Study sets matching "terms cervical cancer"

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Study sets matching "terms cervical cancer"

114 terms
Cervical cancer
GOG 240
what 2 studies have shown improved OS…
chemo regimens for 1st line therapy in…
chemo regimens for 2nd line recurrence:
Tewari et al... improved survival with addition of bev... 3.7m inc…
GOG 179... GOG 240
combo therapy:... cis/tax +/- bev... carbo/tax... topo/tax... single age…
all single agents:... Bev... taxotere... 5-FU... Gemzar... IFEX... topo... pemetre…
GOG 240
Tewari et al... improved survival with addition of bev... 3.7m inc…
what 2 studies have shown improved OS…
GOG 179... GOG 240
6 terms
Cervical Cancer
<p style="text-align: center;">Cervica…
<p style="text-align: center;">Treatme…
<p style="text-align: center;">Treatme…
<p style="text-align: center;">Treatme…
<p style="text-align: center;">The most appropriate imaging m…
<p style="text-align: center;">Observation</p><p style="text-…
<p style="text-align: center;">Laparoscopic or open lymph nod…
<p style="text-align: center;">Patients with positive lymph n…
<p style="text-align: center;">Cervica…
<p style="text-align: center;">The most appropriate imaging m…
<p style="text-align: center;">Treatme…
<p style="text-align: center;">Observation</p><p style="text-…
Cervical cancer
How long does it take to develop an ab…
How much time from first detection of…
HPV persistence
How is detection of HPV defined
4 months
14.1 months
- Majority infections are transient and clear in 12-18 months…
Detection is defined as having same HPV type on 2-3 consecuti…
How long does it take to develop an ab…
4 months
How much time from first detection of…
14.1 months
Cervical Cancer
Risk Factors
Pathology
Screening
Prevention
1) HPV (16,18)... 2) Early sexual activity... 3) Smoking... 4) Multipl…
Squamous cell most common... Adenocarcinoma worse prognosis
Liquid PAP test better than traditional scraping... Age <21- no…
1) Gardasil- ages 9-26, males and females, strains 6, 11,16,1…
Risk Factors
1) HPV (16,18)... 2) Early sexual activity... 3) Smoking... 4) Multipl…
Pathology
Squamous cell most common... Adenocarcinoma worse prognosis
18 terms
Cervical Cancer
Cervical Cancer Incidence
Transformation zone cervix
ASC-US cervical cancer
RF for cervical cancer
2nd most common cancer in women worldwide and in the USA... -Wom…
between old SCJ and new SCJ that has regressed to endocervix…
Atypical squamous cells of undetermined significance... >24 years
-Multiple sexual partners, intercourse at an early age, other…
Cervical Cancer Incidence
2nd most common cancer in women worldwide and in the USA... -Wom…
Transformation zone cervix
between old SCJ and new SCJ that has regressed to endocervix…
7 terms
Cervical Cancer
risk factors
screening
clinical manifestations
treatment
low SES, early sexual activity, multiple sex partners, STIs,…
PAP, HPV DNA test, biopsy, colposcopy, electrical wire loop
early asymptomatic, leukorrhea, intermenstrual bleeding, disc…
fertility preservation: conization, laser therapy, cautery, c…
risk factors
low SES, early sexual activity, multiple sex partners, STIs,…
screening
PAP, HPV DNA test, biopsy, colposcopy, electrical wire loop
17 terms
Cervical Cancer
What type of cells is the cervix of fe…
Where does cervical cancer develop?
What happens at the squamocolumnar jun…
Of all the female cancers, which is mo…
Stratified squamous and columnar epithelial cells.
In the squamocolumnar junction of the cervix.
Metaplasia which transforms columnar cells to squamous.
Cervical cancer.
What type of cells is the cervix of fe…
Stratified squamous and columnar epithelial cells.
Where does cervical cancer develop?
In the squamocolumnar junction of the cervix.
40 terms
Cervical Cancer
Cervix
Cancer Defined
Stages of cancers (4)
other views of cancer initiation (3)
runaway cell growth
1) normal cells; 2) abnormal cells; 3) abnormal cells multipl…
1) failure of DNA repair... 2) chromosomal instability... 3) evolut…
Cervix
Cancer Defined
runaway cell growth
Cervical cancer
Etiology
Increased risk factors
Decreased risk factors
Screening
Most significant causative link: Human Papilloma Virus (HPV)... O…
HPV infections-particularly with oncogenic subtypes 16 & 18... S…
Nulliparity ... Sexual Inactivity
21-29: PAP smears q3 years... 30-65: Pap + HPV every 5 years (pr…
Etiology
Most significant causative link: Human Papilloma Virus (HPV)... O…
Increased risk factors
HPV infections-particularly with oncogenic subtypes 16 & 18... S…
46 terms
Cervical Cancer
What age range does cervical cancer us…
Cervical cancer is the ____ most commo…
What places in the world have the high…
How much has the rate of cervical canc…
Midlife (ages 20-50)
4th most common... Behind breast, colorectal, and lung cancers
Central/South America and sub-Saharan Africa because of minim…
Declined by 70%... Decline of cancer rate & deaths due to routin…
What age range does cervical cancer us…
Midlife (ages 20-50)
Cervical cancer is the ____ most commo…
4th most common... Behind breast, colorectal, and lung cancers
83 terms
Cervical Cancer
Cervical cancer scope
cervical cancer caused by...
By age 50 more than 80% of American wo…
How many strains of HPV affect you uro…
- 2nd most common cancer affecting women worldwide... - 510,000…
HPV
contracted at least 1 strain of HPV
40 out of all 100
Cervical cancer scope
- 2nd most common cancer affecting women worldwide... - 510,000…
cervical cancer caused by...
HPV
37 terms
Cervical Cancer
Cervical Cancer is the _____ most comm…
Cervical Cancer ranks what in the USA?
How many new cases per Year of Cervica…
It is the ____ most common Gyn Ca in U…
4th... 2nd
12th. Because we have such great screening
13,000. Most common in Blacks nd Hispanics
3rd. After Endometrial (40,000) and Ovarian(25,000)
Cervical Cancer is the _____ most comm…
4th... 2nd
Cervical Cancer ranks what in the USA?
12th. Because we have such great screening
39 terms
Cervical Cancer
What HPV is associated with squamous c…
What HPV is associated with adenocarci…
What are the risk factors for cervical…
What are the common signs of cervical…
HPV 16
HPV 18
1. Immunosuppression... 2. Infection with HIV ... 3. History of STD…
1. Metrorrhagia (abnormal bleeding of the uterus)... 2. Postcoit…
What HPV is associated with squamous c…
HPV 16
What HPV is associated with adenocarci…
HPV 18
18 terms
cervical cancer
etiology
risk factors
cervical cancer
pre invasive
- cervical cancer: HPV infection responsible for most cervica…
- smoking... - daughters of DES (diethylstilbestrol) users... - vit…
- pre invasive: limited to cervix... - invasive: in cervix and o…
- CIN (cervical intraepithelial neoplasia)... - mild: CIN I... - mo…
etiology
- cervical cancer: HPV infection responsible for most cervica…
risk factors
- smoking... - daughters of DES (diethylstilbestrol) users... - vit…
5 terms
Cervical cancer
Incidence of cervical cancer
HPV
CIN1
CIN3
6.6/110K, mortality 2.3/100K... AA women with higher incidence a…
50-75% of sexually active adults... usually transient in young w…
60% regress, 30% persist, 10% progress to CIN3, 1% progress t…
33% regress, 55% persist, >12% progress to cancer
Incidence of cervical cancer
6.6/110K, mortality 2.3/100K... AA women with higher incidence a…
HPV
50-75% of sexually active adults... usually transient in young w…
Cervical Cancer
Colpo always
1. 48 yo... 2. 35-39yo
anexa
lower genital tract
next step always for : ... HSIL... Carcinoma... LISIL-H... ASUCUS-H,
1. avg. age for cervical cancer... 2. avg. peak age for cervica…
upper genital tract (ovaries, uterus, fall. tubes)
cervix, vagina, vulva
Colpo always
next step always for : ... HSIL... Carcinoma... LISIL-H... ASUCUS-H,
1. 48 yo... 2. 35-39yo
1. avg. age for cervical cancer... 2. avg. peak age for cervica…
11 terms
Cervical Cancer
CIN... GRADE 1
CIN... GRADE 2
CIN ... GRADE 3
Stage O... Cervical carcinoma
Mild dysplasia
Moderate dysplasia
Severe dysplasia/carcinoma in situ
CIN 3
CIN... GRADE 1
Mild dysplasia
CIN... GRADE 2
Moderate dysplasia
cervical cancer
LSIL
hpv incidence
when to repeat LSIL pap.
how many will clear LSIL in 12 month
low grade, active virus replicating
93%
12 months
78%
LSIL
low grade, active virus replicating
hpv incidence
93%
20 terms
Cervical Cancer
Epidemiology
Human Papilloma Virus
HPV Risk Factors
Persistent HPV Infection
2nd leading cause of cancer mortality in women ... 75% occur in…
100 types of HPV, circular dsDNA, 30 types affect lower genit…
Immunocompromised... Smoking ... Early age of first intercourse... M…
Less likely to occur... The longer the infection lasts, the more…
Epidemiology
2nd leading cause of cancer mortality in women ... 75% occur in…
Human Papilloma Virus
100 types of HPV, circular dsDNA, 30 types affect lower genit…
11 terms
Cervical Cancer
IA1
IA2
IB1
IB2
≤3 mm depth, no wider than 7 mm, only microscopic
>3mm, ≤5mm depth, no wider than 7 mm, only microscopic
≤4cm, confined to cervix, larger than IA
>4cm, confined to cervix
IA1
≤3 mm depth, no wider than 7 mm, only microscopic
IA2
>3mm, ≤5mm depth, no wider than 7 mm, only microscopic
cervical cancer
RF
Types of HPV and associated types of CA
Presentation
PE
early coitarche, multiple sexual partners, increased parity,…
Squamous (most common) HPV 16, Adeno HPV 18
water, blood tinged vaginal d/c, bleeding, LE edema, low back…
supraclavicular and inguinal lymphadenopathy, cervical or vag…
RF
early coitarche, multiple sexual partners, increased parity,…
Types of HPV and associated types of CA
Squamous (most common) HPV 16, Adeno HPV 18
8 terms
Cervical Cancer
Cervical Cancer Screening Modalities
Pap smear
Bethseda System
Pap test recommendations. Begin at age…
Pap smear, HPV test
1. Principle screening for cervical ca.... 2. Cellular specimen…
Developed in 1998 and updated in 2001. Used for reporting uni…
21... 3 to 5... Yearly screening no longer recommended because gene…
Cervical Cancer Screening Modalities
Pap smear, HPV test
Pap smear
1. Principle screening for cervical ca.... 2. Cellular specimen…
Cervical Cancer
Pathology
Aetiology
Signs & Symptoms
Investigations
Pre-Invasive:... minimal cervical dysplasia --> Carcinoma in sit…
HPV - 16,18, 31... - sex @ young age... - multiple sexual partners…
Pre-Invasive - asymptomatic (picked up smear)... Early Invasive…
Smear/PAP... Colposcopy - detail exam cervix, curettage... Cone Bio…
Pathology
Pre-Invasive:... minimal cervical dysplasia --> Carcinoma in sit…
Aetiology
HPV - 16,18, 31... - sex @ young age... - multiple sexual partners…
38 terms
Cervical Cancer
Early age of coitus, STDs, early child…
Abnormal cellular maturation, nuclear…
Cervical squamous epithelium
Uterus, cervix, supporting ligaments
Risk factors for cervical cancer
Cellular characteristics of cervical intraepithelial neoplasia
What epithelium does HPV infect?
What is removed in radical hysterectomy
Early age of coitus, STDs, early child…
Risk factors for cervical cancer
Abnormal cellular maturation, nuclear…
Cellular characteristics of cervical intraepithelial neoplasia
7 terms
Cervical Cancer
page of CIN & cervical cancer
Investigations of cervical cancer
TTT of CIN
CP of CIN
.
.
CIN I : follow up cytology every 6mo\nCIN II : 1)
.
page of CIN & cervical cancer
.
Investigations of cervical cancer
.
Cervical Cancer
increased risk of cervical cancer is a…
How many women get diagnosed with cerv…
How many women die annually from cervi…
mortality rate higher in african ameri…
1. low socioeconomic status ... 2. early sexual activity (< age…
approximately 12,000
approx 4200
african american women
increased risk of cervical cancer is a…
1. low socioeconomic status ... 2. early sexual activity (< age…
How many women get diagnosed with cerv…
approximately 12,000
Cervical Cancer
Pathology
Aetiology
Signs & Symptoms
Investigations
Pre-Invasive:... minimal cervical dysplasia --> Carcinoma in sit…
HPV - 16,18, 31... - sex @ young age... - multiple sexual partners…
Pre-Invasive - asymptomatic (picked up smear)... Early Invasive…
Smear/PAP... Colposcopy - detail exam cervix, curettage... Cone Bio…
Pathology
Pre-Invasive:... minimal cervical dysplasia --> Carcinoma in sit…
Aetiology
HPV - 16,18, 31... - sex @ young age... - multiple sexual partners…
71 terms
Cervical Cancer
Most common cancer in developing nations
HPV DNA detected in what % of cervical…
Biggest risk factor for going from HPV…
Most infections are transient and are…
- Cervical... - higher mortality rates too
- 90%... - up to 94% of those with pre-invasive lesions
Smoking
8-24 months
Most common cancer in developing nations
- Cervical... - higher mortality rates too
HPV DNA detected in what % of cervical…
- 90%... - up to 94% of those with pre-invasive lesions
29 terms
Cervical Cancer
ASCUS
when to begin screening PAP
how often to screen
when to finish testing
perform HPV DNA testing... - if positive = Colpo... - if negative =…
at age 21 (regardles of coitarche) b/c 90% will clear by teen…
age 30-65 ... - q5 years = cotesting (cytology + HPV testing)... -…
at age 65 if:... 1. three consequetive negative cytology (q3 X 3…
ASCUS
perform HPV DNA testing... - if positive = Colpo... - if negative =…
when to begin screening PAP
at age 21 (regardles of coitarche) b/c 90% will clear by teen…
Cervical cancer
What is the most common cancer in deve…
Women with Cervical cancer in the US o…
HPV DNA is detected in > what percenta…
HPV is also associated with what other…
-cervical carcinoma ... -less resources and access to screening…
- have not had or do not have regularly scheduled pap smears
>90%
Most common:... -Cervix ... -Anal/rectal ... -Penis ... Less common; ... -vu…
What is the most common cancer in deve…
-cervical carcinoma ... -less resources and access to screening…
Women with Cervical cancer in the US o…
- have not had or do not have regularly scheduled pap smears
5 terms
Cervical Cancer
R/F
Patho.
Clin. Manif.
Diagnostic
AA, >50 y/o, low socioeconomic status, early sexual activity,…
Caused by mult. injury to the cervix. Progression over years.…
Precancerous changes are asymptomatic. Bleeding (1st watery a…
Screening w/pap smear @ 21 y/o and q 3 years. Suspected cance…
R/F
AA, >50 y/o, low socioeconomic status, early sexual activity,…
Patho.
Caused by mult. injury to the cervix. Progression over years.…
11 terms
Cervical Cancer
Etiology
Types that cause cancer
Risk factors
Signs and Symptoms
infection with Human Papilloma Virus (HPV) - most sexually ac…
Types 16 and 18 (high risk HPV) cause 70% of all cervical can…
multiple sexual partners... smoking
Asymptomatic until late
Etiology
infection with Human Papilloma Virus (HPV) - most sexually ac…
Types that cause cancer
Types 16 and 18 (high risk HPV) cause 70% of all cervical can…
28 terms
Cervical Cancer
Slow-growing
HPV vaccination ... (Ages 9-26)
Risk factors:
HPV INFECTION
Manifestations don't show until invasion has occurred
Limit sexual partners ... (Use condoms)
Risk factors:
Chronic cervical inflammation/infection
Slow-growing
Manifestations don't show until invasion has occurred
HPV vaccination ... (Ages 9-26)
Limit sexual partners ... (Use condoms)
23 terms
cervical cancer
screening
HRHPV DNA testing
pap smear
no
women age 21 and every 3 years
co testing, > 30yo, every 3yrs with pap
high false negative rate, very specific in the detection of a…
is cytology a diagnostic tool for invasive disease?
screening
women age 21 and every 3 years
HRHPV DNA testing
co testing, > 30yo, every 3yrs with pap
21 terms
Cervical Cancer
most common age of diagnosis
Screening/Early detection key
Under served countries
Decrease Cervical Cancer Mortality
35-55y/o
91% survival if tumor localized
2nd most common cancer death, not common US to die
min. HPV exposure risk, vaccine, screen, remove precancerous…
most common age of diagnosis
35-55y/o
Screening/Early detection key
91% survival if tumor localized
32 terms
Cervical Cancer
2nd... 12th
coitarche<16/16x,... menarche-coitarch in…
16, 18, 31, 45
6, 11
Cervical Cancer... __ most common worldwide... __ most common in USA
Cervical Cancer risk factors and RR (8)
HPV types most a/w cancer (4)
HPV types most a/w condyloma (2)
2nd... 12th
Cervical Cancer... __ most common worldwide... __ most common in USA
coitarche<16/16x,... menarche-coitarch in…
Cervical Cancer risk factors and RR (8)
14 terms
cervical cancer
risk factors
health promotion
manifestation for invasive... noninvasive
diagnostic assessments
HPV infection... multiple sexual partners... HIV/AIDS... Hx of STDS
Gardasil vaccine- 3 injection series... yearly pap tests- look a…
invasive: painless vaginal bleeding... noninvasive- asymptomatic
abnormal pap test changes... colposcopy and biopsy... endocervical…
risk factors
HPV infection... multiple sexual partners... HIV/AIDS... Hx of STDS
health promotion
Gardasil vaccine- 3 injection series... yearly pap tests- look a…
cervical cancer
97% of cervical cancer arise from _____
3% of cervical cancer arise from
risk factors for endometrial hyperplasia
patho
glands of endometrium/ endometrial carcinomas/adenocarcinoma
mesenchymal uterine components... Sarcomas
LT use if high doses of menopausal estrogens... living in N. ame…
Proliferation of the endometrium is under the control of estr…
97% of cervical cancer arise from _____
glands of endometrium/ endometrial carcinomas/adenocarcinoma
3% of cervical cancer arise from
mesenchymal uterine components... Sarcomas
10 terms
Cervical Cancer
It is the third most common, usually o…
Risk factors of cervical cancer
instruct the patient to do a
Teach all you patient about the import…
cervical cancer
infection with HPV, smoking, younger than 18 at first interco…
yearly check ups
HPV vaccine
It is the third most common, usually o…
cervical cancer
Risk factors of cervical cancer
infection with HPV, smoking, younger than 18 at first interco…
Cervical Cancer
Cervix
Angiogenesis
Metastasis
Cancer defined
Entrance to the uterus
growth of blood vessels
Cells move from primary tumor to other parts of the body via…
Runaway cell growth
Cervix
Entrance to the uterus
Angiogenesis
growth of blood vessels
23 terms
Cervical cancer
Predisposing Factors (10)
HPV test detects... recommend for age...
Preinvasive starts in
Invasive starts from and then spreads…
Age ... Smoking***... Lower socioeconomic status ... Higher rate in…
- Directly detects the presence of high-risk types of the HPV…
epithelium
From basement membrane spreads to pelvic structures or lympha…
Predisposing Factors (10)
Age ... Smoking***... Lower socioeconomic status ... Higher rate in…
HPV test detects... recommend for age...
- Directly detects the presence of high-risk types of the HPV…
37 terms
Cervical Cancer
what is key in cervical cancer survival?
strategies for decreasing cervical can…
risk factors for cervical cancer
risk factors for HPV infection
screening and early detection
1. minimize HPV exposure risks ... 2. minimize persistent HPV vi…
1. genital HPV infection ... 2. high parity ... 3. cigarette smokin…
1. number of sexual partners ... 2. partner's number of sexual p…
what is key in cervical cancer survival?
screening and early detection
strategies for decreasing cervical can…
1. minimize HPV exposure risks ... 2. minimize persistent HPV vi…
Cervical Cancer
Cervical Cancer
Risk Factors for Cervical Cancer
Prevention and Screening in Cervical C…
Cervical Cancer Presentation
Decreasing in US due to widespread screening & vaccine... Still…
-HPV infection (16&18 accounts for 70-80% of all Cervical can…
-Vaccinate... >11-26yo men and women/high risk... >3 shots... -PAP s…
Early- typically asymptomatic but may see... -*Irregular or he…
Cervical Cancer
Decreasing in US due to widespread screening & vaccine... Still…
Risk Factors for Cervical Cancer
-HPV infection (16&18 accounts for 70-80% of all Cervical can…
39 terms
Cervical Neoplasia and Cervical Cancer
CIN
Severity of CIN
CIN I
CIN II
Premalignant changes in the cervical epithelium that have the…
Determined by the portion of epithelium showing disordered gr…
Changes restricted to lower 1/3 of the epithelium
2/3 of epithelium involved
CIN
Premalignant changes in the cervical epithelium that have the…
Severity of CIN
Determined by the portion of epithelium showing disordered gr…
82 terms
cervical cancer
causative agent of cervical cancer
how long do most hpv infections last
biggest risk factor for progression
what cells are affected in HPV
-HPV
-transient-lasting short time 8-24 months
smoking
-basal ketayinocytes due to microabrasions
causative agent of cervical cancer
-HPV
how long do most hpv infections last
-transient-lasting short time 8-24 months
Cervical Cancer
How many women develop/die from a gyne…
What type of gyn cancers are most prev…
What is the worst-best prognosis for g…
Cercival cancer is the ___th most comm…
Develop: 92,000 ... Die: 28,000
Uterine/endometrial : 50%... Ovarian: 30%... Cervical: 15%... Vulva…
Ovarian: 55%... Cervical: 15%... Vaginal ... Vulvar ... Endometrial
4th ... 1:breast... 2:colorectal... 3:lung... 4:cervical ... 5:ovarian
How many women develop/die from a gyne…
Develop: 92,000 ... Die: 28,000
What type of gyn cancers are most prev…
Uterine/endometrial : 50%... Ovarian: 30%... Cervical: 15%... Vulva…
18 terms
Cervical Cancer
Rates
Spread
What is cancer?
cancer initiation
rates are going down ... 3 stages: early IB , late IB, IIB... secon…
- starts with normal cells ... through mutation or genetics, abn…
runaway cell growth
failure of DNA repair... chromosomal instability... evolutionary co…
Rates
rates are going down ... 3 stages: early IB , late IB, IIB... secon…
Spread
- starts with normal cells ... through mutation or genetics, abn…
14 terms
Cervical cancer
-in the transformation zone of the cer…
-HPV... -HIV... -smoking... -high risk sex beha…
-usually asymptomatic... -abnormal vag bl…
-no visible signs usually... -but can see…
cervical cancer originates
risk factors
symptoms
signs
-in the transformation zone of the cer…
cervical cancer originates
-HPV... -HIV... -smoking... -high risk sex beha…
risk factors
Cervical Cancer
Cancer starts at _
Cervical is the __ most common cancer…
Start in cells on surface of cervix. T…
Majority of cervical cancers from
Cervix
Third
Squamous and columnar
Squamous cells
Cancer starts at _
Cervix
Cervical is the __ most common cancer…
Third
Cervical Cancer
5 year survival
highest racial incidence
what is percentage of squamous cell ca…
what is percentage of adenocarcinomas
68%
African Americans and Hispanics
80-90%
10-20%
5 year survival
68%
highest racial incidence
African Americans and Hispanics
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