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Study sets matching "term:interferon = proteins that interfere with viral replication."

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Study sets matching "term:interferon = proteins that interfere with viral replication."

39 terms
Viral Replication
Amantadine
Enfuvirtide (Fuzeon)
Immunoglobulin
Interferon Alpha
Influenza A... Blocks M2 ion channels... Blocks disassembly/penetr…
HIV... Blocks penetration... CD4 analog
Almost anything... Blocks attachment &/or penetration
Not rabies... Blocks transcription/translation
Amantadine
Influenza A... Blocks M2 ion channels... Blocks disassembly/penetr…
Enfuvirtide (Fuzeon)
HIV... Blocks penetration... CD4 analog
32 terms
Viral pathogenesis 2
Virus interaction with innate immune s…
Type 1 interferons
Type 2 interferons
Viral evasion mechanisms
1. Inhibit viral replication... 2. Activates NK cells... 3. Enhance…
1. Inhibit viral replication... 2. Activates macrophages... 3. Enha…
- avoid recognition... - interfere with immune system
Virus interaction with innate immune s…
Type 1 interferons
1. Inhibit viral replication... 2. Activates NK cells... 3. Enhance…
29 terms
17 - Control of Viral Populations
Ways to control Viral Populations
Viral populations in the healthcare se…
Control of Viral Diseases - prevention…
Control of Viral Population -> vaccina…
Ways to control Viral Populations
Viral populations in the healthcare se…
29 terms
Micro 17, Control of Viral Populations
Ways to control Viral Populations
Viral populations in the healthcare se…
Control of Viral Diseases - prevention…
Control of Viral Population -> vaccina…
Ways to control Viral Populations
Viral populations in the healthcare se…
23 terms
Micro Ch 5
Virus
few/no enzymes of their own... interfere…
capsid ... envelope
Morphology
Latin for poison... obligate intracellular parasite... contain a si…
Why are they difficult to fight
Structure
helical... polyhedral... enveloped... complex
Virus
Latin for poison... obligate intracellular parasite... contain a si…
few/no enzymes of their own... interfere…
Why are they difficult to fight
8 terms
Type I Interferon Antiviral Response
How is transcription of IFN-B initiated?
What does IFN-B do to nearby cells?
What is oligoadenylate synthetase?
What is Protein Kinase R (PKR)?
- Cell senses infection or ligand marker... - Triggers phosphory…
- IFN-B binds to receptors that are linked to Jak1 & Tyk2 kin…
- An enzyme that is part of the interferon response... - Produce…
- An enzyme that is part of the interferon response... - Inhibit…
How is transcription of IFN-B initiated?
- Cell senses infection or ligand marker... - Triggers phosphory…
What does IFN-B do to nearby cells?
- IFN-B binds to receptors that are linked to Jak1 & Tyk2 kin…
12 terms
Ch 19 Viral Structure, Function & Replication
virus
pathogen
viroid
prion
a nonliving, infectious particle composed of a nucleic acid a…
An organism that causes disease
An infectious particle, similar to but smaller than a virus,…
Protein particles that cause disease
virus
a nonliving, infectious particle composed of a nucleic acid a…
pathogen
An organism that causes disease
18 terms
antiviral agents interferon
interferons are
interferons inhibit
interferons function in
3 types of interferons
glycoproteins
viral cell growth... cell multiplication... immunomodulatory activi…
cell communication
alpha ... beta... gamma
interferons are
glycoproteins
interferons inhibit
viral cell growth... cell multiplication... immunomodulatory activi…
9 terms
antimicrobial proteins
antimicrobial proteins
interferons
interferons
interferons
provide second line of defense against bacteria and virus tha…
have produced and released by cells that have become infected…
stimulate uninfected neighbor cells to manufacture antiviral…
enhance phagocytosis and activate natural killer cells
antimicrobial proteins
provide second line of defense against bacteria and virus tha…
interferons
have produced and released by cells that have become infected…
13 terms
Chapter 12 and 13 Microbiology Vocab
aerosol
antiseptic
autoclave
disinfectant
cloud of tiny liquid droplets in the air
external agent to destroy microorganisms
instrument for sterilization using moist heat under pressure
agent used on inanimate objects to destroy microorganisms
aerosol
cloud of tiny liquid droplets in the air
antiseptic
external agent to destroy microorganisms
16 terms
antiinfective mechs of action
sulfamexazole, trimethoprim
penicillins, vancomycins, cephalosporin
ciprofloxicin
streptomycin, gentamycin
inhibit folic acid and nucleotide biosynthesis
inhibit cell wall synthesis (3 classes)
topoisomerase inhibitor that blocks the unwinding of DNA and…
inhibit translocation of ribosome along RNA codon
sulfamexazole, trimethoprim
inhibit folic acid and nucleotide biosynthesis
penicillins, vancomycins, cephalosporin
inhibit cell wall synthesis (3 classes)
18 terms
Viral Structure, Classification and Replication
Virus
Virion
Satellite Virus
Viroid
Sub cellular infectious agents, that are fully obligate paras…
Mature extracellular virus particle.
A sub-viral agent dependent on co-infection with other viruse…
Smallest infectious particle known, consisting of single stra…
Virus
Sub cellular infectious agents, that are fully obligate paras…
Virion
Mature extracellular virus particle.
22 terms
Anti-Viral Drugs
Miraviroc
Enfuvirtide
(N)NRTI
Nevirapine
Chemokine co-receptor Blocker (for HIV). Blocks CD4 co-recept…
Fusion inhibitor (HIV). Prevents fusion of cell membrane and…
(Non)-Nucleoside Reverse Transcriptase Inhibitors... All preven…
NNRTI... Non-nucleoside Reverse Transcriptase blocker (HIV).... Bi…
Miraviroc
Chemokine co-receptor Blocker (for HIV). Blocks CD4 co-recept…
Enfuvirtide
Fusion inhibitor (HIV). Prevents fusion of cell membrane and…
21 terms
inflammation steps & complement proteins and MACS, effects of interferon
inflammation
inflammation step 1
inflammation step 2
inflammation step 3
5 steps
bacteria invade a tissue & directly kill cells or release met…
mast cells in tissue release histamine which triggers arterio…
fluid & plasma proteins leak out of capillaries, localized ed…
inflammation
5 steps
inflammation step 1
bacteria invade a tissue & directly kill cells or release met…
8 terms
Chapter 15 Vocab
Parenteral
Siderophores
Antigenic Variation
Hemolysin
Portal of entry directly into tissue or mucous membrane throu…
Protein secreted by pathogen to obtain iron
Process when a pathogen alters its surface antigens
Membrane disrupting toxin that destroys erythrocytes by formi…
Parenteral
Portal of entry directly into tissue or mucous membrane throu…
Siderophores
Protein secreted by pathogen to obtain iron
11 terms
virus treatment
Hepatitis C
Herpes types
HIV
influenza
AZT, Ribavirin, interferon
Acyclovir and AZT
interferon and AZT
Amantadine and Tamiflu
Hepatitis C
AZT, Ribavirin, interferon
Herpes types
Acyclovir and AZT
14 terms
Week 5: Antimicrobials - Types of Drugs
Antifungal
Azoles (antifungal)
Polyenes (antifungal)
Antiparasitic
difficult, structure similar to human cells (increase toxicit…
Inhibits enzymes involved in sterol biosynthesis, increases a…
Combines with ergosterol, causing leakage of cell contents an…
Parasites (helminths and protozoa), dtructurally similar to h…
Antifungal
difficult, structure similar to human cells (increase toxicit…
Azoles (antifungal)
Inhibits enzymes involved in sterol biosynthesis, increases a…
32 terms
Second line of defence: Antimicrobial substances
second line of defence
second line of defence
second line of defence
antimicrobial substances
internal defences
any pathogens that get past surface barriers (first line of d…
consist of internal, antimicrobial substances, phagocytes, na…
various body fluids contain four main types of these that dis…
second line of defence
internal defences
second line of defence
any pathogens that get past surface barriers (first line of d…
52 terms
Med Micro Exam 5 Pt 2
Respiratory
Fecal/Oral
Vectors
Sexually Transmission
-a form of viral transmission... -via aerosols
-a form of viral transmission... -via ingestions-food or water c…
-a form of viral transmission... -particularly anthropoid bites
-a form of viral transmission... -intercourse
Respiratory
-a form of viral transmission... -via aerosols
Fecal/Oral
-a form of viral transmission... -via ingestions-food or water c…
21 terms
Viruses
Capsid
Genome
Envelope
Class I
Coat made of capsomers (protein monomers)
Core of either DNA or RNA (never both)
Host cell membrane with viral glycoproteins (antigenic determ…
ds DNA Viruses
Capsid
Coat made of capsomers (protein monomers)
Genome
Core of either DNA or RNA (never both)
65 terms
Viral Replication
Viral Replication Steps
Eclipse phase
Dissemination
Viremia
1) Recognition... 2) Attachment... 3) Penetration... 4) Uncoating... 5) M…
time when virus cannot be detected by body
spread of virus from initial site of infection to distant site
presence of infectious virus in the blood (like w/ HIV1)
Viral Replication Steps
1) Recognition... 2) Attachment... 3) Penetration... 4) Uncoating... 5) M…
Eclipse phase
time when virus cannot be detected by body
10 terms
BIO 2150 Exam 4 Page 4
antimicrobial proteins
antimicrobial proteins
viruses
interferon
enhance innate defenses
either attack pathogens or prevent their proliferation
are nucleic acids surrounded by a protein coat; do not have m…
viruses infected cells cannot save themselves from distributi…
antimicrobial proteins
enhance innate defenses
antimicrobial proteins
either attack pathogens or prevent their proliferation
50 terms
Viruses
Capsid
Genome
Envelope
Class I
Coat made of capsomers (protein monomers)
Core of either DNA or RNA (never both)
Host cell membrane with viral glycoproteins (antigenic determ…
ds DNA Viruses
Capsid
Coat made of capsomers (protein monomers)
Genome
Core of either DNA or RNA (never both)
8 terms
immunology terms
antigen
sentinel cells
pathogen recognition receptors
cytokines
molecules of the foreign invaders that stimulate the generati…
-recognize invader/tissue damage... -primary activators of the i…
-recognize molecules on the surface of microbes - PAMPS, DAMP…
-small protein molecules... -regulate cell communication... -impact…
antigen
molecules of the foreign invaders that stimulate the generati…
sentinel cells
-recognize invader/tissue damage... -primary activators of the i…
18 terms
test 3 (1)
immediate-early genes
early genes
late genes
VP16
transactivators of other viral gens
include enzymes involved in DNA metabolism
includes structural/tegument proteins
-HSV-1 protein ... -essential transactivator of viral immediate…
immediate-early genes
transactivators of other viral gens
early genes
include enzymes involved in DNA metabolism
21 terms
Basic Virology
Icosahedron
Nucleocapsid
Enveloped viruses have
In helical nucleocapsid symmetry arran…
a polyhedron with 20 faces
a capsid composed of protomer subunits containing nucleic acid
transmembrane glycoproteins spikes on their outer membrane
the size is determined by the length of the nucleic acid core
Icosahedron
a polyhedron with 20 faces
Nucleocapsid
a capsid composed of protomer subunits containing nucleic acid
44 terms
Viral Classification, Structure, and Replication; DNA Viruses
Virion
Capsid
Nucleocapsid
Envelope
The mature infectious virus particle
The protein shell that encloses and protects the viral nuclei…
Consists of the nucleic acid and closely associated capsid pr…
The viral membrane, consisting of a lipid bilayer, proteins,…
Virion
The mature infectious virus particle
Capsid
The protein shell that encloses and protects the viral nuclei…
61 terms
Virology
Virus Basics
Naked DNA
Nucleocapsid
Virion
RNA/DNA, protein
Lack a membrane
Nucleic acid protein assembly packaged in a virion
Individual viral unit
Virus Basics
RNA/DNA, protein
Naked DNA
Lack a membrane
12 terms
Components of the Immune System
The first of cell to the site of phago…
This cell suppresses the inflammatory…
Heat labile, 18 plasma proteins
Associated with inflammatory condition…
neutrohil
eosinophil
compliment system
increased compliment levels
The first of cell to the site of phago…
neutrohil
This cell suppresses the inflammatory…
eosinophil
31 terms
Pharm: Anti-viral drugs
toxic
toxicity to mammalian cells
virus-specific, host target
infected cells
Viral replication is intimately associated with the host cell…
What is the most severe limiting factor of antiviral drugs?
a successful drug interferes with ________ function or with a…
Antiviral drugs could interfere with cell function necessary…
toxic
Viral replication is intimately associated with the host cell…
toxicity to mammalian cells
What is the most severe limiting factor of antiviral drugs?
More Viruses/ Controlling viruses
Lysogenic Cycle of a Temperate Virus
White blood cells
Antibodies
Interferon
- Virus attaches itself and injects its DNA into host cell... -…
engulf viruses in the blood and digest and destroy them
build of up immune system - blood protien used ot provide pas…
proteins that bind to cells and disable virus abilities to tr…
Lysogenic Cycle of a Temperate Virus
- Virus attaches itself and injects its DNA into host cell... -…
White blood cells
engulf viruses in the blood and digest and destroy them
10 terms
Immune response
Macrophages
MHC proteins
Cell-mediated immunity
Antibody mediated immune
Engulf and digest pathogens create antigen fragments that dis…
Major histocompatibility complex. Found on membrane of all nu…
Active T cell divide... Cytotoxic T cells-travel to find cell w…
Active B cells divide ... Plasma cells- make secret large amoun…
Macrophages
Engulf and digest pathogens create antigen fragments that dis…
MHC proteins
Major histocompatibility complex. Found on membrane of all nu…
14 terms
Interferons
Avonex generic
Avonex pharm cat
Avonex indication
What is an interferon?
interferon beta-1a
interferon
treats relapsing forms of multiple sclerosis
a protein released due to an entry of a virus, that has the p…
Avonex generic
interferon beta-1a
Avonex pharm cat
interferon
54 terms
12,13 - Viral Replication
Virus life cycle stages (5)
What does a virus need to do to propag…
1. describe virus multiplication: adso…
virus multiplication: hemagglutinin
1) attachment (adsorption)... 2) penetration (injection)... 3) prot…
- Infect an appropriate host cell - Use the host cell to gene…
-aka attachment... -specific & nonspecific mechanisms... -*viral…
aids in endocytosis of virus?
Virus life cycle stages (5)
1) attachment (adsorption)... 2) penetration (injection)... 3) prot…
What does a virus need to do to propag…
- Infect an appropriate host cell - Use the host cell to gene…
27 terms
Anti-Viral Agents
1. Zovirax;... 2. Herpex
1. Famciclovir;... 2. Valaciclovir;... 3. Ga…
Narrow
1.. HSV 1 & 2;... 2. Varicella zoster;... 3.…
2 brand names of acyclovir
3 derivatives of acyclovir
Spectrum of acyclovir
5 viruses susceptible to acyclovir
1. Zovirax;... 2. Herpex
2 brand names of acyclovir
1. Famciclovir;... 2. Valaciclovir;... 3. Ga…
3 derivatives of acyclovir
44 terms
28. Viral Replication
What are the Steps of the Viral Replic…
Steps of the Viral Replicative Cycle :…
Steps of the Viral Replicative Cycle :…
Steps of the Viral Replicative Cycle :…
Attachment... Penetration (entry)... Uncoating... Replication... Assembly…
attachment and penetration by fusion
immediate early protein synthesis
-early protein synthesis ... -genome replication by RNA-dependen…
What are the Steps of the Viral Replic…
Attachment... Penetration (entry)... Uncoating... Replication... Assembly…
Steps of the Viral Replicative Cycle :…
attachment and penetration by fusion
68 terms
Innate immunity
Susceptibility
Immunity
Innate immunity
Adaptive immunity
Lack of resistance to a disease
Ability to ward off disease
Non-specific defenses against
Immunity or resistance to a specific pathogen
Susceptibility
Lack of resistance to a disease
Immunity
Ability to ward off disease
20 terms
Week 3- Lecture 3- Host Defenses
cell that permits production of progen…
virus cannot replicate but may transfo…
no progeny virus produced but cell can…
small number virus particles produced…
permissive cell
non-permissive cell
abortive infection
persistent infection
cell that permits production of progen…
permissive cell
virus cannot replicate but may transfo…
non-permissive cell
16 terms
Viral Pathogenesis 2
what is the cause of a lytic infection…
What is syncytium formation
Can viruses cause hyperplasia?... Examples
process of producing hyperplasia
Viral replication in a cell and the cell breaking open to rel…
A single cell with multiple nuclei formed by the fusion of ce…
yes. Viruses can cause cells to replicate abnormally ... Epstei…
Viral proteins can interfere with cell cycle control permanen…
what is the cause of a lytic infection…
Viral replication in a cell and the cell breaking open to rel…
What is syncytium formation
A single cell with multiple nuclei formed by the fusion of ce…
20 terms
Viruses and Viral Replication
What is a Virion and what is its fxn?
What does it mean the host cell is sus…
What does it mean the host cell is per…
What is positive-polarity, single stra…
...
The cell has proper receptors for binding. Thats it!
The cell contains ALL required info for viral replication-->l…
This RNA acts like mRNA in that it is ready to code for a gen…
What is a Virion and what is its fxn?
...
What does it mean the host cell is sus…
The cell has proper receptors for binding. Thats it!
15 terms
Viral replication
Viral replication overview
Determinants of mode of viral replicat…
Attachment
Penetration/uncoating
Attachment, penetration/uncoating of viral protective shell,…
Viral factors: genome structure, naked/enveloped morphology,…
Can either happen with capsid or envelope- with the capsid, t…
Receptor mediated endocytosis. Fusion- with enveloped viruses…
Viral replication overview
Attachment, penetration/uncoating of viral protective shell,…
Determinants of mode of viral replicat…
Viral factors: genome structure, naked/enveloped morphology,…
57 terms
Combo with "Lymphatics System and Immunity" and 1 other
LYMPH
Lymphatic vessels
THYMUS
Interstitial fluid
fluid formed in the tissue spaces
carry lymph (a clear, watery fluid containing protein molecul…
small lymphoid tissue organ located in the mediastinum .
liquid found between the cells of the body that provides much…
LYMPH
fluid formed in the tissue spaces
Lymphatic vessels
carry lymph (a clear, watery fluid containing protein molecul…
24 terms
Cytokines and MHC
Classes of cytokines
Cytokines moa
Cytokines actions
Pleiotrophy
Interleukins, TNF, interferons, CSF
Activate the transcription of genes for proteins involved in…
Endocrine... Paracrine... Autocrine
The same cytokines producing the same actions on different ce…
Classes of cytokines
Interleukins, TNF, interferons, CSF
Cytokines moa
Activate the transcription of genes for proteins involved in…
31 terms
Viral structure and replication
When was smallpox eradicated?
First virus discovered
First human virus discovered
First cancer causing virus discovered
1979
TMV (1892 and 1898)
FMD (1889)
Avian sarcoma virus (1911)
When was smallpox eradicated?
1979
First virus discovered
TMV (1892 and 1898)
Biology, Chapter 18.2, Viruses and Prions
virus
capsid
lytic cycle
Lysogenic cycle
a nonliving strand of genetic material within a protein coat;…
outer layer of all viruses made of proteins
viral replication process in which genetic material of the vi…
viral replication process in which viral DNA inserts into the…
virus
a nonliving strand of genetic material within a protein coat;…
capsid
outer layer of all viruses made of proteins
69 terms
Immune system handout-Cates Carney
two major categories of innate defenses
surface barriers of the innate system…
three properties of skin that help it…
the stomach secretes...
external and internal
skin and mucous
keratin, intracellular junctions and skin secretions or Ph
protein digesting enzymes with a Low ph
two major categories of innate defenses
external and internal
surface barriers of the innate system…
skin and mucous
27 terms
microbio CH 16 prt 2 Innate
fever
fever progression: shivering
fever progression: crisis
advantages of fevers
abnormally high body temperature... Can occur as a result of Gra…
Body wants to raise temperature set by the hypothalamus. ... --C…
vasodilation and sweating occur as the body temperature falls
- increased IL-1 activity--> increases T cell activity ... - hig…
fever
abnormally high body temperature... Can occur as a result of Gra…
fever progression: shivering
Body wants to raise temperature set by the hypothalamus. ... --C…
Viral Pathogenesis and Vaccines I
Infectivity:
viremia
Virulence
Incidence
transmitted infection/susceptible contacts
when we are able to detect virus in the blood
# of fatal or severe disease cases/total cases of infection…
- # new disease cases within specified time period
Infectivity:
transmitted infection/susceptible contacts
viremia
when we are able to detect virus in the blood
9 terms
Immune System
Innate immunity
Adaptive immunity, or acquired immunity
TOLL receptors,
Interferons
present before any exposure to pathogens and is effective fro…
develops after exposure to agents such as microbes, toxins, o…
fungal ... cell wall fragments bind, causing signal transduction…
Interfere with viral replication and aid in activation of man…
Innate immunity
present before any exposure to pathogens and is effective fro…
Adaptive immunity, or acquired immunity
develops after exposure to agents such as microbes, toxins, o…
virus and immune system
identification
injection
macrophage
histamine
attachment, recognition
viral DNA injected into host cell
eats pathogens and displays antigens
make blood cells leaky
identification
attachment, recognition
injection
viral DNA injected into host cell
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