Study sets matching "term:myeldysplasia = abnormal formation in bone marrow"

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Study sets matching "term:myeldysplasia = abnormal formation in bone marrow"

Bone Marrow and Cell Formation
1. Erythropoietic Marrow
2. Erythropoietic Marrow
3. Erythropoietic Marrow
4. Formed In Erythropoietic Marrow
erythropoiesis: formation of red blood cells
found in hip bones, proximal ends of femur and humerus, bones…
is the medium for the development and storage of 95% of the b…
red blood cells, which carry oxygen to and return CO2 and oth…
1. Erythropoietic Marrow
erythropoiesis: formation of red blood cells
2. Erythropoietic Marrow
found in hip bones, proximal ends of femur and humerus, bones…
Bone marrow and blood cell formation
Pluripotential hematopoetic cells
megakaryocytes
red bone marrow
axial skeleton
most immature stem cells
live in the caves. Platelet forming cell in bone marrow
active. producing blood cells.
where is red bone marrow
Pluripotential hematopoetic cells
most immature stem cells
megakaryocytes
live in the caves. Platelet forming cell in bone marrow
28 terms
bone marrow and blood cell formation
hematopoietic cell compartments in bon…
basic blood cell differentiation from…
how does a limited number of HSCs prov…
myelopoiesis
<0.1% hematopoietic stem cells (HSCs marked with CD34+s) = a…
Hematopoietic stem cell (HSC pluripotent) --> common myeloid…
self renewal through asymmetric divison
myeloblast (inside bone marrow) --> --> --> band (peripheral…
hematopoietic cell compartments in bon…
<0.1% hematopoietic stem cells (HSCs marked with CD34+s) = a…
basic blood cell differentiation from…
Hematopoietic stem cell (HSC pluripotent) --> common myeloid…
Bone Marrow and Blood Cell Formation
Hematopoiesis
Red marrow
Yellow marrow
Hemopoietic stem cell
Process by which blood cells are formed
Actively generates new blood cells, in adults found in proxim…
Dormant marrow, contains many fat cells, located in most of t…
Most undifferentiated blood stem cell, gives rise to two prog…
Hematopoiesis
Process by which blood cells are formed
Red marrow
Actively generates new blood cells, in adults found in proxim…
Chapter 6 (abnormalities of bone formation and growth)
Atypical skeleton growth
Pituitary growth failure
Achondroplasia
Gigantism
A variety of Endocrine or metabolism problems can result in t…
In adequate production of growth hormone and childhood leads…
Results from earlier replacement of the Epiphyseal plates wit…
Results from overproduction of growth hormone before puberty…
Atypical skeleton growth
A variety of Endocrine or metabolism problems can result in t…
Pituitary growth failure
In adequate production of growth hormone and childhood leads…
9 terms
Anatomy Ch 2: Bone Growth, Bone Formation, and Abnormal Bone Growth and Development
Appositional Bone Growth
Endochondral Ossification
Intramembrous Ossification
Pituitary Growth Failure
Increases the diameter of existing bones; osteoprogenitor cel…
Forms most of the bones in the skeleton; how bones grow in le…
Forms spongey bone initially, later remodeled to make compact…
Reduction in growth hormone that leads to shorter bones
Appositional Bone Growth
Increases the diameter of existing bones; osteoprogenitor cel…
Endochondral Ossification
Forms most of the bones in the skeleton; how bones grow in le…
Bone Formation
Ossification or Osteogenesis
Intramembranous Ossification
Endrochondrial Ossification
Growth in Length - Epiphyseal plate... o…
The process by which bone is formed... All embryonic connective…
Forms flat bone's like the skull - bone forms directly within…
Mesenchyme first becomes hyaline cartilage that is then repla…
Cartilage cells are produced by mitosis on the epiphyseal sid…
Ossification or Osteogenesis
The process by which bone is formed... All embryonic connective…
Intramembranous Ossification
Forms flat bone's like the skull - bone forms directly within…
16 terms
Bone Formation
Compact Bone Tissue
Spongy Bone Tissue
Ossification
Intramembranous Ossification
Contains few spaces and is arranged in repeating structural u…
Does not contain osetons, consists of units called Trabeculae…
The process in which bone is formed.
First type of ossification, bone forms in sheet like layers.
Compact Bone Tissue
Contains few spaces and is arranged in repeating structural u…
Spongy Bone Tissue
Does not contain osetons, consists of units called Trabeculae…
31 terms
Bone marrow
What germ layer is blood derived from?
Describe fetal hematopoiesis
What are the functions of bone marrow?
Describe the monophyletic theory of he…
Blood is a specialized connective tissue derived from extraem…
-Liver produces granulocytes, platelets, and definitive eryth…
-Hematopoiesis... -Part of reticulo-endothelial system... -macroph…
-Blood cells derived from single pluripotent stem cell... Note:…
What germ layer is blood derived from?
Blood is a specialized connective tissue derived from extraem…
Describe fetal hematopoiesis
-Liver produces granulocytes, platelets, and definitive eryth…
Bone Marrow
Selective erythroid hypoplasia
Selective myeloid hypoplasia
Selective megakaryocytic hypoplasia
Ehlichiosis and leukemias
Erythroid precursors are decreased but the granulocytic and m…
Decreased neutrophils in the bone marrow but the erythroid an…
Decreased megakaryocytes but normal numbers of erythroid and…
What is the classic causes of bone marrow lymphocytosis?
Selective erythroid hypoplasia
Erythroid precursors are decreased but the granulocytic and m…
Selective myeloid hypoplasia
Decreased neutrophils in the bone marrow but the erythroid an…
19 terms
Bone Marrow
Why do we do a Bone Marrow?
Abnormal PB Findings - for a BM proced…
Sites for BM Aspiration - Adult
Sites for BM Aspiration - Infant
a. Hematologic disorders: Diagnosis and staging; Follow up ... b…
a. Pancytopenia ... b. Leukopenia ... c. Anemia ... d. Thrombocytopeni…
a. Most Common: posterior iliac crest ... b. Others: ... i. Sternu…
a. Most Common: Tibia ... b. Others: Anterior or posterior ilia…
Why do we do a Bone Marrow?
a. Hematologic disorders: Diagnosis and staging; Follow up ... b…
Abnormal PB Findings - for a BM proced…
a. Pancytopenia ... b. Leukopenia ... c. Anemia ... d. Thrombocytopeni…
18 terms
Bone marrow
Percent of active bone marrow in newbo…
Percent of active bone marrow in young…
Percent of active bone marrow in older…
What is the definition of bone marrow…
80-90%
60%
40% active bone marrow... 60% fat
The ratio of marrow cells to fat, red marrow & yellow marrow…
Percent of active bone marrow in newbo…
80-90%
Percent of active bone marrow in young…
60%
17 terms
Bone Formation
Ossification or Osteogenesis
Intramembranous Ossification
Endrochondrial Ossification
Growth in Length - Epiphyseal plate... o…
The process by which bone is formed... All embryonic connective…
Forms flat bone's like the skull - bone forms directly within…
Mesenchyme first becomes hyaline cartilage that is then repla…
Cartilage cells are produced by mitosis on the epiphyseal sid…
Ossification or Osteogenesis
The process by which bone is formed... All embryonic connective…
Intramembranous Ossification
Forms flat bone's like the skull - bone forms directly within…
26 terms
Blood and bone marrow
Erythrocytes
T-lymphocytes
B-lymphocytes
Monocytes
-7um... -No nucleus... -Carry oxygen to tissues via hemoglobin
-10um... -Few azurophilic granules... -Generate cell-mediated immun…
-10um... -Few azurophilic granules... -Generate humoral immune resp…
-15um... -Many azurophilic granules... -Become macrophages in conne…
Erythrocytes
-7um... -No nucleus... -Carry oxygen to tissues via hemoglobin
T-lymphocytes
-10um... -Few azurophilic granules... -Generate cell-mediated immun…
57 terms
Bone Formation
Osteocytes
Osteoblasts
Osteoclasts
Ossification
Bone Cell
Form new bone
Break down old or damaged area of bones
Process by which cartilaginous tissue is changed into bone fr…
Osteocytes
Bone Cell
Osteoblasts
Form new bone
6 terms
Bone Marrow
Medullary cavity
Cavity contains marrow
Marrow found in
Red marrow
Hollow space/tube within the diaphysis
Marrow is a soft, netlike mass of connective tissue
Medullary cavaities of long bones, irregular space of spongy…
highly vascular, functions in the formation of blood cells
Medullary cavity
Hollow space/tube within the diaphysis
Cavity contains marrow
Marrow is a soft, netlike mass of connective tissue
Bone Marrow
Hematopoiesis
Red marrow
Red marrow
Yellow marrow
blood cell formation
In newborns found in medullary cavity of diaphysis, in all ar…
In adults found mainly in epiphyses of humerus and femur, in…
Stores fat
Hematopoiesis
blood cell formation
Red marrow
In newborns found in medullary cavity of diaphysis, in all ar…
13 terms
Bone Marrow
How many blood cells are produced per…
Red bone marrow vs. yellow bone marrow…
Structure of bone marrow and how does…
Role of stromal cells
- 200 billion RBCs produced/day... - 10 billion WBCs... - 400 billi…
- Red: active in hematopoiesis... - Yellow: fatty marrow, inacti…
- BLood reaches the marrow via arteries which traverse the bo…
- Reticular cells, adipocytes, macrophages... - Secrete cytokine…
How many blood cells are produced per…
- 200 billion RBCs produced/day... - 10 billion WBCs... - 400 billi…
Red bone marrow vs. yellow bone marrow…
- Red: active in hematopoiesis... - Yellow: fatty marrow, inacti…
24 terms
Bone Marrow
Hematopoiesis
When evaluate Bone Marrow
Purpose of Bone Marrow Analysis
Adult Bone Marrow
Formation and development of blood cells in the bone marrow
When see unexplained, abnormal results in peripheral blood.... T…
To identify underlying marrow cellular, abnormalities
50% Nucleated Cells & 50% Fat Cells
Hematopoiesis
Formation and development of blood cells in the bone marrow
When evaluate Bone Marrow
When see unexplained, abnormal results in peripheral blood.... T…
54 terms
Bone formation
which secondary center of ossification…
Two mechanisms Bone Formation
Locations of bone formation... 2
mesenchyme
the one in the proximal epiphysis ... shortly after the distal…
1. Intramembranous... 2. encondrondral
1. Membrane mesenchym= intramemranous ossification... 2. Hyalin…
embyotic connective tissue
which secondary center of ossification…
the one in the proximal epiphysis ... shortly after the distal…
Two mechanisms Bone Formation
1. Intramembranous... 2. encondrondral
25 terms
Tollon- bone marrow
What causes hypocalcemia?
What causes hypercalcemia?
Metastasis means what?
What kind of patients are bone marrow…
Eclampsia ... Milk fever
Metastatic neoplasia
Spreading
Cancer patients
What causes hypocalcemia?
Eclampsia ... Milk fever
What causes hypercalcemia?
Metastatic neoplasia
137 terms
Bone Marrow
When is a bone marrow evaluation indic…
What are the main indications to perfo…
What will cause abnormalities in produ…
T/F: Persistent, poorly regenerative o…
When the routine exam of a blood smear has failed to answer w…
• prolonged peripheral cytopeniass* (very strong reason) or c…
• suppression or destruction of hematopoietic cells (hypoplas…
True. Acute blood loss and regenerative anemias do not require.
When is a bone marrow evaluation indic…
When the routine exam of a blood smear has failed to answer w…
What are the main indications to perfo…
• prolonged peripheral cytopeniass* (very strong reason) or c…
Hemopoiesis and Bone Marrow
Hemopoiesis/Hematopoiesis
Erythropoiesis
Thrombopoiesis
Granulopoiesis
the formation of blood cellular components. All cellular bloo…
development of erythrocytes
development of platelets
development of granulocytes
Hemopoiesis/Hematopoiesis
the formation of blood cellular components. All cellular bloo…
Erythropoiesis
development of erythrocytes
49 terms
Histo- Bone Marrow and Hematopoiesis
hematopoiesis
3 stages of hemopoiesis in embryo
where does hemopoiesis occur after bir…
bone marrow
blood cells constantly produced in hematopoietic tissues... -hig…
1. yolk sac phase/mesoblastic- 2nd-3rd week gestation, blood…
red bone marrow & lymphatic tissues... - if bone marrow is damag…
-connective tissue found in the cavity of long bones... -account…
hematopoiesis
blood cells constantly produced in hematopoietic tissues... -hig…
3 stages of hemopoiesis in embryo
1. yolk sac phase/mesoblastic- 2nd-3rd week gestation, blood…
20 terms
bone marrow
hematopoesis
lymphoid cells
myeloid cells
hematopoiesis cell progression
I. Hematopoiesis - a continuous process that replaces the pop…
Those that become commited form either lymphoid or myeloid li…
The myeloid cells will form the erythrocytes, granulocytes, m…
1. stem cell - few in number, but rapidly divide... 2. progenito…
hematopoesis
I. Hematopoiesis - a continuous process that replaces the pop…
lymphoid cells
Those that become commited form either lymphoid or myeloid li…
42 terms
bone marrow histology
hematopoiesis
all cellular blood components derived…
HSCs reside in
all formed elements within blood form…
formation of blood cellular components
hematopoietic stem cells
medella of Bone
Multipotential HSC
hematopoiesis
formation of blood cellular components
all cellular blood components derived…
hematopoietic stem cells
93 terms
Toolbox for Evaluation of Bone Marrow
Morphologic, cytochemical, and immunop…
Cytogenetic and molecular genetic stud…
Various methodologies in diagnosis: Mo…
_______ examination is the cornerstone…
lineage (hematolymphoid vs non-hematolymphoid), maturation (m…
markers, prognosis, targets
immunophenotype, molecular studies
MORPHOLOGIC (important**)
Morphologic, cytochemical, and immunop…
lineage (hematolymphoid vs non-hematolymphoid), maturation (m…
Cytogenetic and molecular genetic stud…
markers, prognosis, targets
Bodacious Bone Marrow
Aplastic Anemia
Pancytopenia
Hemosiderosis
Hypercellular (bone marrow)
pancytopenia due to drug toxicity suppression of bone marrow
decrease in granulocytes, erythrocytes and platelets in blood
systemic acculmulation of iron inclusions within macrophages…
extravascular space of bone marrow >75%
Aplastic Anemia
pancytopenia due to drug toxicity suppression of bone marrow
Pancytopenia
decrease in granulocytes, erythrocytes and platelets in blood
17 terms
Anatomy chp2 pt2: Bone marrow and other defs
Red marrow
Yellow marrow
Cancellous bone
Endosteum
Makes blood cells
fatty tissue
bone that does not have spaces
lines the medullary cavity
Red marrow
Makes blood cells
Yellow marrow
fatty tissue
16 terms
Bone Marrow
bone marrow
Red marrow (myeloid tissue)
Yellow marrow
intramembranous ossification abdendoch…
- general term for soft tissue that occupies the marrow cavit…
- in nearly every bone in a child... - hemopoietic tissue - prod…
found in adults... most red marrow turns into fatty yellow marro…
n the human fetus and infant, bone develops by two methods:
bone marrow
- general term for soft tissue that occupies the marrow cavit…
Red marrow (myeloid tissue)
- in nearly every bone in a child... - hemopoietic tissue - prod…
69 terms
Bone Formation
Skeletal Cartilage
What does skeletal cartilage surround?
Chondrocyte
Chondroblast
-composed mainly of water... -provides resilience and pops back…
well vascularized perichondrium helps hold cartilage in place
adult cartilage cells
blast=baby baby cartilage cells
Skeletal Cartilage
-composed mainly of water... -provides resilience and pops back…
What does skeletal cartilage surround?
well vascularized perichondrium helps hold cartilage in place
17 terms
Anatomy chp2 pt2: Bone marrow and other defs
Red marrow
Yellow marrow
Cancellous bone
Endosteum
Makes blood cells
fatty tissue
bone that does not have spaces
lines the medullary cavity
Red marrow
Makes blood cells
Yellow marrow
fatty tissue
17 terms
Bone Formation
Compact Bone Tissue
Spongy Bone Tissue
Ossification
Intramembranous Ossification
Contains few spaces and is arranged in repeating structural u…
Does not contain osetons, consists of units called Trabeculae…
The process in which bone is formed.
First type of ossification, bone forms in sheet like layers.
Compact Bone Tissue
Contains few spaces and is arranged in repeating structural u…
Spongy Bone Tissue
Does not contain osetons, consists of units called Trabeculae…
49 terms
Blood/Bone Marrow/Hormones/Bone Health
Blood Cell Formation
Yolk Sac
Marrow
Medullary Cavities
-Hemopoiesis or Hematopoiesis; Begins in the yolk sac which l…
-Soft, net-like mass of connective tissue within the medullar…
- Marrow cavity ... - Continuous with the spaces of the spongy b…
Blood Cell Formation
-Hemopoiesis or Hematopoiesis; Begins in the yolk sac which l…
Yolk Sac
28 terms
Blood/Bone Marrow/Hormones/Bone Health
Blood Cell Formation
Yolk Sac
Marrow
Medullary Cavities
-Hemopoiesis or Hematopoiesis; Begins in the yolk sac which l…
-Soft, net-like mass of connective tissue within the medullar…
- Marrow cavity ... - Continuous with the spaces of the spongy b…
Blood Cell Formation
-Hemopoiesis or Hematopoiesis; Begins in the yolk sac which l…
Yolk Sac
35 terms
Hematopoiesis & Bone Marrow
Granulocytes
Types of bone marrow:
Red Bone marrow contains:
What is formed w/in bone marrow?
1) Eosinophils ... 2) Neutrophils... 3) Basophils
1) Red... 2) Yellow
1) Stroma (reticular cells)... 2) blood-forming cords... 3) Endothe…
- Erythrocytes... - Granulocytes... - Monocytes... - Platelets ... - Lymp…
Granulocytes
1) Eosinophils ... 2) Neutrophils... 3) Basophils
Types of bone marrow:
1) Red... 2) Yellow
65 terms
Bone Marrow Overview
Red bone marrow
Yellow bone marrow
At birth...
By age 50...
Blood cell production
Fat
most marrow is producing blood cells
Only about 60% is red marrow, the rest is fatty tissue
Red bone marrow
Blood cell production
Yellow bone marrow
Fat
135 terms
Bone Marrow I
When is a bone marrow evaluation indic…
What are examples of indications for b…
What will cause abnormalities in produ…
T/F: Persistent, poorly regenerative o…
When the routine exam of a blood smear has failed to answer w…
• prolonged peripheral cytopeniass* (very strong reason) or c…
• suppression or destruction of hematopoietic cells (hypoplas…
True. Acute blood loss and regenerative anemias do not.
When is a bone marrow evaluation indic…
When the routine exam of a blood smear has failed to answer w…
What are examples of indications for b…
• prolonged peripheral cytopeniass* (very strong reason) or c…
Histo- Bone Marrow and Hematopoiesis
hematopoiesis
3 stages of hemopoiesis in embryo
where does hemopoiesis occur after bir…
bone marrow
blood cells constantly produced in hematopoietic tissues... -hig…
1. yolk sac phase/mesoblastic- 2nd-3rd week gestation, blood…
red bone marrow & lymphatic tissues... - if bone marrow is damag…
-connective tissue found in the cavity of long bones... -account…
hematopoiesis
blood cells constantly produced in hematopoietic tissues... -hig…
3 stages of hemopoiesis in embryo
1. yolk sac phase/mesoblastic- 2nd-3rd week gestation, blood…
24 terms
Bone formation
What are the two methods of bone forma…
Which method of bone formation is refe…
Which method of bone formation is refe…
Explain the sequence of intramembranou…
1. intramembranous ossification 2. endochondral ossification
intramembranous ossification- because there is no cartilagino…
endochondral ossification- because a cartilaginous template i…
1. mesenchymal cells condense into a connective tissue membra…
What are the two methods of bone forma…
1. intramembranous ossification 2. endochondral ossification
Which method of bone formation is refe…
intramembranous ossification- because there is no cartilagino…
64 terms
Stem Cells and Bone Marrow
Progenitor Cells
Precursor Cells
Myeloid
Stages of maturation of precursor cells
Next step from stem cells. Form colonies when cultured in sem…
Usually a precursor cell is a stem cell which has the capacit…
Blood cells that arise from a progenitor cell for granulocyte…
Myeloblasts -> Proerythrolasts -> Basophilic erythroblasts ->…
Progenitor Cells
Next step from stem cells. Form colonies when cultured in sem…
Precursor Cells
Usually a precursor cell is a stem cell which has the capacit…
11 terms
Bone Cells, Marrow, Cartilage
bone repair process
fibrocartilage
elastic cartilage
hyaline cartilage
injury broken blood vessels; hematoma - invasion of blood ves…
rows of chondrocytes with thick collage fibers; highly compre…
similar to hyaline cartilage, more elastic fibers
fine collagen fibers matrix, most abundant type
bone repair process
injury broken blood vessels; hematoma - invasion of blood ves…
fibrocartilage
rows of chondrocytes with thick collage fibers; highly compre…
12 terms
Bone marrow
spicules
Hypoproliferative disorders: Aplastic…
Hypoproliferative disorders: aplastic…
Hypoproliferative disorders: aplastic…
-bone particles that may contain hematopoeitic precursors
-fat replaces bone marrow
-bone marrow cells <25%... -granulocyte count <0.5x10^9/L... -plate…
-immunosuppression... -deficient stem cells... -problem w/ growth f…
spicules
-bone particles that may contain hematopoeitic precursors
Hypoproliferative disorders: Aplastic…
-fat replaces bone marrow
38 terms
HO3 Bone Marrow
Embryo yolk-sac
Liver and spleen
Extramedullary hematopoiesis
Red bone marrow
Erythropoiesis occurs in blood islands and angiogenic cell cl…
Major site of hematopoiesis from 8-28 weeks gestation
Hematopoiesis generally ceases in liver and spleen around bir…
Major site of hematopoiesis after 28 weeks gestation
Embryo yolk-sac
Erythropoiesis occurs in blood islands and angiogenic cell cl…
Liver and spleen
Major site of hematopoiesis from 8-28 weeks gestation
9 terms
Bone Marrow
bone marrow
red marrow
yellow marrow
mesenchymal
nutrient rich spongey tissue located in long flat bones that…
born with all red marrow, myeloid tissue that creates most bl…
high number of fat cells, converts with age
stem cell found in stroma, supports hematopoietic cells, embr…
bone marrow
nutrient rich spongey tissue located in long flat bones that…
red marrow
born with all red marrow, myeloid tissue that creates most bl…
74 terms
skin and bone formation
uses of skin
epidermis
dermis
hypodermis
1. protective barrier... 2. sensory organ... 3. excretory organ... 4.…
1. stratified squamous epithelium ... 2. keritinized epithelium=…
1. CT w/ collagen and elastic fibers ... 2. has blood vessels, n…
1. subcutaneous fat under the skin ... 2. aka subcutaneous fasci…
uses of skin
1. protective barrier... 2. sensory organ... 3. excretory organ... 4.…
epidermis
1. stratified squamous epithelium ... 2. keritinized epithelium=…
28 terms
Bone Marrow Collection and Evaluation
Bone marrow samples may be collected by:
Red marrow
Yellow marrow
Samples from adults
-Aspiration... or... -Removing a bone marrow core
-Active and highly cellular marrow in young, growing animals
-Cavities of the bones become larger and have increased fat c…
-50% nucleated cells and 50% fat cells
Bone marrow samples may be collected by:
-Aspiration... or... -Removing a bone marrow core
Red marrow
-Active and highly cellular marrow in young, growing animals
microanatomy blood and bone marrow
Define Anisocytosis
central Pallor is_________ and is most…
what is crenation?
what is hematocrit?
variations in size... common in ruminants
pale staining... canine erythrocytes
abnormal notching in edges. most prominent in feline erythroc…
Packed cell volume. packed RBC
Define Anisocytosis
variations in size... common in ruminants
central Pallor is_________ and is most…
pale staining... canine erythrocytes
50 terms
Blood Smear & Bone Marrow (ppt 2)
Named Stages of erythroblastic maturat…
Progression of cell appearance in eryt…
proerythroblast/pronormoblast
basophilic erythroblast/normoblast
After common myeloid progenitor:... 1) proerythroblast/pronormob…
NOTE : as stages progress = chromatin gets more dense, cytopl…
Erythroblastic maturation stage 1... -> open chromatin, large nu…
Erythroblastic maturation stage 2... -> small nucleus
Named Stages of erythroblastic maturat…
After common myeloid progenitor:... 1) proerythroblast/pronormob…
Progression of cell appearance in eryt…
NOTE : as stages progress = chromatin gets more dense, cytopl…
14 terms
Bone Marrow Response Glossary
Pancytopenia
Abnormal growth of cells
Systemic excessive accumulation of iro…
More than 75% of the marrow interstiti…
aplastic anemia
Dysplasia
Hemosiderosis
Hypercellular bone marrow
Pancytopenia
aplastic anemia
Abnormal growth of cells
Dysplasia
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