Study sets matching "term:plasma cells = cells that develop from b cells and produce antibodies."

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Study sets matching "term:plasma cells = cells that develop from b cells and produce antibodies."

31 terms
B cells and antibodies
Fc and Fab regions of antibody
Regions of antibody that interact with…
Affinity
Avidity
Vh and Vl chains
strength of binding between a single binding site and a singl…
Strength of binding between a molecule and a complex ligand.
Fc and Fab regions of antibody
Regions of antibody that interact with…
Vh and Vl chains
92 terms
Immunology Chapter 9: Immunity mediated by B cells and Antibodies
Principle role of antibodies
Coating a bacterium with IgG does what?
Coating a bacterium with IgE does what?
neutralization
to bind to the pathogen using the variable regions and to com…
coating a bacterium with IgG promotes it uptake and destructi…
coating a bacterium by IgE activates mast cells to induce vio…
the mechanism by which antibodies binding to sites on pathoge…
Principle role of antibodies
to bind to the pathogen using the variable regions and to com…
Coating a bacterium with IgG does what?
coating a bacterium with IgG promotes it uptake and destructi…
b cells and plasma cells
lymphocyte that matures in bone marrow…
antibody-producing machine, produce la…
lymphocytes (b cells and t cells) deve…
process of differentiation
b cells
plasma cells
stem; red bone marrow
become t and b cells
lymphocyte that matures in bone marrow…
b cells
antibody-producing machine, produce la…
plasma cells
26 terms
Antibodies and Cell fractionation
Antibodies are carried in the cell mem…
Use of Immunocytochemistry
When antigen binds to this receptor, t…
Antibodies are made by a class of ____…
B lymphocytes... Blood
Immunostaining
B cell
White
Antibodies are carried in the cell mem…
B lymphocytes... Blood
Use of Immunocytochemistry
Immunostaining
8 terms
B Cells
B Lymphocyte
Macrophage
Clonal Selection
Antibody
WBC that forms and mature in the bone marrow and release anti…
Found within the lymph nodes, they are phagocytes that destro…
Production of a clone of cells from a single lymphocyte
Protein produced by B-cells that has a specific shape complem…
B Lymphocyte
WBC that forms and mature in the bone marrow and release anti…
Macrophage
Found within the lymph nodes, they are phagocytes that destro…
B cells and antibodies
arise from stem cells in bone marrow
CD19, CD20
part of humoral response and different…
clock face chromatin
B cells
B cell surface markers
B cells
plasma cells
arise from stem cells in bone marrow
B cells
CD19, CD20
B cell surface markers
80 terms
B cells and Antibodies
What in the serum protects you from in…
How many antibodies are in your body?
Antibody structure
The tips of the VH and VL (variable) c…
serum proteins only
greater than 10^9
antigens
What in the serum protects you from in…
serum proteins only
How many antibodies are in your body?
greater than 10^9
77 terms
GD 47 Plasma Cell Disorders dyscrasias
Maturation process of lymphoid cells
Plasma cell
Where are plasma cells usually found?
difference between plasma cells and B…
1) common lymphoid progenitor in bone marrow... 2) small lymphoc…
mature B lymphocyte that is specialized for antibody (immunog…
Plasma cells are rarely found in the peripheral blood. They c…
B cells mature into plasma cells
Maturation process of lymphoid cells
1) common lymphoid progenitor in bone marrow... 2) small lymphoc…
Plasma cell
mature B lymphocyte that is specialized for antibody (immunog…
cells
plasma membrane
nucleus
cell wall
mitochondria
A flexible boundary that controls the movement of substances…
A cell structure that contains nucleic acids, the chemical in…
This is a thick outer layer in plant cells made of cellulose.
Cell organelle in both plants and animals that converts the e…
plasma membrane
A flexible boundary that controls the movement of substances…
nucleus
A cell structure that contains nucleic acids, the chemical in…
46 terms
BHD - Immunology, B Cells & Antibodies (Chap 3)
Adaptive Immune System
B-cell
B-Cell Receptor (BCR)
BCR development details
Mutations in microbes such as bacteria and viruses can change…
B cells are born in the bone marrow, where they are descended…
The BCR is made up of two kinds of proteins:... 1. heavy chain…
The gene segments that will be chosen to make up the final Hc…
Adaptive Immune System
Mutations in microbes such as bacteria and viruses can change…
B-cell
B cells are born in the bone marrow, where they are descended…
8 terms
B Cells
Antigen presenting cell
B cell
Lymphocyte
Mitosis
These cells engulf pathogens and present fragments of these a…
Cells manufactured in the bone marrow that create antibodies…
The two types of white blood cells that are part of the body'…
Cell's division. Final product is 2 cells that are exactly li…
Antigen presenting cell
These cells engulf pathogens and present fragments of these a…
B cell
Cells manufactured in the bone marrow that create antibodies…
76 terms
Antibody Structure and the Generation of B-cell diversity
Antibodies
Antibodies produced by
Antibodies are a major component of
Antibodies bind to
are the secreted form of glycoproteins known generally as imm…
B lymphocytes in response to infection
plasma in the blood and lymph
pathogenic microorganisms and their toxins in extracellular s…
Antibodies
are the secreted form of glycoproteins known generally as imm…
Antibodies produced by
B lymphocytes in response to infection
44 terms
B cells and antibodies
Antibodies have how many binding sites…
Variable region of antibody is associa…
Constant region is associated with whi…
Naive B cells expression which classes…
2 antigen binding sites
N terminus
C terminus
IgD, IgM
Antibodies have how many binding sites…
2 antigen binding sites
Variable region of antibody is associa…
N terminus
Antibodies produced by B cells
What are the 5 antibodies produced by…
Most abundant
Crosses placenta part of primary secon…
Protects mucosal surfaces from pathogens
IgG... A... M... E... D
G
G
A
What are the 5 antibodies produced by…
IgG... A... M... E... D
Most abundant
G
9 terms
T cells and B cells
originates in bone marrow from hemocyt…
progeny are plasma cells
progeny include suppressors, helpers,…
progeny include memory cells
T and B cells
B cells
T cells
T and B cells
originates in bone marrow from hemocyt…
T and B cells
progeny are plasma cells
B cells
31 terms
L3 - B cell development and the structure of antibodies
Describe the innate immune system.
Describe the adaptive immune system.
Describe the immune response leading t…
What are antibodies?
• Present in earlier organisms ... • Relies on receptors and mol…
• Only present in higher vertebrates ... • Relies on unique rece…
• Proteins secreted by activated B cells (plasma cells), the…
Describe the innate immune system.
• Present in earlier organisms ... • Relies on receptors and mol…
Describe the adaptive immune system.
• Only present in higher vertebrates ... • Relies on unique rece…
16 terms
B and T cells
T lymphocyte
Antibody
Clonal selection
Antigen Presenting Cell
Lymphocytes that maturein the thymus and are responsible for…
Protein produced by B-cells that has a specific shape complem…
Production of a clone of cells from a single lymphocyte
Cells that ingest bacteria and viruses and destroy them, pres…
T lymphocyte
Lymphocytes that maturein the thymus and are responsible for…
Antibody
Protein produced by B-cells that has a specific shape complem…
40 terms
Lecture 4: B Cell Development and Clinical Applications
B Cell Primary Lymphoid Organ
T Cell Primary Lymphoid Organ
What happens in primary lymphoid organs?
RAG
Bone Marrow
Thymus
Lymphocytes develop and express their antigen-specific recept…
Recombination-Activating Gene... Critical for the development o…
B Cell Primary Lymphoid Organ
Bone Marrow
T Cell Primary Lymphoid Organ
Thymus
B Cells and Antibodies
Do all animals have adaptive immunity?
What makes up cell-mediated immunity?…
What makes up humoral response? What i…
What modulates the immune system throu…
no ... only jawed vertebrates (Ig, TCR, MHC)... variable lymphocyte…
T cells, NK cells... direct killing of cells with foreign antige…
B cells, plasma cells... make antigen specific soluble molecules…
B cells, T cells, NK cells, innate lymphocytes... modulate immun…
Do all animals have adaptive immunity?
no ... only jawed vertebrates (Ig, TCR, MHC)... variable lymphocyte…
What makes up cell-mediated immunity?…
T cells, NK cells... direct killing of cells with foreign antige…
Immunity Mediated by B Cells and Antibodies: Chapter 9
What are the two major functions of An…
How many CDR loops on an Ig molecule?
What part of the Ig molecule is respon…
What is cross linking (clustering)
Opsonize: Tag antigen for destruction (Phagocytosis or classi…
6... 3 CDR loops on each Fab variable region (arms) and there ar…
Fc
Many copies of the same transmembrane receptor on the surface…
What are the two major functions of An…
Opsonize: Tag antigen for destruction (Phagocytosis or classi…
How many CDR loops on an Ig molecule?
6... 3 CDR loops on each Fab variable region (arms) and there ar…
32 terms
Ch-9 Immunity Mediated by B cells and Antibodies
Naive B cell activation threshold
Where B cell response happens?
1st signal required for B cell responses
After it binds to antigen
When multiple immunoglobulin signaling complexes are engaged…
lymph node and spleen
Antigen... -present often in soluble form... -can be also in outsid…
phosph relay system leads to signal transduction
Naive B cell activation threshold
When multiple immunoglobulin signaling complexes are engaged…
Where B cell response happens?
lymph node and spleen
33 terms
B Cells & Antibodies
This term implies a chemical description
Strength of a single antibody-antigen…
Antibodies made by a single clone of p…
Each person has _________ of _________…
glycoprotein
affinity
monoclonal
millions, different
This term implies a chemical description
glycoprotein
Strength of a single antibody-antigen…
affinity
65 terms
Immunology Exam 2 Lecture 5- Immunity mediated by B cells and Antibodies
What must happen for a B cell to becom…
CD19
T-dependent antibody responses by B ce…
Which CD4+ T cell subset is involved i…
surface AB on the B cell must be cross-linked with its specif…
co-receptor for B cells involved in co-stimulatory signal
involves CD4+ TH2 T cells ... required for the MAJORITY of AB re…
TH2
What must happen for a B cell to becom…
surface AB on the B cell must be cross-linked with its specif…
CD19
co-receptor for B cells involved in co-stimulatory signal
17 terms
Immunity Mediated by B Cells and Antibodies part 1
How antibodies work
Competing requirements for antibody re…
What happens when B cell receptors are…
How the B cell lowers the activation t…
-neutralize pathogens: by blocking molecules necessary for in…
-speed: IgM are made quickly and provide fast defense ... -quali…
-ITAMs become phosphorylated on the tails of Ig(alpha) and Ig…
-by interactions of complement fragments with co-receptors by…
How antibodies work
-neutralize pathogens: by blocking molecules necessary for in…
Competing requirements for antibody re…
-speed: IgM are made quickly and provide fast defense ... -quali…
Cell Signaling-35.2
Lymphocytes-35.2
Thymus-35.2
T Cells and B Cells-35.2
Antigen Receptor-35.2
type of white blood cells
organ in thoracic cavity above the heart
T cells are the lymphocytes that mature in thymus and B cells…
specific enough to bind to just one part of one molecule from…
Lymphocytes-35.2
type of white blood cells
Thymus-35.2
organ in thoracic cavity above the heart
B cell Development
B cell development occurs in _____
in this stage of B cell development ... V…
in this stage of B cell development... re…
this type of cell______ is non lymphoi…
Test 100... bone marrow
pro- B cell
** Test Pre- B cell
stromal cell
B cell development occurs in _____
Test 100... bone marrow
in this stage of B cell development ... V…
pro- B cell
6 terms
T and B cells
Helper T cells
Suppressor T cells
Killer T cells
Memory T cells
Stimulate the production of antibodies by B cells
Inhibit function of T and B cells
Lymphocytes that use enzymes to destroy the cell membranes of…
long-lived antigen-specific T cells that are activated in sec…
Helper T cells
Stimulate the production of antibodies by B cells
Suppressor T cells
Inhibit function of T and B cells
107 terms
Chapter 9 Immunology: Immunity Mediated by B cells and Antibodies
B lymphocytes recognize
Recognition stimulates
Proliferation and differentation
B lymphocytes generally require
extracellular pathogens and toxins transported to secondary l…
proliferation and differentiation
plasma cells and memory B cells
help from activated T lymphocytes for differentiation into pl…
B lymphocytes recognize
extracellular pathogens and toxins transported to secondary l…
Recognition stimulates
proliferation and differentiation
HUBS191- Immune system: Cells and Antibodies
B cell
Bone marrow
IgD or monomeric IgM
Activates
The antibody-generating lymphocyte cell of the adaptive immun…
Where B cells develop
The two types of unique receptors that each B cell can display
Once the B cell binds to its antigen it...
B cell
The antibody-generating lymphocyte cell of the adaptive immun…
Bone marrow
Where B cells develop
24 terms
B Cell Development
Lymphocyte-releated tumors tend to ori…
Treatment of lymphoma depends on
B cell development begins in
Phase 1 goal
One cell
Stage of development and cell type
Bone marrow
Produce a functional B cell receptor with heavy and light cha…
Lymphocyte-releated tumors tend to ori…
One cell
Treatment of lymphoma depends on
Stage of development and cell type
76 terms
LCCW Cell Physiology: Lecture 7-10
Integral proteins
Functions of Integral Proteins
Peripheral Proteins
Functions of Peripheral Proteins
Transmembrabe proteins that span the entire membrane protrudi…
Channels, carriers or receptors
A network of filaments that help support the membrane from it…
Enzymes, motor proteins, and some link two cells together
Integral proteins
Transmembrabe proteins that span the entire membrane protrudi…
Functions of Integral Proteins
Channels, carriers or receptors
9 terms
B cells and Antibodies
How does B cell development occur
What does the antibody molecule consis…
B cell activation takes place by which…
What are the initial steps in B cell a…
- B cell precursor rearranges its immunoglobulin genes (gener…
- Bifunctional molecule that consists of 2 heavy& 2 light cha…
clonal selection
- Antigen binding B cells are trapped in the T cell zone of t…
How does B cell development occur
- B cell precursor rearranges its immunoglobulin genes (gener…
What does the antibody molecule consis…
- Bifunctional molecule that consists of 2 heavy& 2 light cha…
10 terms
White Blood Cells
B cells
B cells
T cells
T cells
Produce Antibodies
Involved in Antibody mediated immunity
Have receptors
Involved in Cell mediated immunity
B cells
Produce Antibodies
B cells
Involved in Antibody mediated immunity
B and T cells
T lymphocyte
Antibody
Clonal selection
Antigen Presenting Cell
Lymphocytes that maturein the thymus and are responsible for…
Protein produced by B-cells that has a specific shape complem…
Production of a clone of cells from a single lymphocyte
Cells that ingest bacteria and viruses and destroy them, pres…
T lymphocyte
Lymphocytes that maturein the thymus and are responsible for…
Antibody
Protein produced by B-cells that has a specific shape complem…
42 terms
B cells and Antibody-mediated Immunity
cytotoxic T cells
B cells
B cells
plasma cells, memory cells
leave lymphatic tissues to seek out and destroy a foreign ant…
stay put; do not leave lymphatic tissues to seek out foreign…
in the presence of a foreign antigen, specifics of these in a…
once activated, B cells undergo clonal selection forming a cl…
cytotoxic T cells
leave lymphatic tissues to seek out and destroy a foreign ant…
B cells
stay put; do not leave lymphatic tissues to seek out foreign…
47 terms
B cells and Humoral Immunity
B lymphocytes are responsible for
B lymphocytes develop in the
B lymphocytes are precursors of
Antigen-unstimulated B lymphocytes hav…
humoral immunity
bone marrow
plasma cells or memory cells
IgM and IgD
B lymphocytes are responsible for
humoral immunity
B lymphocytes develop in the
bone marrow
71 terms
Lecture 2: B Cell Development and Functions
B Cells Produce antibodies which exist…
What can antibodies recognize
Antibodies, what are they, where produ…
Antibodies contain _ polypeptides like…
-membrane bound antigen receptors: at surface of B cells (=Bc…
-shapes, conformations, lipids, carbs, nucleic acids, and sma…
Large proteins produced and secreted by activated B cells... Pre…
four... disulfide... Two identical heavy chains (HC) And two identi…
B Cells Produce antibodies which exist…
-membrane bound antigen receptors: at surface of B cells (=Bc…
What can antibodies recognize
-shapes, conformations, lipids, carbs, nucleic acids, and sma…
62 terms
Immunology Ch.9: Immunity Mediated by B-Cells and Antibodies
What is required for B-cell activation?
Where does the second signal for activ…
How do CD4 T cells aid in B cell activ…
Thymus-Independent Antigens
Cross-linking of surface IgM with antigen; Ig-alpha and Ig-Be…
The B-cells receptor associating with B-cell co-receptor; CR2…
CD4 TFH cells recognize MHC class 2 receptors with peptide an…
polysaccharides, lipopolysaccharides, and... peptidoglycans on t…
What is required for B-cell activation?
Cross-linking of surface IgM with antigen; Ig-alpha and Ig-Be…
Where does the second signal for activ…
The B-cells receptor associating with B-cell co-receptor; CR2…
25 terms
T and B cell development
Activation of antibody producing cells
Summery of T cell and B cell developme…
Clonal expansion hypothesis
Activation of antibody producing cells…
-B lymphocytes recognize intact pathogenic microorganisms and…
Humeral Response ... -B cell receptor epoxsed to antigen ... -Activ…
-generation of diversity from the stem cell... -Each lymphocyte…
When the B cells get activated by antigen leading to clonal e…
Activation of antibody producing cells
-B lymphocytes recognize intact pathogenic microorganisms and…
Summery of T cell and B cell developme…
Humeral Response ... -B cell receptor epoxsed to antigen ... -Activ…
18 terms
B Cells and the Antibody - PPT
IgD and IgM
kappa and lambda
paratopes
complementarity determining region
two antibody classes on the surface of naive B cells
two types of light chains
antigen binding sites
CDR
IgD and IgM
two antibody classes on the surface of naive B cells
kappa and lambda
two types of light chains
15 terms
B Cell Development & Activation
6 stages of B Cell Development/ Mechan…
κ & λ Chain development
CD34
Earliest Identifiable cell of B Cell l…
1) Generation of diverse B cell receptors in the bone marrow…
κ light chains first to rearrange... If κ chain doesn't rearran…
Surface marker found on all hematopoietic stem cells.
Pro-B Cell. ... common lymphoid progenitor cells can produce B…
6 stages of B Cell Development/ Mechan…
1) Generation of diverse B cell receptors in the bone marrow…
κ & λ Chain development
κ light chains first to rearrange... If κ chain doesn't rearran…
38 terms
B cell development and antibody Function
B Cell development signal
B cell surface Development
B Cell development rearrangement of Ig
Location of B Cells in development
Bone marrow stromal cells signal Multipotent progenitor, IL-7…
Large Pre B cell surface u chain (IgM) presents when heavy ch…
Heavy chain first and then light chains
Bone marrow until express IgM (immature) ... Move to periphery t…
B Cell development signal
Bone marrow stromal cells signal Multipotent progenitor, IL-7…
B cell surface Development
Large Pre B cell surface u chain (IgM) presents when heavy ch…
29 terms
F2-W3-B Cell Function
B Cell activation (First step)
B Cell activation Co-receptor
What happens if I am mutant for CD19 o…
Naïve B cells require T cells for acti…
BCR binds an antigen (on a pathogen), The surface IgM molecul…
B cell activation also requires a co-receptor composed of *CD…
Mutations in CD19 and CD81 are associated with a profound def…
Bacteria and Dendritic cell are brought into lymph node via *…
B Cell activation (First step)
BCR binds an antigen (on a pathogen), The surface IgM molecul…
B Cell activation Co-receptor
B cell activation also requires a co-receptor composed of *CD…
Major Types of T Cells and B Cells
T cells
cytotoxic T (Tc) Cells
helper T (Th) Cells
memory T cells
lymphocytes derived from the thymus; T lymphocytes
lymphocytes that directly attack other cells both physically…
lymphocytes that cooperate with B cells to amplify antibody p…
long-lived lymphocytes that can respond to subsequent encount…
T cells
lymphocytes derived from the thymus; T lymphocytes
cytotoxic T (Tc) Cells
lymphocytes that directly attack other cells both physically…
74 terms
B cell development, activation, and antibody production
Describe B-2 lymphocytes.
Describe B-1 lymphocytes.
Describe Marginal Zone B cells.
Where does B cell development occur?
traditional B cells and recognize foreign antigens. follicula…
peritoneal and pleural cavities. IgM only. not reliant on BAF…
splenic marginal zone. IgM only. small amount of IgD. do not…
in the bone marrow
Describe B-2 lymphocytes.
traditional B cells and recognize foreign antigens. follicula…
Describe B-1 lymphocytes.
peritoneal and pleural cavities. IgM only. not reliant on BAF…
9 terms
B-cells and T-cells
B-cells
B-cells
Plasma cells
Memory cells
Have antigen receptors and antibodies, and they work to fight…
Can form plasma cells and memory cells.
Cells that develop from B cells and produce antibodies.
Cells that remember a particular antibody
B-cells
Have antigen receptors and antibodies, and they work to fight…
B-cells
Can form plasma cells and memory cells.
Anton van Leeuwenhoek
Robert Hooke
Matthias Schleiden
Theodore Schwann
developed the first light microscope
studied cork; called the box-like structures "cells"
said all plants were composed of cells
said all animals were composed of cells
Anton van Leeuwenhoek
developed the first light microscope
Robert Hooke
studied cork; called the box-like structures "cells"
9 terms
T cells and B cells
Originates in bone marrow from stem ce…
progeny are plasma cells
progeny include regulatory, helper, an…
progeny include memory cells
t&b
b
t
t&b
Originates in bone marrow from stem ce…
t&b
progeny are plasma cells
b
189 terms
Cells FINAL
Where do B cells and T cells develop i…
What cells control Antibody mediated i…
What cells control Cell mediated immun…
What do B cells differentiate into?
B cells: in secondary lymph tissue... T cells: in the thymus
Bcells
T cells
memory cells... Plasma cells... APC
Where do B cells and T cells develop i…
B cells: in secondary lymph tissue... T cells: in the thymus
What cells control Antibody mediated i…
Bcells
19 terms
Hemo Ch. 16 Lymphocytes and Plasma Cells
Bone marrow and thymus
Spleen, lymph nodes, Peyer patches
B cells
nRBC
What are the two primary lymphoid tissues?
What are the three secondary lymphoid tissues?
Which cells turn into plasma cells?
What might you confuse a small lymphocyte with?
Bone marrow and thymus
What are the two primary lymphoid tissues?
Spleen, lymph nodes, Peyer patches
What are the three secondary lymphoid tissues?
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