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Study sets matching "toxicology"

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Study sets matching "toxicology"

Toxicology
Toxicology
dose response relationship
Paracelsus
Antagonism
-study of the adverse interactions of a living organisms with…
-fundamental principal of toxicology ... -the dose of a compound…
All substances are poisons, there is none which is not a pois…
- when two chemicals that can produce results where the obser…
Toxicology
-study of the adverse interactions of a living organisms with…
dose response relationship
-fundamental principal of toxicology ... -the dose of a compound…
28 terms
Toxicology
A - airway... B - breathing... C - circulati…
Rapid glucose check &... IV thiamine or I…
B
D. Atropine is an antidote used to com…
List the order for maintenance of vital functions (ABCDE).
If a patient is a known alcoholic or malnourished, how should…
Which of the following should not be used to prevent further…
Which of the following is not used to prevent further absorpt…
A - airway... B - breathing... C - circulati…
List the order for maintenance of vital functions (ABCDE).
Rapid glucose check &... IV thiamine or I…
If a patient is a known alcoholic or malnourished, how should…
11 terms
Toxicology
Asclepias... dried photo
Asclepias signs
Baileya multiradiata... live photo
Baileya multiradiata
Milkweeds
bradycardia... negative chronotrope... positive ionotrope
Aorexia, emaciation, depression ... Rapid pounding heart audible…
Asclepias... dried photo
Milkweeds
Asclepias signs
bradycardia... negative chronotrope... positive ionotrope
118 terms
Toxicology
Acetaminophen
Salicylates
NSAIDs
Opioids
Tox: Hepatotoxicity... Tx: N-acetylcysteine
Tox: Acidosis... Tx: Bicarbonate
Tox: Acidosis... Tx: Bicarbonate, Multidose Activated Charcoal
Tox: Respiratory Depression... Tx: Naloxone
Acetaminophen
Tox: Hepatotoxicity... Tx: N-acetylcysteine
Salicylates
Tox: Acidosis... Tx: Bicarbonate
9 terms
Toxicology
Neurotoxin blocking agents
Neurotoxin depolarizing agents
Neurotoxin depressants
Neurotoxin anti-cholinesrerase agents
Acetylcholine, attopine
DDT
Aromatics, solvents, VOCs, alcohols
Organophosphate and carbamate pesticides
Neurotoxin blocking agents
Acetylcholine, attopine
Neurotoxin depolarizing agents
DDT
118 terms
Toxicology
Acetaminophen
Salicylates
NSAIDs
Opioids
Tox: Hepatotoxicity... Tx: N-acetylcysteine
Tox: Acidosis... Tx: Bicarbonate
Tox: Acidosis... Tx: Bicarbonate, Multidose Activated Charcoal
Tox: Respiratory Depression... Tx: Naloxone
Acetaminophen
Tox: Hepatotoxicity... Tx: N-acetylcysteine
Salicylates
Tox: Acidosis... Tx: Bicarbonate
209 terms
Toxicology
toxicology
toxicant
toxin
toxicity
the knowledge of poisons, including their chemical properties…
another term for POISON; refers to any substance that, when a…
usually reserved for poisons that originate from BIOLOGICAL P…
refers to the amount of poison that, under a set of condition…
toxicology
the knowledge of poisons, including their chemical properties…
toxicant
another term for POISON; refers to any substance that, when a…
272 terms
Toxicology
Toxins causing bradypnea
Toxins causing tachypnea
Toxins causing Tachycardia
Toxins causing bradycardia
Opioids... Clonidine... Sedative-Hypnotics (benzo, barb, GHB)... EtOH/…
Metabolic Acidosis (MUDPILES CAT - esp toxic alcohols, ASA)... S…
Sympathomimetic... Anticholinergic... Methylxanthines... Cholinergics…
ßB... Benzos... Barbiturates... Opioids... CCB... Clonidine... Cholinergics (la…
Toxins causing bradypnea
Opioids... Clonidine... Sedative-Hypnotics (benzo, barb, GHB)... EtOH/…
Toxins causing tachypnea
Metabolic Acidosis (MUDPILES CAT - esp toxic alcohols, ASA)... S…
125 terms
Toxicology
Puffer fish
Bonaventure Orfila
Digoxin
Poison
- deadlier than cyanide... - the toxins in single puffer fish ar…
established toxicology as a discipline, separate from clinica…
Dose-determined poison... Therapeutic level" 0.5-2 ng/ml... Cardi…
any agent that is capable of producing deleterious or harmful…
Puffer fish
- deadlier than cyanide... - the toxins in single puffer fish ar…
Bonaventure Orfila
established toxicology as a discipline, separate from clinica…
13 terms
Toxicology
Escitalopram
Opioid
Tricyclic antidepressant
Benzodiazepine
Escitalopram
Opioid
73 terms
Toxicology
Barbituate
Benzodiazepines
__Poison__
___Hypoxia_______
any class of sedative-hypnotic agents made from barbituric ac…
group of __minor tranquilizers_____, having a common molecula…
any substance that alters the regular biological processes ch…
: no oxygen, cyanosis, gasping for breath
Barbituate
any class of sedative-hypnotic agents made from barbituric ac…
Benzodiazepines
group of __minor tranquilizers_____, having a common molecula…
640 terms
Toxicology
Cocklebur
Cocklebur susceptibilty
Cockelbur
Cocklebur toxicity
Xanthium
swine>>cattle, sheep>horses
Xanthium
cotyledonary stage, seeds
Cocklebur
Xanthium
Cocklebur susceptibilty
swine>>cattle, sheep>horses
258 terms
Toxicology
Incidence of poisonings
Etiologies of poisonings
What is the poison control center # &…
Regulations enacted by the Poison Prev…
2nd leading cause of unintentional death/injury in the US
-Pediatric unintentional ingestions (~50% in children under 6…
1-800-222-1222 or www.illinoispoisoncenter.org (both free)
Child-resistant packaging:... -Significantly difficult for child…
Incidence of poisonings
2nd leading cause of unintentional death/injury in the US
Etiologies of poisonings
-Pediatric unintentional ingestions (~50% in children under 6…
122 terms
Toxicology
Hazard
Risk
Air Pollutants
Air Pollutants: Carbon monoxide
The ability of a chemical to cause injury in a given setting
The expected occurring frequency of an undesirable effect ari…
Carbon monoxide ... Sulfer dioxide ... Nitrogen oxides ... Ozone
Byproduct of incomplete combustion ... Colorless, tasteless, odo…
Hazard
The ability of a chemical to cause injury in a given setting
Risk
The expected occurring frequency of an undesirable effect ari…
18 terms
Toxicology
Controlled Substance
Drug
Narcotic
Poison
a drug or other chemical compound whose manufacture, distribu…
a chemical substance that affects the processes of the mind o…
an addictive drug, such as opium, that relieves pain by supre…
A naturally occurring or manufactured substance that can caus…
Controlled Substance
a drug or other chemical compound whose manufacture, distribu…
Drug
a chemical substance that affects the processes of the mind o…
196 terms
Toxicology
Define LD50 and pros/cons of its use
Define acute vs subacute vs subchronic…
Chronicity factor
Why are cats so sensitive to phenolic…
Ld50 = standardized toxicity test that depends on a quantal (…
acute = single dose or multiple doses during 24 hr period. If…
LD50/90 day LD50... for example warfarin LD50 = 1.6 mg/kg and 90…
Due to limited glucuronyl transferase activity which is neces…
Define LD50 and pros/cons of its use
Ld50 = standardized toxicity test that depends on a quantal (…
Define acute vs subacute vs subchronic…
acute = single dose or multiple doses during 24 hr period. If…
163 terms
Toxicology
Toxicology 1: Introduction and Analges…
Decontamination
Syrup of Ipecac
Charcoal
...
-Majority of overdoses self limited: will get better on the…
DON'T ever give ... -CNS and GI effects—85% efficacy (causes…
CLASS: GI Decontamination... MECHANISM OF ACTION: ... -Decreas…
Toxicology 1: Introduction and Analges…
...
Decontamination
-Majority of overdoses self limited: will get better on the…
22 terms
Toxicology
controlled substance
drug
narcotic
poison
a drug or other chemical compound whose manufacture, distribu…
a chemical substance that affects the processes of the mind o…
an addictive drug, such as opium, that relieves pain, alters…
a naturally occurring or manufactured substance that can caus…
controlled substance
a drug or other chemical compound whose manufacture, distribu…
drug
a chemical substance that affects the processes of the mind o…
100 terms
Toxicology
Toxicology
Toxin
Toxicant
acute toxicity
the study of the adverse effects of chemicals on living organ…
poisionous substance produced within living cells or organisms
poisonous substance created by artificial processes
usually one or very few exposures
Toxicology
the study of the adverse effects of chemicals on living organ…
Toxin
poisionous substance produced within living cells or organisms
60 terms
Toxicology
Difference between toxicant and toxin
Toxicity
Graded vs Quantal response
Therapeutic Ratio
toxicant = poison... toxin (biotoxin) = toxicant that is biologi…
Relative potency of a toxicant-usually toxicants are compared…
Graded = toxic effects increase w/ dose... Quantal = a binary re…
LD50 / ED50 (lethal dose 50%/ effective dose 50%)... Standard Sa…
Difference between toxicant and toxin
toxicant = poison... toxin (biotoxin) = toxicant that is biologi…
Toxicity
Relative potency of a toxicant-usually toxicants are compared…
8 terms
Toxicology
Ketosis without acidosis is the charac…
Characteristic findings of Coral snake…
Pit viper species? Treatment of pit vi…
Arsenic MOA? Arsenic poisoning treatme…
Isopropyl Alcohol ingestion. Serum creatinine may be falsely…
"Red on yellow kill a fellow"... Vs Scarlet King Snake... All pat…
Mocassins, Rattlesnakes, Bushmasters... Observation. If no signs…
Arsenic replaces phosphate in ATP bonds and decreases energy…
Ketosis without acidosis is the charac…
Isopropyl Alcohol ingestion. Serum creatinine may be falsely…
Characteristic findings of Coral snake…
"Red on yellow kill a fellow"... Vs Scarlet King Snake... All pat…
8 terms
Toxicology
Ketosis without acidosis is the charac…
Characteristic findings of Coral snake…
Pit viper species? Treatment of pit vi…
Arsenic MOA? Arsenic poisoning treatme…
Isopropyl Alcohol ingestion. Serum creatinine may be falsely…
"Red on yellow kill a fellow"... Vs Scarlet King Snake... All pat…
Mocassins, Rattlesnakes, Bushmasters... Observation. If no signs…
Arsenic replaces phosphate in ATP bonds and decreases energy…
Ketosis without acidosis is the charac…
Isopropyl Alcohol ingestion. Serum creatinine may be falsely…
Characteristic findings of Coral snake…
"Red on yellow kill a fellow"... Vs Scarlet King Snake... All pat…
42 terms
Toxicology
APAP
general adsorbant
organophosphate and carbamide insectic…
symptomatic bradycardia
N-acetylcysteine
activated charcoal
atropine
atropine
APAP
N-acetylcysteine
general adsorbant
activated charcoal
29 terms
Toxicology
Acute toxicity
Subacute toxicity
Chronic toxicity
gastric lavage: When is it not recomme…
arises from a single or multiple exposure of a agent over 1 t…
occurs from repeated exposures of a agent over a period no lo…
occurs from repeated exposures over a period greater than 3 m…
not recommended after 4 hours;... contraindications for gastric…
Acute toxicity
arises from a single or multiple exposure of a agent over 1 t…
Subacute toxicity
occurs from repeated exposures of a agent over a period no lo…
50 terms
Toxicology
the degree to which a substance is poi…
the toxicity depends on a variety of f…
toxic related to poisonous or deadly e…
any chemical that can cause injury or…
toxicology
- dose ... - duration and route of exposure ... - shape and structu…
- inhalation (breathing) ... - ingestion (eating) ... - absorption…
a toxicant (a poison)
the degree to which a substance is poi…
toxicology
the toxicity depends on a variety of f…
- dose ... - duration and route of exposure ... - shape and structu…
8 terms
Toxicology
controlled substance
drug
narcotic
poison
a drug or other chemical compound whose manufacture, distribu…
a chemical substance that affects the processes of the mind o…
an addictive drug, such as opium, that relieves pain, alters…
a naturally occurring or manufactured substance that can caus…
controlled substance
a drug or other chemical compound whose manufacture, distribu…
drug
a chemical substance that affects the processes of the mind o…
34 terms
Toxicology
toxicology
poison
philippus aureolus theophrastus bombst…
forensic toxicology
science of poisons (toxicants). The study of adverse effects…
-any substance that can produce adverse effects on biological…
all things are poison and nothing is without posion. only the…
-deals with the detection of poisoning from a legal point of…
toxicology
science of poisons (toxicants). The study of adverse effects…
poison
-any substance that can produce adverse effects on biological…
22 terms
Toxicology
Efficacy
Potency
Acute toxicity
Chronic toxicity
ability of a compound to produce a given effect
relative dose of a compound required for a given response
Occurs within minutes-days of exposure. ... Takes only one or a…
Toxic effect takes months or years to manifest. Requires many…
Efficacy
ability of a compound to produce a given effect
Potency
relative dose of a compound required for a given response
118 terms
toxicology
APAP and other hepatotoxins
organophosphates/ nerve agents
lead
iron
N-acetylcysteine
atropine
calcium EDTA
deferoxamine
APAP and other hepatotoxins
N-acetylcysteine
organophosphates/ nerve agents
atropine
72 terms
Toxicology
apomorphine
syrup of ipecac
emesis inducing:
mechanical emesis therapy
emesis inducing
emesis inducing
apomorphine, ipecac... or mechanical ... to remove unabsorbed into…
gastric lavage... apply topical anesthetic, tube into stomach,…
apomorphine
emesis inducing
syrup of ipecac
emesis inducing
218 terms
Toxicology
List 6 signs and 5 causes of the antic…
List 7 signs and 5 causes of the choli…
List 9 signs and 4 causes of the sympa…
List 7 signs and 5 causes of Opioid/et…
Signs... 1. mad... 2. dry... 3. red... 4. blind (mydriasis)... 5. hot... 6. con…
Signs - muscarinic... 1. diarrea... 2. urination... 3. miosis/muscle w…
Signs... 1. delusions... 2. paranoid... 3. tachycardia... 4. HTN... 5. eleva…
signs... 1. coma... 2. resp depression... 3. miosis... 4. hypotension... 5.…
List 6 signs and 5 causes of the antic…
Signs... 1. mad... 2. dry... 3. red... 4. blind (mydriasis)... 5. hot... 6. con…
List 7 signs and 5 causes of the choli…
Signs - muscarinic... 1. diarrea... 2. urination... 3. miosis/muscle w…
67 terms
toxicology
golden goals in toxicology pt
treatment for respiratory depression
therapy to improve circulation
anticholinergic toxidromes
1. stabilization... 2. exposure history... 3. assessment... 4. deconta…
-oxygen... -intubation... -mechanical ventilation
-fluids (a lot)... -vasopressors (NE)... -antiarrhythmics if in arr…
-blind... -hot... -red... -dry... -mad
golden goals in toxicology pt
1. stabilization... 2. exposure history... 3. assessment... 4. deconta…
treatment for respiratory depression
-oxygen... -intubation... -mechanical ventilation
254 terms
toxicology
Chemicals are
Experimentation is essential in observ…
Can anyone think of something right no…
Sometimes only dose distinguishes
the primary toxic agent
responses to chemicals
cancer treatments... ,Chemotherapies, radiation
between harmful and helpful
Chemicals are
the primary toxic agent
Experimentation is essential in observ…
responses to chemicals
80 terms
Toxicology
Management of Metabolic Acidosis:
Calcium channel blocker overdose (hypo…
if cardiovascular contractility is low…
BRM's
Sodium bicarbonate, achieve pH of achieving 7.2 or above
calcium chloride infusion,
glucagon -->positive inotropic agent, raises cAMP in cardiac…
Natalizumab: MS... Gemtuzumab - multiple myeloma and lymphoma…
Management of Metabolic Acidosis:
Sodium bicarbonate, achieve pH of achieving 7.2 or above
Calcium channel blocker overdose (hypo…
calcium chloride infusion,
30 terms
Toxicology
Chemicals in the workplace
Pollutants of the environment
Toxic effects on populations and commu…
Causes hypoxia, psychomotor impairment…
Occupational Toxicology
Environmental Toxicology
Ecotoxicology
Carbon monoxide
Chemicals in the workplace
Occupational Toxicology
Pollutants of the environment
Environmental Toxicology
49 terms
Toxicology
Aspirin Toxicity
Treatment of Aspirin Toxicity
Acetaminophen toxicity
treatment of acetaminophen toxicity
• acid-base disturbances... • Early respiratory alkalosis, follo…
emergency/supportive measures, enhance the elimination of sal…
• Management of Toxicity: N-acetylcysteine is the antidote... o…
N-acetylcysteine
Aspirin Toxicity
• acid-base disturbances... • Early respiratory alkalosis, follo…
Treatment of Aspirin Toxicity
emergency/supportive measures, enhance the elimination of sal…
9 terms
Toxicology
Aspirin
C3 Tox review
Peds tox
Serotonin syndrome
https://www.emrap.org/episode/july2011/aspirintoxicity
https://www.emrap.org/episode/july2011/c3project
https://www.emrap.org/episode/january2011/pediatric... https://…
https://www.emrap.org/episode/february2012/seratonin... https:/…
Aspirin
https://www.emrap.org/episode/july2011/aspirintoxicity
C3 Tox review
https://www.emrap.org/episode/july2011/c3project
33 terms
Toxicology
Pollution
Pollutant
Contamination
Toxicology
Process of degradation, undesirable change
Substance that has a harmful effect
Introduction of undesirable materials/substances
The study of poisons and their effects
Pollution
Process of degradation, undesirable change
Pollutant
Substance that has a harmful effect
49 terms
Toxicology
Aspirin Toxicity
Treatment of Aspirin Toxicity
Acetaminophen toxicity
treatment of acetaminophen toxicity
• acid-base disturbances... • Early respiratory alkalosis, follo…
emergency/supportive measures, enhance the elimination of sal…
• Management of Toxicity: N-acetylcysteine is the antidote... o…
N-acetylcysteine
Aspirin Toxicity
• acid-base disturbances... • Early respiratory alkalosis, follo…
Treatment of Aspirin Toxicity
emergency/supportive measures, enhance the elimination of sal…
40 terms
Toxicology
Risk
Risk Probability
Risk Assessment
Hazard
the chance of being harmed by a hazard
0-1.0
the science of predicting harm to human health
something that has the potential to cause harm
Risk
the chance of being harmed by a hazard
Risk Probability
0-1.0
31 terms
Toxicology
alcohol
Grapefruit
Dibucaine number
Cyp2D6
this substance stops all cytP450 activity when it is present,…
this inhibits cyp3A4 which is responsible for metabolism of c…
________ measures the pseudocholinesterase activity, an enzym…
this CytP450 enzyme clears beta-blockers, anti-arrhythmics, a…
alcohol
this substance stops all cytP450 activity when it is present,…
Grapefruit
this inhibits cyp3A4 which is responsible for metabolism of c…
toxicology
Functional
Chemical
Dispositional:
Carbon Monoxide (CO)
have opposite physiological responses e,g., amphetamines and…
two chemicals react to form a less toxic substance; e.g., dim…
: one substance interferes with absorption, distribution, met…
CO binding to heme Fe is 210 times stronger than O2.... • Air wi…
Functional
have opposite physiological responses e,g., amphetamines and…
Chemical
two chemicals react to form a less toxic substance; e.g., dim…
103 terms
Toxicology
Define toxicity
T/F There is nothing in that cannot be…
Reasons for overdose
Hx taking for overdoses
Ingestion of or exposure to toxic substance or overdose of pr…
True
-Intentional: suicide, homicide, recreational drug abuse... -Uni…
-Substance: dose, time, med hx... -Neuro: dev delay (with hx of…
Define toxicity
Ingestion of or exposure to toxic substance or overdose of pr…
T/F There is nothing in that cannot be…
True
15 terms
Toxicology
Absorption
Caffine
Carcinogenic
Chemical
The process of taking in, as when a sponge takes up water. Ch…
A bitter crystalline alkaloid found in coffee, tea, and kola…
Any substance that may produce cancer.
Any substance having a defined molecular composition.
Absorption
The process of taking in, as when a sponge takes up water. Ch…
Caffine
A bitter crystalline alkaloid found in coffee, tea, and kola…
15 terms
toxicology
delirium tremens
hypnotic
opiate
sedative
a rapid onset of confusion usually caused by withdrawal from…
A sleep-inducing effect or agent
a subset of the opioid family. (natural, non synthetic opioids)
A substance that decreases activity and excitement
delirium tremens
a rapid onset of confusion usually caused by withdrawal from…
hypnotic
A sleep-inducing effect or agent
19 terms
Toxicology
ASPIRIN... ASPIRIN- ACID-BASE ABNORMALITIES
ASPIRIN - MECHANISM OF TOXICITY
ASPIRIN TOXICITY - CAUSES OF METABOLIC…
• Variety of acid-base disturbances can occur with... salicylate…
• Central stimulation of the respiratory center... results in hy…
1. Salicylates inhibit key dehydrogenases in the Krebs... cycle,…
ASPIRIN... ASPIRIN- ACID-BASE ABNORMALITIES
• Variety of acid-base disturbances can occur with... salicylate…
ASPIRIN - MECHANISM OF TOXICITY
• Central stimulation of the respiratory center... results in hy…
13 terms
Toxicology
Microcystis aeruginosa
Cycad (Sago Palm)
Amanita phalloides (deadly amanita, de…
Xanthium strumarium
A cyanobacteria, that colonizes in clusters of small coccoid…
Ornamental in tropical IS... Distribution:... Toxic principle... MOA... S…
...
Cocklebur... Distribution: Throughout US... Toxic principle: Carbox…
Microcystis aeruginosa
A cyanobacteria, that colonizes in clusters of small coccoid…
Cycad (Sago Palm)
Ornamental in tropical IS... Distribution:... Toxic principle... MOA... S…
97 terms
Toxicology
Toxicants-
Toxin-
Fundamental point of toxicology is ....
Questions to ask
man-made products, artificial products introduced into the en…
natural products such as the ones found in poisonous mushroom…
"the dose makes the poison".
What is the current clinical status of the animal... What was th…
Toxicants-
man-made products, artificial products introduced into the en…
Toxin-
natural products such as the ones found in poisonous mushroom…
106 terms
Toxicology
Mercury
Mercury toxicokinetics
Minamata Disease
Copper
Hg; methyl and dimethyl forms; natural but global increases;…
Poorly absorbed as metal; vapor easily absorbed; methylmercur…
Wastewater release of mercury from factory on Japanese island…
Cu; Nutritionally essential; exposure can be environmental an…
Mercury
Hg; methyl and dimethyl forms; natural but global increases;…
Mercury toxicokinetics
Poorly absorbed as metal; vapor easily absorbed; methylmercur…
243 terms
Toxicology
zinc phosphide/phosphide gas is found in
zinc phosphide/phosphide gas MOA
acetylene breath is clinical sign of
what toxin should be treated for in ve…
mole and gopher bait
forms phosphine gas in stomach
zinc phosphide/phosphide gas
zinc phosphide/phosphide gas
zinc phosphide/phosphide gas is found in
mole and gopher bait
zinc phosphide/phosphide gas MOA
forms phosphine gas in stomach
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