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Study sets matching "term:myeldysplasia = abnormal formation in bone marrow"

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Study sets matching "term:myeldysplasia = abnormal formation in bone marrow"

33 terms
Bone Marrow and Blood Cell Formation
Hematopoiesis
Red marrow
Yellow marrow
Hemopoietic stem cell
Process by which blood cells are formed
Actively generates new blood cells, in adults found in proxim…
Dormant marrow, contains many fat cells, located in most of t…
Most undifferentiated blood stem cell, gives rise to two prog…
Hematopoiesis
Process by which blood cells are formed
Red marrow
Actively generates new blood cells, in adults found in proxim…
28 terms
bone marrow and blood cell formation
hematopoietic cell compartments in bon…
basic blood cell differentiation from…
how does a limited number of HSCs prov…
myelopoiesis
<0.1% hematopoietic stem cells (HSCs marked with CD34+s) = a…
Hematopoietic stem cell (HSC pluripotent) --> common myeloid…
self renewal through asymmetric divison
myeloblast (inside bone marrow) --> --> --> band (peripheral…
hematopoietic cell compartments in bon…
<0.1% hematopoietic stem cells (HSCs marked with CD34+s) = a…
basic blood cell differentiation from…
Hematopoietic stem cell (HSC pluripotent) --> common myeloid…
9 terms
Anatomy Ch 2: Bone Growth, Bone Formation, and Abnormal Bone Growth and Development
Appositional Bone Growth
Endochondral Ossification
Intramembrous Ossification
Pituitary Growth Failure
Increases the diameter of existing bones; osteoprogenitor cel…
Forms most of the bones in the skeleton; how bones grow in le…
Forms spongey bone initially, later remodeled to make compact…
Reduction in growth hormone that leads to shorter bones
Appositional Bone Growth
Increases the diameter of existing bones; osteoprogenitor cel…
Endochondral Ossification
Forms most of the bones in the skeleton; how bones grow in le…
16 terms
Bone Formation
Compact Bone Tissue
Spongy Bone Tissue
Ossification
Intramembranous Ossification
Contains few spaces and is arranged in repeating structural u…
Does not contain osetons, consists of units called Trabeculae…
The process in which bone is formed.
First type of ossification, bone forms in sheet like layers.
Compact Bone Tissue
Contains few spaces and is arranged in repeating structural u…
Spongy Bone Tissue
Does not contain osetons, consists of units called Trabeculae…
26 terms
Blood and bone marrow
Erythrocytes
T-lymphocytes
B-lymphocytes
Monocytes
-7um... -No nucleus... -Carry oxygen to tissues via hemoglobin
-10um... -Few azurophilic granules... -Generate cell-mediated immun…
-10um... -Few azurophilic granules... -Generate humoral immune resp…
-15um... -Many azurophilic granules... -Become macrophages in conne…
Erythrocytes
-7um... -No nucleus... -Carry oxygen to tissues via hemoglobin
T-lymphocytes
-10um... -Few azurophilic granules... -Generate cell-mediated immun…
Bone Formation
Ossification or Osteogenesis
Intramembranous Ossification
Endrochondrial Ossification
Growth in Length - Epiphyseal plate... o…
The process by which bone is formed... All embryonic connective…
Forms flat bone's like the skull - bone forms directly within…
Mesenchyme first becomes hyaline cartilage that is then repla…
Cartilage cells are produced by mitosis on the epiphyseal sid…
Ossification or Osteogenesis
The process by which bone is formed... All embryonic connective…
Intramembranous Ossification
Forms flat bone's like the skull - bone forms directly within…
31 terms
Bone marrow
What germ layer is blood derived from?
Describe fetal hematopoiesis
What are the functions of bone marrow?
Describe the monophyletic theory of he…
Blood is a specialized connective tissue derived from extraem…
-Liver produces granulocytes, platelets, and definitive eryth…
-Hematopoiesis... -Part of reticulo-endothelial system... -macroph…
-Blood cells derived from single pluripotent stem cell... Note:…
What germ layer is blood derived from?
Blood is a specialized connective tissue derived from extraem…
Describe fetal hematopoiesis
-Liver produces granulocytes, platelets, and definitive eryth…
14 terms
Bone Marrow
Selective erythroid hypoplasia
Selective myeloid hypoplasia
Selective megakaryocytic hypoplasia
Ehlichiosis and leukemias
Erythroid precursors are decreased but the granulocytic and m…
Decreased neutrophils in the bone marrow but the erythroid an…
Decreased megakaryocytes but normal numbers of erythroid and…
What is the classic causes of bone marrow lymphocytosis?
Selective erythroid hypoplasia
Erythroid precursors are decreased but the granulocytic and m…
Selective myeloid hypoplasia
Decreased neutrophils in the bone marrow but the erythroid an…
25 terms
Tollon- bone marrow
What causes hypocalcemia?
What causes hypercalcemia?
Metastasis means what?
What kind of patients are bone marrow…
Eclampsia ... Milk fever
Metastatic neoplasia
Spreading
Cancer patients
What causes hypocalcemia?
Eclampsia ... Milk fever
What causes hypercalcemia?
Metastatic neoplasia
18 terms
Bone marrow
Percent of active bone marrow in newbo…
Percent of active bone marrow in young…
Percent of active bone marrow in older…
What is the definition of bone marrow…
80-90%
60%
40% active bone marrow... 60% fat
The ratio of marrow cells to fat, red marrow & yellow marrow…
Percent of active bone marrow in newbo…
80-90%
Percent of active bone marrow in young…
60%
Blood and Bone Marrow Histology
Neutrophil appearance
Lymphocyte appearance
Basophil appearance
Monocyte appearance
3-5 lobed nuclei, 2nd most abundant white blood cell, granule…
Only a little bigger than RBC (which is 7-8 um), 90% of cell…
Purple granules, may barely see nucleus (bilobed), about twic…
18 um (2-3 times bigger than RBC), big kidney-shaped nucleus,…
Neutrophil appearance
3-5 lobed nuclei, 2nd most abundant white blood cell, granule…
Lymphocyte appearance
Only a little bigger than RBC (which is 7-8 um), 90% of cell…
17 terms
Bone Formation
Ossification or Osteogenesis
Intramembranous Ossification
Endrochondrial Ossification
Growth in Length - Epiphyseal plate... o…
The process by which bone is formed... All embryonic connective…
Forms flat bone's like the skull - bone forms directly within…
Mesenchyme first becomes hyaline cartilage that is then repla…
Cartilage cells are produced by mitosis on the epiphyseal sid…
Ossification or Osteogenesis
The process by which bone is formed... All embryonic connective…
Intramembranous Ossification
Forms flat bone's like the skull - bone forms directly within…
65 terms
Bone Marrow Overview
Red bone marrow
Yellow bone marrow
At birth...
By age 50...
Blood cell production
Fat
most marrow is producing blood cells
Only about 60% is red marrow, the rest is fatty tissue
Red bone marrow
Blood cell production
Yellow bone marrow
Fat
57 terms
Bone Formation
Osteocytes
Osteoblasts
Osteoclasts
Ossification
Bone Cell
Form new bone
Break down old or damaged area of bones
Process by which cartilaginous tissue is changed into bone fr…
Osteocytes
Bone Cell
Osteoblasts
Form new bone
19 terms
Bone Marrow
Why do we do a Bone Marrow?
Abnormal PB Findings - for a BM proced…
Sites for BM Aspiration - Adult
Sites for BM Aspiration - Infant
a. Hematologic disorders: Diagnosis and staging; Follow up ... b…
a. Pancytopenia ... b. Leukopenia ... c. Anemia ... d. Thrombocytopeni…
a. Most Common: posterior iliac crest ... b. Others: ... i. Sternu…
a. Most Common: Tibia ... b. Others: Anterior or posterior ilia…
Why do we do a Bone Marrow?
a. Hematologic disorders: Diagnosis and staging; Follow up ... b…
Abnormal PB Findings - for a BM proced…
a. Pancytopenia ... b. Leukopenia ... c. Anemia ... d. Thrombocytopeni…
13 terms
Bone Marrow
How many blood cells are produced per…
Red bone marrow vs. yellow bone marrow…
Structure of bone marrow and how does…
Role of stromal cells
- 200 billion RBCs produced/day... - 10 billion WBCs... - 400 billi…
- Red: active in hematopoiesis... - Yellow: fatty marrow, inacti…
- BLood reaches the marrow via arteries which traverse the bo…
- Reticular cells, adipocytes, macrophages... - Secrete cytokine…
How many blood cells are produced per…
- 200 billion RBCs produced/day... - 10 billion WBCs... - 400 billi…
Red bone marrow vs. yellow bone marrow…
- Red: active in hematopoiesis... - Yellow: fatty marrow, inacti…
54 terms
Bone formation
which secondary center of ossification…
Two mechanisms Bone Formation
Locations of bone formation... 2
mesenchyme
the one in the proximal epiphysis ... shortly after the distal…
1. Intramembranous... 2. encondrondral
1. Membrane mesenchym= intramemranous ossification... 2. Hyalin…
embyotic connective tissue
which secondary center of ossification…
the one in the proximal epiphysis ... shortly after the distal…
Two mechanisms Bone Formation
1. Intramembranous... 2. encondrondral
137 terms
Bone Marrow
When is a bone marrow evaluation indic…
What are the main indications to perfo…
What will cause abnormalities in produ…
T/F: Persistent, poorly regenerative o…
When the routine exam of a blood smear has failed to answer w…
• prolonged peripheral cytopeniass* (very strong reason) or c…
• suppression or destruction of hematopoietic cells (hypoplas…
True. Acute blood loss and regenerative anemias do not require.
When is a bone marrow evaluation indic…
When the routine exam of a blood smear has failed to answer w…
What are the main indications to perfo…
• prolonged peripheral cytopeniass* (very strong reason) or c…
19 terms
MedTerm Chapter 6: Diagnostic Terms
acquired immunodeficiency syndrome (AI…
anemia
aplastic anmeia
iron deficiency anmeia
a syndrome caused by the human immunodeficiency virus (HIV) t…
a condition of reduced numbers of RBC, hemoglobin, or packed…
a normocytic-normocromic type of anemia characterized by the…
a microcytic-hypochromic type of anemia characterized by a la…
acquired immunodeficiency syndrome (AI…
a syndrome caused by the human immunodeficiency virus (HIV) t…
anemia
a condition of reduced numbers of RBC, hemoglobin, or packed…
36 terms
Bone Marrow Analysis
% cellularity
14-15
anteriomedial surface of tibia
anterior iliac crest
? = 100-age
how many pounds of red marrow does an adult have?
what is the preferred site for bone marrow collection in chil…
what is the preferred site for bone marrow collection in adul…
% cellularity
? = 100-age
14-15
how many pounds of red marrow does an adult have?
27 terms
Anatomy of a Bone
epiphysis
diaphysis
epiphyseal line
spongy bone
the end part of a long bone, initially growing separately fro…
the shaft or central part of a long bone.
also known as the growth plate
Also called cancellous bone.
epiphysis
the end part of a long bone, initially growing separately fro…
diaphysis
the shaft or central part of a long bone.
17 terms
Anatomy chp2 pt2: Bone marrow and other defs
Red marrow
Yellow marrow
Cancellous bone
Endosteum
Makes blood cells
fatty tissue
bone that does not have spaces
lines the medullary cavity
Red marrow
Makes blood cells
Yellow marrow
fatty tissue
17 terms
Anatomy chp2 pt2: Bone marrow and other defs
Red marrow
Yellow marrow
Cancellous bone
Endosteum
Makes blood cells
fatty tissue
bone that does not have spaces
lines the medullary cavity
Red marrow
Makes blood cells
Yellow marrow
fatty tissue
26 terms
Bone Marrow and Hemopoiesis
Red Marrow Space
Vascular Sinusoids
REticular cells
Hemopoietic Compartments
lined by endosteum and composed of vascular sinusoids, hemopo…
located in the blood circulation between arterioles and venul…
extend sheet-like fibers into hemopoietic compartments to hel…
lie between sinusoids or between bone and sinusoids; they con…
Red Marrow Space
lined by endosteum and composed of vascular sinusoids, hemopo…
Vascular Sinusoids
located in the blood circulation between arterioles and venul…
87 terms
Hemopoiesis and Bone Marrow
Hemopoiesis/Hematopoiesis
Erythropoiesis
Thrombopoiesis
Granulopoiesis
the formation of blood cellular components. All cellular bloo…
development of erythrocytes
development of platelets
development of granulocytes
Hemopoiesis/Hematopoiesis
the formation of blood cellular components. All cellular bloo…
Erythropoiesis
development of erythrocytes
93 terms
Toolbox for Evaluation of Bone Marrow
Morphologic, cytochemical, and immunop…
Cytogenetic and molecular genetic stud…
Various methodologies in diagnosis: Mo…
_______ examination is the cornerstone…
lineage (hematolymphoid vs non-hematolymphoid), maturation (m…
markers, prognosis, targets
immunophenotype, molecular studies
MORPHOLOGIC (important**)
Morphologic, cytochemical, and immunop…
lineage (hematolymphoid vs non-hematolymphoid), maturation (m…
Cytogenetic and molecular genetic stud…
markers, prognosis, targets
11 terms
Bone marrow cells
Cellularity of sample
Erythroids
Granulocytic cells
Lymphocytes marrow
- Evaluate the cells versus fat ratio... - If more than 75% cell…
- Erythroids are smaller, more spherical and have condensed n…
- Larger, paler cells are usually granulocyte precursors... - Nu…
- High numbers indicate neoplastic leukemias
Cellularity of sample
- Evaluate the cells versus fat ratio... - If more than 75% cell…
Erythroids
- Erythroids are smaller, more spherical and have condensed n…
24 terms
Bone Marrow
Hematopoiesis
When evaluate Bone Marrow
Purpose of Bone Marrow Analysis
Adult Bone Marrow
Formation and development of blood cells in the bone marrow
When see unexplained, abnormal results in peripheral blood.... T…
To identify underlying marrow cellular, abnormalities
50% Nucleated Cells & 50% Fat Cells
Hematopoiesis
Formation and development of blood cells in the bone marrow
When evaluate Bone Marrow
When see unexplained, abnormal results in peripheral blood.... T…
17 terms
Bone Formation
Compact Bone Tissue
Spongy Bone Tissue
Ossification
Intramembranous Ossification
Contains few spaces and is arranged in repeating structural u…
Does not contain osetons, consists of units called Trabeculae…
The process in which bone is formed.
First type of ossification, bone forms in sheet like layers.
Compact Bone Tissue
Contains few spaces and is arranged in repeating structural u…
Spongy Bone Tissue
Does not contain osetons, consists of units called Trabeculae…
49 terms
Blood/Bone Marrow/Hormones/Bone Health
Blood Cell Formation
Yolk Sac
Marrow
Medullary Cavities
-Hemopoiesis or Hematopoiesis; Begins in the yolk sac which l…
-Soft, net-like mass of connective tissue within the medullar…
- Marrow cavity ... - Continuous with the spaces of the spongy b…
Blood Cell Formation
-Hemopoiesis or Hematopoiesis; Begins in the yolk sac which l…
Yolk Sac
28 terms
Blood/Bone Marrow/Hormones/Bone Health
Blood Cell Formation
Yolk Sac
Marrow
Medullary Cavities
-Hemopoiesis or Hematopoiesis; Begins in the yolk sac which l…
-Soft, net-like mass of connective tissue within the medullar…
- Marrow cavity ... - Continuous with the spaces of the spongy b…
Blood Cell Formation
-Hemopoiesis or Hematopoiesis; Begins in the yolk sac which l…
Yolk Sac
19 terms
Ch. 6- Diagnostic Terms
acquired immunodeficiency syndrome (AI…
anemia
aplastic anemia
iron deficiency anemia
a syndrome caused by the human immunodeficiency virus (HIV) t…
a condition of reduced number of red blood cells, hemoglobin,…
a normocytic- normochromic type of anemia characterized by th…
a microcytic- hypochromic type of anemia characterized by a l…
acquired immunodeficiency syndrome (AI…
a syndrome caused by the human immunodeficiency virus (HIV) t…
anemia
a condition of reduced number of red blood cells, hemoglobin,…
37 terms
Bone Tissue
Osteo...
Functions of Skeleton
Bones form using...
Mineralization/calcification
Related to bones
Support, Protection, Movement, Electrolyte balance, Acid-Base…
metals (Calcium, Magnesium)
Hardening process of osseous tissue through the deposition of…
Osteo...
Related to bones
Functions of Skeleton
Support, Protection, Movement, Electrolyte balance, Acid-Base…
11 terms
Histo Lab 7: Bone Formation and Joints
Osteon
Marrow
Periosteum
Osteoclast
Complex of concentric lamellae surrounding a small central ca…
Soft fatty substance in the cavities of bones, in which blood…
Layer of dense connective tissue on the outer surface of bone…
Very large cell formed by fusion of several blood monocytes w…
Osteon
Complex of concentric lamellae surrounding a small central ca…
Marrow
Soft fatty substance in the cavities of bones, in which blood…
34 terms
Skeletal System_Bone Composition & Formation
Articular cartilage
Cortical bone
Diaphysis
Epiphyseal plate
Covers the ends of the epiphyses; Provides a smooth, slippery…
Dense, outer surface of most bones, shafts of long bones, and…
Shaft of long bone.
Growth Plate
Articular cartilage
Covers the ends of the epiphyses; Provides a smooth, slippery…
Cortical bone
Dense, outer surface of most bones, shafts of long bones, and…
microanatomy blood and bone marrow
Define Anisocytosis
central Pallor is_________ and is most…
what is crenation?
what is hematocrit?
variations in size... common in ruminants
pale staining... canine erythrocytes
abnormal notching in edges. most prominent in feline erythroc…
Packed cell volume. packed RBC
Define Anisocytosis
variations in size... common in ruminants
central Pallor is_________ and is most…
pale staining... canine erythrocytes
35 terms
Hematopoiesis & Bone Marrow
Granulocytes
Types of bone marrow:
Red Bone marrow contains:
What is formed w/in bone marrow?
1) Eosinophils ... 2) Neutrophils... 3) Basophils
1) Red... 2) Yellow
1) Stroma (reticular cells)... 2) blood-forming cords... 3) Endothe…
- Erythrocytes... - Granulocytes... - Monocytes... - Platelets ... - Lymp…
Granulocytes
1) Eosinophils ... 2) Neutrophils... 3) Basophils
Types of bone marrow:
1) Red... 2) Yellow
135 terms
Bone Marrow I
When is a bone marrow evaluation indic…
What are examples of indications for b…
What will cause abnormalities in produ…
T/F: Persistent, poorly regenerative o…
When the routine exam of a blood smear has failed to answer w…
• prolonged peripheral cytopeniass* (very strong reason) or c…
• suppression or destruction of hematopoietic cells (hypoplas…
True. Acute blood loss and regenerative anemias do not.
When is a bone marrow evaluation indic…
When the routine exam of a blood smear has failed to answer w…
What are examples of indications for b…
• prolonged peripheral cytopeniass* (very strong reason) or c…
Bone Tissue
long bone
short bone
flat bone
irregular bone
typically as long as they are wide; mostly compact bone; exam…
generally cubed shape; contain mostly spongy bone; examples a…
thin, flattened, usually curved bones; found in areas of prot…
bones that do not fit into any other classification of bone;…
long bone
typically as long as they are wide; mostly compact bone; exam…
short bone
generally cubed shape; contain mostly spongy bone; examples a…
22 terms
Bone Classification and Formation
Osteoblast
Osteoclast
Osteocyte
Epiphysis
Bone forming cells... Can become an osteocyte if buried
Bone removal... Breaks down calcified extracellular matrix by... di…
Result from osteoblast surrounded my extracellular matrix... Sig…
The ends of the long bone
Osteoblast
Bone forming cells... Can become an osteocyte if buried
Osteoclast
Bone removal... Breaks down calcified extracellular matrix by... di…
42 terms
bone marrow histology
hematopoiesis
all cellular blood components derived…
HSCs reside in
all formed elements within blood form…
formation of blood cellular components
hematopoietic stem cells
medella of Bone
Multipotential HSC
hematopoiesis
formation of blood cellular components
all cellular blood components derived…
hematopoietic stem cells
24 terms
Bone formation
What are the two methods of bone forma…
Which method of bone formation is refe…
Which method of bone formation is refe…
Explain the sequence of intramembranou…
1. intramembranous ossification 2. endochondral ossification
intramembranous ossification- because there is no cartilagino…
endochondral ossification- because a cartilaginous template i…
1. mesenchymal cells condense into a connective tissue membra…
What are the two methods of bone forma…
1. intramembranous ossification 2. endochondral ossification
Which method of bone formation is refe…
intramembranous ossification- because there is no cartilagino…
11 terms
Parts of a Long Bone
Diaphysis
Epiphysis
Articular Cartilage
Periosteum
Long main portion of a bone
End of a long bone
Covers end of bones to prevent friction
A dense fibrous membrane covering the surface of bones (excep…
Diaphysis
Long main portion of a bone
Epiphysis
End of a long bone
38 terms
HO3 Bone Marrow
Embryo yolk-sac
Liver and spleen
Extramedullary hematopoiesis
Red bone marrow
Erythropoiesis occurs in blood islands and angiogenic cell cl…
Major site of hematopoiesis from 8-28 weeks gestation
Hematopoiesis generally ceases in liver and spleen around bir…
Major site of hematopoiesis after 28 weeks gestation
Embryo yolk-sac
Erythropoiesis occurs in blood islands and angiogenic cell cl…
Liver and spleen
Major site of hematopoiesis from 8-28 weeks gestation
64 terms
Stem Cells and Bone Marrow
Progenitor Cells
Precursor Cells
Myeloid
Stages of maturation of precursor cells
Next step from stem cells. Form colonies when cultured in sem…
Usually a precursor cell is a stem cell which has the capacit…
Blood cells that arise from a progenitor cell for granulocyte…
Myeloblasts -> Proerythrolasts -> Basophilic erythroblasts ->…
Progenitor Cells
Next step from stem cells. Form colonies when cultured in sem…
Precursor Cells
Usually a precursor cell is a stem cell which has the capacit…
11 terms
Bodacious Bone Marrow
Aplastic Anemia
Pancytopenia
Hemosiderosis
Hypercellular (bone marrow)
pancytopenia due to drug toxicity suppression of bone marrow
decrease in granulocytes, erythrocytes and platelets in blood
systemic acculmulation of iron inclusions within macrophages…
extravascular space of bone marrow >75%
Aplastic Anemia
pancytopenia due to drug toxicity suppression of bone marrow
Pancytopenia
decrease in granulocytes, erythrocytes and platelets in blood
23 terms
Chapter 11 Patho "Diseases of Blood Cells and Blood Coagulation"
Microcytic
Hypochromatic
Hyperspleenism
Spleenomegaly
small RBC's
small amount of pigment (pale RBC's)
spleen becomes increasingly active and then rapidly removes t…
abnormal enlargement of the spleen
Microcytic
small RBC's
Hypochromatic
small amount of pigment (pale RBC's)
74 terms
skin and bone formation
uses of skin
epidermis
dermis
hypodermis
1. protective barrier... 2. sensory organ... 3. excretory organ... 4.…
1. stratified squamous epithelium ... 2. keritinized epithelium=…
1. CT w/ collagen and elastic fibers ... 2. has blood vessels, n…
1. subcutaneous fat under the skin ... 2. aka subcutaneous fasci…
uses of skin
1. protective barrier... 2. sensory organ... 3. excretory organ... 4.…
epidermis
1. stratified squamous epithelium ... 2. keritinized epithelium=…
56 terms
Microscopic Bone
Hyaline cartilage
Elastic cartilage
Fibrocartilage
axial skeleton
cartilage covering ends of long bones, makes up rib cage, end…
found in ears and epiglottis
cartilage that resists compression, found in menisci of knees…
bones connected to vertebrae
Hyaline cartilage
cartilage covering ends of long bones, makes up rib cage, end…
Elastic cartilage
found in ears and epiglottis
33 terms
Bones Shapes and Long Bone Anatomy
Diaphysis
Medullary cavity
Epiphysis (plural = epiphyses)
Articular Cartilage
Diaphysis
Medullary cavity
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