Study sets matching "toxicology"

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Study sets matching "toxicology"

Toxicology
Toxicology
dose response relationship
Paracelsus
Antagonism
-study of the adverse interactions of a living organisms with…
-fundamental principal of toxicology ... -the dose of a compound…
All substances are poisons, there is none which is not a pois…
- when two chemicals that can produce results where the obser…
Toxicology
-study of the adverse interactions of a living organisms with…
dose response relationship
-fundamental principal of toxicology ... -the dose of a compound…
Toxicology
A - airway... B - breathing... C - circulati…
Rapid glucose check &... IV thiamine or I…
B
D. Atropine is an antidote used to com…
List the order for maintenance of vital functions (ABCDE).
If a patient is a known alcoholic or malnourished, how should…
Which of the following should not be used to prevent further…
Which of the following is not used to prevent further absorpt…
A - airway... B - breathing... C - circulati…
List the order for maintenance of vital functions (ABCDE).
Rapid glucose check &... IV thiamine or I…
If a patient is a known alcoholic or malnourished, how should…
Toxicology
Toxicology
Toxin
Toxicant
acute toxicity
the study of the adverse effects of chemicals on living organ…
poisionous substance produced within living cells or organisms
poisonous substance created by artificial processes
usually one or very few exposures
Toxicology
the study of the adverse effects of chemicals on living organ…
Toxin
poisionous substance produced within living cells or organisms
11 terms
Toxicology
Asclepias... dried photo
Asclepias signs
Baileya multiradiata... live photo
Baileya multiradiata
Milkweeds
bradycardia... negative chronotrope... positive ionotrope
Aorexia, emaciation, depression ... Rapid pounding heart audible…
Asclepias... dried photo
Milkweeds
Asclepias signs
bradycardia... negative chronotrope... positive ionotrope
9 terms
Toxicology
Neurotoxin blocking agents
Neurotoxin depolarizing agents
Neurotoxin depressants
Neurotoxin anti-cholinesrerase agents
Acetylcholine, attopine
DDT
Aromatics, solvents, VOCs, alcohols
Organophosphate and carbamate pesticides
Neurotoxin blocking agents
Acetylcholine, attopine
Neurotoxin depolarizing agents
DDT
Toxicology
Acute toxicity
Subacute toxicity
Chronic toxicity
gastric lavage: When is it not recomme…
arises from a single or multiple exposure of a agent over 1 t…
occurs from repeated exposures of a agent over a period no lo…
occurs from repeated exposures over a period greater than 3 m…
not recommended after 4 hours;... contraindications for gastric…
Acute toxicity
arises from a single or multiple exposure of a agent over 1 t…
Subacute toxicity
occurs from repeated exposures of a agent over a period no lo…
42 terms
Toxicology
APAP
general adsorbant
organophosphate and carbamide insectic…
symptomatic bradycardia
N-acetylcysteine
activated charcoal
atropine
atropine
APAP
N-acetylcysteine
general adsorbant
activated charcoal
118 terms
Toxicology
Acetaminophen
Salicylates
NSAIDs
Opioids
Tox: Hepatotoxicity... Tx: N-acetylcysteine
Tox: Acidosis... Tx: Bicarbonate
Tox: Acidosis... Tx: Bicarbonate, Multidose Activated Charcoal
Tox: Respiratory Depression... Tx: Naloxone
Acetaminophen
Tox: Hepatotoxicity... Tx: N-acetylcysteine
Salicylates
Tox: Acidosis... Tx: Bicarbonate
209 terms
Toxicology
toxicology
toxicant
toxin
toxicity
the knowledge of poisons, including their chemical properties…
another term for POISON; refers to any substance that, when a…
usually reserved for poisons that originate from BIOLOGICAL P…
refers to the amount of poison that, under a set of condition…
toxicology
the knowledge of poisons, including their chemical properties…
toxicant
another term for POISON; refers to any substance that, when a…
97 terms
Toxicology
Toxins causing bradypnea
Toxins causing tachypnea
Toxins causing Tachycardia
Toxins causing bradycardia
Opioids... Clonidine... Sedative-Hypnotics (benzo, barb, GHB)... EtOH/…
Metabolic Acidosis (MUDPILES CAT - esp toxic alcohols, ASA)... S…
Sympathomimetic... Anticholinergic... Methylxanthines... Cholinergics…
ßB... Benzos... Barbiturates... Opioids... CCB... Clonidine... Cholinergics (la…
Toxins causing bradypnea
Opioids... Clonidine... Sedative-Hypnotics (benzo, barb, GHB)... EtOH/…
Toxins causing tachypnea
Metabolic Acidosis (MUDPILES CAT - esp toxic alcohols, ASA)... S…
Toxicology
Aspirin Toxicity
Treatment of Aspirin Toxicity
Acetaminophen toxicity
treatment of acetaminophen toxicity
• acid-base disturbances... • Early respiratory alkalosis, follo…
emergency/supportive measures, enhance the elimination of sal…
• Management of Toxicity: N-acetylcysteine is the antidote... o…
N-acetylcysteine
Aspirin Toxicity
• acid-base disturbances... • Early respiratory alkalosis, follo…
Treatment of Aspirin Toxicity
emergency/supportive measures, enhance the elimination of sal…
118 terms
Toxicology
Acetaminophen
Salicylates
NSAIDs
Opioids
Tox: Hepatotoxicity... Tx: N-acetylcysteine
Tox: Acidosis... Tx: Bicarbonate
Tox: Acidosis... Tx: Bicarbonate, Multidose Activated Charcoal
Tox: Respiratory Depression... Tx: Naloxone
Acetaminophen
Tox: Hepatotoxicity... Tx: N-acetylcysteine
Salicylates
Tox: Acidosis... Tx: Bicarbonate
125 terms
Toxicology
Puffer fish
Bonaventure Orfila
Digoxin
Poison
- deadlier than cyanide... - the toxins in single puffer fish ar…
established toxicology as a discipline, separate from clinica…
Dose-determined poison... Therapeutic level" 0.5-2 ng/ml... Cardi…
any agent that is capable of producing deleterious or harmful…
Puffer fish
- deadlier than cyanide... - the toxins in single puffer fish ar…
Bonaventure Orfila
established toxicology as a discipline, separate from clinica…
640 terms
Toxicology
Cocklebur
Cocklebur susceptibilty
Cockelbur
Cocklebur toxicity
Xanthium
swine>>cattle, sheep>horses
Xanthium
cotyledonary stage, seeds
Cocklebur
Xanthium
Cocklebur susceptibilty
swine>>cattle, sheep>horses
258 terms
Toxicology
Incidence of poisonings
Etiologies of poisonings
What is the poison control center # &…
Regulations enacted by the Poison Prev…
2nd leading cause of unintentional death/injury in the US
-Pediatric unintentional ingestions (~50% in children under 6…
1-800-222-1222 or www.illinoispoisoncenter.org (both free)
Child-resistant packaging:... -Significantly difficult for child…
Incidence of poisonings
2nd leading cause of unintentional death/injury in the US
Etiologies of poisonings
-Pediatric unintentional ingestions (~50% in children under 6…
163 terms
Toxicology
Toxicology 1: Introduction and Analges…
Decontamination
Syrup of Ipecac
Charcoal
...
-Majority of overdoses self limited: will get better on the…
DON'T ever give ... -CNS and GI effects—85% efficacy (causes…
CLASS: GI Decontamination... MECHANISM OF ACTION: ... -Decreas…
Toxicology 1: Introduction and Analges…
...
Decontamination
-Majority of overdoses self limited: will get better on the…
258 terms
Toxicology
Incidence of poisonings
Etiologies of poisonings
What is the poison control center # &…
Regulations enacted by the Poison Prev…
2nd leading cause of unintentional death/injury in the US
-Pediatric unintentional ingestions (~50% in children under 6…
1-800-222-1222 or www.illinoispoisoncenter.org (both free)
Child-resistant packaging:... -Significantly difficult for child…
Incidence of poisonings
2nd leading cause of unintentional death/injury in the US
Etiologies of poisonings
-Pediatric unintentional ingestions (~50% in children under 6…
196 terms
Toxicology
Define LD50 and pros/cons of its use
Define acute vs subacute vs subchronic…
Chronicity factor
Why are cats so sensitive to phenolic…
Ld50 = standardized toxicity test that depends on a quantal (…
acute = single dose or multiple doses during 24 hr period. If…
LD50/90 day LD50... for example warfarin LD50 = 1.6 mg/kg and 90…
Due to limited glucuronyl transferase activity which is neces…
Define LD50 and pros/cons of its use
Ld50 = standardized toxicity test that depends on a quantal (…
Define acute vs subacute vs subchronic…
acute = single dose or multiple doses during 24 hr period. If…
18 terms
Toxicology
Controlled Substance
Drug
Narcotic
Poison
a drug or other chemical compound whose manufacture, distribu…
a chemical substance that affects the processes of the mind o…
an addictive drug, such as opium, that relieves pain by supre…
A naturally occurring or manufactured substance that can caus…
Controlled Substance
a drug or other chemical compound whose manufacture, distribu…
Drug
a chemical substance that affects the processes of the mind o…
22 terms
Toxicology
controlled substance
drug
narcotic
poison
a drug or other chemical compound whose manufacture, distribu…
a chemical substance that affects the processes of the mind o…
an addictive drug, such as opium, that relieves pain, alters…
a naturally occurring or manufactured substance that can caus…
controlled substance
a drug or other chemical compound whose manufacture, distribu…
drug
a chemical substance that affects the processes of the mind o…
Toxicology
Ketosis without acidosis is the charac…
Characteristic findings of Coral snake…
Pit viper species? Treatment of pit vi…
Arsenic MOA? Arsenic poisoning treatme…
Isopropyl Alcohol ingestion. Serum creatinine may be falsely…
"Red on yellow kill a fellow"... Vs Scarlet King Snake... All pat…
Mocassins, Rattlesnakes, Bushmasters... Observation. If no signs…
Arsenic replaces phosphate in ATP bonds and decreases energy…
Ketosis without acidosis is the charac…
Isopropyl Alcohol ingestion. Serum creatinine may be falsely…
Characteristic findings of Coral snake…
"Red on yellow kill a fellow"... Vs Scarlet King Snake... All pat…
73 terms
Toxicology
Barbituate
Benzodiazepines
__Poison__
___Hypoxia_______
any class of sedative-hypnotic agents made from barbituric ac…
group of __minor tranquilizers_____, having a common molecula…
any substance that alters the regular biological processes ch…
: no oxygen, cyanosis, gasping for breath
Barbituate
any class of sedative-hypnotic agents made from barbituric ac…
Benzodiazepines
group of __minor tranquilizers_____, having a common molecula…
118 terms
toxicology
APAP and other hepatotoxins
organophosphates/ nerve agents
lead
iron
N-acetylcysteine
atropine
calcium EDTA
deferoxamine
APAP and other hepatotoxins
N-acetylcysteine
organophosphates/ nerve agents
atropine
15 terms
Toxicology
Hepatotoxicant
Nephrotoxicant
Neurotoxicants
Immunotoxicants
Causes damage to liver - Acetaminophen, ethyl alcohol
Causes damage to kidneys - Cadmium, mercury
Damage to the nervous system - Lead
Damage to the immune system - Toluene
Hepatotoxicant
Causes damage to liver - Acetaminophen, ethyl alcohol
Nephrotoxicant
Causes damage to kidneys - Cadmium, mercury
toxicology
mutagenesis
no
gene level mutations, mutations in the…
point mutation, chromosomal aberration…
types of mutations
are all types of mutations bad
what are the three broad types of mutations
what are the three diff types of gene level mutations
mutagenesis
types of mutations
no
are all types of mutations bad
Toxicology
toxicology
Mechanistic Toxicology
Descriptive Toxicology
Regulatory Toxicology
study of the adverse effects of chemicals on living organism
Identifies the cellular, biochemical, and molecular mechanism…
Toxicity tests in experimental animals are designed to yield…
Determines whether a drug or another chemical poses a suffici…
toxicology
study of the adverse effects of chemicals on living organism
Mechanistic Toxicology
Identifies the cellular, biochemical, and molecular mechanism…
30 terms
Toxicology
toxicology
toxicant (poison)
toxicity
hazard
study or knowledge of toxicants (poisons) including their che…
any solid, liquid, gas, or energy, which when introduced into…
amount of a toxicant which under specified conditions will re…
1. likelihood that a toxicant will produce a disease state ... 2…
toxicology
study or knowledge of toxicants (poisons) including their che…
toxicant (poison)
any solid, liquid, gas, or energy, which when introduced into…
22 terms
Toxicology
Acetone or fruity (diabetic/ketoacidos…
Bitter almond
Carrots
Garlic
Acetone or isopropyl alcohol
Cyanide
Hemlock
Arsenic... Organophosphates... Selinium... Thallium
Acetone or fruity (diabetic/ketoacidos…
Acetone or isopropyl alcohol
Bitter almond
Cyanide
Toxicology
Areas of Toxicology
Factors Affecting Toxicology
Toxicology
Poison
Forensic, Clinical, Environmentental, and Toxicogenetics/geno…
Route of Exposure, Duration of exposure (chronic or acute), F…
The science of poisons (toxicants). The study of adverse effe…
Any substance that can produce adverse effects on biological…
Areas of Toxicology
Forensic, Clinical, Environmentental, and Toxicogenetics/geno…
Factors Affecting Toxicology
Route of Exposure, Duration of exposure (chronic or acute), F…
Toxicology
Ketosis without acidosis is the charac…
Characteristic findings of Coral snake…
Pit viper species? Treatment of pit vi…
Arsenic MOA? Arsenic poisoning treatme…
Isopropyl Alcohol ingestion. Serum creatinine may be falsely…
"Red on yellow kill a fellow"... Vs Scarlet King Snake... All pat…
Mocassins, Rattlesnakes, Bushmasters... Observation. If no signs…
Arsenic replaces phosphate in ATP bonds and decreases energy…
Ketosis without acidosis is the charac…
Isopropyl Alcohol ingestion. Serum creatinine may be falsely…
Characteristic findings of Coral snake…
"Red on yellow kill a fellow"... Vs Scarlet King Snake... All pat…
90 terms
Toxicology
Definition of toxicology
Areas of toxicology
Effects of heliborin (hemlock toxin)
Difference between coniine and heliborin
Study of the harmful effects of chemical or physical agents o…
Experimental (regulatory)... Environmental ... Clinical ... Industrial…
Targets Na/K pump, stops the heart beating
Both from hemlock but coniine has similar actions to nicotine
Definition of toxicology
Study of the harmful effects of chemical or physical agents o…
Areas of toxicology
Experimental (regulatory)... Environmental ... Clinical ... Industrial…
28 terms
Toxicology
Common Toxins
First step in any anti-toxins
Management: Step one
Absorbants and Cathartics: Toxiban a…
- Chocolate... - Raisins... - Lillie's... - Yeast Dough... - ibuprofen... -…
Assess and stabilize patient... Get Vitals... - TPR... - MM... - CRT…
Decontamination... - for most toxicities that have been recent…
- (bloody) diarrhea... - Careful with administering if animal is…
Common Toxins
- Chocolate... - Raisins... - Lillie's... - Yeast Dough... - ibuprofen... -…
First step in any anti-toxins
Assess and stabilize patient... Get Vitals... - TPR... - MM... - CRT…
56 terms
Toxicology
caustic substances
cannot vommit
3% Hydrogen Peroxide
Apomorphine
Do not induce vommiting with ingestion of _______ substances…
Rodents... Rabbits... Horses... Ruminants... Avian... Reptiles... what do all…
used to induce vomitting in DOGS only... -GI irritation... -1ml/lb,…
Centrally acting emetic... -Mediated through dopamine receptors…
caustic substances
Do not induce vommiting with ingestion of _______ substances…
cannot vommit
Rodents... Rabbits... Horses... Ruminants... Avian... Reptiles... what do all…
141 terms
Toxicology
Toxicology
Poison
The dose
Forensic toxicology
The science of poisons (toxicants). The study of adverse effe…
Any substance that can produce adverse effects on biological…
What determines that a substance is not a poison?
This area of toxicology deals with the detection of poisoning…
Toxicology
The science of poisons (toxicants). The study of adverse effe…
Poison
Any substance that can produce adverse effects on biological…
Toxicology
LADME
Half-Life
Zero order kinetics
First order kinetics
liberation, absorption, distribution, metabolism, elimination
time required to reduce a drug level to 1/2 its original valu…
Constant amount of drug is eliminated per unit of time; indep…
Excrete drug based on what's there; dependent on plasma conce…
LADME
liberation, absorption, distribution, metabolism, elimination
Half-Life
time required to reduce a drug level to 1/2 its original valu…
25 terms
Toxicology
Carbon Monoxide
Sulfur Oxide
Ozone
Particulate Matter
Mechanism... a) Adheres to hemoglobin 240x more strongly than…
Colorless irritant gas, generated by combustion of fossil ful…
Bluish irritant gas generated from oxidation of hydrocarbons…
Variety of dust of different sizes and composition... *Pneumoco…
Carbon Monoxide
Mechanism... a) Adheres to hemoglobin 240x more strongly than…
Sulfur Oxide
Colorless irritant gas, generated by combustion of fossil ful…
103 terms
Toxicology
Top 5 substances involved in poison ex…
Top 3 categories with largest deaths N…
Top agent for acute LD50
Characteristics of excposure to Toxica…
Analgesics... Cleaning substances... Cosmetics... Foreign bodies... Sedat…
Analgesics... Sedatives/antipsychotics... Antidepressants
eTHYL ALCOHOL
Is present at a site -in a sufficient conc AND... -for a suffic…
Top 5 substances involved in poison ex…
Analgesics... Cleaning substances... Cosmetics... Foreign bodies... Sedat…
Top 3 categories with largest deaths N…
Analgesics... Sedatives/antipsychotics... Antidepressants
Toxicology
Poison
Intentional poisoning
Drug intoxication
Screening the patient
Any substance which can cause damage or death to a living org…
Poisoning one's self or others with the intent to harm
Using a dose that is more than what is required
Obtaining patient information
Poison
Any substance which can cause damage or death to a living org…
Intentional poisoning
Poisoning one's self or others with the intent to harm
Toxicology
Disability Adjusted Life Year
Risk assessment
Risk management
Non- transmittable disease
Combines premature deaths and loss of healthy life resulting…
1. ID potential hazard... 2. Probability of occurrence... 3. Determ…
1. How serious?... 2. Can it be reduced?... 3. How can it be reduce…
Not caused by living organisms and does not spread from perso…
Disability Adjusted Life Year
Combines premature deaths and loss of healthy life resulting…
Risk assessment
1. ID potential hazard... 2. Probability of occurrence... 3. Determ…
151 terms
Toxicology
How many cases are malicious poisonings?
What is a toxicant?
What is toxicology?
What is an antidote?
1-2%
Something synthetic, neutral, or other poison that causes a t…
Study concerned with ID, treatment, and assessment of poisons
Any substance that prevents/relieves the effect of a toxicant
How many cases are malicious poisonings?
1-2%
What is a toxicant?
Something synthetic, neutral, or other poison that causes a t…
23 terms
Toxicology
parts per million (ppm)
parts per billion (ppb)
parts per trillion (ppt)
toxicology
...
...
...
the study of harmful effects of chemicals on humans and other…
parts per million (ppm)
...
parts per billion (ppb)
...
59 terms
Toxicology
Activated Charcoal
Ingestion
Absorbtion
Injection
A substance used to absorb toxins by chemically binding to it…
The entrance of a substance into the body through the GI tract
The entrance of a substance into the body directly through th…
The entrance of a substance into the body through a break in…
Activated Charcoal
A substance used to absorb toxins by chemically binding to it…
Ingestion
The entrance of a substance into the body through the GI tract
5 terms
TOXICOLOGY
HORSES ... dopaminiergic effect ... can't ch…
cebtaurea ( yellow star thristlem russ…
High mountain disease ... BRISKET DISEASE…
Mare reproductive loss syndrom
Centaurea spp.(Yellow star thistle, Russian knapweed)
Nigropallidal Encephalomalacia
LOCOweed makes cows high
eastern tent caterpillar and wild cherry tress can cause what…
HORSES ... dopaminiergic effect ... can't ch…
Centaurea spp.(Yellow star thistle, Russian knapweed)
cebtaurea ( yellow star thristlem russ…
Nigropallidal Encephalomalacia
272 terms
Toxicology
Who is the father of toxicology
Toxicant
Toxicology
Xenobiotic
Paracelsus
a compound that causes toxicity . May be natural or man-made
concerned with identification, treatment, and assessing risks…
foreign substance
Who is the father of toxicology
Paracelsus
Toxicant
a compound that causes toxicity . May be natural or man-made
14 terms
Toxicology
Describe the pharmacokinetic parameter…
Toxicodynamics is...
Toxicokinetics is...
Syrup of Ipecac
1. Concretion or sedimentation might slow rate and extent of…
The effect of toxins on the body (i.e. mechanism of action)
The movement of toxins in the body. How the "body effects the…
Induces vomiting. Only agent approved in US for induction of…
Describe the pharmacokinetic parameter…
1. Concretion or sedimentation might slow rate and extent of…
Toxicodynamics is...
The effect of toxins on the body (i.e. mechanism of action)
28 terms
Toxicology
acute
chronic
lethal dose
lethal concentration
short term
long term
will kill from one time dose
concentration in the air/water that kills organisms
acute
short term
chronic
long term
56 terms
Toxicology
Heroin... Category
Heroin
Ecstasy ... Category
Ecstasy
Narcotic
Derived from opium... (schedule1)... -High risk of overdose because…
Stimulant and Hallucinogen
-Synthetic "party drug" made in clandestine labs. Distorts pe…
Heroin... Category
Narcotic
Heroin
Derived from opium... (schedule1)... -High risk of overdose because…
17 terms
Toxicology
Anticholinergic Toxidrome
Etiology of Anticholinergic
Physostigmine
Cholinergic Toxidrome
Hot as a pistol (hyperthermia), red as a beet (vasodilation),…
Antihistamine, anticholinergics, antipsychotics, antidepressa…
AchE antagonist. Increased cleavage of ACh at junction. Used…
Increases PANS activity. Use organophosphates, carbamates, la…
Anticholinergic Toxidrome
Hot as a pistol (hyperthermia), red as a beet (vasodilation),…
Etiology of Anticholinergic
Antihistamine, anticholinergics, antipsychotics, antidepressa…
toxicology
poison
toxicology
suicide
homicide
cause damage or death
study of poisons
using drugs/household/industrial chemicals to kill yourself
used as a weapon
poison
cause damage or death
toxicology
study of poisons
toxicology
General Topics
POST-MORTEM... General Considerations
TYPES OF SPECIMENS
ANALYTES
Post-mortem toxicology... Forensic drug testing... Human Performanc…
ME/Coroner... AFIP... Scene Evidence... Homicides... Accidents... Presumed n…
Blood... Central ... Peripheral... Vitreous humor... Urine... Bile/Liver... Gas…
Gases... Volatiles... Drugs... Metals/anions... Pesticides... Other
General Topics
Post-mortem toxicology... Forensic drug testing... Human Performanc…
POST-MORTEM... General Considerations
ME/Coroner... AFIP... Scene Evidence... Homicides... Accidents... Presumed n…
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