertaline
Extrapyramidal side effects
Longest acting, do not use it for rapid control or agitated o…
Avoided in patient with suicidal rend
Useful in juvenile depression
Typical antipsychotis
Extrapyramidal side effects
Fluoxtine
Longest acting, do not use it for rapid control or agitated o…
45 terms
Pharmacotherapy
What are the indications for anti-psyc…
What are the key side effects in the '…
What are the key side effects in the '…
What are the key features of Haloperid…
- acute psychosis... - prophylactic in schizophrenia / schizoaf…
1. Anticholinergic (dry eyes / mouth, constipation, urinary r…
1. Dyslipidaemia... 2. Hyperglycaemia (T2DM)... 3. Orthostatic hypo…
- key use in treatment of positive symptoms of psychosis... - ca…
What are the indications for anti-psyc…
- acute psychosis... - prophylactic in schizophrenia / schizoaf…
What are the key side effects in the '…
1. Anticholinergic (dry eyes / mouth, constipation, urinary r…
220 terms
Pharmacotherapy
Intravascular fluid
Intracellular fluid
Interstitial fluid
Extracellular fluid
fluid inside the blood vessel
inside the cell
outside blood vessel and the cell
intravascular and interstitial
Intravascular fluid
fluid inside the blood vessel
Intracellular fluid
inside the cell
14 terms
Pharmacotherapy
Vitamin A... (fat soluble)
Vitamin D3... (fat soluble)
Vitamin D2... (fat soluble)
Vitamin E... (fat soluble)
Retinol
Cholecalciferol
Ergocalciferol
Alphatocopherol
Vitamin A... (fat soluble)
Retinol
Vitamin D3... (fat soluble)
Cholecalciferol
83 terms
Pharmacotherapy
Symptoms
Signs
Objective symptoms
Subjective symptoms
What the patient is experiencing
What the examiner, HCP, detects
Kind of symptom that can be seen - swelling or rash
Kind of symptom a patient can only tell you about - headache
Symptoms
What the patient is experiencing
Signs
What the examiner, HCP, detects
8 terms
Pharmacotherapy
Aspirin
Oral Glucose
Activated Charcoal
Bronchodilators
Given during heart attack to prevent repair of arterial plaqu…
Given to hypoglycermic patient who may not be able to maintai…
Given to patients that have ingested caustic material by coat…
Given to patients with asthma, emphysema by enlarges constric…
Aspirin
Given during heart attack to prevent repair of arterial plaqu…
Oral Glucose
Given to hypoglycermic patient who may not be able to maintai…
119 terms
PHARMACOTHERAPY
Pharmacotherapy
Pharmacokinetics
Pharmacodynamics
Drug
Application of drugs to prevent, treat, or diagnose disease
Study of Absorption, Distribution, Metablodm, Excretion (ADME…
Study of biochemical and physiologic mechanisms of drug action
Any substance that alters physiological function
Pharmacotherapy
Application of drugs to prevent, treat, or diagnose disease
Pharmacokinetics
Study of Absorption, Distribution, Metablodm, Excretion (ADME…
19 terms
Pharmacotherapy
Broad Spectrum Inducers
Selective CYP3A Inducers
Selective CYP1A2 Inducer
Selective CYP2E1 Inducer
Carbamazepine... Phenytoin... Phenobarbital... Rifampin... CYP1A2, CYP2C…
Griseofulvin... Esclicarbezepine... Topiramate... Felbamate*... Oxcarbaz…
Smoke
EtOH (stabilizes E)
Broad Spectrum Inducers
Carbamazepine... Phenytoin... Phenobarbital... Rifampin... CYP1A2, CYP2C…
Selective CYP3A Inducers
Griseofulvin... Esclicarbezepine... Topiramate... Felbamate*... Oxcarbaz…
22 terms
Pharmacotherapy
Growth
Development
Teratogen
Pregnancy Periods
progressive increase in physical size... -predictable sequence... -…
refers to functional changes in physical, psychomotor and cog…
a substance, organism, or physical agent to which a fetus is…
-Preimplantation period: weeks 1-2 of first trimester; terato…
Growth
progressive increase in physical size... -predictable sequence... -…
Development
refers to functional changes in physical, psychomotor and cog…
10 terms
Pharmacotherapy
2 Gram Negative Cocci
4 Gram Negative Coccibaccilus
6 Gram Positive Bacilli
Found in esophagus
Neisseria gonnohoare & N. meningitis
Hemophilus fluenza; bortdella pertussis; brucella; legionella…
Listeria; clostridium; carynebacterium; lactobacillus; bacill…
Streptoccus
2 Gram Negative Cocci
Neisseria gonnohoare & N. meningitis
4 Gram Negative Coccibaccilus
Hemophilus fluenza; bortdella pertussis; brucella; legionella…
29 terms
Pharmacotherapy
Pharmacotherapy
Pharmacotherapy
Pharmacokinetics
Pharmacodynamics
Application of drugs in the PREVENTION, TREATMENT and USE in…
Correlates PHARMACODYNAMICS with biochemical aspect of disease
study of ABSORPTION, DISTRIBUTION, METABOLISM and EXCRETION o…
Study of biochemical and physiologic mechanisms
Pharmacotherapy
Application of drugs in the PREVENTION, TREATMENT and USE in…
Pharmacotherapy
Correlates PHARMACODYNAMICS with biochemical aspect of disease
32 terms
Pharmacotherapy
aa
ac
ad
as
Affected area
Before meals
Right ear
Left ear
aa
Affected area
ac
Before meals
179 terms
Pharmacotherapy
This term is abnormalities that are pe…
Symptoms can either be: (2 terms)
Swelling of the ankle is a (subjective…
Bruising on the knee is a (subjective,…
Symptoms
Subjective or Objective
objective (can be measured)
Objective (can be measured)
This term is abnormalities that are pe…
Symptoms
Symptoms can either be: (2 terms)
Subjective or Objective
8 terms
Pharmacotherapy
antipsychotics
treat schizophrenia and other types of…
block dopamine receptor sites and uptake
anxiolytics
treat schizophrenia and other types of severe thought disorde…
antipsychotics
antipsychotics
depress activity in CNS, anti-anxiety
antipsychotics
treat schizophrenia and other types of severe thought disorde…
treat schizophrenia and other types of…
antipsychotics
12 terms
Pharmacotherapy
Varenicline (Chantix)
Bupropion (Wellbutrin, Zyban)
Nortriptyline (Aventyl, Pamelor)
Methadone (Dolophine)
partial agonist for nicotine receptors, has been found to dou…
norepinephrine-dopamine reuptake inhibitor that also works on…
inhibits norepinephrine reuptake, reduces cravings, and reduc…
opiate agonist, reduces withdrawal symptoms, still controvers…
Varenicline (Chantix)
partial agonist for nicotine receptors, has been found to dou…
Bupropion (Wellbutrin, Zyban)
norepinephrine-dopamine reuptake inhibitor that also works on…
68 terms
Pharmacotherapy
Fluoxetine (Prozac)
Sertraline (Zoloft)
Paroxetine (Paxil)
Fluvoxamine (Luvox)
Longest half-life with active metabolites; no taper... Safe in P…
First line PTSD... Highest risk for GI Side effects... Few drug int…
Short half-life leading to withdrawal phenomenon (flu) ... Prote…
OCD... nausea and vomiting ... Drug interactions
Fluoxetine (Prozac)
Longest half-life with active metabolites; no taper... Safe in P…
Sertraline (Zoloft)
First line PTSD... Highest risk for GI Side effects... Few drug int…
41 terms
Pharmacotherapy
analgesic
narcotic
anesthetic
antacid
a drug that relieves pain
a potent analgesic with addictive properties
a drug that temporarily blocks transmission of nerve conducti…
a drug that neutralizes stomach acid
analgesic
a drug that relieves pain
narcotic
a potent analgesic with addictive properties
22 terms
Pharmacotherapy
Immediate Gas OTC
Preventative Gas OTC
Hemorrhoid Treatmen
Exclusions for Self Treatment: Gas
Simethicone... Activated charcoal
Beano... Lactase supplements... Probiotic
Local anesthetics... Vasoconstrictors... Protectants... Corticosteroid…
Unintended weight loss... Worse symptoms after eating wheat... Use…
Immediate Gas OTC
Simethicone... Activated charcoal
Preventative Gas OTC
Beano... Lactase supplements... Probiotic
22 terms
Pharmacotherapy
Goal for pharmacotherapy
Systemic
Local
Cs
-Deliver to site of action at rate/concentration to achieve m…
...
...
-Drug concentration at site of action... -Can also indicate conc…
Goal for pharmacotherapy
-Deliver to site of action at rate/concentration to achieve m…
Systemic
...
24 terms
Pharmacotherapy
Ultra rapid insulin
Short acting insulin
Intermediate insulin
Long acting insulin
Aspart... Lispro
Regular
Isophane... Protamine
Glargine... Detemir
Ultra rapid insulin
Aspart... Lispro
Short acting insulin
Regular
77 terms
Pharmacotherapy
drug receptor classification
Drug receptor properties: ... affinity
Drug receptor properties: ... intrinsic a…
agonist
effects of specific antagonists... relative potencies of known a…
ability of a drug to bind at receptor site to form a stable c…
ability of the drug receptor complex to initiate a pharmacolo…
drug that activates a receptor by binding to it... d/r complex h…
drug receptor classification
effects of specific antagonists... relative potencies of known a…
Drug receptor properties: ... affinity
ability of a drug to bind at receptor site to form a stable c…
18 terms
Pharmacotherapy
Acetaminophen (children dosing)
Acetaminophen (adult dosing)
NSAIDs (children dosing)
NSAIDs (adult dosing)
10-15 mg/kg/dose PO every 4-6 hours; max = 5 doses in 24 hours
325-1000 mg PO every 4-6 hours
5-10 mg/kg/dose every 6-8 hours; max = 4 doses in 24 hours
200-400 mg every 4-6 hours; max = 1200 mg in 24 hours
Acetaminophen (children dosing)
10-15 mg/kg/dose PO every 4-6 hours; max = 5 doses in 24 hours
Acetaminophen (adult dosing)
325-1000 mg PO every 4-6 hours
656 terms
Pharmacotherapy
Antigens
Nonliving substances that can also be…
The immune system recognizes and destr…
HLA Antigens
Substances (proteins) on the surface of cells, viruses, fungi…
Toxins, chemicals, drugs
Antigens
Human leukocyte antigens... Our immune system learns to see thes…
Antigens
Substances (proteins) on the surface of cells, viruses, fungi…
Nonliving substances that can also be…
Toxins, chemicals, drugs
14 terms
pharmacotherapy
benzodiazepines
benzodiazepine drugs
alprazolam
lorazepam
prescribed for anxiety disorders on an as needed basis like…
...
xanax
ativan
benzodiazepines
prescribed for anxiety disorders on an as needed basis like…
benzodiazepine drugs
...
29 terms
pharmacotherapy
GABA (γ-aminobutyric acid) action
Serotonin action
Norepinephrine action
Anxiety Disorders Tx:... Medications to C…
key neurotransmitters involved in anxiety and in the anxiolyt…
Extensive overlap with depressive disorders
"Fight or flight"... Noradrenergic hyperactivity can not only re…
SSRIs Selective Serotonin Reuptake Inhibitors... SNRIs Selective…
GABA (γ-aminobutyric acid) action
key neurotransmitters involved in anxiety and in the anxiolyt…
Serotonin action
Extensive overlap with depressive disorders
8 terms
Pharmacotherapy
Define pharmacotherapy
What determines treatment
What is ... the bioavailability of a drug…
PO
Area of pharmacy practice that is responsible for ensuring th…
Disease State, other disease states, other medications, drug…
100%
Per os, by mouth
Define pharmacotherapy
Area of pharmacy practice that is responsible for ensuring th…
What determines treatment
Disease State, other disease states, other medications, drug…
38 terms
Pharmacotherapy
Parkinson's Drugs
Cause of Parkinson's
Levodopa (MoA)
DA agonists
Dopaminergic Agents, Anticholinergic Agents
imbalance in DA and Ach... Ach causes excessive stimulation of G…
promotes DA synthesis
stimulate DA receptors directly
Parkinson's Drugs
Dopaminergic Agents, Anticholinergic Agents
Cause of Parkinson's
imbalance in DA and Ach... Ach causes excessive stimulation of G…
26 terms
Pharmacotherapy
Name all the thiazides
Chlorthalidone type
Hydrochlorothiazide type
Indapamide type
Chlorthalidone, Hydrochlorothiazide, Indapamide, Metolazone
diuretic thiazide
diuretic thiazide
diuretic thiazide
Name all the thiazides
Chlorthalidone, Hydrochlorothiazide, Indapamide, Metolazone
Chlorthalidone type
diuretic thiazide
71 terms
Pharmacotherapy
Sensitivity
specificity
basic metabolic panel
Glucose level
Proportion of + tests that are truly positive
proportion of - tests that are truly -
glucose, Na, Cl, K, bicarb, BUN, Cr, Ca
70-110 mg/dl
Sensitivity
Proportion of + tests that are truly positive
specificity
proportion of - tests that are truly -
770 terms
Pharmacotherapy
Eukaryote
Cell wall of fungi contains
Target of antifungals
Fungi mode of transmission
Contain true nucleus and other organelles
Chitin (polymer of N-acetylglucosamine
Ergosterol in the cytoplasm
Inhalation of spores produced during reproduction
Eukaryote
Contain true nucleus and other organelles
Cell wall of fungi contains
Chitin (polymer of N-acetylglucosamine
70 terms
PHARMACOTHERAPY
deelopment
during pregnancy, Abdominal/gastric ch…
during pregnancy, Inhaled drugs may be…
during pregnancy, Drug excretion rates…
functional changes in physical, psychomotor, and cognitive ca…
absorption
faster
increase
deelopment
functional changes in physical, psychomotor, and cognitive ca…
during pregnancy, Abdominal/gastric ch…
absorption
11 terms
Pharmacotherapy
Homeopathy
Naturopathy
Reflexology
Accupressure
distinct system of medicine based on the principle of like cu…
philosophy of life and an approach to living that incorporate…
focus therapy on points on hands or feet that correspond to d…
uses same meridian points as acupuncture but uses pressure in…
Homeopathy
distinct system of medicine based on the principle of like cu…
Naturopathy
philosophy of life and an approach to living that incorporate…
Pharmacotherapy
Agonist
Antagonist
What percentage of people who attempt…
What is the percentage that NRT's will…
It facilitates or increases the job of the receptor; opiate
It blocks the receptor site
90%
50-70%
Agonist
It facilitates or increases the job of the receptor; opiate
Antagonist
It blocks the receptor site
30 terms
Pharmacotherapy
Development
Teratogen
Preimplantation period
Embryonic period
Refers to functional changes in physical, psychomotor, and co…
A substance, organism, or physical agent to which a fetus is…
Weeks 1-2 of first trimester ... -Teratogen either causes death…
Weeks 3-8... -period of maximum sensitivity to teratogens
Development
Refers to functional changes in physical, psychomotor, and co…
Teratogen
A substance, organism, or physical agent to which a fetus is…
46 terms
Pharmacotherapy
Selective Drugs
Non-selective Drugs
Antagonist Drugs
Agonist Drugs
The primary effect of the drug is only on Tissue A. ... these ha…
Side effect on Tissue A & B. More likely to occur, but all dr…
Blockers ---> sympatholytics & Cholinolytics
Activators --> Sympathomimetics & Cholinomimetics
Selective Drugs
The primary effect of the drug is only on Tissue A. ... these ha…
Non-selective Drugs
Side effect on Tissue A & B. More likely to occur, but all dr…
15 terms
Pharmacotherapy
Neostigmine
Uses of cholinesterase inhibitors in d…
Adverse reactions of cholinergic (musc…
What do we give to block excessive mus…
cholinesterase inhibitor ... quaternary amine (charged) - NO CNS…
for treatment of xerostomia!!... use for a patient who takes dr…
S salivation... L lacrimation ... U urination... D defecation…
atropine
Neostigmine
cholinesterase inhibitor ... quaternary amine (charged) - NO CNS…
Uses of cholinesterase inhibitors in d…
for treatment of xerostomia!!... use for a patient who takes dr…
9 terms
Pharmacotherapy
LT: applying concepts of drug therapeu…
What is pharmacotherapy?
what things do you think about when se…
What are some aspects of the individua…
...
the area of pharmacy practice that is responsible for ensurin…
disease state, other medications, other disease states, drug…
age, ethnicity, gender, weight, height, genetics, etc
LT: applying concepts of drug therapeu…
...
What is pharmacotherapy?
the area of pharmacy practice that is responsible for ensurin…
35 terms
pharmacotherapy
What are the age related pharmacokinet…
What are the age related pharmacodynam…
What kind of absorption problems to ol…
What kind of changes occur with oldies…
absorption... distribution... metabolism... excretion
changes in receptor affinity... changes in receptor number... chang…
decreased gastric acid production
decreased GI motility, so the exposure time of the drugs in t…
What are the age related pharmacokinet…
absorption... distribution... metabolism... excretion
What are the age related pharmacodynam…
changes in receptor affinity... changes in receptor number... chang…
12 terms
Pharmacothérapie
Les antihypertenseurs
Hypertension artérielle
Hypertension systolique isolée
HTA Primaire
Diurétiques Thiazidiques... Bêtabloquants... Inhibiteurs de l'enzym…
P.A systolique > ou = 140mmHg... P.A diastolique < 90mmHg
Plus courante chez les personnes agées; causée par une perte…
P.A élevée sans cause précise.... Facteurs considérables : surpr…
Les antihypertenseurs
Diurétiques Thiazidiques... Bêtabloquants... Inhibiteurs de l'enzym…
Hypertension artérielle
P.A systolique > ou = 140mmHg... P.A diastolique < 90mmHg
19 terms
Pharmacotherapies
causes unpleasant symptoms if alcohol…
not very effective, because people don…
reduces alcohol cravings, days per wee…
given that its mechanism of action is…
disulfiram (alcohol drug) (antabuse)
disulfiram (alcohol drug) (antabuse)
naltrexone (alcohol drug)
naltrexone (alcohol drug)
causes unpleasant symptoms if alcohol…
disulfiram (alcohol drug) (antabuse)
not very effective, because people don…
disulfiram (alcohol drug) (antabuse)
13 terms
Pharmacotherapies
Cytotoxic therapy
Types of cytotoxic therapy
Targeted therapy
Types of targeted therapy
Kills all fast proliferating cells - goes into mitotic catast…
Chemotherapy, radiation therapy
Kills only cells with specific molecular target
Hormone therapy, inhibitors of proliferation pathways
Cytotoxic therapy
Kills all fast proliferating cells - goes into mitotic catast…
Types of cytotoxic therapy
Chemotherapy, radiation therapy
9 terms
Pharmacotherapies
The two types of pharmacotherapies
Cytotoxic therapy
Types of cytotoxic therapy
Chemotherapy
Cytotoxic therapy... Targeted Therapy
Kills ALL fast proliferating cells (not cancer specific and s…
Chemotherapy... Radiation therapy
Interferes with DNA function and interferes with cell division
The two types of pharmacotherapies
Cytotoxic therapy... Targeted Therapy
Cytotoxic therapy
Kills ALL fast proliferating cells (not cancer specific and s…
80 terms
HTN Pharmacotherapy
What's the recommended therapy for CKD…
True or False:... In African Americans T…
Review the algorithm per JNC 8 guideli…
True or False... Per ASH/ISH guidelines…
A. ACEI/ARB
True
False that's per JNC 8
What's the recommended therapy for CKD…
A. ACEI/ARB
True or False:... In African Americans T…
True
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