Study sets matching "toxicology final"

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Study sets matching "toxicology final"

13 terms
Toxicology
NOAEL (no observable adverse effect le…
Ocular dilution
When do you not induce vomiting
3 % Hydrogen peroxide
highest dose at which no significant adverse (negative) effec…
Tepid tap water, normal saline, artificial tear, NOT VISINE O…
With ingestion of caustic substances or petroleum distillate.…
Acts locally by GI irritation. Give 1ml/lb, up to 45 ml and y…
NOAEL (no observable adverse effect le…
highest dose at which no significant adverse (negative) effec…
Ocular dilution
Tepid tap water, normal saline, artificial tear, NOT VISINE O…
29 terms
Toxicology
Veterinary toxicology
Poison
Intoxication
Classification of poisons
1. Poisons effecting animals where man has pleasure/economic…
Any substance applied to/entering/developed within the body,…
Disease of an organism with certain clinical symptomatology c…
1. Drugs... 2. Food additives... 3. Pesticides... 4. Industrial chemic…
Veterinary toxicology
1. Poisons effecting animals where man has pleasure/economic…
Poison
Any substance applied to/entering/developed within the body,…
94 terms
Toxicology
Organophosphate
Atropine challenge
OPIDN
Ivermectin
- pesticide, flea collars, etc.... - MOA: irreversible AChE inhi…
Diagnostic tool to diagnose OP toxicity in which atropine is…
Organophosphate-induced delayed neurotoxicity: condition in w…
- pesticide, anthelminic, worm medication... - MOA: GABA-r agoni…
Organophosphate
- pesticide, flea collars, etc.... - MOA: irreversible AChE inhi…
Atropine challenge
Diagnostic tool to diagnose OP toxicity in which atropine is…
72 terms
Toxicology
apomorphine
syrup of ipecac
emesis inducing:
mechanical emesis therapy
emesis inducing
emesis inducing
apomorphine, ipecac... or mechanical ... to remove unabsorbed into…
gastric lavage... apply topical anesthetic, tube into stomach,…
apomorphine
emesis inducing
syrup of ipecac
emesis inducing
Toxicology
Poison
Toxin
Toxicant
Latency
Any agent capable of producing a deletrious response in a bio…
Toxic substance produced from a biological system (plants, an…
Toxic substance that is man-made
Period it takes before it starts affecting the body
Poison
Any agent capable of producing a deletrious response in a bio…
Toxin
Toxic substance produced from a biological system (plants, an…
Toxicology
Mycotoxins
Phytotoxins
Biological toxins
Galanthamine
Toxin produced by fungi
Toxin produced by plants
Toxin produced by either plants or animals
Toxin found in flowers that is a competitive antagonist on ac…
Mycotoxins
Toxin produced by fungi
Phytotoxins
Toxin produced by plants
33 terms
Toxicology
Pollution
Pollutant
Contamination
Toxicology
Process of degradation, undesirable change
Substance that has a harmful effect
Introduction of undesirable materials/substances
The study of poisons and their effects
Pollution
Process of degradation, undesirable change
Pollutant
Substance that has a harmful effect
6 terms
Toxicology
understand the terms used in toxicolog…
understand the importance of the "spec…
differentiate between LD50 and ED50 an…
know the risk associated with specific…
...
understand the terms used in toxicolog…
understand the importance of the "spec…
Toxicology
zinc phosphide/phosphide gas is found in
zinc phosphide/phosphide gas MOA
acetylene breath is clinical sign of
what toxin should be treated for in ve…
mole and gopher bait
forms phosphine gas in stomach
zinc phosphide/phosphide gas
zinc phosphide/phosphide gas
zinc phosphide/phosphide gas is found in
mole and gopher bait
zinc phosphide/phosphide gas MOA
forms phosphine gas in stomach
71 terms
Toxicology
toxicology
poison
theraputic effect
side effect
essence of toxicology is to understand the effects of chemica…
any agent capable of producing an injurious effect or respons…
purpose for which medicinal (or chemical) is administered
any effect other than that for which medicinal is administered
toxicology
essence of toxicology is to understand the effects of chemica…
poison
any agent capable of producing an injurious effect or respons…
Toxicology
Escitalopram
Opioid
Tricyclic antidepressant
Benzodiazepine
Escitalopram
Opioid
28 terms
Toxicology
toxicology
poison
toxin
overdose
study of toxic or poisonous substances
substance whose chemical action damages/impairs body structur…
poisonous substance produced by bacteria/animals/plants acts…
PT takes toxic or lethal dose of a substance
toxicology
study of toxic or poisonous substances
poison
substance whose chemical action damages/impairs body structur…
17 terms
toxicology
acetaminophen
benzodiazepine
calcium channel blockers
carbon monoxide
n-acetylcysteine
flumazenil
calcium, vasopressors, high-dose insulin, glucagon (bradycard…
oxygen
acetaminophen
n-acetylcysteine
benzodiazepine
flumazenil
24 terms
Toxicology
FDA
Iscotope
Acetadehyde
Field sobriety test
Food & Drug Adminstration approve or disapprove
Same atom but different neutrons
Product of the breakdown of alcohol
A test to conclude whether or not you're sober
FDA
Food & Drug Adminstration approve or disapprove
Iscotope
Same atom but different neutrons
31 terms
Toxicology
Toxicology
Standardized Sobriety Test
Acute Toxictiy
Nystagmus
The study of adverse effects of chemicals or physical agents
Three different tests during a traffic test to see if someone…
Small dose that can kill you
Rapid involuntary movements of the eyes
Toxicology
The study of adverse effects of chemicals or physical agents
Standardized Sobriety Test
Three different tests during a traffic test to see if someone…
Toxicology
Top 5 agents involved in Drug related…
Risk
Disadvantage of using Therapeutic Index
On-target adverse drug effects
-cocaine... -opioids... -benzodiazepine... -alcohol... -antidepressants
- exposure + Hazard... - Dose determines the response
- Therapeutic index does not take into account the slope of t…
-overdose at the intended tissue
Top 5 agents involved in Drug related…
-cocaine... -opioids... -benzodiazepine... -alcohol... -antidepressants
Risk
- exposure + Hazard... - Dose determines the response
Toxicology
Toxicology
Poison
intoxicant
exposure
the study of poisons and the identification of drugs and othe…
Any substance that when taken in sufficient quantities cause…
requires a large amount
ingestion, inhalation, injection, absportion
Toxicology
the study of poisons and the identification of drugs and othe…
Poison
Any substance that when taken in sufficient quantities cause…
Toxicology
Metabolism
FDA
LD50
Isotope
Breaks down substances
Food and drug administration, approve whether food and drug i…
Amount that would kill 50% of population
Same element with different number of neutrons
Metabolism
Breaks down substances
FDA
Food and drug administration, approve whether food and drug i…
Toxicology
Toxicology
Field sobriety test
Minor impossession (MIP)
Wid Mark curve
The study of toxins pertaining to humans and adverse effects
A battery of 3 tests that determine if a person is not I atte…
A person that is under 21 that has alcohol
Test determining alcohol concentration in the blood
Toxicology
The study of toxins pertaining to humans and adverse effects
Field sobriety test
A battery of 3 tests that determine if a person is not I atte…
Toxicology
Adverse effects
Medical examiner
Drug testing
Olympias
Toxicology is the study of the ________of chemicals or physci…
Who would be most likely to use postmortem forensic toxicology
How would forensic toxicology come into play in the workplace?
Who was the famous Greek poisoner?
Adverse effects
Toxicology is the study of the ________of chemicals or physci…
Medical examiner
Who would be most likely to use postmortem forensic toxicology
9 terms
Toxicology
Acetaminophen
Anticholinergics
Warfarin
Opioid
Acetylcysteine
Physostigmine
Phytonadione
Naloxone
Acetaminophen
Acetylcysteine
Anticholinergics
Physostigmine
Toxicology
What is toxicology?
The changes in a human due to toxic su…
it may occur at various levels
Paracelsus and Orfila were writing that
the study of the adverse effects of chemicals or physical age…
immediate and life threatening to subtle changes that may not…
biochemical... cellular... organism as a whole
specific chemicals actually responsible for the effects... A sys…
What is toxicology?
the study of the adverse effects of chemicals or physical age…
The changes in a human due to toxic su…
immediate and life threatening to subtle changes that may not…
9 terms
Toxicology
acetaminophen
anticholinergics
warfarin
benzo
acetylcysteine
physostigmine
phytonadione (vit K) + fresh frozen plasma
flumazenil - injectible, very short acting
acetaminophen
acetylcysteine
anticholinergics
physostigmine
TOXICOLOGY
Toxicology
Paracelsus
major concept of Toxicology
Toxic agent
The study of the adverse effect of the chemicals or physical…
creator of the scientific of the discipline toxicology
Dose Response Relationship
Anything that can produce an adverse biological effect.
Toxicology
The study of the adverse effect of the chemicals or physical…
Paracelsus
creator of the scientific of the discipline toxicology
Toxicology
Toxicology
Environmental toxicology
Disposition
Absorption
Science of poisons
Scientific knowledge to understand natural and anthropogenic…
Combination of 4 different events aka Absorption ... Distributio…
Ability of compound to enter the blood
Toxicology
Science of poisons
Environmental toxicology
Scientific knowledge to understand natural and anthropogenic…
37 terms
Toxicology
Ciguatera toxin
Scombroid toxicity
Saxitoxin
Pufferfish poisoning
Why Alexander the Great refused to let his troops eat fish. S…
- 1997 case of employees eating blue marlin at the World bank…
- Potent neurotoxin associated with shellfish (mussels, clams…
- Caused by tetrodotoxin... - Supportive care, gastric lavage, c…
Ciguatera toxin
Why Alexander the Great refused to let his troops eat fish. S…
Scombroid toxicity
- 1997 case of employees eating blue marlin at the World bank…
49 terms
toxicology
Managing Poison Emergencies
Assessment
Stabilization
Ocular Exposures
Assessment... Stabilization... Decontamination... Control clinical sig…
-Starts with a thorough case assessment... Should include the f…
Stabilizing the pet is a priority... If the animal is dyspneic…
The eyes should be flushed repeatedly with water or saline so…
Managing Poison Emergencies
Assessment... Stabilization... Decontamination... Control clinical sig…
Assessment
-Starts with a thorough case assessment... Should include the f…
11 terms
Toxicology
Toxicology
Poison
Toxin
Toxicant
study of adverse effects of xenobiotic compounds (toxins or t…
any substance capable of causing a deleterious response in a…
poisons that originate from living organisms (zootoxins from…
Toxic substances, chemicals produced by human-made activities
Toxicology
study of adverse effects of xenobiotic compounds (toxins or t…
Poison
any substance capable of causing a deleterious response in a…
Toxicology
Addiction
Antidote
Delirium Tremens-DTs
Emesis
A state of overwhelming obsession or physical need to continu…
A substance that is used to neutralize or counteract a posion
A severe withdrawal syndrome seen in alcoholics who are depri…
Vomiting
Addiction
A state of overwhelming obsession or physical need to continu…
Antidote
A substance that is used to neutralize or counteract a posion
37 terms
Toxicology
Ciguatera toxin
Scombroid toxicity
Saxitoxin
Pufferfish poisoning
Why Alexander the Great refused to let his troops eat fish. S…
- 1997 case of employees eating blue marline at the World ban…
- Potent neurotoxin associated with shellfish (mussels, clams…
- Caused by tetrodotoxin... - Supportive care, gastric lavage, c…
Ciguatera toxin
Why Alexander the Great refused to let his troops eat fish. S…
Scombroid toxicity
- 1997 case of employees eating blue marline at the World ban…
toxicology
Toxicology
Toxicologic Specimens
Lead Poisoning
lead poisoning signs
Presumptive diagnosis may be made from accurate history and t…
Whole blood, serum, vomitus, gastric lavage fluid, feces, uri…
Air, old lead-based paints, lead shot, linoleum, car batterie…
Clinical signs vary with species and are related chiefly to G…
Toxicology
Presumptive diagnosis may be made from accurate history and t…
Toxicologic Specimens
Whole blood, serum, vomitus, gastric lavage fluid, feces, uri…
79 terms
toxicology
toxicology
dose-response relationship
toxic substances work by
xenobiotic
the study of poisons/ of the adverse chemical and physical ag…
large doses of something that isn't always toxic may be toxic…
causing changes in specific cellular molecules and biochemicals
general term for a foreign substance taken into the body; may…
toxicology
the study of poisons/ of the adverse chemical and physical ag…
dose-response relationship
large doses of something that isn't always toxic may be toxic…
9 terms
Toxicology
Acetaminophen
Benzodiazepines
Carbon monoxide
Digoxin
N-Acetylcysteine
Flumazenil
Oxygen
Digoxin immune Fab
Acetaminophen
N-Acetylcysteine
Benzodiazepines
Flumazenil
51 terms
Toxicology
Toxic exposure
Toxic deaths
Most frequent exposures
MC assoc with death
-49% kids <6 yo... -80% unintentional ... -10% suicide attempts
-79% from intentional poisoning... -72% 20-59 yo
1. analgesics... 2. cosmetics/ personal care... 3. household cleani…
1. sedatives/hypnotics/antipsychotics... 2. cardiovascular drugs…
Toxic exposure
-49% kids <6 yo... -80% unintentional ... -10% suicide attempts
Toxic deaths
-79% from intentional poisoning... -72% 20-59 yo
38 terms
Toxicology
CO
CO
CO
CO
heat generator
binds to hemoglobin (greater affinity), prevents O2 uptake
headache, nausea, vomiting, chest pain, dyspnea, dizziness
removal from source, O2 (hyperbaric)
CO
heat generator
CO
binds to hemoglobin (greater affinity), prevents O2 uptake
15 terms
Toxicology
Anticholinergic toxidrome
Sympathomimetic toxidrome
Differences between Sympathomimetic an…
Opioid(narcotic)/Sedative/Etoh toxidrome
Hyperthermia (hot as a hare), Mydriasis (blind as bat), Dry s…
tachycardia, dysrhythmias, HTN, diaphoresis, goosebumps, AMS…
1. skin (diaphoretic vs dry)... 2. Pupils reaction (reactive vs…
1. Miosis... 2. Resp depression (due to dec. sensitivity of resp…
Anticholinergic toxidrome
Hyperthermia (hot as a hare), Mydriasis (blind as bat), Dry s…
Sympathomimetic toxidrome
tachycardia, dysrhythmias, HTN, diaphoresis, goosebumps, AMS…
54 terms
Toxicology
Toxicology
What are the three factors that modify…
What variables in the host would modif…
What variables in the environment woul…
study of the nature and mechanism of toxic effects on living…
Host, environment, chemical interactions.
Age, sex, race, metabolism, nutritional status
Physical factors such as temperature and pressure, social fac…
Toxicology
study of the nature and mechanism of toxic effects on living…
What are the three factors that modify…
Host, environment, chemical interactions.
28 terms
Toxicology
OUI
DUI
DWI
Field sobriety test
Operating under the influence
Driving under the influence
Driving while intoxicated
Series of three tests that test the impairment of the driver
OUI
Operating under the influence
DUI
Driving under the influence
toxicology
toxicology
toxicology effects
chemical agents
physical agents
the study of poisons or the adverse effects of chemical and p…
home environment current events workplace school government d…
natural or manufactured bacteria plants animals caffeine manu…
temperature damage fish sound damage hearing
toxicology
the study of poisons or the adverse effects of chemical and p…
toxicology effects
home environment current events workplace school government d…
9 terms
Toxicology
ASA
APAP
CCB
Clonidine
toxic dose: 150mg/kg ... toxic salicylate: 100mg/kg... Charcoal, r…
toxic dose:... -<12 yo: >200mg/kg... ->12 yo: >7.5g... Acetylcysteine…
toxic dose: ... -nifedipine: >2.7mg/kg... -verapamil: >12mg/kg... cha…
very small toxic doses... -children: 0.03mg... -adults: 0.25-7mg... w…
ASA
toxic dose: 150mg/kg ... toxic salicylate: 100mg/kg... Charcoal, r…
APAP
toxic dose:... -<12 yo: >200mg/kg... ->12 yo: >7.5g... Acetylcysteine…
35 terms
Toxicology
Drug
Poison
Illicit Drugs
Hallucinagens
natural or synthetic substance designed to affect humans
...
...
...
Drug
natural or synthetic substance designed to affect humans
Poison
...
Toxicology
Toxicology
Chemical associated with fish
Chemical associated with meat
Chemical associated with buns
The study of the effects of chemicals on living organisms
Omega 3 fats (reduce heart disease)
Dioxins
Acrylamide (carcinogen)
Toxicology
The study of the effects of chemicals on living organisms
Chemical associated with fish
Omega 3 fats (reduce heart disease)
14 terms
Toxicology
Activated Charcoal
Polyethylene Glycol
Organophosphate insecticides, methyl p…
Fomepizole
-Non-specific chelator, not effective is drug is rapidly abso…
-Useful if a drug is poorly absorbed by activated charcoal
-Acetylcholinesterase inhibitors. Use 2-Prolodoxime
-ADH inhibitor... -Used to Tx Methanol and Ethylene Glycol pois…
Activated Charcoal
-Non-specific chelator, not effective is drug is rapidly abso…
Polyethylene Glycol
-Useful if a drug is poorly absorbed by activated charcoal
Toxicology
Acetaminophen P
Organophosphates P
Iron salts P
Digoxin P
Acetylcysteine A
Atropine A
Deforoxamine A
Digibind A
Acetaminophen P
Acetylcysteine A
Organophosphates P
Atropine A
Toxicology
Anticholinergic
Anticoagulant
Cyanide
Heavy metals (copper, lead)
Physostigmine
Phytonadione
Hydroxocobalamin (or thiamine sulfate)
Dimercaprol or Penicillamine
Anticholinergic
Physostigmine
Anticoagulant
Phytonadione
Toxicology
analgestic
amphetamine
.02%
mouth
narcotic drug that relieves pain by depressing the central ne…
synthetic drug that stimulates CNS(stimulant)
alcohol wears off at a rate of _____ per hour
pathway of alcohol: 1
analgestic
narcotic drug that relieves pain by depressing the central ne…
amphetamine
synthetic drug that stimulates CNS(stimulant)
25 terms
Toxicology
toxicology
significance of toxicology
birth of toxicology
post WWII
study of adverse effects of chemical, physical, or biological…
needed in order to understand effects of chemicals on organis…
1920's-30's - Copeland Act (1930s) - guaranteed earned wages…
minamata (1953) - mercury poisoning from eating seafood that…
toxicology
study of adverse effects of chemical, physical, or biological…
significance of toxicology
needed in order to understand effects of chemicals on organis…
73 terms
Toxicology
acute exposure
subacute exposure
chronic exposure
examples of zero order elimination
<24 hrs
24 hrs to 3 mos.
>3 mos
alcohol, aspirin
acute exposure
<24 hrs
subacute exposure
24 hrs to 3 mos.
Toxicology
Toxicology
Mechanistic toxicology
Mechanistic toxicology
Descriptive toxicology
Study of poisonous substances, their actions on the living or…
Cellular and biochemical effects of toxin
Investigates metabolic transformation of drugs or potentially…
Study using animal testing for determining the level of expos…
Toxicology
Study of poisonous substances, their actions on the living or…
Mechanistic toxicology
Cellular and biochemical effects of toxin
Toxicology
OTC meds, human rx meds
20-30 minutes
warm water or saline
corneal ulcers
What are the two most common toxicoses according to the ASPCA?
How long should you rinse a patient's eyes if they have been…
What should you use to rinse a patient's eyes if they have co…
When a patient has ocular exposure to a toxin, what should we…
OTC meds, human rx meds
What are the two most common toxicoses according to the ASPCA?
20-30 minutes
How long should you rinse a patient's eyes if they have been…
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