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Study sets matching "term:plasma cells = cells that develop from b cells and produce antibodies."

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Study sets matching "term:plasma cells = cells that develop from b cells and produce antibodies."

8 terms
B Cells
B Lymphocyte
Macrophage
Clonal Selection
Antibody
WBC that forms and mature in the bone marrow and release anti…
Found within the lymph nodes, they are phagocytes that destro…
Production of a clone of cells from a single lymphocyte
Protein produced by B-cells that has a specific shape complem…
B Lymphocyte
WBC that forms and mature in the bone marrow and release anti…
Macrophage
Found within the lymph nodes, they are phagocytes that destro…
31 terms
B cells and antibodies
Fc and Fab regions of antibody
Regions of antibody that interact with…
Affinity
Avidity
Vh and Vl chains
strength of binding between a single binding site and a singl…
Strength of binding between a molecule and a complex ligand.
Fc and Fab regions of antibody
Regions of antibody that interact with…
Vh and Vl chains
8 terms
B Cells
Antigen presenting cell
B cell
Lymphocyte
Mitosis
These cells engulf pathogens and present fragments of these a…
Cells manufactured in the bone marrow that create antibodies…
The two types of white blood cells that are part of the body'…
Cell's division. Final product is 2 cells that are exactly li…
Antigen presenting cell
These cells engulf pathogens and present fragments of these a…
B cell
Cells manufactured in the bone marrow that create antibodies…
92 terms
Immunology Chapter 9: Immunity mediated by B cells and Antibodies
Principle role of antibodies
Coating a bacterium with IgG does what?
Coating a bacterium with IgE does what?
neutralization
to bind to the pathogen using the variable regions and to com…
coating a bacterium with IgG promotes it uptake and destructi…
coating a bacterium by IgE activates mast cells to induce vio…
the mechanism by which antibodies binding to sites on pathoge…
Principle role of antibodies
to bind to the pathogen using the variable regions and to com…
Coating a bacterium with IgG does what?
coating a bacterium with IgG promotes it uptake and destructi…
16 terms
B and T cells
T lymphocyte
Antibody
Clonal selection
Antigen Presenting Cell
Lymphocytes that maturein the thymus and are responsible for…
Protein produced by B-cells that has a specific shape complem…
Production of a clone of cells from a single lymphocyte
Cells that ingest bacteria and viruses and destroy them, pres…
T lymphocyte
Lymphocytes that maturein the thymus and are responsible for…
Antibody
Protein produced by B-cells that has a specific shape complem…
17 terms
Immunity Mediated by B Cells and Antibodies part 1
How antibodies work
Competing requirements for antibody re…
What happens when B cell receptors are…
How the B cell lowers the activation t…
-neutralize pathogens: by blocking molecules necessary for in…
-speed: IgM are made quickly and provide fast defense ... -quali…
-ITAMs become phosphorylated on the tails of Ig(alpha) and Ig…
-by interactions of complement fragments with co-receptors by…
How antibodies work
-neutralize pathogens: by blocking molecules necessary for in…
Competing requirements for antibody re…
-speed: IgM are made quickly and provide fast defense ... -quali…
46 terms
BHD - Immunology, B Cells & Antibodies (Chap 3)
Adaptive Immune System
B-cell
B-Cell Receptor (BCR)
BCR development details
Mutations in microbes such as bacteria and viruses can change…
B cells are born in the bone marrow, where they are descended…
The BCR is made up of two kinds of proteins:... 1. heavy chain…
The gene segments that will be chosen to make up the final Hc…
Adaptive Immune System
Mutations in microbes such as bacteria and viruses can change…
B-cell
B cells are born in the bone marrow, where they are descended…
77 terms
GD 47 Plasma Cell Disorders dyscrasias
Maturation process of lymphoid cells
Plasma cell
Where are plasma cells usually found?
difference between plasma cells and B…
1) common lymphoid progenitor in bone marrow... 2) small lymphoc…
mature B lymphocyte that is specialized for antibody (immunog…
Plasma cells are rarely found in the peripheral blood. They c…
B cells mature into plasma cells
Maturation process of lymphoid cells
1) common lymphoid progenitor in bone marrow... 2) small lymphoc…
Plasma cell
mature B lymphocyte that is specialized for antibody (immunog…
59 terms
B cells and antibodies
arise from stem cells in bone marrow
CD19, CD20
part of humoral response and different…
clock face chromatin
B cells
B cell surface markers
B cells
plasma cells
arise from stem cells in bone marrow
B cells
CD19, CD20
B cell surface markers
65 terms
Immunology Exam 2 Lecture 5- Immunity mediated by B cells and Antibodies
What must happen for a B cell to becom…
CD19
T-dependent antibody responses by B ce…
Which CD4+ T cell subset is involved i…
surface AB on the B cell must be cross-linked with its specif…
co-receptor for B cells involved in co-stimulatory signal
involves CD4+ TH2 T cells ... required for the MAJORITY of AB re…
TH2
What must happen for a B cell to becom…
surface AB on the B cell must be cross-linked with its specif…
CD19
co-receptor for B cells involved in co-stimulatory signal
40 terms
Lecture 4: B Cell Development and Clinical Applications
B Cell Primary Lymphoid Organ
T Cell Primary Lymphoid Organ
What happens in primary lymphoid organs?
RAG
Bone Marrow
Thymus
Lymphocytes develop and express their antigen-specific recept…
Recombination-Activating Gene... Critical for the development o…
B Cell Primary Lymphoid Organ
Bone Marrow
T Cell Primary Lymphoid Organ
Thymus
21 terms
cells
plasma membrane
nucleus
cell wall
mitochondria
A flexible boundary that controls the movement of substances…
A cell structure that contains nucleic acids, the chemical in…
This is a thick outer layer in plant cells made of cellulose.
Cell organelle in both plants and animals that converts the e…
plasma membrane
A flexible boundary that controls the movement of substances…
nucleus
A cell structure that contains nucleic acids, the chemical in…
80 terms
B cells and Antibodies
What in the serum protects you from in…
How many antibodies are in your body?
Antibody structure
The tips of the VH and VL (variable) c…
serum proteins only
greater than 10^9
antigens
What in the serum protects you from in…
serum proteins only
How many antibodies are in your body?
greater than 10^9
9 terms
T cells and B cells
originates in bone marrow from hemocyt…
progeny are plasma cells
progeny include suppressors, helpers,…
progeny include memory cells
T and B cells
B cells
T cells
T and B cells
originates in bone marrow from hemocyt…
T and B cells
progeny are plasma cells
B cells
76 terms
Antibody Structure and the Generation of B-cell diversity
Antibodies
Antibodies produced by
Antibodies are a major component of
Antibodies bind to
are the secreted form of glycoproteins known generally as imm…
B lymphocytes in response to infection
plasma in the blood and lymph
pathogenic microorganisms and their toxins in extracellular s…
Antibodies
are the secreted form of glycoproteins known generally as imm…
Antibodies produced by
B lymphocytes in response to infection
107 terms
Chapter 9 Immunology: Immunity Mediated by B cells and Antibodies
B lymphocytes recognize
Recognition stimulates
Proliferation and differentation
B lymphocytes generally require
extracellular pathogens and toxins transported to secondary l…
proliferation and differentiation
plasma cells and memory B cells
help from activated T lymphocytes for differentiation into pl…
B lymphocytes recognize
extracellular pathogens and toxins transported to secondary l…
Recognition stimulates
proliferation and differentiation
31 terms
L3 - B cell development and the structure of antibodies
Describe the innate immune system.
Describe the adaptive immune system.
Describe the immune response leading t…
What are antibodies?
• Present in earlier organisms ... • Relies on receptors and mol…
• Only present in higher vertebrates ... • Relies on unique rece…
• Proteins secreted by activated B cells (plasma cells), the…
Describe the innate immune system.
• Present in earlier organisms ... • Relies on receptors and mol…
Describe the adaptive immune system.
• Only present in higher vertebrates ... • Relies on unique rece…
10 terms
White Blood Cells
B cells
B cells
T cells
T cells
Produce Antibodies
Involved in Antibody mediated immunity
Have receptors
Involved in Cell mediated immunity
B cells
Produce Antibodies
B cells
Involved in Antibody mediated immunity
57 terms
wk2-L3-B cells and antibody structure and function
cells of the innate and adaptive immun…
Antigen
Epitope
affinity
-Innate immunity:... >components:... •NK cells ... •monocytes/macropha…
=anything that binds to a specific receptor on T/B cells(gene…
=portion of an antigen that is recognized and bound by a rece…
strength of interaction between a single antigen binding site…
cells of the innate and adaptive immun…
-Innate immunity:... >components:... •NK cells ... •monocytes/macropha…
Antigen
=anything that binds to a specific receptor on T/B cells(gene…
26 terms
Antibodies and Cell fractionation
Antibodies are carried in the cell mem…
Use of Immunocytochemistry
When antigen binds to this receptor, t…
Antibodies are made by a class of ____…
B lymphocytes... Blood
Immunostaining
B cell
White
Antibodies are carried in the cell mem…
B lymphocytes... Blood
Use of Immunocytochemistry
Immunostaining
32 terms
Ch-9 Immunity Mediated by B cells and Antibodies
Naive B cell activation threshold
Where B cell response happens?
1st signal required for B cell responses
After it binds to antigen
When multiple immunoglobulin signaling complexes are engaged…
lymph node and spleen
Antigen... -present often in soluble form... -can be also in outsid…
phosph relay system leads to signal transduction
Naive B cell activation threshold
When multiple immunoglobulin signaling complexes are engaged…
Where B cell response happens?
lymph node and spleen
16 terms
B and T cells
T lymphocyte
Antibody
Clonal selection
Antigen Presenting Cell
Lymphocytes that maturein the thymus and are responsible for…
Protein produced by B-cells that has a specific shape complem…
Production of a clone of cells from a single lymphocyte
Cells that ingest bacteria and viruses and destroy them, pres…
T lymphocyte
Lymphocytes that maturein the thymus and are responsible for…
Antibody
Protein produced by B-cells that has a specific shape complem…
29 terms
F2-W3-B Cell Function
B Cell activation (First step)
B Cell activation Co-receptor
What happens if I am mutant for CD19 o…
Naïve B cells require T cells for acti…
BCR binds an antigen (on a pathogen), The surface IgM molecul…
B cell activation also requires a co-receptor composed of *CD…
Mutations in CD19 and CD81 are associated with a profound def…
Bacteria and Dendritic cell are brought into lymph node via *…
B Cell activation (First step)
BCR binds an antigen (on a pathogen), The surface IgM molecul…
B Cell activation Co-receptor
B cell activation also requires a co-receptor composed of *CD…
16 terms
B and T cells
T lymphocyte
Antibody
Clonal selection
Antigen Presenting Cell
Lymphocytes that maturein the thymus and are responsible for…
Protein produced by B-cells that has a specific shape complem…
Production of a clone of cells from a single lymphocyte
Cells that ingest bacteria and viruses and destroy them, pres…
T lymphocyte
Lymphocytes that maturein the thymus and are responsible for…
Antibody
Protein produced by B-cells that has a specific shape complem…
21 terms
B cell Development
B cell development occurs in _____
in this stage of B cell development ... V…
in this stage of B cell development... re…
this type of cell______ is non lymphoi…
Test 100... bone marrow
pro- B cell
** Test Pre- B cell
stromal cell
B cell development occurs in _____
Test 100... bone marrow
in this stage of B cell development ... V…
pro- B cell
24 terms
B Cell Development
Lymphocyte-releated tumors tend to ori…
Treatment of lymphoma depends on
B cell development begins in
Phase 1 goal
One cell
Stage of development and cell type
Bone marrow
Produce a functional B cell receptor with heavy and light cha…
Lymphocyte-releated tumors tend to ori…
One cell
Treatment of lymphoma depends on
Stage of development and cell type
14 terms
Types of B and T cells
T cells
Helper T cells
Memory cells
Suppressor T cells
Control the immune response and the production of the B cells…
When a macrophage encounters an antigen marker that is not se…
Take no part in the attack response, but remain in the body i…
Prime agents for turning off the immune system. Maybe involve…
T cells
Control the immune response and the production of the B cells…
Helper T cells
When a macrophage encounters an antigen marker that is not se…
Major Types of T Cells and B Cells
T cells
cytotoxic T (Tc) Cells
helper T (Th) Cells
memory T cells
lymphocytes derived from the thymus; T lymphocytes
lymphocytes that directly attack other cells both physically…
lymphocytes that cooperate with B cells to amplify antibody p…
long-lived lymphocytes that can respond to subsequent encount…
T cells
lymphocytes derived from the thymus; T lymphocytes
cytotoxic T (Tc) Cells
lymphocytes that directly attack other cells both physically…
9 terms
Antibodies produced by B cells
What are the 5 antibodies produced by…
Most abundant
Crosses placenta part of primary secon…
Protects mucosal surfaces from pathogens
IgG... A... M... E... D
G
G
A
What are the 5 antibodies produced by…
IgG... A... M... E... D
Most abundant
G
18 terms
L6T4: B cells and Antibodies
Antibodies
Fab region and Fc region
Heavy and light chains
Epitope
Y shaped antigen specific proteins produced by B lymphocytes…
Fragment antigen binding and fragment crystallisable region.
Part of antigen that binds to antibody.
Antibodies
Y shaped antigen specific proteins produced by B lymphocytes…
Fab region and Fc region
Fragment antigen binding and fragment crystallisable region.
297 terms
Immunity Mediated by B Cells and Antibodies: Chapter 9
What are the two major functions of An…
How many CDR loops on an Ig molecule?
What part of the Ig molecule is respon…
What is cross linking (clustering)
Opsonize: Tag antigen for destruction (Phagocytosis or classi…
6... 3 CDR loops on each Fab variable region (arms) and there ar…
Fc
Many copies of the same transmembrane receptor on the surface…
What are the two major functions of An…
Opsonize: Tag antigen for destruction (Phagocytosis or classi…
How many CDR loops on an Ig molecule?
6... 3 CDR loops on each Fab variable region (arms) and there ar…
25 terms
T and B cell development
Activation of antibody producing cells
Summery of T cell and B cell developme…
Clonal expansion hypothesis
Activation of antibody producing cells…
-B lymphocytes recognize intact pathogenic microorganisms and…
Humeral Response ... -B cell receptor epoxsed to antigen ... -Activ…
-generation of diversity from the stem cell... -Each lymphocyte…
When the B cells get activated by antigen leading to clonal e…
Activation of antibody producing cells
-B lymphocytes recognize intact pathogenic microorganisms and…
Summery of T cell and B cell developme…
Humeral Response ... -B cell receptor epoxsed to antigen ... -Activ…
71 terms
Lecture 2: B Cell Development and Functions
B Cells Produce antibodies which exist…
What can antibodies recognize
Antibodies, what are they, where produ…
Antibodies contain _ polypeptides like…
-membrane bound antigen receptors: at surface of B cells (=Bc…
-shapes, conformations, lipids, carbs, nucleic acids, and sma…
Large proteins produced and secreted by activated B cells... Pre…
four... disulfide... Two identical heavy chains (HC) And two identi…
B Cells Produce antibodies which exist…
-membrane bound antigen receptors: at surface of B cells (=Bc…
What can antibodies recognize
-shapes, conformations, lipids, carbs, nucleic acids, and sma…
HUBS191- Immune system: Cells and Antibodies
B cell
Bone marrow
IgD or monomeric IgM
Activates
The antibody-generating lymphocyte cell of the adaptive immun…
Where B cells develop
The two types of unique receptors that each B cell can display
Once the B cell binds to its antigen it...
B cell
The antibody-generating lymphocyte cell of the adaptive immun…
Bone marrow
Where B cells develop
42 terms
B cells and Antibody-mediated Immunity
cytotoxic T cells
B cells
B cells
plasma cells, memory cells
leave lymphatic tissues to seek out and destroy a foreign ant…
stay put; do not leave lymphatic tissues to seek out foreign…
in the presence of a foreign antigen, specifics of these in a…
once activated, B cells undergo clonal selection forming a cl…
cytotoxic T cells
leave lymphatic tissues to seek out and destroy a foreign ant…
B cells
stay put; do not leave lymphatic tissues to seek out foreign…
61 terms
B Cells and Antibodies
Do all animals have adaptive immunity?
What makes up cell-mediated immunity?…
What makes up humoral response? What i…
What modulates the immune system throu…
no ... only jawed vertebrates (Ig, TCR, MHC)... variable lymphocyte…
T cells, NK cells... direct killing of cells with foreign antige…
B cells, plasma cells... make antigen specific soluble molecules…
B cells, T cells, NK cells, innate lymphocytes... modulate immun…
Do all animals have adaptive immunity?
no ... only jawed vertebrates (Ig, TCR, MHC)... variable lymphocyte…
What makes up cell-mediated immunity?…
T cells, NK cells... direct killing of cells with foreign antige…
76 terms
Antibody Structure and the Generation of B-cell diversity
Antibodies
Antibodies produced by
Antibodies are a major component of
Antibodies bind to
are the secreted form of glycoproteins known generally as imm…
B lymphocytes in response to infection
plasma in the blood and lymph
pathogenic microorganisms and their toxins in extracellular s…
Antibodies
are the secreted form of glycoproteins known generally as imm…
Antibodies produced by
B lymphocytes in response to infection
9 terms
B-cells and T-cells
B-cells
B-cells
Plasma cells
Memory cells
Have antigen receptors and antibodies, and they work to fight…
Can form plasma cells and memory cells.
Cells that develop from B cells and produce antibodies.
Cells that remember a particular antibody
B-cells
Have antigen receptors and antibodies, and they work to fight…
B-cells
Can form plasma cells and memory cells.
44 terms
B cells and antibodies
Antibodies have how many binding sites…
Variable region of antibody is associa…
Constant region is associated with whi…
Naive B cells expression which classes…
2 antigen binding sites
N terminus
C terminus
IgD, IgM
Antibodies have how many binding sites…
2 antigen binding sites
Variable region of antibody is associa…
N terminus
35 terms
B cells
B cells common progenitor, originates,…
Surface expressed antibodies serve as…
upon activation, B cells secrete
Clonal selection theory of lymphocytes
lymphoid, originates and matures in the bone marrow
b cell receptor, BCR
large quantities of immunoglobulins
...
B cells common progenitor, originates,…
lymphoid, originates and matures in the bone marrow
Surface expressed antibodies serve as…
b cell receptor, BCR
41 terms
Cell Biology: Cell Structure and Function
Cells
Basic Cellular Structure
Plasma Membrane
Nucleus
Are the smallest units having the complex organization, metab…
Plasma Membrane, Nucleus, Cytoplasm
This outermost membrane of a cell separates internal metaboli…
This membrane-bound compartment contains hereditary instructi…
Cells
Are the smallest units having the complex organization, metab…
Basic Cellular Structure
Plasma Membrane, Nucleus, Cytoplasm
15 terms
B Cell Development & Activation
6 stages of B Cell Development/ Mechan…
κ & λ Chain development
CD34
Earliest Identifiable cell of B Cell l…
1) Generation of diverse B cell receptors in the bone marrow…
κ light chains first to rearrange... If κ chain doesn't rearran…
Surface marker found on all hematopoietic stem cells.
Pro-B Cell. ... common lymphoid progenitor cells can produce B…
6 stages of B Cell Development/ Mechan…
1) Generation of diverse B cell receptors in the bone marrow…
κ & λ Chain development
κ light chains first to rearrange... If κ chain doesn't rearran…
Cells
Anton van Leeuwenhoek
Robert Hooke
Matthias Schleiden
Theodore Schwann
developed the first light microscope
studied cork; called the box-like structures "cells"
said all plants were composed of cells
said all animals were composed of cells
Anton van Leeuwenhoek
developed the first light microscope
Robert Hooke
studied cork; called the box-like structures "cells"
17 terms
B cells
binding and stimulation
-plasma cells... -memory B cells
plasma cells
immunoglobulins, y-shaped proteins
activation of b cells require antigen ______ (no presentation…
activated B cells will divide producing:
differentiated B cells that produce antibodies (5-7 day lifes…
other names for antibodies
binding and stimulation
activation of b cells require antigen ______ (no presentation…
-plasma cells... -memory B cells
activated B cells will divide producing:
29 terms
HUBS191 - B Cells and Antibodies - 45 & 46
What are B cells?
What are the three functions of antibo…
Antibody neutralisation
Antibody opsonisation
- Lymphocytes that grow and mature in bone marrow
- Neutralisation, opsonisation and complement activation
- Antibody binds to surface structure on microbes that preven…
- Antibodies bind to the surface of pathogens ... - Antibody tai…
What are B cells?
- Lymphocytes that grow and mature in bone marrow
What are the three functions of antibo…
- Neutralisation, opsonisation and complement activation
14 terms
Immune Cells
Neutrophils
Basophils
Eosinophils
Monocytes
Infection fighting; First to arrive to scene of infection aft…
WBC bind to IgE; release histamine in anaphylaxis
WBC involved in allergic reactions
WBC replenish macrophages & dendritic cells; respond to infla…
Neutrophils
Infection fighting; First to arrive to scene of infection aft…
Basophils
WBC bind to IgE; release histamine in anaphylaxis
Cells
Plasma membrane
Nucleus
Cell Wall
Mitochondria
a microscopic membrane of lipids and proteins that forms the…
a dense organelle present in most eukaryotic cells, typically…
a rigid layer of polysaccharides lying outside the plasma mem…
an organelle found in large numbers in most cells, in which t…
Plasma membrane
a microscopic membrane of lipids and proteins that forms the…
Nucleus
a dense organelle present in most eukaryotic cells, typically…
32 terms
B Cell Development
Antibody heavy chain
Antibody Light chain
B cell development phases
hematopoietic stem cell
Green
Yellow
*Repertoire assembly... *Negative Selection... *B cell Maturation…
Can become any leukocyte
Antibody heavy chain
Green
Antibody Light chain
Yellow
23 terms
B cells and antibody
what do B cells recognise?
what are B cells?
2 ways in which B cells are activated
where do B cells develop and mature?
whole (native) protein antigens
lymphocytes and antigen presenting cells
recognition of an antigen and CD4+ help
bone marrow
what do B cells recognise?
whole (native) protein antigens
what are B cells?
lymphocytes and antigen presenting cells
24 terms
Vaccines, Antibodies, HIV, T and B Cells
lymphocytes
b lymphocytes (b cells)
t lymphocytes (t cells)
cloned t cells
produced by stem cells in bone marrow
mature in bone marrow ... produce antibodies ... dissolve in blood…
mature in thymus gland ... cell sedated immunity ... respond to ant…
if has complimentary receptors can clone itself
lymphocytes
produced by stem cells in bone marrow
b lymphocytes (b cells)
mature in bone marrow ... produce antibodies ... dissolve in blood…
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